Preoperative thrombin generation is predictive for the risk of blood loss after cardiac surgery: A research article

Journal of Cardiothoracic Surgery

Volumn 8, Issue 1, 2013, Pages

  Bosch, Yvonne ^a   Al Dieri, Raed ^b   ten Cate, Hugo ^b   Nelemans, Patty ^b   Bloemen, Saartje ^b   Hemker, Coenraad ^b   Weerwind, Patrick ^a   Maessen, Jos ^a   Mochtar, Baheramsjah ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Bleeding; Blood (anti)coagulation; Blood loss; CABG; CPB; Thrombin generation

Indexed keywords

THROMBIN;

AGED; ARTICLE; BLOOD CLOTTING TEST; CARDIOPULMONARY BYPASS; CHI SQUARE DISTRIBUTION; CORONARY ARTERY BYPASS GRAFT; HUMAN; MALE; METABOLISM; MIDDLE AGED; OPERATIVE BLOOD LOSS; PREDICTIVE VALUE; PREOPERATIVE PERIOD; RECEIVER OPERATING CHARACTERISTIC; RISK FACTOR; STATISTICAL MODEL; THROMBOCYTE COUNT; THROMBOCYTE RICH PLASMA;

AGED; BLOOD COAGULATION TESTS; BLOOD LOSS, SURGICAL; CARDIOPULMONARY BYPASS; CHI-SQUARE DISTRIBUTION; CORONARY ARTERY BYPASS; HUMANS; LINEAR MODELS; MALE; MIDDLE AGED; PLATELET COUNT; PLATELET-RICH PLASMA; PREDICTIVE VALUE OF TESTS; PREOPERATIVE PERIOD; RISK FACTORS; ROC CURVE; THROMBIN;

EID: 84878816308     PISSN: None     EISSN: 17498090     Source Type: Journal    
DOI: 10.1186/1749-8090-8-154     Document Type: Article

References (23)

