Measurement of thrombin generation intra-operatively and its association with bleeding tendency after cardiac surgery

Thrombosis Research

Volumn 133, Issue 3, 2014, Pages 488-494

  Bosch, Yvonne P J ^a   Al Dieri, Raed ^a   Ten Cate, Hugo ^a   Nelemans, Patty J ^a   Bloemen, Saartje ^a   De Laat, Bas ^a   Hemker, Coenraad ^a   Weerwind, Patrick W ^a   Maessen, Jos G ^a   Mochtar, Baheramsjah ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

blood loss; cardiopulmonary bypass; heparinization; monitoring of haemostasis; thrombin generation

Indexed keywords

ANTICOAGULANT AGENT; HEPARIN; THROMBIN;

AGED; BIOSYNTHESIS; BLOOD; BLOOD COAGULATION DISORDERS; CARDIOPULMONARY BYPASS; HEART SURGERY; HUMAN; MALE; PEROPERATIVE CARE; POSTOPERATIVE HEMORRHAGE; PROCEDURES;

AGED; ANTICOAGULANTS; BLOOD COAGULATION DISORDERS; CARDIAC SURGICAL PROCEDURES; CARDIOPULMONARY BYPASS; HEPARIN; HUMANS; INTRAOPERATIVE CARE; MALE; POSTOPERATIVE HEMORRHAGE; THROMBIN;

EID: 84893940061     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2013.12.017     Document Type: Article

References (40)

