Calycosin entered HUVECs and ameliorated AGEs-promoted cell apoptosis via the Bcl-2 pathway

Journal of Natural Medicines

Volumn 68, Issue 1, 2014, Pages 163-172

  Xu, You Hua ^a   Xiong, Jianfeng ^a   Wang, Shan Shan ^a,b   Tang, Dan ^a,c   Wang, Ru Shang ^c   Zhu, Quan ^a,c  

^a MACAU UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Macao)

^b MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^c Institute of Consun Co for Chinese Medicine in Kidney Diseases   (China)

Author keywords

Advanced glycation end products; Apoptosis; Calycosin; Diabetes; Endothelial cell

Indexed keywords

ACRIDINE ORANGE; ADVANCED GLYCATION END PRODUCT; CALYCOSIN; ETHIDIUM BROMIDE; PHYTOESTROGEN; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG; 7,3'-DIHYDROXY-4'-METHOXYISOFLAVONE; ANTIOXIDANT; BAD PROTEIN, HUMAN; BAX PROTEIN, HUMAN; CALYCOSIN-7-O-GLUCOPYRANOSIDE; GLUCOSIDE; ISOFLAVONE DERIVATIVE;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; FLUORESCENCE; FLUORESCENCE ABSORPTION ASSAY; FLUORESCENCE POLARIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MOLECULAR INTERACTION; MOLECULAR MECHANICS; MTT ASSAY; OXIDATIVE STRESS; PROTEIN EXPRESSION; UMBILICAL VEIN ENDOTHELIAL CELL; CELL CULTURE; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; TIME; TRANSPORT AT THE CELLULAR LEVEL;

ANTIOXIDANTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-ASSOCIATED DEATH PROTEIN; BIOLOGICAL TRANSPORT; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSIDES; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; ISOFLAVONES; OXIDATIVE STRESS; PHYTOESTROGENS; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84893752361     PISSN: 13403443     EISSN: 18610293     Source Type: Journal    
DOI: 10.1007/s11418-013-0787-7     Document Type: Article

References (36)

