Surfactant before the first inflation at birth improves spatial distribution of ventilation and reduces lung injury in preterm lambs

Journal of Applied Physiology

Volumn 116, Issue 3, 2014, Pages 251-258

  Tingay, David G ^a,b,c   Wallace, Megan J ^d   Bhatia, Risha ^a,b,c   Schmölzer, Georg M ^a,b,d   Zahra, Valerie A ^d   Dolan, Melinda J ^d   Hooper, Stuart B ^d   Davis, Peter G ^a,b,c  

^a ROYAL CHILDREN'S HOSPITAL   (Australia)

^b ROYAL WOMEN'S HOSPITAL   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d MONASH UNIVERSITY   (Australia)

Author keywords

Alveolar recruitment; Infant; Lung mechanics; Mechanical ventilation; Neonate; Surfactant

Indexed keywords

LUNG SURFACTANT; SURFACTANT;

ALVEOLAR RECRUITMENT; ANIMAL; ARTICLE; ARTIFICIAL VENTILATION; DRUG EFFECT; FEMALE; INFANT; LUNG GAS EXCHANGE; LUNG INJURY; LUNG MECHANICS; LUNG VENTILATION; METHODOLOGY; NEWBORN; PATHOPHYSIOLOGY; PHYSIOLOGY; POSITIVE END EXPIRATORY PRESSURE; PREGNANCY; PREMATURITY; RANDOMIZATION; SHEEP;

ALVEOLAR RECRUITMENT; INFANT; LUNG MECHANICS; MECHANICAL VENTILATION; NEONATE; SURFACTANT;

ANIMALS; ANIMALS, NEWBORN; FEMALE; LUNG INJURY; POSITIVE-PRESSURE RESPIRATION; PREGNANCY; PREMATURE BIRTH; PULMONARY GAS EXCHANGE; PULMONARY SURFACTANTS; PULMONARY VENTILATION; RANDOM ALLOCATION; SHEEP;

EID: 84893852908     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01142.2013     Document Type: Article

References (38)