1. W.L. Chandler, and T. Velan Estimating the rate of thrombin and fibrin generation in vivo during cardiopulmonary bypass Blood 101 2003 4355 4362
2. B.J. Hunt, R.N. Parratt, H.C. Segal, S. Sheikh, P. Kallis, and M. Yacoub Activation of coagulation and fibrinolysis during cardiothoracic operations Ann Thorac Surg 65 1998 712 718
3. R.C. Woodman, and L.A. Harker Bleeding complications associated with cardiopulmonary bypass Blood 76 1990 1680 1697
4. J.F. Hardy, and P. De Moerloose Samama M; Groupe d'intérêt en Hémostase Périopératoire. Massive transfusion and coagulopathy: pathophysiology and implications for clinical management Can J Anaesth 51 2004 293 310
5. F. De Somer, Y. Van Belleghem, F. Caes, K. Francois, H. Van Overbeke, and J. Arnout et al. Tissue factor as the main activator of the coagulation system during cardiopulmonary bypass J Thorac Cardiovasc Surg 123 2002 951 958
6. G. Despotis, M. Avidan, and C. Eby Prediction and management of bleeding in cardiac surgery J Thromb Haemost 7 Suppl. 1 2009 111 117
7. H.C. Hemker, P.L. Giesen, M. Ramjee, R. Wagenvoord, and S. Beguin The thrombogram: monitoring thrombin generation in platelet-rich plasma Thromb Haemost 83 2000 589 591
8. G.J. Despotis, A.L. Summerfield, J.H. Joist, L.T. Goodnough, S.A. Santoro, and E. Spitznagel et al. Comparison of activated coagulation time and whole blood heparin measurements with laboratory plasma anti-Xa heparin concentration in patients having cardiac operations J Thorac Cardiovasc Surg 108 1994 1076 1082
9. M. Coakley, J.E. Hall, C. Evans, E. Duff, V. Billing, and L. Yang et al. Assessment of thrombin generation measured before and after cardiopulmonary bypass surgery and its association with postoperative bleeding J Thromb Haemost 9 2011 282 292
10. R. Al Dieri, B. De Laat, and H.C. Hemker Thrombin generation: what have we learned? Blood Rev 26 2012 197 203
11. C. Solomon, N. Rahe-Meyer, and B. Sorensen Fibrin formation is more impaired than thrombin generation and platelets immediately following cardiac surgery Thromb Res 128 2011 277 282
12. H.C. Hemker, and S. Beguin Phenotyping the clotting system Thromb Haemost 84 2000 747 751
13. M. Adams Assessment of thrombin generation: useful or hype? Semin Thromb Hemost 35 2009 104 110
14. T. Baglin Unraveling the thrombophilia paradox: from hypercoagulability to the prothrombotic state J Thromb Haemost 8 2010 228 233
15. J.J. van Veen, A. Gatt, and M. Makris Thrombin generation testing in routine clinical practice: are we there yet? Br J Haematol 142 2008 889 903
16. Y.P.J. Bosch, R. Al Dieri, H. Ten Cate, P.J. Nelemans, S. Bloemen, and H.C. Hemker et al. Preoperative thrombin generation is predictive for the risk of blood loss after cardiac surgery: a research article J Cardiothorac Surg 8 2013 154
17. H.C. Hemker, P. Giesen, R. Al Dieri, V. Regnault, E. De Smedt, and R. Wagenvoord et al. Calibrated automated thrombin generation measurement in clotting plasma Pathophysiol Haemost Thromb 33 2003 4 15
18. D.H. Bevan Cardiac bypass haemostasis: putting blood through the mill Br J Haematol 104 1999 208 219
19. S. Bloemen, H.C. Hemker, and Dieri R. Al Large inter-individual variation of the pharmacodynamic effect of anticoagulant drugs on thrombin generation Haematologica 98 2013 549 554
20. S. Robert, J. Ghiotto, B. Pirotte, J.L. David, B. Masereel, and L. Pochet et al. Is thrombin generation the new rapid, reliable and relevant pharmacological tool for the development of anticoagulant drugs? Pharmacol Res 59 2009 160 166
21. R. Al Dieri, S. Alban, S. Beguin, and H.C. Hemker Thrombin generation for the control of heparin treatment, comparison with the activated partial thromboplastin time J Thromb Haemost 2 2004 1395 1401
22. P.M. Sandset, U. Abildgaard, and M.L. Larsen Heparin induces release of extrinsic coagulation pathway inhibitor (EPI) Thromb Res 50 1988 803 813
23. M. Koestenberger, G. Cvirn, B. Nagel, A. Rosenkranz, B. Leschnik, and A. Gamillscheg et al. Thrombin generation determined by calibrated automated thrombography (CAT) in pediatric patients with congenital heart disease Thromb Res 122 2008 13 19
24. E. De Smed, R. Wagenvoord, and H.C. Hemker The technique of measuring thrombin generation with fluorogenic substrates: 3. The effects of sample dilution Thromb Haemost 101 2009 165 170
25. M.J. Adams, R.A. Cardigan, W.A. Marchant, M.P. Grocott, M.G. Mythen, and M. Mutch et al. Tissue factor pathway inhibitor antigen and activity in 96 patients receiving heparin for cardiopulmonary bypass J Cardiothorac Vasc Anesth 16 2002 59 63
26. B.S. Donahu, D. Gailani, and A.E. Mast Disposition of tissue factor pathway inhibitor during cardiopulmonary bypass J Thromb Haemost 4 2006 1011 1016
27. T. Fischer, H. Kuppe, and A. Koster Impact of heparin management on release of tissue factor pathway inhibitor during cardiopulmonary bypass Anesthesiology 100 2004 1040
28. L.B. Sun, J. Utoh, C. Kunitomo, S. Tsurusaki, S. Tagami, and H. Hirata et al. Altered plasma antigen levels of tissue factor pathway inhibitor during open-heart surgery Surg Today 30 2000 122 126
29. K. Karkouti, S.A. McCluskey, S. Syed, C. Pazaratz, H. Poonawala, and M.A. Crowther The influence of perioperative coagulation status on postoperative blood loss in complex cardiac surgery: a prospective observational study Anesth Analg 110 2010 1533 1540
30. A. Koster, G. Despotis, M. Gruendel, T. Fischer, M. Praus, and H. Kuppe et al. The plasma supplemented modified activated clotting time for monitoring of heparinization during cardiopulmonary bypass: a pilot investigation Anesth Analg 95 2002 26 30
31. S. Kitchen, R. Iampietro, A.M. Woolley, and F.E. Preston Anti Xa monitoring during treatment with low molecular weight heparin or danaparoid: inter-assay variability Thromb Haemost 82 1999 1289 1293
32. S. Kitchen, J. Theaker, and F.E. Preston Monitoring unfractionated heparin therapy: relationship between eight anti-Xa assays and a protamine titration assay Blood Coagul Fibrinolysis 11 2000 137 144
33. M.J. Kovacs, M. Keeney, K. Mackinnon, and E. Boyle Three different chromogenic methods do not give equivalent anti-Xa levels for patients on therapeutic low molecular weight heparin (dalteparin) or unfractionated heparin Clin Lab Haematol 21 1999 55 60
34. M. Greaves, and Control of Anticoagulation Subcommittee of the Scientific and Standardization Committee of the International Society of Thrombosis and Haemostasis Limitations of the laboratory monitoring of heparin therapy. Scientific and Standardization Committee Communications: on behalf of the Control of Anticoagulation Subcommittee of the Scientific and Standardization Committee of the International Society of Thrombosis and Haemostasis Thromb Haemost 87 2002 163 164
35. G.J. Despotis, G. Gravlee, K. Filos, and J. Levy Anticoagulation monitoring during cardiac surgery: a review of current and emerging techniques Anesthesiology 91 1999 1122 1151
36. A.T. Culliford, S.N. Gitel, N. Starr, S.T. Thomas, F.G. Baumann, and S. Wessler et al. Lack of correlation between activated clotting time and plasma heparin during cardiopulmonary bypass Ann Surg 193 1981 105 111
37. J.W. Eikelboom, and J. Hirsh Monitoring unfractionated heparin with the aPTT: time for a fresh look Thromb Haemost 96 2006 547 552
38. J. Hirsh, T.E. Warkentin, S.G. Shaughnessy, S.S. Anand, J.L. Halperin, and R. Raschke et al. Heparin and low-molecular-weight heparin: mechanisms of action, pharmacokinetics, dosing, monitoring, efficacy, and safety Chest 119 1 Suppl. 2001 64S 94S
39. S.J. Davidson, J.F. Burman, S.M. Philips, S.J. Onis, A.A. Kelleher, and A.C. De Souza et al. Correlation between thrombin potential and bleeding after cardiac surgery in adults Blood Coagul Fibrinolysis 14 2003 175 179
40. H.C. Hemker, R. Al Dieri, and S. Beguin Thrombin generation assays: accruing clinical relevance Curr Opin Hematol 11 2004 170 175