메뉴 건너뛰기




Volumn 74, Issue 3, 2014, Pages 695-704

Metastatic growth progression caused by PSGL-1- Mediated recruitment of monocytes to metastatic sites

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; CELL COMMUNICATION; CELL LINE, TUMOR; CELL SURVIVAL; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; MONOCYTES; MYELOID CELLS; NEOPLASM METASTASIS; NEOPLASMS;

EID: 84893846552     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-13-0946     Document Type: Article
Times cited : (31)

References (45)
  • 1
    • 0030811894 scopus 로고    scopus 로고
    • Carbohydrate-mediated cell adhesion involved in hematogenous metastasis of cancer
    • Kannagi R. Carbohydrate-mediated cell adhesion involved in hematogenous metastasis of cancer. Glycoconj J 1997;14:577-84.
    • (1997) Glycoconj J , vol.14 , pp. 577-584
    • Kannagi, R.1
  • 2
    • 0030745147 scopus 로고    scopus 로고
    • Perspectives on the significance of altered glycosylation of glycoproteins in cancer
    • Kim YJ, Varki A. Perspectives on the significance of altered glycosylation of glycoproteins in cancer. Glycoconj J 1997;14:569-76.
    • (1997) Glycoconj J , vol.14 , pp. 569-576
    • Kim, Y.J.1    Varki, A.2
  • 3
    • 0032418052 scopus 로고    scopus 로고
    • Immunohistochemical expression of the sialyl Lewis x antigen on gastric cancer cells correlates with the presence of liver metastasis
    • Tatsumi M, Watanabe A, Sawada H, Yamada Y, Shino Y, Nakano H. Immunohistochemical expression of the sialyl Lewis x antigen on gastric cancer cells correlates with the presence of liver metastasis. Clin Exp Metastasis 1998;16:743-50.
    • (1998) Clin Exp Metastasis , vol.16 , pp. 743-750
    • Tatsumi, M.1    Watanabe, A.2    Sawada, H.3    Yamada, Y.4    Shino, Y.5    Nakano, H.6
  • 4
    • 0027250266 scopus 로고
    • Increased expression of sialyl Lewisx antigen correlates with poor survival in patients with colorectal carcinoma: Clinicopathological and immunohistochemical study
    • Nakamori S, Kameyama M, Imaoka S, Furukawa H, Ishikawa O, Sasaki Y, et al. Increased expression of sialyl Lewisx antigen correlates with poor survival in patients with colorectal carcinoma: clinicopathological and immunohistochemical study. Cancer Res 1993;53:3632-7.
    • (1993) Cancer Res , vol.53 , pp. 3632-3637
    • Nakamori, S.1    Kameyama, M.2    Imaoka, S.3    Furukawa, H.4    Ishikawa, O.5    Sasaki, Y.6
  • 5
    • 0033813975 scopus 로고    scopus 로고
    • Expression of SIALYL-Le(x) antigen defined by MAb AM-3 is an independent prognostic marker in colorectal carcinoma patients
    • Grabowski P, Mann B, Mansmann U, Lovin N, Foss HD, Berger G, et al. Expression of SIALYL-Le(x) antigen defined by MAb AM-3 is an independent prognostic marker in colorectal carcinoma patients. Int J Cancer 2000;88:281-6.
    • (2000) Int J Cancer , vol.88 , pp. 281-286
    • Grabowski, P.1    Mann, B.2    Mansmann, U.3    Lovin, N.4    Foss, H.D.5    Berger, G.6
  • 6
    • 38549159585 scopus 로고    scopus 로고
    • The selectin-selectin ligand axis in tumor progression
    • Witz IP. The selectin-selectin ligand axis in tumor progression. Cancer Metastasis Rev 2008;27:19-30.
