Curcumin regulates the metabolism of low density lipoproteins by improving the C-to-U RNA editing efficiency of apolipoprotein B in primary rat hepatocytes

Molecular Medicine Reports

Volumn 9, Issue 1, 2014, Pages 132-136

  Tian, Nan ^a   Li, Xiaoling ^a   Luo, Yang ^a   Han, Ziwu ^a   Li, Zhaohui ^b   Fan, Chunlei ^a  

^a ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

^b JILIN UNIVERSITY   (China)

Author keywords

ApoB 48; Atherosclerosis; Curcumin; MRNA editing; Primary rat hepatocytes

Indexed keywords

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; CURCUMIN; CYTIDINE; CYTIDINE DEAMINASE; HEPATOCYTES; LIPOPROTEINS, LDL; RATS; RATS, SPRAGUE-DAWLEY; RNA EDITING; RNA, MESSENGER; URIDINE;

EID: 84893829037     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2013.1754     Document Type: Article

References (16)

1. Young SG: Recent progress in understanding apolipoprotein B. Circulation 82: 1574-1594, 1990.
2. Innerarity TL, Borén J, Yamanaka S and Olofsson SO: Biosynthesis of apolipoprotein B48-containing lipoproteins. Regulation by novel post-transcriptional mechanisms. J Biol Chem 271: 2353-2356, 1996.
3. Anant S, Blanc V and Davidson NO: Molecular regulation, evolutionary, and functional adaptations associated with C to U editing of mammalian apolipoproteinB mRNA. Prog Nucleic Acid Res Mol Biol 75: 1-41, 2003.
4. Anant S and Davidson NO: Molecular mechanisms of apolipoprotein B mRNA editing. Curr Opin Lipidol 12: 159-165, 2001.
5. Pitas RE, Innerarity TL and Mahley RW: Cell surface receptor binding of phospholipid protein complexes containing different ratios of receptor active and inactive E apoprotein. J Biol Chem 255: 5454-5460, 1980.
6. Innerarity TL and Mahley RW: Enhanced binding by cultured human fibroblasts of apo-E-containing lipoproteins as compared with low density lipoproteins. Biochemistry 17: 1440-1447, 1978.
7. Gupta SC, Patchva S, Koh W and Aggarwal BB: Discovery of curcumin, a component of the golden spice, and its miraculous biological activities. Clin Exp Pharmacol Physiol 39: 283-299, 2012.
8. Joe B, Vijaykumar M and Lokesh BR: Biological properties of curcumin-cellular and molecular mechanisms of action. Crit Rev Food Sci Nutr 44: 97-111, 2004.
9. Egan ME, Pearson M, Weiner SA, et al.: Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects. Science 304: 600-602, 2004.
10. Dou X, Fan C, Wo L, Yan J, Qian Y and Wo X: Curcumin up-regulates LDL receptor expression via the sterol regulatory element pathway in HepG2 cells. Planta Med 74: 1374-1379, 2008.
11. Zhao JF, Ching LC, Huang YC, et al.: Molecular mechanism of curcumin on the suppression of cholesterol accumulation in macrophage foam cells and atherosclerosis. Mol Nutr Food Res 56: 691-701, 2012.
12. Srinivasan K and Sambaiah K: The effect of spices on cholesterol 7 alpha-hydroxylase activity and on serum and hepatic cholesterol levels in the rat. Int J Vitam Nutr Res 61: 364-369, 1991.
13. Wang K, Shindoh H, Inoue T and Horii I: Advantages of in vitro cytotoxicity testing by using primary rat hepatocytes in comparison with established cell lines. J Toxicol Sci 27: 229-237, 2002.
14. Teng B, Blumenthal S, Forte T, et al.: Adenovirus-mediated gene transfer of rat apolipoprotein B mRNA-editing protein in mice virtually eliminates apolipoprotein B-100 and normal low density lipoprotein production. J Biol Chem 269: 29395-29404, 1994.
15. Cheng AL, Hsu CH, Lin JK, et al.: Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res 21: 2895-2900, 2001.
16. Hersberger M, Patarroyo-White S, Qian X, et al.: Regulatable liver expression of the rabbit apolipoprotein B mRNA-editing enzyme catalytic polypeptide 1 (APOBEC-1) in mice lacking endogenous APOBEC-1 leads to aberrant hyperediting. Biochem J 369: 255-262, 2003.