Improved storage stability and immunogenicity of hepatitis B vaccine after spray-freeze drying in presence of sugars

European Journal of Pharmaceutical Sciences

Volumn 55, Issue 1, 2014, Pages 36-45

  Tonnis, W F ^a   Amorij, J P ^b   Vreeman, M A ^a   Frijlink, H W ^a   Kersten, G F ^b,c   Hinrichs, W L J ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b Institute for Translational Vaccinology   (Netherlands)

^c LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Dextran; Hepatitis B surface antigen; Inulin; Powder formulation; Stabilization; Trehalose

Indexed keywords

DEXTRAN; HEPATITIS B SURFACE ANTIGEN; INULIN; POWDER FORMULATION; STABILIZATION; TREHALOSE;

ADJUVANTS, IMMUNOLOGIC; ALUMINUM HYDROXIDE; ANIMALS; CARBOHYDRATES; CHEMISTRY, PHARMACEUTICAL; DEXTRANS; DRUG STABILITY; DRUG STORAGE; FEMALE; FREEZE DRYING; HEPATITIS B ANTIBODIES; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VACCINES; INJECTIONS, INTRAMUSCULAR; INULIN; MICE; MICE, INBRED BALB C; POWDERS; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; TH1 CELLS; TH2 CELLS; TIME FACTORS; TREHALOSE;

EID: 84893963900     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2014.01.005     Document Type: Article

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