Inhibition of hepatic endothelial E-selectin expression by C-raf antisense oligonucleotides blocks colorectal carcinoma liver metastasis

Cancer Research

Volumn 62, Issue 19, 2002, Pages 5393-5398

  Khatib, Abdel Majid ^a   Fallavollita, Lucia ^a   Wancewicz, Edward V ^b   Monia, Brett P ^b   Brodt, Pnina ^a  

^a ROYAL VICTORIA HOSPITAL   (Canada)

^b ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; RAF PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL ADHESION; COLORECTAL CARCINOMA; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; LIVER METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION;

ANIMALS; CELL ADHESION; COLORECTAL NEOPLASMS; E-SELECTIN; ENDOTHELIUM; FEMALE; HUMANS; INTERLEUKIN-1; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED C57BL; OLIGONUCLEOTIDES, ANTISENSE; PROTO-ONCOGENE PROTEINS C-RAF; RATS; RNA, MESSENGER; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0036791127     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Cohen, A. M., Shank, B., and Friedman, M. A. Cancer: principles and practice of oncology. In: D. S. Hellmann and S. Rosenberg (eds.), pp. 907-911. Philadelphia: Lippincott, 1989.
2. Brodt, P. Adhesion receptors and proteolytic mechanisms in cancer invasion and metastasis. In: P. Brodt (ed.), Cell Adhesion and Invasion in Cancer Metastasis, pp. 167-242. Landes (Austin, TX): Springer-Verlag Heidelberg, Germany, 1996.
3. Zetter, B. R. Adhesion molecules in tumor metastasis. Semin. Cancer Biol., 4: 215-218, 1993.
4. Krause, T., and Turner, G. A. Are selectins involved in metastasis? Clin. Exp. Metastasis, 17: 183-192, 1999.
5. Springer, T. A. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell, 76: 301-314, 1994.
6. Watson, M. L., Kingsmore, S. F., Johnston, G. I., Siegelman, M. H., Le Beau, M. M., Lemons, R. S., Bora, N. S., Howard, T. A., Weissman, I. L., McEver, R. P., et al. Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome I. J. Exp. Med., 172: 263-272, 199.
7. Slowik, M. R., De Luca L. G., Fiers, W., and Pober, J. S. Tumor necrosis factor activates human endothelial cells through the p55 tumor necrosis factor receptor but the p75 receptor contributes to activation at low tumor necrosis factor concentration. Am. J. Pathol., 143: 1724-1730, 1993.
8. Mackay, F., Loetscher, H., Stueber, D., Gehr, G., and Lesslauer, W. Tumor necrosis factor α (TNF-α)-induced cell adhesion to human endothelial cells is under dominant control of one TNF receptor type, TNF-R55. J. Exp. Med., 177: 1277-1286, 1993.
9. Modur, V., Zimmerman, G. A., Prescott, S. M., and McIntyre, T. M. Endothelial cell inflammatory responses to tumor necrosis factor α. Ceramide-dependent and -independent mitogen-activated protein kinase cascades. J. Biol. Chem., 271: 13094-13102, 1996.
10. Read, M. A., Whitley, M. Z., Gupta, S., Pierce, J. W., Best, J., Davis, R. J., and Collins, T. Tumor necrosis factor α-induced E-selectin expression is activated by the nuclear factor-κB and c-JUN N-terminal kinase/p38 mitogen-activated protein kinase pathways. J. Biol. Chem., 272: 2753-2761, 1997.
11. Khatib, A. M., Kontogiannea, M., Fallavollita, L., Jamison, B., Meterissian, S., and Brodt, P. Rapid induction of cytokine and E-selectin expression in the liver in response to metastatic tumor cells. Cancer Res., 59: 1356-1361, 1999.
12. Brodt, P., Fallavollita, L., Bresalier, R., Meterissian, S., Norton, C., and Wolitzky, B. A. Liver endothelial E-selectin mediates carcinoma cell adhesion and promotes liver metastasis. Int. J. Cancer, 71: 612-619, 1997.
