메뉴 건너뛰기




Volumn 141, Issue , 2014, Pages 71-76

Dihydrotestosterone deteriorates cardiac insulin signaling and glucose transport in the rat model of polycystic ovary syndrome

Author keywords

Dihydrotestosterone; Glucose transporters; Heart; Insulin signaling pathway; Polycystic ovary syndrome

Indexed keywords

DIHYDROTESTOSTERONE; GLUCOSE TRANSPORTERS; HEART; INSULIN SIGNALING PATHWAY; POLYCYSTIC OVARY SYNDROME;

EID: 84893964210     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2014.01.006     Document Type: Article
Times cited : (14)

References (45)
  • 1
    • 84878110506 scopus 로고    scopus 로고
    • Longterm management of polycystic ovarian syndrome (PCOS)
    • G.W. Bates, and R.S. Legro Longterm management of polycystic ovarian syndrome (PCOS) Mol. Cell. Endocrinol. 373 2013 91 97
    • (2013) Mol. Cell. Endocrinol. , vol.373 , pp. 91-97
    • Bates, G.W.1    Legro, R.S.2
  • 2
    • 59349098805 scopus 로고    scopus 로고
    • The androgen excess and PCOS society criteria for the polycystic ovary syndrome: The complete task force report
    • R. Azziz, E. Carmina, and D. Dewailly et al. The androgen excess and PCOS society criteria for the polycystic ovary syndrome: the complete task force report Fertil. Steril. 91 2009 456 488
    • (2009) Fertil. Steril. , vol.91 , pp. 456-488
    • Azziz, R.1    Carmina, E.2    Dewailly, D.3
  • 3
    • 0031753605 scopus 로고    scopus 로고
    • How possible is the prevention of polycystic ovary syndrome development in adolescent patients with early onset of hyperandrogenism
    • D. Apter How possible is the prevention of polycystic ovary syndrome development in adolescent patients with early onset of hyperandrogenism J. Endocrinol. Invest. 21 1998 613 617 (Pubitemid 28532468)
    • (1998) Journal of Endocrinological Investigation , vol.21 , Issue.9 , pp. 613-617
    • Apter, D.1
  • 4
    • 0036034768 scopus 로고    scopus 로고
    • Adult polycystic ovary syndrome begins in childhood
    • S. Franks Adult polycystic ovary syndrome begins in childhood Best Pract. Res. Clin. Endocrinol. Metab. 16 2002 263 272
    • (2002) Best Pract. Res. Clin. Endocrinol. Metab. , vol.16 , pp. 263-272
    • Franks, S.1
  • 5
    • 78751697857 scopus 로고    scopus 로고
    • Age of onset of polycystic ovarian syndrome in girls may be earlier than previously thought
    • J. Bronstein, S. Tawdekar, and Y. Liu et al. Age of onset of polycystic ovarian syndrome in girls may be earlier than previously thought J. Pediatr. Adolesc. Gynecol. 24 2011 15 20
    • (2011) J. Pediatr. Adolesc. Gynecol. , vol.24 , pp. 15-20
    • Bronstein, J.1    Tawdekar, S.2    Liu, Y.3
  • 9
    • 84870986039 scopus 로고    scopus 로고
    • Insulin resistance and the polycystic ovary syndrome revisited: An update on mechanisms and implications
    • E. Diamanti-Kandarakis, and A. Dunaif Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications Endocr. Rev. 33 2012 981 1030
    • (2012) Endocr. Rev. , vol.33 , pp. 981-1030
    • Diamanti-Kandarakis, E.1    Dunaif, A.2
  • 11
    • 42749094854 scopus 로고    scopus 로고
    • Insulin signaling pathways and cardiac growth
    • B.J. DeBosch, and A.J. Muslin Insulin signaling pathways and cardiac growth J. Mol. Cell. Cardiol. 44 2008 855 864
    • (2008) J. Mol. Cell. Cardiol. , vol.44 , pp. 855-864
    • Debosch, B.J.1    Muslin, A.J.2
  • 13
    • 33746220070 scopus 로고    scopus 로고
    • Molecular mechanisms of insulin resistance in polycystic ovary syndrome
    • DOI 10.1016/j.molmed.2006.05.006, PII S1471491406001134