    • (2008) Cancer Metastasis Rev , vol.27 , pp. 19-30
    • Witz, I.P.1
  • 7
    • 77956614939 scopus 로고    scopus 로고
    • Selectins promote tumor metastasis
    • Läubli H, Borsig L. Selectins promote tumor metastasis. Semin Cancer Biol 2010;20:169-77.
    • (2010) Semin Cancer Biol , vol.20 , pp. 169-177
    • Läubli, H.1    Borsig, L.2
  • 8
    • 0030748084 scopus 로고    scopus 로고
    • Selectin-carbohydrate interactions during inflammation and metastasis
    • McEver RP. Selectin-carbohydrate interactions during inflammation and metastasis. Glycoconj J 1997;14:585-91.
    • (1997) Glycoconj J , vol.14 , pp. 585-591
    • McEver, R.P.1
  • 10
    • 32944476784 scopus 로고    scopus 로고
    • L-selectin facilitation of metastasis involves temporal induction of fut7-dependent ligands at sites of tumor cell arrest
    • Läubli H, Stevenson JL, Varki A, Varki NM, Borsig L. L-selectin facilitation of metastasis involves temporal induction of fut7-dependent ligands at sites of tumor cell arrest. Cancer Res 2006;66:1536-42.
    • (2006) Cancer Res , vol.66 , pp. 1536-1542
    • Läubli, H.1    Stevenson, J.L.2    Varki, A.3    Varki, N.M.4    Borsig, L.5
  • 11
    • 0036791127 scopus 로고    scopus 로고
    • Inhibition of hepatic endothelial E-selectin expression by C-raf antisense oligonucleotides blocks colorectal carcinoma liver metastasis
    • Khatib AM, Fallavollita L, Wancewicz EV, Monia BP, Brodt P. Inhibition of hepatic endothelial E-selectin expression by C-raf antisense oligonucleotides blocks colorectal carcinoma liver metastasis. Cancer Res 2002;62:5393-8.
    • (2002) Cancer Res , vol.62 , pp. 5393-5398
    • Khatib, A.M.1    Fallavollita, L.2    Wancewicz, E.V.3    Monia, B.P.4    Brodt, P.5
  • 12
    • 79952756887 scopus 로고    scopus 로고
    • Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation
    • Hiratsuka S, Goel S, Kamoun WS, Maru Y, Fukumura D, Duda DG, et al. Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation. Proc Natl Acad Sci U S A 2011;108:3725-30.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 3725-3730
    • Hiratsuka, S.1    Goel, S.2    Kamoun, W.S.3    Maru, Y.4    Fukumura, D.5    Duda, D.G.6
  • 13
    • 16544390675 scopus 로고    scopus 로고
    • Endothelial P-selectin as a target of heparin action in experimental melanoma lung metastasis
    • Ludwig RJ, Boehme B, Podda M, Henschler R, Jager E, Tandi C, et al. Endothelial P-selectin as a target of heparin action in experimental melanoma lung metastasis. Cancer Res 2004;64: 2743-50.
    • (2004) Cancer Res , vol.64 , pp. 2743-2750
    • Ludwig, R.J.1    Boehme, B.2    Podda, M.3    Henschler, R.4    Jager, E.5    Tandi, C.6
  • 14
    • 0029153610 scopus 로고
    • Differential colon cancer cell adhesion to E-, P-, and L-selectin: Role of mucin-type glycoproteins
    • Mannori G, Crottet P, Cecconi O, Hanasaki K, Aruffo A, Nelson RM, et al. Differential colon cancer cell adhesion to E-, P-, and L-selectin: role of mucin-type glycoproteins. Cancer Res 1995;55:4425-31.
    • (1995) Cancer Res , vol.55 , pp. 4425-4431
    • Mannori, G.1    Crottet, P.2    Cecconi, O.3    Hanasaki, K.4    Aruffo, A.5    Nelson, R.M.6
  • 15
    • 41949129307 scopus 로고    scopus 로고
    • The dual role of CD44 as a functional P-selectin ligand and fibrin receptor in colon carcinoma cell adhesion
    • Alves CS, Burdick MM, Thomas SN, Pawar P, Konstantopoulos K. The dual role of CD44 as a functional P-selectin ligand and fibrin receptor in colon carcinoma cell adhesion. Am J Physiol Cell Physiol 2008;294: C907-16.
