Mepivacaine-induced contraction involves increased calcium sensitization mediated via Rho kinase and protein kinase C in endothelium-denuded rat aorta

European Journal of Pharmacology

Volumn 723, Issue 1, 2014, Pages 185-193

  Ok, Seong Ho ^a   Kwon, Seong Chun ^b   Yeol Han, Jeong ^c   Yu, Jongsun ^c   Shin, Il Woo ^a   Lee, Heon Keun ^a   Chung, Young Kyun ^a   Choi, Mun Jeoung ^c   Sohn, Ju Tae ^a  

^a Gyeongsang National University School of Medicine   (South Korea)

^b Kwandong University College of Medicine   (South Korea)

^c Gyeongsang National University   (South Korea)

Author keywords

Aorta; Calcium sensitization; Contraction; Mepivacaine; Protein kinase C; Rho kinase

Indexed keywords

AORTA; CALCIUM SENSITIZATION; CONTRACTION; GF 109203X (PUBCHEM CID: 2396); MEPIVACAINE; MEPIVACAINE (PUBCHEM CID: 66070); PD 98059 (PUBCHEM CID: 4713); PROTEIN KINASE C; RHO KINASE; SB 203580 (PUBCHEM CID: 176155); SP600125 (PUBCHEM CID: 8515); Y-27632 (PUBCHEM CID: 9901617);

ANESTHETICS, LOCAL; ANIMALS; AORTA, THORACIC; CALCIUM; ENDOTHELIUM, VASCULAR; MALE; MEPIVACAINE; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; RHO-ASSOCIATED KINASES;

EID: 84893733000     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.11.040     Document Type: Article

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