    • E. Diamanti-Kandarakis, and A.G. Papavassiliou Molecular mechanisms of insulin resistance in polycystic ovary syndrome Trends Mol. Med. 12 2006 324 332 (Pubitemid 44094292)
    • (2006) Trends in Molecular Medicine , vol.12 , Issue.7 , pp. 324-332
    • Diamanti-Kandarakis, E.1    Papavassiliou, A.G.2
  • 14
    • 63049114314 scopus 로고    scopus 로고
    • The effects of insulin sensitizers on the cardiovascular risk factors in women with polycystic ovary syndrome
    • E. Kassi, and E. Diamanti-Kandarakis The effects of insulin sensitizers on the cardiovascular risk factors in women with polycystic ovary syndrome J. Endocrinol. Invest. 31 2008 1124 1131
    • (2008) J. Endocrinol. Invest. , vol.31 , pp. 1124-1131
    • Kassi, E.1    Diamanti-Kandarakis, E.2
  • 15
    • 17444385941 scopus 로고    scopus 로고
    • Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling
    • A. Corbould, Y.B. Kim, and J.F. Youngren et al. Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling Am. J. Physiol. Endocrinol. Metab. 288 2005 E1047 E1054
    • (2005) Am. J. Physiol. Endocrinol. Metab. , vol.288
    • Corbould, A.1    Kim, Y.B.2    Youngren, J.F.3
  • 16
    • 0034891885 scopus 로고    scopus 로고
    • Defects in insulin receptor signaling in vivo in the polycystic ovary syndrome (PCOS)
    • A. Dunaif, X. Wu, and A. Lee et al. Defects in insulin receptor signaling in vivo in the polycystic ovary syndrome (PCOS) Am. J. Physiol. Endocrinol. Metab. 281 2001 E392 E399
    • (2001) Am. J. Physiol. Endocrinol. Metab. , vol.281
    • Dunaif, A.1    Wu, X.2    Lee, A.3
  • 17
    • 40749119800 scopus 로고    scopus 로고
    • Impaired insulin-stimulated phosphorylation of Akt and AS160 in skeletal muscle of women with polycystic ovary syndrome is reversed by pioglitazone treatment
    • K. Hojlund, D. Glintborg, and N.R. Andersen et al. Impaired insulin-stimulated phosphorylation of Akt and AS160 in skeletal muscle of women with polycystic ovary syndrome is reversed by pioglitazone treatment Diabetes 57 2008 357 366
    • (2008) Diabetes , vol.57 , pp. 357-366
    • Hojlund, K.1    Glintborg, D.2    Andersen, N.R.3
  • 18
    • 33644779914 scopus 로고    scopus 로고
    • Enhanced mitogenic signaling in skeletal muscle of women with polycystic ovary syndrome
    • A. Corbould, H. Zhao, and S. Mirzoeva et al. Enhanced mitogenic signaling in skeletal muscle of women with polycystic ovary syndrome Diabetes 55 2006 751 759 (Pubitemid 43343232)
    • (2006) Diabetes , vol.55 , Issue.3 , pp. 751-759
    • Corbould, A.1    Zhao, H.2    Mirzoeva, S.3    Aird, F.4    Dunaif, A.5
  • 19
    • 62149138077 scopus 로고    scopus 로고
    • Insulin resistance in polycystic ovary syndrome is associated with defective regulation of ERK1/2 by insulin in skeletal muscle in vivo
    • M. Rajkhowa, S. Brett, and D.J. Cuthbertson et al. Insulin resistance in polycystic ovary syndrome is associated with defective regulation of ERK1/2 by insulin in skeletal muscle in vivo Biochem. J. 418 2009 665 671
    • (2009) Biochem. J. , vol.418 , pp. 665-671
    • Rajkhowa, M.1    Brett, S.2    Cuthbertson, D.J.3
  • 20
    • 58149383818 scopus 로고    scopus 로고
    • Polycystic ovary syndrome is associated with tissue-specific differences in insulin resistance
    • T.P. Ciaraldi, V. Aroda, and S. Mudaliar et al. Polycystic ovary syndrome is associated with tissue-specific differences in insulin resistance J. Clin. Endocrinol. Metab. 94 2009 157 163
    • (2009) J. Clin. Endocrinol. Metab. , vol.94 , pp. 157-163
    • Ciaraldi, T.P.1    Aroda, V.2    Mudaliar, S.3
  • 21
    • 4644301532 scopus 로고    scopus 로고
