Versatile and enhanced tumour modelling in mice via somatic cell transduction

Journal of Pathology

Volumn 232, Issue 4, 2014, Pages 449-457

  Rodriguez, Esther ^a   Mannion, Liz ^a   D'Santos, Paula ^a   Griffiths, Meryl ^b   Arends, Mark J ^a   Brindle, Kevin M ^a   Lyons, Scott K ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

imaging; lentivirus; preclinical model; tumour

Indexed keywords

CRE RECOMBINASE; GENOMIC DNA; LENTIVIRUS VECTOR; SHORT HAIRPIN RNA; TAMOXIFEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLUMINESCENCE; CONTROLLED STUDY; FLOW CYTOMETRY; GENE EXPRESSION; GENE INACTIVATION; GENETIC RECOMBINATION; GENETICALLY ENGINEERED MOUSE STRAIN; GENOTYPE; HISTOLOGY; IMMUNOHISTOCHEMISTRY; IN VITRO GENE TRANSFER; LUCIFERASE ASSAY; LUNG ADENOMA; MOUSE; NONHUMAN; ONCOGENE K RAS; PHENOTYPE; PRIORITY JOURNAL; REPORTER GENE; SOMATIC CELL; TUMOR GROWTH; TUMOR MODEL; TUMOR SUPPRESSOR GENE;

IMAGING; LENTIVIRUS; PRECLINICAL MODEL; TUMOUR;

ANIMALS; CARCINOMA, NON-SMALL-CELL LUNG; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; GENETIC PREDISPOSITION TO DISEASE; GENETIC VECTORS; HEK293 CELLS; HUMANS; INTEGRASES; LENTIVIRUS; LUCIFERASES; LUMINESCENT MEASUREMENTS; LUNG NEOPLASMS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEOPLASM GRADING; PHENOTYPE; PROTO-ONCOGENE PROTEINS P21(RAS); REPRODUCIBILITY OF RESULTS; RNA, SMALL INTERFERING; TIME FACTORS; TRANSDUCTION, GENETIC; TUMOR BURDEN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84893864171     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4313     Document Type: Article

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