    • (2008) Am J Physiol Cell Physiol , vol.294
    • Alves, C.S.1    Burdick, M.M.2    Thomas, S.N.3    Pawar, P.4    Konstantopoulos, K.5
  • 16
    • 0032771908 scopus 로고    scopus 로고
    • Distinct selectin ligands on colon carcinoma mucins can mediate pathological interactions among platelets, leukocytes, and endothelium
    • Kim YJ, Borsig L, Han HL, Varki NM, Varki A. Distinct selectin ligands on colon carcinoma mucins can mediate pathological interactions among platelets, leukocytes, and endothelium. Am J Pathol 1999;155: 461-72.
    • (1999) Am J Pathol , vol.155 , pp. 461-472
    • Kim, Y.J.1    Borsig, L.2    Han, H.L.3    Varki, N.M.4    Varki, A.5
  • 17
    • 0035853111 scopus 로고    scopus 로고
    • Heparin and cancer revisited: Mechanistic connections involving platelets, Pselectin, carcinoma mucins, and tumor metastasis
    • Borsig L, Wong R, Feramisco J, Nadeau DR, Varki NM, Varki A. Heparin and cancer revisited: mechanistic connections involving platelets, Pselectin, carcinoma mucins, and tumor metastasis. Proc Natl Acad Sci U S A 2001;98:3352-7.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 3352-3357
    • Borsig, L.1    Wong, R.2    Feramisco, J.3    Nadeau, D.R.4    Varki, N.M.5    Varki, A.6
  • 18
    • 34548230927 scopus 로고    scopus 로고
    • Getting to the site of inflammation: The leukocyte adhesion cascade updated
    • Ley K, Laudanna C, Cybulsky MI, Nourshargh S. Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat Rev Immunol 2007;7:678-89.
    • (2007) Nat Rev Immunol , vol.7 , pp. 678-689
    • Ley, K.1    Laudanna, C.2    Cybulsky, M.I.3    Nourshargh, S.4
  • 19
    • 34247108244 scopus 로고    scopus 로고
    • Complete identification of E-selectin ligands on neutrophils reveals distinct functions of PSGL-1, ESL-1, and CD44
    • Hidalgo A, Peired AJ, Wild MK, Vestweber D, Frenette PS. Complete identification of E-selectin ligands on neutrophils reveals distinct functions of PSGL-1, ESL-1, and CD44. Immunity 2007;26:477-89.
    • (2007) Immunity , vol.26 , pp. 477-489
    • Hidalgo, A.1    Peired, A.J.2    Wild, M.K.3    Vestweber, D.4    Frenette, P.S.5
  • 20
    • 0038190854 scopus 로고    scopus 로고
    • P-selectin glycoprotein ligand-1 mediates L-selectin-dependent leukocyte rolling in venules
    • Sperandio M, Smith ML, Forlow SB, Olson TS, Xia L, McEver RP, et al. P-selectin glycoprotein ligand-1 mediates L-selectin-dependent leukocyte rolling in venules. J Exp Med 2003;197:1355-63.
    • (2003) J Exp Med , vol.197 , pp. 1355-1363
    • Sperandio, M.1    Smith, M.L.2    Forlow, S.B.3    Olson, T.S.4    Xia, L.5    McEver, R.P.6
  • 21
    • 0034910611 scopus 로고    scopus 로고
    • The alpha(1,3)fucosyltransferases FucT-IV and FucT-VII exert collaborative control over selectin-dependent leukocyte recruitment and lymphocyte homing
    • Homeister JW, Thall AD, Petryniak B, Maly P, Rogers CE, Smith PL, et al. The alpha(1,3)fucosyltransferases FucT-IV and FucT-VII exert collaborative control over selectin-dependent leukocyte recruitment and lymphocyte homing. Immunity 2001;15:115-26.