13. Xu, X. S., Vanderziel, C., Bennett, C. F., and Monia, B. P. A role for C-raf and Ha-Ras in cytokine mediated induction of cell adhesion molecules. J. Biol. Chem., 273: 33230-33238, 1998.
14. Stepkowski, S. M., Qu, X., Wang, M. E., Tian, L., Chen, W., Wancewicz, E. V., Johnston, J. F., Bennett, C. F., and Monia, B. P. Inhibition of C-raf expression by antisense oligonucleotides extends heart allograft survival in rats. Transplantation, 70: 656-6561, 2000.
15. Wagner, H. E., Thomas, P., Wolf, B. C., Zamcheck, N., Jessup, J. M., and Steele, G. D., Jr. Characterization of the tumorigenic and metastatic potential of a poorly differentiated human colon cancer cell line. Invasion Metastasis, 10: 253-266, 1990.
16. Long, L., Rubin, R., and Brodt, P. Increased invasive and metastatic potential in tumor cells overexpressing the receptor for type 1 insulin-like growth factor receptor. Exp. Cell Res., 238: 116-121, 1998.
17. Winer, J., Jung, C. K., Shackel, I., and Williams, P. M. Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro. Anal. Biochem., 270: 41-49, 1999.
18. Geiger, T., Muller, M., Monia, B. P., and Fabbro, D. Antitumor activity of a C-raf antisense oligonucleotide in combination with standard chemotherapeutic agents against various human tumors transplanted subcutaneously into nude mice. Clin Cancer Res. 3: 1179-1185, 1997.
19. Hu, Y., Szente, B., Kiely, J. M., and Gimbrone, M. A., Jr. Molecular events in transmembrane signaling via E-selectin. SHP2 association, adaptor protein complex formation and ERK1/2 activation. J. Biol. Chem., 276: 48549-48553, 2001.
20. Laferriere, J., Houle, F., Taher, M. M., Valerie, K., and Huot, J. Transendothelial migration of colon carcinoma cells requires expression of E-selectin by endothelial cells and activation of stress-activated protein kinase-2 (SAPK2/p38) in the tumor cells. J. Biol. Chem., 276: 33762-33772, 2001.
21. Clauss, M., Sunderkotter, C., Sveinbjornsson, B., Hippenstiel, S., Willuweit, A, Marino. M., Haas, E. Seljelid, R., Scheurich, P., Suttorp, N., Grell, M., and Risau, W. A permissive role for tumor necrosis factor in vascular endothelial growth factor-induced vascular permeability. Blood. 97: 1321-1329, 2001.
22. Kobayashi, K., Matsumoto, S., Morishima, T., Kawabe, T., and Okamoto, T. Cimetidine inhibits cancer cell adhesion to endothelial cells and prevents metastasis by blocking E-selectin expression. Cancer Res., 60: 3978-3984, 2000.
23. Matsumoto, S., Imaeda, Y., Umemoto, S., Kobayashi, K., Suzuki, H., and Okamoto, T. Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis - A epitope expression on tumour cells. Br. J. Cancer. 86: 161-167, 2002.
24. Minami, S., Furui, J., and Kanematsu, T. Role of carcinoembryonic antigen in the progression of colon cancer that express carbohydrate antigen. Cancer Res., 61: 2732-2735, 2001.
25. Gangopadhyay, A., Lazure, D. A., and Thomas, P. Adhesion of colorectal carcinoma cells to the endothelium is mediated by cytokines from CEA stimulated Kupffer cells. Clin. Exp. Metastasis, 16: 703-712, 1998.
26. van der Bruggen, T., Nijenhuis, S., van Raaij, E., Verhoef, J., and van Asbeck, B. S. Lipopolysaccharide-induced tumor necrosis factor a production by human monocytes involves the raf-1/MEK1-MEK2/ERK1-ERK2 pathway. Infect. Immun., 67: 3824-3829, 1999.
27. Han, Y. P., Tuan, T. L., Wu, H., Hughes, M., and Garner, W. L. TNF-α stimulates activation of pro-MMP2 in human skin through NF-κB mediated induction of MT1-MMP. J. Cell Sci., 114: 131-139, 2001.