Lymph node ratio is an independent prognostic factor after resection of periampullary malignancies: Data from a tertiary referral center in the middle east

American Journal of Clinical Oncology: Cancer Clinical Trials

Volumn 37, Issue 1, 2014, Pages 13-18

  Shamseddine, Ali I ^a   Mukherji, Deborah ^a   Melki, Christian ^a   Elias, Elias ^a   Eloubeidi, Mohammad ^a   Dimassi, Hani ^b   Khalife, Mohammad ^a   Abou Alfa, Ghassan ^c   O'Reilly, Eileen ^c   Faraj, Walid ^a  

^a AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

^b LEBANESE AMERICAN UNIVERSITY   (Lebanon)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

lymph node ratio; pancreatic cancer; positive lymph nodes; survival

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER PROGNOSIS; CANCER SURGERY; CANCER SURVIVAL; FEMALE; HAZARD RATIO; HUMAN; KAPLAN MEIER METHOD; LYMPH NODE RATIO; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MIDDLE EAST; MULTIVARIATE ANALYSIS; OVERALL SURVIVAL; PANCREAS CARCINOMA; PANCREATICODUODENECTOMY; PERIAMPULLARY CANCER; PROPORTIONAL HAZARDS MODEL; RETROSPECTIVE STUDY; SURVIVAL RATE; TERTIARY CARE CENTER; VERY ELDERLY; YOUNG ADULT; ADENOCARCINOMA; CANCER STAGING; LEBANON; LYMPH NODE; LYMPH NODE DISSECTION; LYMPH NODE METASTASIS; MORTALITY; PANCREATIC NEOPLASMS; PATHOLOGY; PREDICTIVE VALUE; PROGNOSIS;

ADENOCARCINOMA; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; LEBANON; LYMPH NODE EXCISION; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM STAGING; PANCREATIC NEOPLASMS; PANCREATICODUODENECTOMY; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; TERTIARY CARE CENTERS;

EID: 84893737174     PISSN: 02773732     EISSN: 1537453X     Source Type: Journal    
DOI: 10.1097/COC.0b013e31826b9c74     Document Type: Article

References (22)

1. Jemal A, Siegel R, Xu J, et al. Cancer statistics, 2010. CA Cancer J Clin. 2010;60:277-300.
2. House MG, Gonen M, Jarnagin WR, et al. Prognostic significance of pathologic nodal status in patients with resected pancreatic cancer. J Gastrointest Surg. 2007;11:1549-1555.
3. Winter JM, Cameron JL, Campbell KA, et al. 1423 pancreatico- duodenectomies for pancreatic cancer: a single-institution experience. J Gastrointest Surg. 2006;10:1199-1211.
4. Richter A, Niedergethmann M, Sturm JW, et al. Long-term results of partial pancreaticoduodenectomy for ductal adenocarcinoma of the pancreatic head: 25-year experience. World J Surg. 2003; 27:324-329.
5. Ueda M, Endo I, Nakashima M, et al. Prognostic factors after resection of pancreatic cancer. World J Surg. 2009;33:104-110.
6. Kure S, Kaneko T, Takeda S, et al. Analysis of long-term survivors after surgical resection for invasive pancreatic cancer. HPB (Oxford). 2005;7:129-134.
7. Lim JE, Chien MW, Earle CC. Prognostic factors following curative resection for pancreatic adenocarcinoma: a population based, linked database analysis of 396 patients. Ann Surg. 2003; 237:74-85.
8. Sohn TA, Yeo CJ, Cameron JL, et al. Resected adenocarcinoma of the pancreas-616 patients: results, outcomes, and prognostic indicators. J Gastrointest Surg. 2000;4:567-579.
9. Riediger H, Makowiec F, Fischer E, et al. Postoperative morbidity and long-term survival after pancreaticoduodenectomy with superior mesenterico-portal vein resection. J Gastrointest Surg. 2006;10:1106-1115.
10. Berger AC, Watson JC, Ross EA, et al. The metastatic/examined lymph node ratio is an important prognostic factor after pancreati-coduodenectomy for pancreatic adenocarcinoma. Am Surg. 2004;70:235-240.
11. Sierzega M, Popiela T, Kulig J, et al. The ratio of metastatic/resected lymph nodes is an independent prognostic factor in patients with node-positive pancreatic head cancer. Pancreas. 2006;33:240-245.
12. Pawlik TM, Gleisner AL, Cameron JL, et al. Prognostic relevance of lymph node ratio following pancreaticoduodenectomy for pancreatic cancer. Surgery. 2007;14:610-618.
13. American Joint Committee on Cancer. AJCC Cancer Staging Manual. 6th ed. New York, NY: Springer; 2002.
14. Jonnalagadda S, Arcinega J, Smith C, et al. Validation of the Lymph node ratio as a prognostic factor in patients with N1 non-small cell lung cancer. Cancer. 2011, doi: 101002/cncr.26093.
15. Ceelen W, Van Nieuwenhove Y, Pattyn P. Prognostic value of the lymph node ratio in stage III colorectal cancer: asymmetric review. Ann Surg Oncol. 2010;17:2847-2855.
16. Marchet A, Mocellin S, Ambrosi A, et al. The ratio between metastatic and examined lymph nodes (N ratio) is an independent prognostic factor in gastric cancer regardless of the type of lymphadenectomy: results from an Italian multicentric study in 1853 patients. Ann Surg. 2007;245:543-553.
17. Wilson M, Rosato EL, Chojnacki KA, et al. Prognostic significance of lymph node metastases and ratio in esophageal cancer. J Surg Res. 2008;146:11-15.
18. Hatoum HA, Jamali FR, El-Saghir NS, et al. Ratio between positive lymph nodes and total excised axillary lymph nodes as an independent prognostic factor for overall survival in patients with non metastatic lymph node-positive breast cancer. Ann Surg Oncol. 2009;16:3388-3395.
19. Ishikawa O, Ohhigashi H, Sasaki Y, et al. Practical usefulness of lymphatic and connective tissue clearance for the carcinoma of the pancreas head. Ann Surg. 2008;208:215-220.
20. Manabe T, Ohshio G, Baba N, et al. Radical pancreatectomy for ductal cell carcinoma of the head of the pancreas. Cancer. 1989;64:1132-1137.
21. Pedrazzoli S, DiCarlo V, Dionigi R, et al. Standard versus extended lymphadenectomy associated with pancreatoduoden-ectomy in the surgical treatment of adenocarcinoma of the head of the pancreas: a multicenter, prospective, randomized study. Ann Surg. 1998;228:508-517.
22. Yeo CJ, Cameron JL, Lillemoe KD, et al. Pancreaticoduodenec-tomy with or without distal gastrectomy and extended retroper-itoneal lymphadenectomy for periampullary adenocarcinoma, part 2: randomized controlled trial evaluating survival, morbidity and mortality. Ann Surg. 2002;236:355-368.