1. Armstrong RK, Carlisle HR, Davis PG, Schibler A, Tingay DG. Distribution of tidal ventilation during volume-targeted ventilation is variable and influenced by age in the preterm lung. Intensive Care Med 37: 839-846, 2011.
2. Bhatia R, Schmölzer GM, Davis PG, Tingay DG. Electrical impedance tomography can rapidly detect small pneumothoraces in surfactant-depleted piglets. Intensive Care Med 38: 308-315, 2012.
3. Bhatia R, Morley CJ, Argus B, Tingay DG, Donath S, Davis PG. The stable microbubble test for determining continuous positive airway pressure (CPAP) success in very preterm infants receiving nasal CPAP from birth. Neonatology 104: 188-193, 2013.
4. Bilek AM, Dee KC, Gaver DP. Mechanisms of surface-tension-induced epithelial cell damage in a model of pulmonary airway reopening. J Appl Physiol 94: 770-783, 2003.
5. Bjorklund LJ, Ingimarsson J, Curstedt T, John J, Robertson B, Werner O, Vilstrup CT. Manual ventilation with a few large breaths at birth compromises the therapeutic effect of subsequent surfactant replacement in immature lambs. Pediatr Res 42: 348-355, 1997.
6. Bjorklund LJ, Ingimarsson J, Curstedt T, Larsson A, Robertson B, Werner O. Lung recruitment at birth does not improve lung function in immature lambs receiving surfactant. Acta Anaesthesiol Scand 45: 986-993, 2001.
7. Carlisle HR, Armstrong RK, Davis PG, Schibler A, Frerichs I, Tingay DG. Regional distribution of blood volume within the preterm infant thorax during synchronised mechanical ventilation. Intensive Care Med 36: 2101-2108, 2010.
8. Carney D, DiRocco J, Nieman G. Dynamic alveolar mechanics and ventilator-induced lung injury. Crit Care Med 33: S122-S128, 2005.
9. Cummings JJ, Holm BA, Nickerson PA, Ferguson WH, Egan EA. Preversus post-ventilatory surfactant treatment in surfactant-deficient preterm lambs. Reprod Fertil Dev 7: 1333-1338, 1995.
10. Frerichs I, Dargaville PA, van Genderingen H, Morel DR, Rimensberger PC. Lung volume recruitment after surfactant administration modifies spatial distribution of ventilation. Am J Respir Crit Care Med 174: 772-779, 2006.
11. Hepponstall JM, Tingay DG, Bhatia R, Loughnan PM, Copnell B. Effect of closed endotracheal tube suction method, catheter size, and post-suction recruitment during high-frequency jet ventilation in an animal model. Pediatr Pulmonol 47: 749-756, 2012.
12. Hooper SB, Kitchen MJ, Wallace MJ, Yagi N, Uesugi K, Morgan MJ, Hall C, Siu KK, Williams IM, Siew M, Irvine SC, Pavlov K, Lewis RA. Imaging lung aeration and lung liquid clearance at birth. FASEB J 21: 3329-3337, 2007.
13. Hooper SB, Fouras A, Siew ML, Wallace MJ, Kitchen MJ, Te Pas AB, Klingenberg C, Lewis RA, Davis PG, Morley CJ, Schmölzer GM. Expired CO2 levels indicate degree of lung aeration at birth. PLoS One 8: e70895, 2013.
14. Jobe AH, Hillman N, Polglase G, Kramer BW, Kallapur S, Pillow J. Injury and inflammation from resuscitation of the preterm infant. Neonatology 94: 190-196, 2008.
15. Jobe AJ. The new BPD: an arrest of lung development. Pediatr Res 46: 641-643, 1999.
16. Leonhardt S, Lachmann B. Electrical impedance tomography: the holy grail of ventilation and perfusion monitoring? Intensive Care Med 38: 1917-1929, 2012.
17. Miedema M, de Jongh FH, Frerichs I, van Veenendaal MB, van Kaam AH. Regional respiratory time constants during lung recruitment in high-frequency oscillatory ventilated preterm infants. Intensive Care Med 38: 294-299, 2012.
18. Naik AS, Kallapur SG, Bachurski CJ, Jobe AH, Michna J, Kramer BW, Ikegami M. Effects of ventilation with different positive endexpiratory pressures on cytokine expression in the preterm lamb lung. Am J Respir Crit Care Med 164: 494-498, 2001.
19. Perlman JM, Wyllie J, Kattwinkel J, Atkins DL, Chameides L, Goldsmith JP, Guinsburg MF, Hazinski MF, Morley CJ, Richmond S, Simon WM, Singhal N, Szyld E, Tamura M, Velaphi S. Neonatal resuscitation: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations. Pediatrics 126: e1319-e1344, 2010.