    • Tyrosine phosphorylation and protein expression of insulin receptor substrate-1 in the patients with polycystic ovary syndrome
    • Y.L. Chu, Y.Y. Sun, and H.Y. Qiu et al. [Tyrosine phosphorylation and protein expression of insulin receptor substrate-1 in the patients with polycystic ovary syndrome] Zhonghua Fu Chan Ke Za Zhi 39 2004 176 179
    • (2004) Zhonghua Fu Chan Ke Za Zhi , vol.39 , pp. 176-179
    • Chu, Y.L.1    Sun, Y.Y.2    Qiu, H.Y.3
  • 22
    • 0027450302 scopus 로고
    • Insulin resistance in polycystic ovary syndrome: Decreased expression of GLUT-4 glucose transporters in adipocytes
    • D. Rosenbaum, R.S. Haber, and A. Dunaif Insulin resistance in polycystic ovary syndrome: decreased expression of GLUT-4 glucose transporters in adipocytes Am. J. Physiol. 264 1993 E197 E202
    • (1993) Am. J. Physiol. , vol.264
    • Rosenbaum, D.1    Haber, R.S.2    Dunaif, A.3
  • 23
    • 34147180940 scopus 로고    scopus 로고
    • The adipose cell lineage is not intrinsically insulin resistant in polycystic ovary syndrome
    • DOI 10.1016/j.metabol.2006.12.021, PII S0026049507000467
    • A. Corbould, and A. Dunaif The adipose cell lineage is not intrinsically insulin resistant in polycystic ovary syndrome Metabolism 56 2007 716 722 (Pubitemid 46574736)
    • (2007) Metabolism: Clinical and Experimental , vol.56 , Issue.5 , pp. 716-722
    • Corbould, A.1    Dunaif, A.2
  • 25
    • 0035787357 scopus 로고    scopus 로고
    • Insulin resistance in polycystic ovary syndrome: Progress and paradoxes
    • A.M. Venkatesan, A. Dunaif, and A. Corbould Insulin resistance in polycystic ovary syndrome: progress and paradoxes Recent Prog. Horm. Res. 56 2001 295 308
    • (2001) Recent Prog. Horm. Res. , vol.56 , pp. 295-308
    • Venkatesan, A.M.1    Dunaif, A.2    Corbould, A.3
  • 26
    • 77958142112 scopus 로고    scopus 로고
    • Levels of Rabs and WAVE family proteins associated with translocation of GLUT4 to the cell surface in endometria from hyperinsulinemic PCOS women
    • C. Rosas, F. Gabler, and D. Vantman et al. Levels of Rabs and WAVE family proteins associated with translocation of GLUT4 to the cell surface in endometria from hyperinsulinemic PCOS women Hum. Reprod. 25 2010 2870 2877
    • (2010) Hum. Reprod. , vol.25 , pp. 2870-2877
    • Rosas, C.1    Gabler, F.2    Vantman, D.3
  • 27
    • 77649099574 scopus 로고    scopus 로고
    • Changes in the expression of insulin signaling pathway molecules in endometria from polycystic ovary syndrome women with or without hyperinsulinemia
    • R. Fornes, P. Ormazabal, and C. Rosas et al. Changes in the expression of insulin signaling pathway molecules in endometria from polycystic ovary syndrome women with or without hyperinsulinemia Mol. Med. 16 2010 129 136
    • (2010) Mol. Med. , vol.16 , pp. 129-136
    • Fornes, R.1    Ormazabal, P.2    Rosas, C.3
  • 28
    • 59249091114 scopus 로고    scopus 로고
    • Effect of testosterone on insulin stimulated IRS1 ser phosphorylation in primary rat myotubes - A potential model for PCOS-related insulin resistance
    • M.C. Allemand, B.A. Irving, and Y.W. Asmann et al. Effect of testosterone on insulin stimulated IRS1 Ser phosphorylation in primary rat myotubes - a potential model for PCOS-related insulin resistance PLoS One 4 2009 e4274
    • (2009) PLoS One , vol.4 , pp. 4274
    • Allemand, M.C.1    Irving, B.A.2    Asmann, Y.W.3
  • 29
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man
    • DOI 10.1007/BF00280883