1. Rahman S, Rahman T, Ismail AA, Rashid AR (2007) Diabetesassociated macrovasculopathy: pathophysiology and pathogenesis. Diabetes Obes Metab 9:767-780
2. Bonetti PO, Lerman LO, Lerman A (2003) Endothelial dysfunction: a marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol 23:168-175
3. Orasanu G, Plutzky J (2009) The pathologic continuum of diabetic vascular disease. J Am Coll Cardiol 53:S35-S42
4. Singh R, Barden A, Mori T, Beilin L (2001) Advanced glycation end-products: a review. Diabetologia 44:129-146
5. Yamagishi S, Inagaki Y, Okamoto T, Amano S, Koga K, Takeuchi M, Makita Z (2002) Advanced glycation end productinduced apoptosis and overexpression of vascular endothelial growth factor and monocyte chemoattractant protein-1 in humancultured mesangial cells. J Biol Chem 277:20309-20315
6. Xu Y, Wang S, Feng L, Zhu Q, Xiang P, He B (2010) Blockade of PKC-beta protects HUVEC from advanced glycation end products induced inflammation. Int Immunopharmacol 10:1552-1559
7. Xu Y, Feng L, Wang S, Zhu Q, Lin J, Lou C, Xiang P, He B, Zheng Z, Tang D, Zuo G (2011) Phytoestrogen calycosin-7-O-β-D-glucopyranoside ameliorates advanced glycation end productsinduced HUVEC damage. J Cell Biochem 112:2953-2965
8. Fan Y, Wu DZ, Gong YQ, Zhou JY, Hu ZI (2003) Effects of calycosin on the impairment of barrier function induced by hypoxia in human umbilical vein endothelial cells. Eur J Pharmacol 481:33-40
9. Yu DH, Duan YL, Bao YM, Wei CL, An LJ (2005) Isoflavonoids from Astragalus mongholicus protect PC12 cells from toxicity induced by L-glutamate. J Ethnopharmacol 98:89-94
10. Tang JY, Li S, Li ZH, Zhang ZJ, Hu G, Cheang LC, Alex D, Hoi MP, Kwan YW, Chan SW, Leung GP, Lee SM (2010) Calycosin promotes angiogenesis involving estrogen receptor and mitogenactivated protein kinase (MAPK) signaling pathway in zebrafish and HUVEC. PLoS ONE 5:e11822
11. Xu Y, Feng L, Wang S, Zhu Q, Zheng Z, Xiang P, He B, Tang D (2011) Calycosin protects HUVECs from advanced glycation end products-induced macrophage infiltration. J Ethnopharmacol 137:359-370
12. Ge J, Jia Q, Liang C, Luo Y, Huang D, Sun A, Wang K, Zou Y, Chen H (2005) Advanced glycosylation end products might promote atherosclerosis through inducing the immune maturation of dendritic cells. Arterioscler Thromb Vasc Biol 25:2157-2163
13. Jolley ME, Nasir MS (2003) The use of fluorescence polarization assays for the detection of infectious diseases. Comb Chem High Throughput Screen 6:235-244
14. Brownlee M, Vlassara H, Kooney A, Ulrich P, Cerami A (1986) Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking. Science 232:1629-1632
15. Li F, Ambrosini G, Chu EY, Plescia J, Tognin S, Marchisio PC, Altieri DC (1998) Control of apoptosis and mitotic spindle checkpoint by surviving. Nature 396:580-584
16. Baynes JW (1991) Role of oxidative stress in development of complications in diabetes. Diabetes 40:405-412
17. Lal MA, Brismar H, Eklöf AC, Aperia A (2002) Role of oxidative stress in advanced glycation end product-induced mesangial cell activation. Kidney Int 61:2006-2014
18. Guo C, Tong L, Xi M, Yang H, Dong H, Wen A (2012) Neuroprotective effect of calycosin on cerebral ischemia and reperfusion injury in rats. J Ethnopharmacol 144:768-774
19. Jia W, Gao W, Tang L (2003) Antidiabetic herbal drugs officially approved in China. Phytother Res 17:1127-1134
20. Lin LZ, He XG, Lindenmaier M, Nolan G, Yang J, Cleary M, Qiu SX, Cordell GA (2000) Liquid chromatography-electrospray ionization mass spectrometry study of the flavonoids of the roots of Astragalus mongholicus and A. membranaceus. J Chromatogr A 876:87-95
21. Kim DH, Yu KU, Bae EA, Han MJ (1998) Metabolism of puerarin and daidzin by human intestinal bacteria and their relation to in vitro cytotoxicity. Biol Pharm Bull 21:628-630
22. Wu DZ, Fan Y, Hen ZF, Song CQ, Hu ZB (2000) Effect of flavonoids isolated from Astragalus membranaceus on the changes of endothelial permeability induced by low osmolarity. Pharmacol Clin Chin Mater Med 16:16-18
23. Goldin A, Beckman JA, Schmidt AM, Creager MA (2006) Advanced glycation end products: sparking the development of diabetic vascular injury. Circulation 114:597-605
24. Schmidt AM, Yan SD, Yan SF, Stern DM (2001) The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses. J Clin Invest 108:949-955
25. Schmidt AM, Hori O, Chen JX, Li JF, Crandall J, Zhang J, Cao R, Yan SD, Brett J, Stern D (1995) Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice: a potential mechanism for the accelerated vasculopathy of diabetes. J Clin Invest 96:1395-1403
26. Schmidt AM, Yan SD, Wautier JL, Stern D (1999) Activation of receptor for advanced glycation end products: a mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosis. Circ Res 84:489-497
27. Checovich WJ, Bolger RE, Burke T (1995) Fluorescence polarization: a new tool for cell and molecular biology. Nature 375:254-256
28. Kislinger T, Fu C, Huber B, Qu W, Taguchi A, Du Yan S, Hofmann M, Yan SF, Pischetsrieder M, Stern D, Schmidt AM (1999) Ne-(Carboxymethyl)lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expression. J Biol Chem 274:31740-31749
29. Quagliaro L, Piconi L, Assaloni R, Da Ros R, Maier A, Zuodar G, Ceriello A (2005) Intermittent high glucose enhances ICAM-1, VCAM-1 and E-selectin expression in human umbilical vein endothelial cells in culture: the distinct role of protein kinase C and mitochondrial superoxide production. Atherosclerosis 183:259-267
30. Amant C, Holm P, Xu Sh SH, Tritman N, Kearney M, Losordo DW (2001) Estrogen receptor-mediated, nitric oxide-dependent modulation of the immunologic barrier function of the endothelium: regulation of fas ligand expression by estradiol. Circulation 104:2576-2581
31. Lu A, Frink M, Choudhry MA, Schwacha MG, Hubbard WJ, Rue LWIII, Bland KI, Chaudry IH (2007) Mitochondria play an important role in 17beta-estradiol attenuation of H(2)O(2)-induced rat endothelial cell apoptosis. Am J Physiol Endocrinol Metab 292:E585-E593
32. Si H, Liu D (2009) Isoflavone genistein protects human vascular endothelial cells against tumor necrosis factor-alpha-induced apoptosis through the p38beta mitogen-activated protein kinase. Apoptosis 14:66-76
33. Jacobson M, Raff M (1995) Programmed cell death and Bcl-2 protection in very low oxygen. Nature 374:814-816
34. Shimizu S, Eguchi Y, Kosaka H, Kamiike W, Matsuda H, Tsujimoto Y (1995) Prevention of hypoxia-induced cell death by bcl-2 and bcl-XL. Nature 374:811-813
35. Bierhaus A, Hofmann MA, Ziegler R, Nawroth PP (1998) AGEs and their interaction with AGE-receptors in vascular disease and diabetes mellitus. I. TheAGEconcept. Cardiovasc Res 37:586-600
36. Yan SD, Schmidt AM, Anderson GM, Zhang J, Brett J, Zou YS, Pinsky D, Stern D (1994) Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins. J Biol Chem 269:9889-9897