The neuroimmune guidance cue netrin-1: A new therapeutic target in cardiovascular disease

Journal of Cardiology

Volumn 63, Issue 2, 2014, Pages 95-98

  Bongo, Joseph Bertrand ^a   Peng, Dao Quan ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Angiogenesis; Atherosclerosis; Cardioprotection; Ischemia reperfusion injury; Netrin 1

Indexed keywords

NETRIN 1;

ANGIOGENESIS; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; HEART PROTECTION; HUMAN; NEUROIMMUNOLOGY; NONHUMAN; REPERFUSION INJURY; REVIEW;

ANGIOGENESIS; ATHEROSCLEROSIS; CARDIOPROTECTION; ISCHEMIA-REPERFUSION INJURY; NETRIN-1;

ATHEROSCLEROSIS; CARDIOTONIC AGENTS; CARDIOVASCULAR DISEASES; HUMANS; MOLECULAR TARGETED THERAPY; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; NEOVASCULARIZATION, PATHOLOGIC; NERVE GROWTH FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 84893732321     PISSN: 09145087     EISSN: 18764738     Source Type: Journal    
DOI: 10.1016/j.jjcc.2013.10.006     Document Type: Review

References (49)

1. Kennedy T.E., Serafini T., Torre J.R., Tessier-Lavigne M. Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord. Cell 1994, 78:425-435.
2. Serafini T., Kennedy T.E., Galko M.J., Mirzayan C., Jessell T.M., Tessier-Lavigne M. The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell 1994, 78:409-424.
3. Hedgecock E.M., Culotti J.G., Hall D.H. The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans. Neuron 1990, 4:61-85.
4. Rajasekharan S., Kennedy T.E. The netrin protein family. Genome Biol 2009, 10:239.
5. Meyerhardt J.A. Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas. Cell Growth Differ 1999, 10:35-42.
6. Yin Y., Sanes J.R., Miner J.H. Identification and expression of mouse netrin-4. Mech Dev 2000, 96:115-119.
7. Bányai L., Patthy L. The NTR module domains of netrins secreted frizzled related proteins and type I procollagen C-proteinase enhancer protein are homologous with tissue inhibitors of metalloproteases. Protein Sci 1999, 8:1636-1642.
8. Sun K.L.W., Correia J.P., Kennedy T.E. Netrins: versatile extracellular cues with diverse functions. Development 2011, 138:2153-2169.
9. Lin L., Rao Y., Isacson O. Netrin-1 and slit-2 regulate and direct neurite growth of ventral midbrain dopaminergic neurons. Mol Cell Neurosci 2005, 28:547-555.
10. Alcántara S., Ruiz M., De Castro F., Soriano E., Sotelo C. Netrin 1 acts as an attractive or as a repulsive cue for distinct migrating neurons during the development of the cerebellar system. Development 2000, 127:1359-1372.
11. Mehlen P., Furne C. Netrin-1: when a neuronal guidance cue turns out to be a regulator of tumorigenesis. Cell Mol Life Sci 2005, 62:2599-2616.
12. Arakawa H. Netrin-1 and its receptors in tumorigenesis. Nat Rev Cancer 2004, 4:978-987.
13. Ramesh G., Berg A., Jayakumar C. Plasma netrin-1 is a diagnostic biomarker of human cancers. Biomarkers 2011, 16:172-180.
14. Lu X., Le Noble F., Yuan L., Jiang Q., De Lafarge B., Sugiyama D., Bréant C., Claes F., De Smet F., Thomas J.L., Autiero M., Carmeliet P., Tessier-Lavigne M., Eichmann A. The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature 2004, 432:179-186.
