Plasmodium falciparum population dynamics during the early phase of anti-malarial drug treatment in Tanzanian children with acute uncomplicated malaria

Malaria Journal

Volumn 10, Issue , 2011, Pages

  Carlsson, Anja M ^a   Ngasala, Billy E ^a,b   Dahlström, Sabina ^a   Membi, Christopher ^c   Veiga, Isabel M ^a,d   Rombo, Lars ^a,e   Abdulla, Salim ^c   Premji, Zul ^b   Gil, J Pedro ^a,d,f,g   Björkman, Anders ^a   Mårtensson, Andreas ^a,g,h  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b MUHIMBILI UNIVERSITY OF HEALTH AND ALLIED SCIENCES   (Tanzania)

^c IFAKARA HEALTH INSTITUTE   (Tanzania)

^d UNIVERSITY OF ALGARVE   (Portugal)

^e Sormland County Council   (Sweden)

^f BINGHAMTON UNIVERSITY   (United States)

^g KAROLINSKA INSTITUTE   (Sweden)

^h Kullbergska Hospital   (Sweden)

Author keywords

Anti malarial drug trials; Artemether lumefantrine; Malaria; Parasite population dynamics; PCR; Plasmodium falciparum

Indexed keywords

ARTEMETHER; ARTEMISININ; BENFLUMETOL; MEROZOITE SURFACE PROTEIN 1; MEROZOITE SURFACE PROTEIN 2; MOLECULAR MARKER; PARACETAMOL; ANTIMALARIAL AGENT; ARTEMETHER PLUS BENFLUMETOL; ARTEMISININ DERIVATIVE; ETHANOLAMINE DERIVATIVE; FLUORENE DERIVATIVE; MEROZOITE SURFACE PROTEIN 2, PLASMODIUM; PARASITE ANTIGEN; PROTOZOAL PROTEIN;

ARTICLE; BLOOD SAMPLING; BODY WEIGHT; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE TRANSMISSION; FEMALE; GENE IDENTIFICATION; GENOTYPE; HUMAN; INFANT; MALARIA FALCIPARUM; MALE; POLYMERASE CHAIN REACTION; POPULATION DYNAMICS; PREMEDICATION; PRESCHOOL CHILD; SCHOOL CHILD; TANZANIA; TREATMENT DURATION; CLINICAL TRIAL; DRUG COMBINATION; DRUG EFFECT; GENETIC MARKER; GENETIC VARIABILITY; GENETICS; GENOTYPING TECHNIQUE; ISOLATION AND PURIFICATION; PARASITOLOGY; PHASE 4 CLINICAL TRIAL; PLASMODIUM FALCIPARUM; TIME; TREATMENT OUTCOME;

ANTIGENS, PROTOZOAN; ANTIMALARIALS; ARTEMISININS; BODY WEIGHT; CHILD; CHILD, PRESCHOOL; DRUG COMBINATIONS; ETHANOLAMINES; FEMALE; FLUORENES; GENETIC MARKERS; GENETIC VARIATION; GENOTYPE; GENOTYPING TECHNIQUES; HUMANS; INFANT; MALARIA, FALCIPARUM; MALE; MEROZOITE SURFACE PROTEIN 1; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; PROTOZOAN PROTEINS; TANZANIA; TIME FACTORS; TREATMENT OUTCOME;

EID: 83655183190     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-10-380     Document Type: Article

References (19)