    • (2001) Immunity , vol.15 , pp. 115-126
    • Homeister, J.W.1    Thall, A.D.2    Petryniak, B.3    Maly, P.4    Rogers, C.E.5    Smith, P.L.6
  • 22
    • 16044363014 scopus 로고    scopus 로고
    • The alpha(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis
    • Maly P, Thall A, Petryniak B, Rogers CE, Smith PL, Marks RM, et al. The alpha(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis. Cell 1996;86:643-53.
    • (1996) Cell , vol.86 , pp. 643-653
    • Maly, P.1    Thall, A.2    Petryniak, B.3    Rogers, C.E.4    Smith, P.L.5    Marks, R.M.6
  • 23
    • 77950944395 scopus 로고    scopus 로고
    • Macrophages, innate immunity and cancer: Balance, tolerance, and diversity
    • Mantovani A, Sica A. Macrophages, innate immunity and cancer: balance, tolerance, and diversity. Curr Opin Immunol 2010;22:231-7.
    • (2010) Curr Opin Immunol , vol.22 , pp. 231-237
    • Mantovani, A.1    Sica, A.2
  • 24
    • 63049121364 scopus 로고    scopus 로고
    • The metastatic niche: Adapting the foreign soil
    • Psaila B, Lyden D. The metastatic niche: adapting the foreign soil. Nat Rev Cancer 2009;9:285-93.
    • (2009) Nat Rev Cancer , vol.9 , pp. 285-293
    • Psaila, B.1    Lyden, D.2
  • 26
    • 84873303427 scopus 로고    scopus 로고
    • Recruitment of a myeloid cell subset (CD11b/Gr1(mid))viaCCL2/CCR2 promotes the development of colorectal cancer liver metastasis
    • Zhao L, Lim SY, Gordon-Weeks AN, Tapmeier TT, Im JH, Cao Y, et al. Recruitment of a myeloid cell subset (CD11b/Gr1(mid))viaCCL2/CCR2 promotes the development of colorectal cancer liver metastasis. Hepatology 2013;57:829-39.
    • (2013) Hepatology , vol.57 , pp. 829-839
    • Zhao, L.1    Lim, S.Y.2    Gordon-Weeks, A.N.3    Tapmeier, T.T.4    Im, J.H.5    Cao, Y.6
  • 27
    • 79960411324 scopus 로고    scopus 로고
    • CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
    • Qian BZ, Li J, Zhang H, Kitamura T, Zhang J, Campion LR, et al. CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature 2011;475:222-5.
    • (2011) Nature , vol.475 , pp. 222-225
    • Qian, B.Z.1    Li, J.2    Zhang, H.3    Kitamura, T.4    Zhang, J.5    Campion, L.R.6
  • 28
    • 84863756518 scopus 로고    scopus 로고
    • Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway
    • Wolf MJ, Hoos A, Bauer J, Boettcher S, Knust M, Weber A, et al. Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway. Cancer Cell 2012;22:91-105.
    • (2012) Cancer Cell , vol.22 , pp. 91-105
    • Wolf, M.J.1    Hoos, A.2    Bauer, J.3    Boettcher, S.4    Knust, M.5    Weber, A.6
  • 29
    • 77951631347 scopus 로고    scopus 로고
    • Multiple roles of chemokine (C-C motif) ligand 2 in promoting prostate cancer growth
    • Zhang J, Lu Y, Pienta KJ. Multiple roles of chemokine (C-C motif) ligand 2 in promoting prostate cancer growth. J Natl Cancer Inst 2010;102: 522-8.