    • D.R. Matthews, J.P. Hosker, and A.S. Rudenski et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man Diabetologia 28 1985 412 419 (Pubitemid 15018832)
    • (1985) Diabetologia , vol.28 , Issue.7 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3
  • 30
    • 0001558285 scopus 로고
    • The colorimetric micro-determination of non-esterified fatty acids in plasma
    • W.G. Duncombe The colorimetric micro-determination of non-esterified fatty acids in plasma Clin. Chim. Acta 9 1964 122 125
    • (1964) Clin. Chim. Acta , vol.9 , pp. 122-125
    • Duncombe, W.G.1
  • 31
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • U.K. Laemmli Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 227 1970 680 685
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 32
    • 0036787393 scopus 로고    scopus 로고
    • Insulin stimulates long-chain fatty acid utilization by rat cardiac myocytes through cellular redistribution of FAT/CD36
    • J.J. Luiken, D.P. Koonen, and J. Willems et al. Insulin stimulates long-chain fatty acid utilization by rat cardiac myocytes through cellular redistribution of FAT/CD36 Diabetes 51 2002 3113 3119
    • (2002) Diabetes , vol.51 , pp. 3113-3119
    • Luiken, J.J.1    Koonen, D.P.2    Willems, J.3
  • 33
    • 0029119085 scopus 로고
    • Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome
    • A. Dunaif, J. Xia, and C.B. Book et al. Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome J. Clin. Invest. 96 1995 801 810
    • (1995) J. Clin. Invest. , vol.96 , pp. 801-810
    • Dunaif, A.1    Xia, J.2    Book, C.B.3
  • 34
    • 0036738335 scopus 로고    scopus 로고
    • Decreased insulin receptor (IR) autophosphorylation in fibroblasts from patients with PCOS: Effects of serine kinase inhibitors and IR activators
    • M. Li, J.F. Youngren, and A. Dunaif et al. Decreased insulin receptor (IR) autophosphorylation in fibroblasts from patients with PCOS: effects of serine kinase inhibitors and IR activators J. Clin. Endocrinol. Metab. 87 2002 4088 4093
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 4088-4093
    • Li, M.1    Youngren, J.F.2    Dunaif, A.3
  • 35
    • 14544271905 scopus 로고    scopus 로고
    • Positive and negative regulation of insulin signaling through IRS-1 phosphorylation
    • DOI 10.1016/j.biochi.2004.10.019
    • P. Gual, Y. Le Marchand-Brustel, and J.F. Tanti Positive and negative regulation of insulin signaling through IRS-1 phosphorylation Biochimie 87 2005 99 109 (Pubitemid 40298772)
    • (2005) Biochimie , vol.87 , Issue.1 , pp. 99-109
    • Gual, P.1    Le Marchand-Brustel, Y.2    Tanti, J.-F.3
  • 36
    • 33646449520 scopus 로고    scopus 로고
    • Akt1 is required for physiological cardiac growth
    • B. DeBosch, I. Treskov, and T.S. Lupu et al. Akt1 is required for physiological cardiac growth Circulation 113 2006 2097 2104
    • (2006) Circulation , vol.113 , pp. 2097-2104
    • Debosch, B.1    Treskov, I.2    Lupu, T.S.3
  • 37
    • 79953742344 scopus 로고    scopus 로고
    • Akt2: A critical regulator of cardiomyocyte survival and metabolism
    • A.J. Muslin Akt2: a critical regulator of cardiomyocyte survival and metabolism Pediatr. Cardiol. 32 2011 317 322
    • (2011) Pediatr. Cardiol. , vol.32 , pp. 317-322
    • Muslin, A.J.1
  • 38
    • 85047687699 scopus 로고    scopus 로고
    • MiRNA-93 inhibits GLUT4 and is overexpressed in adipose tissue of polycystic ovary syndrome patients and women with insulin resistance
    • Y.H. Chen, S. Heneidi, and J.M. Lee et al. miRNA-93 inhibits GLUT4 and is overexpressed in adipose tissue of polycystic ovary syndrome patients and women with insulin resistance Diabetes 62 2013 2278 2286