1. Groenenberg I, Weerwind PW, Everts PAM, Maessen JG. Dutch perfusion incident survey. Perfusion 2010, 25:329-336. 10.1177/0267659110377678, 20630919.
2. Coakley M, Hall JE, Evans C, Duff E, Billing V, Yang L, McPherson D, Stephens E, Macartney N, Wilkes AR, Collins PW. Assessment of thrombin generation measured before and after cardiopulmonary bypass surgery and its association with postoperative bleeding. J Thromb Haemost 2011, 9:282-292. 10.1111/j.1538-7836.2010.04146.x, 21091865.
3. Innerhofer P, Kienast J. Principles of perioperative coagulopathy. Best Pract Res Clin Anaesthesiol 2010, 24:1-14.
4. Luddington RJ. Thrombelastography/thromboelastometry. Clin Lab Haematol 2005, 27:81-90. 10.1111/j.1365-2257.2005.00681.x, 15784122.
5. Reinhofer M, Brauer M, Franke U, Barz D, Marx G, Losche W. The value of rotation thromboelastometry to monitor disturbed perioperative haemostasis and bleeding risk in patients with cardiopulmonary bypass. Blood Coagul Fibrinolysis 2008, 19:212-219. 10.1097/MBC.0b013e3282f3f9d4, 18388501.
6. Hemker HC, Giesen P, Al Dieri R, Regnault V, De Smedt E, Wagenvoord R, Lecompte T, Beguin S. The calibrated automated thrombogram (CAT): a universal routine test for hyper- and hypocoagulability. Pathophysiol Haemost Thromb 2002, 32:249-253. 10.1159/000073575, 13679651.
7. Al Dieri R, Peyvandi F, Santagostino E, Giansily M, Mannucci PM, Schved JF, Beguin S, Hemker HC. The thrombogram in rare inherited coagulation disorders: its relation to clinical bleeding. Thromb Haemost 2002, 88:576-582.
8. Orbe J, Zudaire M, Serrano R, Coma-Canella I. Martinez de Sizarrondo S, Rodriguez JA, Paramo JA. Increased thrombin generation after acute versus chronic coronary disease as assessed by the thrombin generation test. Thromb Haemost 2008, 99:382-387.
9. Hemker HC, Giesen P, Al Dieri R, Regnault V, De Smedt E, Wagenvoord R, Lecompte T, Beguin S. Calibrated automated thrombin generation measurement in clotting plasma. Pathophysiol Haemost Thromb 2003, 33:4-15. 10.1159/000071636, 12853707.
10. Hemker HC, Beguin S. Phenotyping the clotting system. Thromb Haemost 2000, 84:747-751.
11. Hemker HC, Al Dieri R, Beguin S. Thrombin generation assays: accruing clinical relevance. Curr Opin Hematol 2004, 11:170-175. 10.1097/01.moh.0000130314.33410.d7, 15257016.
12. Wong RK, Sleep JR, Visner AJ, Raasch DJ, Lanza LA, De Valeria PA, Torloni AS, Arabia FA. Thrombography reveals thrombin generation potential continues to deteriorate following cardiopulmonary bypass surgery despite adequate hemostasis. J Extra Corpor Technol 2011, 43:19-25.
13. Mann KG, Brummel K, Butenas S. What is all that thrombin for?. J Thromb Haemost 2003, 1:1504-1514. 10.1046/j.1538-7836.2003.00298.x, 12871286.
14. Heemskerk JW, Bevers EM, Lindhout T. Platelet activation and blood coagulation. Thromb Haemost 2002, 88:186-193.
15. Karlsson M, Ternstrom L, Hyllner M, Baghaei F, Nilsson S, Jeppsson A. Plasma fibrinogen level, bleeding, and transfusion after on-pump coronary artery bypass grafting surgery: a prospective observational study. Transfusion 2008, 48:2152-2158. 10.1111/j.1537-2995.2008.01827.x, 18657083.
16. Kumar R, Beguin S, Hemker HC. The influence of fibrinogen and fibrin on thrombin generation-evidence for feedback activation of the clotting system by clot bound thrombin. Thromb Haemost 1994, 72:713-721.
17. Bosch YPJ, Weerwind PW, Nelemans PJ, Maessen JG, Mochtar B. An evaluation of factors affecting activated coagulation time. J Cardiothorac Vasc Anesth 2012, 26:563-568. 10.1053/j.jvca.2012.03.011, 22534410.
18. Conley CL, Hartmann RC, Lalley JS. The relationship of heparin activity to platelet concentration. Proc Soc Exp Biol Med 1948, 69:284-287.
19. Horne MK, Chao ES. Heparin binding to resting and activated platelets. Blood 1989, 74:238-243.
20. Lane DA, Denton J, Flynn AM, Thunberg L, Lindahl U. Anticoagulant activities of heparin oligosaccharides and their neutralization by platelet factor 4. Biochem J 1984, 218:725-732. 1153400, 6721831.
21. Innerhofer P, Fries D, Margreiter J, Klingler A, Kuhbacher G, Wachter B, Oswald E, Salner E, Frischhut B, Schobersberger W. The effects of perioperatively administered colloids and crystalloids on primary platelet-mediated hemostasis and clot formation. Anesth Analg 2002, 95:858-865.
22. Schols SE, Feijge MA, Lance MD, Hamulyak K, Ten Cate H, Heemskerk JW, Van Pampus EC. Effects of plasma dilution on tissue-factor-induced thrombin generation and thromboelastography: partly compensating role of platelets. Transfusion 2008, 48:2384-2394. 10.1111/j.1537-2995.2008.01872.x, 18673348.
23. Despotis GJ, Filos KS, Zoys TN, Hogue CW, Spitznagel E, Lappas DG. Factors associated with excessive postoperative blood loss and hemostatic transfusion requirements: a multivariate analysis in cardiac surgical patients. Anesth Analg 1996, 82:13-21.