15. Park K.W., Crouse D., Lee M., Karnik S.K., Sorensen L.K., Murphy K.J., Kuo C.J., Li D.Y. The axonal attractant netrin-1 is an angiogenic factor. Proc Natl Acad Sci U S A 2004, 101:16210-16215.
16. Wang W., Reeves W.B., Pays L., Mehlen P., Ramesh G. Netrin-1 overexpression protects kidney from ischemia-reperfusion injury by suppressing apoptosis. Am J Pathol 2009, 175:1010-1018.
17. Ramesh G. Role of netrin-1 beyond the brain: from biomarker of tissue injury to therapy for inflammatory diseases. Recent Pat Biomark 2012, 2:202-208.
18. Castets M., Mehlen P. Netrin-1 role in angiogenesis: to be or not to be a pro-angiogenic factorα. Cell Cycle 2010, 9:1466-1471.
19. Nguyen A., Cai H. Netrin-1 induces angiogenesis via a DCC-dependent ERK1/2-eNOS feed-forward mechanism. Proc Natl Acad Sci U S A 2006, 103:6530-6535.
20. Durrani S., Haider K.H., Ahmed R.P., Jiang S., Ashraf M. Cytoprotective and pro-angiogenic activity of ex-vivo netrin-1 transgene overexpression protects the heart against ischemia-reperfusion injury. Stem Cells Dev 2012, 21:1769-1778.
21. Lu H., Wang Y., He X., Yuan F., Lin X., Xie B., Tang G., Huang J., Tang Y., Jin K., Chen S., Yang G.Y. Netrin-1 hyperexpression in mouse brain promotes angiogenesis and long-term neurological recovery after transient focal ischemia. Stroke 2012, 43:838-843.
22. Xie H., Zou L., Zhu J., Yang Y. Effects of netrin-1 and netrin-1 knockdown on human umbilical vein endothelial cells and angiogenesis of rat placenta. Placenta 2011, 32:546-553.
23. Larrivée B., Freitas C., Trombe M., Lu X., Delafarge B., Yuan L., Bouvrée K., Bréant C., Del Toro R., Bréchot N., Germain S., Bono F., Dol F., Claes F., Fischer C., et al. Activation of the UNC5B receptor by netrin-1 inhibits sprouting angiogenesis. Genes Dev 2007, 21:2433-2447.
24. Bouvrée K., Larrivée B., Lu X., Yuan L., DeLafarge B., Freitas C., Mathivet T., Bréant C., Tessier-Lavigne M., Bikfalvi A., Eichmann A., Pardanaud L. Netrin-1 inhibits sprouting angiogenesis in developing avian embryos. Dev Biol 2008, 318:172-183.
25. Russell R. Atherosclerosis: an inflammatory disease. N Engl J Med 1999, 340:115-126.
26. Moore K.J., Tabas I. Macrophage in the pathogenesis of atherosclerosis. Cell 2011, 145:341-355.
27. Libby P., Aikawa M. Stabilization of atherosclerotic plaques: new mechanisms and clinical targets. Nat Med 2002, 8:1257-1262.
28. Bellingan G.J., Caldwell H., Howie S.E., Dransfield I., Haslett C. In vivo fate of the inflammatory macrophage during the resolution of inflammation: inflammatory macrophages do not die locally, but emigrate to the draining lymph nodes. J Immunol 1996, 157:2577-2585.
29. Randolph G.J. Emigration of monocyte-derived cells to lymph nodes during resolution of inflammation and its failure in atherosclerosis. Curr Opin Lipidol 2008, 19:462-468.
30. Rong J.X., Li J., Reis E.D., Choudhury R.P., Dansky H.M., Elmalem V.I., Fallon J.T., Breslow J.L., Fisher E.A. Elevating high-density lipoprotein cholesterol in apolipoprotein E-deficient mice remodels advanced atherosclerotic lesions by decreasing macrophage and increasing smooth muscle cell content. Circulation 2001, 104:2447-2452.
