Dual inhibition of HCV and HIV by ring-expanded nucleosides containing the 5:7-fused imidazo[4,5-e][1,3]diazepine ring system. in vitro results and implications

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 4, 2014, Pages 1154-1157

  Zhang, Ning ^a,d   Zhang, Peng ^a,d   Baier, Andrea ^b   Cova, Lucyna ^c,e   Hosmane, Ramachandra S ^a  

^a UNIVERSITY OF MARYLAND BALTIMORE COUNTY   (United States)

^b JOHN PAUL II CATHOLIC UNIVERSITY OF LUBLIN   (Poland)

^c INSERM   (France)

^d Pharmaceutics International Inc   (United States)

^e UNIVERSITÉ LYON 1   (France)

Author keywords

Antiviral compounds; Dual inhibitors of HCV and HIV; Hepatitis C virus (HCV); Human immunodeficiency virus (HIV); Imidazo 4,5 e 1,3 diazepines; In vitro screening; Inhibition of HCV NTPase helicase; Inhibition of RNA helicase DDX3; Organic synthesis; Ring expanded nucleosides

Indexed keywords

ANTIVIRAL COMPOUNDS; DUAL INHIBITORS OF HCV AND HIV; HEPATITIS C VIRUS (HCV); HUMAN IMMUNODEFICIENCY VIRUS (HIV); IMIDAZO[4,5-E][1,3]DIAZEPINES; IN VITRO SCREENING; INHIBITION OF HCV NTPASE/HELICASE; INHIBITION OF RNA HELICASE DDX3; ORGANIC SYNTHESIS; RING-EXPANDED NUCLEOSIDES;

ANTIVIRAL AGENTS; AZEPINES; DEAD-BOX RNA HELICASES; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPACIVIRUS; HIV; HUMANS; IMIDAZOLES; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84893799327     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.12.121     Document Type: Article

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