Heat shock-mediated regulation of IκB-α at the post-transcriptional level by HuR

Molecular Medicine Reports

Volumn 9, Issue 2, 2014, Pages 553-559

  Liu, Yuxin ^a   Yu, Wenyan ^b,c  

^a NINGBO UNIVERSITY   (China)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

^c XINJIANG MEDICAL UNIVERSITY   (China)

Author keywords

Heat shock; HuR; I B ; NF B; Post transcriptional

Indexed keywords

3T3 CELLS; ANIMALS; CELL NUCLEUS; CYTOPLASM; GENE EXPRESSION REGULATION; HEAT-SHOCK RESPONSE; HOT TEMPERATURE; HU PARANEOPLASTIC ENCEPHALOMYELITIS ANTIGENS; I-KAPPA B PROTEINS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NF-KAPPA B; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 84893834730     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2013.1820     Document Type: Article

References (18)

1. Shanley TP, Ryan MA, Eaves-Pyles T and Wong HR: Heat shock inhibits phosphorylation of IkappaBalpha. Shock 14: 447-450, 2000.
2. Grossman BJ, Shanley TP, Odoms K, Dunsmore KE, Denenberg AG and Wong HR: Temporal and mechanistic effects of heat shock on LPS-mediated degradation of IkappaBalpha in macrophages. Inflammation 26: 129-137, 2002.
3. Kohn G, Wong HR, Bshesh K, Zhao B, Vasi N, Denenberg A, Morris C, Stark J and Shanley TP: Heat shock inhibits tnf-induced ICAM-1 expression in human endothelial cells via Ikappakinase inhibition. Shock 17: 91-97, 2002.
4. Pittet JF, Lee H, Pespeni M, O'Mahony A, Roux J and Welch WJ: Stress-induced inhibition of the NF-kappaB signaling pathway results from the insolubilization of the IkappaB kinase complex following its dissociation from heat shock protein. J Immunol 174: 384-394, 2005
5. Deng L, Wang C, Spencer E, Yang L, Braun A, Slaughter C, Pickart C and Chen ZJ: Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin conjugating enzyme complex and a unique polyubiquitin chain. Cell 103: 351-361, 2000.
6. Ouaaz F, Arron J, Zheng Y, Choi Y and Beg AA: Dendritic cell development and survival require distinct NF-kappaB subunits. Immunity 16: 257-270, 2002.
7. Wong HR: Potential protective role of the heat shock response in sepsis. New Horiz 6: 194-200, 1998.
8. Wong HR and Wispé JR: The stress response and the lung. Am J Physiol Lung 273: L1-L9, 1997.
9. Malhotra V and Wong HR: Interactions between the heat shock response and the nuclear factor-kappaB signaling pathway. Crit Care Med 30 (1 Supp): S89-S95, 2002.
10. Beg AA, Sha WC, Bronson RT and Baltimore D: Constitutive NF-kappaB activation, enhanced granulopoiesis and neonatal lethality in IkappaBalpha-deficient mice. Genes Dev 9: 2736-2746, 1995.
11. Peng B, Ling J, Lee AJ, Wang Z, Chang Z, Jin W, Kang Y, Zhang R, Shim D, Wang H, Fleming JB, Zheng H, Sun SC and Chiao PJ: Defective feedback regulation of NF-kappaB underlies Sjogren's syndrome in mice with mutated kappaB enhancers of the IkappaBalpha promoter. Proc Natl Acad USA 107: 15193-15198, 2010.
12. Hoffmann A, Levchenko A, Scott ML and Baltimore D: The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science 298: 1241-1245, 2002.
13. Moore MJ: From birth to death: the complex lives of eukaryotic mRNAs. Science 309: 1514-1518, 2005.
14. Moore MJ and Proudfoot NJ: Pre-mRNA processing reaches back to transcription and ahead to translation. Cell 136: 688-700, 2009.
15. Glisovic T, Bachorik JL, Yong J and Dreyfuss G: RNA-binding proteins and post-transcriptional gene regulation. FEBS Lett 582: 1977-1986, 2008.
16. Sanchez-Diaz P and Penalva LO: Post-transcription meets post-genomic: the saga of RNA binding proteins in a new era. RNA Biol 3: 101-109, 2006.
17. López de Silanes I, Zhan M, Lal A, Yang X and Gorospe M: Identification of a target RNA motif for RNA-binding protein HuR. Proc Natl Acad USA 101: 2987-2992, 2004.
18. Anderson P and Kedersha N: Stressful initiations. Cell 115: 3227-3234, 2002.