1. World Health Organization, Guidelines for the treatment of malaria Geneva: WHO 2 2010
2. MfM Venture, World Health Organization, Methods and techniques for clinical trials on antimalarial drug efficacy: genotyping to identify parasite populations Informal consultation organized by the MMV and cosponsored by the WHO 29-31 May 2007 Amsterdam 2008
3. The use of PCR genotyping in the assessment of recrudescence or reinfection after antimalarial drug treatment. G Snounou, HP Beck, Parasitol Today 1998 14 462 467 10.1016/S0169-4758(98)01340-4 17040849 (Pubitemid 28539852)
4. The perils of PCR: can we accurately 'correct' antimalarial trials? JJ Juliano, N Gadalla, CJ Sutherland, SR Meshnick, Trends Parasitol 2010 26 119 124 10.1016/j.pt.2009.12.007 20083436
5. World Health Organization, Assessment and monitoring of antimalarial drug efficacy for the treatment of uncomplicated falciparum malaria Geneva 2003
6. Daily dynamics of Plasmodium falciparum subpopulations in asymptomatic children in a holoendemic area. A Farnert, G Snounou, I Rooth, A Bjorkman, Am J Trop Med Hyg 1997 56 538 547 9180605 (Pubitemid 27230077)
7. Plasmodium falciparum genotype population dynamics in asymptomatic children from Senegal. S Jafari-Guemouri, C Boudin, N Fievet, P Ndiaye, P Deloron, Microbes Infect 2006 8 1663 1670 10.1016/j.micinf.2006.01.023 16730211 (Pubitemid 44144561)
8. Short report: Limited advantage of multiple consecutive samples for genotyping Plasmodium falciparum populations during the first days of treatment. A Farnert, A Bjorkman, Am J Trop Med Hyg 2005 73 204 206 16014859 (Pubitemid 41278773)
9. Plasmodium falciparum clonal population dynamics during malaria treatment. S Jafari, J Le, O Bouchaud, R Durand, J Infect Dis 2004 189 195 203 10.1086/380910 14722883 (Pubitemid 38147242)
10. No change in parasite genotype during single episodes of Plasmodium falciparum malaria in Gabonese children. MA Missinou, JFJ Kun, PG Kremsner, Parasitol Res 2004 93 322 327 15185144 (Pubitemid 39044234)
11. Influence of consecutive-day blood sampling on polymerase chain reaction-adjusted parasitological cure rates in an antimalarial-drug trial conducted in Tanzania. A Martensson, B Ngasala, J Ursing, MI Veiga, L Wiklund, C Membi, SM Montgomery, Z Premji, A Farnert, A Bjorkman, J Infect Dis 2007 195 597 601 10.1086/510910 17230421 (Pubitemid 46214404)
12. U.S National Institute of Health Clinical Trial register. http://www.Clinicaltrials.gov
13. Population Pharmacokinetics and pharmacodynamics of artemether and lumefantrine during combination treatment in children with uncomplicated falciparum malaria in Tanzania. SF Hietala, A Martensson, B Ngasala, S Dahlstrom, N Lindegardh, A Annerberg, Z Premji, A Farnert, P Gil, A Bjorkman, M Ashton, Antimicrob Agents Chemother 2010 54 4780 4788 10.1128/AAC.00252-10 20713675
14. Diversity of the sarco/endoplasmic reticulum Ca2+-ATPase orthologue of Plasmodium falciparum (PfATP6). S Dahlstrom, MI Veiga, P Ferreira, A Martensson, A Kaneko, B Andersson, A Bjorkman, JP Gil, Infection Genetics and Evolution 2008 8 340 345 10.1016/j.meegid.2008.02.002
15. Genotyping of Plasmodium falciparum infections by PCR: a comparative multicentre study. A Farnert, AP Arez, HA Babiker, HP Beck, A Benito, A Bjorkman, MC Bruce, DJ Conway, KP Day, L Henning, O Mercereau-Puijalon, LC Ranford-Cartwright, JM Rubio, G Snounou, D Walliker, J Zwetyenga, VE do Rosario, Trans R Soc Trop Med Hyg 2001 95 225 232 10.1016/S0035-9203(01)90175-0 11355566 (Pubitemid 34947393)
16. Distinguishing recrudescence from reinfection in a longitudinal antimalarial drug efficacy study: comparison of results based on genotyping of msp-1, msp-2, and glurp. A Cattamanchi, D Kyabayinze, A Hubbard, PJ Rosenthal, G Dorsey, Am J Trop Med Hyg 2003 68 133 139 12641400 (Pubitemid 38240534)
17. Biased distribution of msp1 and msp2 allelic variants in Plasmodium falciparum populations in Thailand. G Snounou, XP Zhu, N Siripoon, W Jarra, S Thaithong, KN Brown, S Viriyakosol, Trans R Soc Trop Med Hyg 1999 93 369 374 10.1016/S0035-9203(99)90120-7 10674079 (Pubitemid 29405860)
18. Short report: Rapid DNA extraction from archive blood spots on filter paper for genotyping of Plasmodium falciparum. S Bereczky, A Martensson, JP Gil, A Farnert, Am J Trop Med Hyg 2005 72 249 251 15772315 (Pubitemid 41278870)
19. Optimization and validation of multi-coloured capillary electrophoresis for genotyping of Plasmodium falciparum merozoite surface proteins (msp1 and 2). A Liljander, L Wiklund, N Falk, M Kweku, A Martensson, I Felger, A Farnert, Malar J 2009 8 78 10.1186/1475-2875-8-78 19386138