    • (2013) Diabetes , vol.62 , pp. 2278-2286
    • Chen, Y.H.1    Heneidi, S.2    Lee, J.M.3
  • 39
    • 84875064627 scopus 로고    scopus 로고
    • Regulation and dysregulation of glucose transport in cardiomyocytes
    • C. Montessuit, and R. Lerch Regulation and dysregulation of glucose transport in cardiomyocytes Biochim. Biophys. Acta 1833 2013 848 856
    • (2013) Biochim. Biophys. Acta , vol.1833 , pp. 848-856
    • Montessuit, C.1    Lerch, R.2
  • 40
    • 34248664707 scopus 로고    scopus 로고
    • Cardiac substrate uptake and metabolism in obesity and type-2 diabetes: Role of sarcolemmal substrate transporters
    • DOI 10.1007/s11010-005-9030-5, Cellular Lipid Binding Proteins
    • S.L. Coort, A. Bonen, and G.J. van der Vusse et al. Cardiac substrate uptake and metabolism in obesity and type-2 diabetes: role of sarcolemmal substrate transporters Mol. Cell. Biochem. 299 2007 5 18 (Pubitemid 46767533)
    • (2007) Molecular and Cellular Biochemistry , vol.299 , Issue.1-2 , pp. 5-18
    • Coort, S.L.M.1    Bonen, A.2    Van Der Vusse, G.J.3    Glatz, J.F.C.4    Luiken, J.J.F.P.5
  • 41
    • 70349248415 scopus 로고    scopus 로고
    • Testosterone induces cardiomyocyte hypertrophy through mammalian target of rapamycin complex 1 pathway
    • F. Altamirano, C. Oyarce, and P. Silva et al. Testosterone induces cardiomyocyte hypertrophy through mammalian target of rapamycin complex 1 pathway J. Endocrinol. 202 2009 299 307
    • (2009) J. Endocrinol. , vol.202 , pp. 299-307
    • Altamirano, F.1    Oyarce, C.2    Silva, P.3
  • 42
    • 84882976310 scopus 로고    scopus 로고
    • Testosterone increases GLUT4-dependent glucose uptake in cardiomyocytes
    • C. Wilson, A. Contreras-Ferrat, and N. Venegas et al. Testosterone increases GLUT4-dependent glucose uptake in cardiomyocytes J. Cell. Physiol. 228 2013 2399 2407
    • (2013) J. Cell. Physiol. , vol.228 , pp. 2399-2407
    • Wilson, C.1    Contreras-Ferrat, A.2    Venegas, N.3
  • 43
    • 44949152536 scopus 로고    scopus 로고
    • Impact of metformin and rosiglitazone treatment on glucose transporter 4 mRNA expression in women with polycystic ovary syndrome
    • DOI 10.1530/EJE-07-0857
    • M. Jensterle, A. Janez, and B. Mlinar et al. Impact of metformin and rosiglitazone treatment on glucose transporter 4 mRNA expression in women with polycystic ovary syndrome Eur. J. Endocrinol. 158 2008 793 801 (Pubitemid 351837367)
    • (2008) European Journal of Endocrinology , vol.158 , Issue.6 , pp. 793-801
    • Jensterle, M.1    Janez, A.2    Mlinar, B.3    Marc, J.4    Prezelj, J.5    Pfeifer, M.6
  • 44
    • 60549110421 scopus 로고    scopus 로고
    • Expression, distribution and regulation of sex steroid hormone receptors in mouse heart
    • E. Lizotte, S.A. Grandy, and A. Tremblay et al. Expression, distribution and regulation of sex steroid hormone receptors in mouse heart Cell. Physiol. Biochem. 23 2009 75 86
    • (2009) Cell. Physiol. Biochem. , vol.23 , pp. 75-86
    • Lizotte, E.1    Grandy, S.A.2    Tremblay, A.3
  • 45
    • 2442581295 scopus 로고    scopus 로고
    • Testosterone regulates mRNA levels of calcium regulatory proteins in cardiac myocytes
    • DOI 10.1055/s-2004-814445
    • K.L. Golden, J.D. Marsh, and Y. Jiang Testosterone regulates mRNA levels of calcium regulatory proteins in cardiac myocytes Horm. Metab. Res. 36 2004 197 202 (Pubitemid 38626405)
    • (2004) Hormone and Metabolic Research , vol.36 , Issue.4 , pp. 197-202
    • Golden, K.L.1    Marsh, J.D.2    Jiang, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.