Human mitochondrial leucyl tRNA synthetase can suppress non cognate pathogenic mt-tRNA mutations

EMBO Molecular Medicine

Volumn 6, Issue 2, 2014, Pages 183-193

  Hornig Do, Hue Tran ^a,c   Montanari, Arianna ^b   Rozanska, Agata ^a   Tuppen, Helen A ^a   Almalki, Abdulraheem A ^a   Abg Kamaludin, Dyg P ^a,d   Frontali, Laura ^b   Francisci, Silvia ^b   Lightowlers, Robert N ^a   Chrzanowska Lightowlers, Zofia M ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF COLOGNE   (Germany)

^d Biochemistry Unit   (Malaysia)

Author keywords

Aminoacyl tRNA synthetase; Disease; Mitochondria; Protein synthesis; Therapy

Indexed keywords

LEUCINE TRANSFER RNA LIGASE; MITOCHONDRIAL LEUCYL TRNA SYNTHETASE; MITOCHONDRIAL RNA; PEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; CELL INTERACTION; CELL STRAIN HEK293; CONTROLLED STUDY; EMBRYO; GENE MUTATION; GENE OVEREXPRESSION; GENE REPRESSION; HUMAN; HUMAN CELL; MITOCHONDRIAL GENE; MITOCHONDRIAL GENOME; MITOCHONDRIAL TRNA GENE; MOLECULAR PATHOLOGY; PRIORITY JOURNAL; PROTEIN RNA BINDING;

AMINO ACYL-TRNA SYNTHETASES; CELL PROLIFERATION; HUMANS; MITOCHONDRIA; MUTATION; OXIDATIVE PHOSPHORYLATION; PHENOTYPE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RNA, TRANSFER, LEU; SUPPRESSION, GENETIC;

EID: 84893751803     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.1002/emmm.201303202     Document Type: Article

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