    • (2010) J Natl Cancer Inst , vol.102 , pp. 522-528
    • Zhang, J.1    Lu, Y.2    Pienta, K.J.3
  • 30
    • 0037133173 scopus 로고    scopus 로고
    • Synergistic effects of L-and P-selectin in facilitating tumor metastasis can involve nonmucin ligands and implicate leukocytes as enhancers of metastasis
    • Borsig L, Wong R, Hynes RO, Varki NM, Varki A. Synergistic effects of L-and P-selectin in facilitating tumor metastasis can involve nonmucin ligands and implicate leukocytes as enhancers of metastasis. Proc Natl Acad Sci U S A 2002;99:2193-8.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 2193-2198
    • Borsig, L.1    Wong, R.2    Hynes, R.O.3    Varki, N.M.4    Varki, A.5
  • 31
    • 78649657094 scopus 로고    scopus 로고
    • Selectins as mediators of lung metastasis
    • Läubli H, Borsig L. Selectins as mediators of lung metastasis. Cancer Microenviron 2010;3:97-105.
    • (2010) Cancer Microenviron , vol.3 , pp. 97-105
    • Läubli, H.1    Borsig, L.2
  • 32
    • 35948980396 scopus 로고    scopus 로고
    • Pselectin-and heparanase-dependent antimetastatic activity of nonanticoagulant heparins
    • Hostettler N, Naggi A, Torri G, Casu B, Vlodavsky I, Borsig L. Pselectin-and heparanase-dependent antimetastatic activity of nonanticoagulant heparins. FASEB J 2007;21:3562-72.
    • (2007) FASEB J , vol.21 , pp. 3562-3572
    • Hostettler, N.1    Naggi, A.2    Torri, G.3    Casu, B.4    Vlodavsky, I.5    Borsig, L.6
  • 33
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001;25:402-8.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 34
    • 63049104211 scopus 로고    scopus 로고
    • Microenvironmental regulation of metastasis
    • Joyce JA, Pollard JW. Microenvironmental regulation of metastasis. Nat Rev Cancer 2009;9:239-52.
    • (2009) Nat Rev Cancer , vol.9 , pp. 239-252
    • Joyce, J.A.1    Pollard, J.W.2
  • 35
    • 77950950894 scopus 로고    scopus 로고
    • Macrophage diversity enhances tumor progression and metastasis
    • Qian BZ, Pollard JW. Macrophage diversity enhances tumor progression and metastasis. Cell 2010;141:39-51.
    • (2010) Cell , vol.141 , pp. 39-51
    • Qian, B.Z.1    Pollard, J.W.2
  • 36
    • 0034613352 scopus 로고    scopus 로고
    • Pselectin glycoprotein ligand-1 and E-selectin ligand-1 are differentially modified by fucosyltransferases Fuc-TIV and Fuc-TVII in mouse neutrophils
    • Huang MC, Zollner O, Moll T, Maly P, Thall AD, Lowe JB, et al. Pselectin glycoprotein ligand-1 and E-selectin ligand-1 are differentially modified by fucosyltransferases Fuc-TIV and Fuc-TVII in mouse neutrophils. J Biol Chem 2000;275:31353-60.
    • (2000) J Biol Chem , vol.275 , pp. 31353-31360
    • Huang, M.C.1    Zollner, O.2    Moll, T.3    Maly, P.4    Thall, A.D.5    Lowe, J.B.6
  • 37
    • 0036218902 scopus 로고    scopus 로고
    • P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flow
    • Xia L, Sperandio M, Yago T, McDaniel JM, Cummings RD, Pearson-White S, et al. P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flow. J Clin Invest 2002;109:939-50.
    • (2002) J Clin Invest , vol.109 , pp. 939-950
    • Xia, L.1    Sperandio, M.2    Yago, T.3    McDaniel, J.M.4    Cummings, R.D.5    Pearson-White, S.6
  • 38
    • 0031029280 scopus 로고    scopus 로고
    • Selectin ligands: Will the real ones please stand up?
    • Varki A. Selectin ligands: will the real ones please stand up? J Clin Invest 1997;99:158-62.