20. Polglase GR, Miller SL, Barton SK, Baburamani AA, Wong FY, Aridas JD, Gill AW, Moss TJ, Tolcos M, Kluckow M, Hooper SB. Initiation of resuscitation with high tidal volumes causes cerebral hemodynamic disturbance, brain inflammation and injury in preterm lambs. PLoS One 7: e39535, 2012.
21. Probyn ME, Hooper SB, Dargaville PA, McCallion N, Harding R, Morley CJ. Effects of tidal volume and positive end-expiratory pressure during resuscitation of very premature lambs. Acta Paediatr 94: 1764-1770, 2005.
22. Rimensberger PC, Beghetti M, Hanquinet S, Berner M. First intention high-frequency oscillation with early lung volume optimization improves pulmonary outcome in very low birth weight infants with respiratory distress syndrome. Pediatrics 105: 1202-1208, 2000.
23. Salazar E, Knowles JH. An analysis of pressure-volume characteristics of the lungs. J Appl Physiol 19: 97-104, 1964.
24. Schmölzer GM, Morley CJ, Wong C, Dawson JA, Kamlin CO, Donath SM, Hooper SB, Davis PG. Respiratory function monitor guidance of mask ventilation in the delivery room: a feasibility study. J Pediatr 160: 377-381, 2012.
25. Siew ML, Te Pas AB, Wallace MJ, Kitchen MJ, Islam MS, Lewis RA, Fouras A, Morley CJ, Davis PG, Yagi K, Uesugi N, Hooper SB. Surfactant increases the uniformity of lung aeration at birth in ventilated preterm rabbits. Pediatr Res 70: 50-55, 2011.
26. Soll RF. Prophylactic natural surfactant extract for preventing morbidity and mortality in preterm infants. Cochrane Database Syst Rev CD000511, 2000.
27. Steinberg JM, Schiller HJ, Halter JM, Gatto A, Lee HM, Pavone LA, Nieman GF. Alveolar instability causes early ventilator-induced lung injury independent of neutrophils. Am J Respir Crit Care Med 169: 57-63, 2004.
28. te Pas AB, Walther FJ. A randomized, controlled trial of delivery-room respiratory management in very preterm infants. Pediatrics 120: 322-329, 2007.
29. te Pas AB, Siew M, Wallace MJ, Kitchen A, Fouras A, Lewis RA, Yagi N, Uesugi K, Donath S, Davis PG, Morley CJ, Hooper SB. Effect of sustained inflation length on establishing functional residual capacity at birth in ventilated premature rabbits. Pediatr Res 66: 295-300, 2009.
30. te Pas AB, Siew M, Wallace MJ, Kitchen MJ, Fouras A, Lewis RA, Yagi N, Uesugi K, Donath S, Davis PG, Morley CJ, Hooper SB. Establishing functional residual capacity at birth: the effect of sustained inflation and positive end-expiratory pressure in a preterm rabbit model. Pediatr Res 65: 537-541, 2009.
31. Tingay DG, Bhatia R, Schmölzer GM, Wallace MJ, Zahra VA, Davis PG. Effect of sustained inflation versus step-wise PEEP strategy at birth on gas exchange and lung mechanics in preterm lambs. Pediatr Res 2013 doi: 10.1038/pr.2013.218.
32. Tingay DG, Mills JF, Morley CJ, Pellicano A, Dargaville PA. Indicators of optimal lung volume during high-frequency oscillatory ventilation in infants. Crit Care Med 41: 232-239, 2013.
33. Tingay DG, Mills JF, Morley CJ, Pellicano A, Dargaville PA. The deflation limb of the pressure-volume relationship in infants during highfrequency ventilation. Am J Respir Crit Care Med 173: 414-420, 2006.
34. Tingay DG, Copnell B, Grant CA, Dargaville PA, Dunster KR, Schibler A. The effect of endotracheal suction on regional tidal ventilation and end-expiratory lung volume. Intensive Care Med 36: 888-896, 2010.
35. van Kaam AH, Haitsma JJ, Dik WA, Naber BA, Alblas EH, De Jaegere A, Kok JH, Lachmann B. Response to exogenous surfactant is different during open lung and conventional ventilation. Crit Care Med 32: 774-780, 2004.
36. Wallace MJ, Probyn ME, Zahra VA, Crossley K, Cole TJ, Davis PG, Morley CJ, Hooper SB. Early biomarkers and potential mediators of ventilation-induced lung injury in very preterm lambs. Respir Res 10: 1-15, 2009.
37. Walsh MC, Carlo WA. Sustained inflation during HFOV improves pulmonary mechanics and oxygenation. J Appl Physiol 65: 368-372, 1988.
38. Wolf GK, Gómez-Laberge C, Rettig JS, Vargas SO, Smallwood CD, Prabhu SP, Vitali SH, Zurakowski D, Arnold JH. Mechanical ventilation guided by electrical impedance tomography in experimental acute lung injury. Crit Care Med 41: 1296-1304, 2013.