    • (1997) J Clin Invest , vol.99 , pp. 158-162
    • Varki, A.1
  • 39
    • 51649118633 scopus 로고    scopus 로고
    • Pselectin glycoprotein ligand-1 is highly expressed on Ly-6Chi monocytes and a major determinant for Ly-6Chi monocyte recruitment to sites of atherosclerosis in mice
    • An G, Wang H, Tang R, Yago T, McDaniel JM, McGee S, et al. Pselectin glycoprotein ligand-1 is highly expressed on Ly-6Chi monocytes and a major determinant for Ly-6Chi monocyte recruitment to sites of atherosclerosis in mice. Circulation 2008;117:3227-37.
    • (2008) Circulation , vol.117 , pp. 3227-3237
    • An, G.1    Wang, H.2    Tang, R.3    Yago, T.4    McDaniel, J.M.5    McGee, S.6
  • 40
    • 67649743525 scopus 로고    scopus 로고
    • Glycosylation in immune cell trafficking
    • Sperandio M, Gleissner CA, Ley K. Glycosylation in immune cell trafficking. Immunol Rev 2009;230:97-113.
    • (2009) Immunol Rev , vol.230 , pp. 97-113
    • Sperandio, M.1    Gleissner, C.A.2    Ley, K.3
  • 42
    • 77955034793 scopus 로고    scopus 로고
    • Transiently entrapped circulating tumor cells interact with neutrophils to facilitate lung metastasis development
    • Huh SJ, Liang S, Sharma A, Dong C, Robertson GP. Transiently entrapped circulating tumor cells interact with neutrophils to facilitate lung metastasis development. Cancer research 2010;70: 6071-82.
    • (2010) Cancer Research , vol.70 , pp. 6071-6082
    • Huh, S.J.1    Liang, S.2    Sharma, A.3    Dong, C.4    Robertson, G.P.5
  • 43
    • 69249222379 scopus 로고    scopus 로고
    • Polarization of tumor-associated neutrophil phenotype by TGF-beta: "n1" versus "n2" TAN
    • Fridlender ZG, Sun J, Kim S, Kapoor V, Cheng G, Ling L, et al. Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN. Cancer Cell 2009;16:183-94.
    • (2009) Cancer Cell , vol.16 , pp. 183-194
    • Fridlender, Z.G.1    Sun, J.2    Kim, S.3    Kapoor, V.4    Cheng, G.5    Ling, L.6
  • 44
    • 0033373335 scopus 로고    scopus 로고
    • Targeted gene disruption demonstrates that P-selectin glycoprotein ligand 1 (PSGL-1) is required for P-selectin-mediated but not Eselectin-mediated neutrophil rolling and migration
    • Yang J, Hirata T, Croce K, Merrill-Skoloff G, Tchernychev B, Williams E, et al. Targeted gene disruption demonstrates that P-selectin glycoprotein ligand 1 (PSGL-1) is required for P-selectin-mediated but not Eselectin-mediated neutrophil rolling and migration. J Exp Med. 1999; 190:1769-82.
    • (1999) J Exp Med. , vol.190 , pp. 1769-1782
    • Yang, J.1    Hirata, T.2    Croce, K.3    Merrill-Skoloff, G.4    Tchernychev, B.5    Williams, E.6
  • 45
    • 41649116240 scopus 로고    scopus 로고
    • Plasticity in tumor-promoting inflammation: Impairment of macrophage recruitment evokes a compensatory neutrophil response
    • Pahler JC, Tazzyman S, Erez N, Chen YY, Murdoch C, Nozawa H, et al. Plasticity in tumor-promoting inflammation: impairment of macrophage recruitment evokes a compensatory neutrophil response. Neoplasia 2008;10:329-40.
    • (2008) Neoplasia , vol.10 , pp. 329-340
    • Pahler, J.C.1    Tazzyman, S.2    Erez, N.3    Chen, Y.Y.4    Murdoch, C.5    Nozawa, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.