31. Llodrá J., Angeli V., Liu J., Trogan E., Fisher E.A., Randolph G.J. Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques. Proc Natl Acad Sci U S A 2004, 101:11779-11784.
32. Feig J.E., Parathath S., Rong J.X., Mick S.L., Vengrenyuk Y., Grauer L., Young S.G., Fisher E.A. Reversal of hyperlipidemia with a genetic switch favorably affects the content and inflammatory state of macrophages in atherosclerotic plaques. Circulation 2011, 123:989-998.
33. Ly N.P., Komatsuzaki K., Fraser I.P., Tseng A.A., Prodhan P., Moore K.J., Kinane T.B. Netrin-1 inhibits leukocyte migration in vitro and in vivo. Proc Natl Acad Sci U S A 2005, 102:14729-14734.
34. Mirakaj V., Thix C.A., Laucher S., Mielke C., Morote-Garcia J.C., Schmit M.A., Henes J., Unertl K.E., Köhler D., Rosenberger P. Netrin-1 dampens pulmonary inflammation during acute lung injury. Am J Respir Crit Care Med 2010, 181:815-824.
35. Rosenberger P., Schwab J.M., Mirakaj V., Masekowsky E., Mager A., Morote-Garcia J.C., Unertl K., Eltzschig H.K. Hypoxia-inducible factor-dependent induction of netrin-1 dampens inflammation caused by hypoxia. Nat Immunol 2009, 10:195-202.
36. Van Gils J.M., Derby M.C., Fernandes L.R., Ramkhelawon B., Ray T.D., Rayner K.J., Parathath S., Distel E., Feig J.L., Alvarez-Leite J.I., Rayner A.J., McDonald T.O., O'Brien K.D., Stuart L.M., Fisher E.A., et al. The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques. Nat Immunol 2012, 13:136-143.
37. Swirski F.K., Nahrendor M., Libby P. The ins and outs of inflammatory cells in atheromata. Cell Metab 2012, 15:135-136.
38. Ramkhelawon B., Yang Y., Van Gils J.M., Hewing B., Rayner K.J., Parathath S., Guo L., Oldebeken S., Feig J.L., Fisher E.A., Moore K.J. Hypoxia induces netrin-1 and Unc5b in atherosclerotic plaques: mechanism for macrophage retention and survival. Arterioscler Thromb Vasc Biol 2013, 33:1180-1188.
39. Prasad A., Stone G.W., Holmes D.R., Gersh B. Reperfusion injury, microvascular dysfunction, and cardioprotection: the dark side of reperfusion. Circulation 2009, 120:2105-2112.
40. Yellon D.M., Hausenloy D.J. Myocardial reperfusion injury. N Engl J Med 2007, 357:1121-1135.
41. Kim H.K., Kang S.W., Jeong S.H., Kim N., Ko J.H., Bang H., Park W.S., Choi T.H., Ha Y.R., Lee Y.S., Youm J.B., Ko K.S., Rhee B.D., Han J. Identification of potential target genes of cardioprotection against ischemia-reperfusion injury by express sequence tags analysis in rat hearts. J Cardiol 2012, 60:98-110.
42. Thuny F., Lairez O., Roubille F., Mewton N., Rioufol G., Sportouch C., Sanchez I., Bergerot C., Thibault H., Cung T.T., Finet G., Argaud L., Revel D., Derumeaux G., Bonnefoy-Cudraz E., et al. Post-conditioning reduces infarct size and edema in patients with ST-segment elevation myocardial infarction. J Am Coll Cadiol 2012, 59:2175-2181.
43. s1177/NO/DCC feed-forward mechanism. J Mol Cell Cardiol 2010, 48:1060-1070.
44. Siu K.L., Zhang J., Lotz C., Ping P., Cai H.L. Netrin-1 abrogates ischemia-reperfusion induced cardiac mitochondrial dysfunction via attenuation of NOX4 and NOS uncoupling. Circulation 2011, 124:A16331.
45. Ovize M., Baxter G.F., Di Lisa F., Ferdinandy P., Garcia-Dorado D., Hausen-loy D.J., Heusch G., Vinten-Johansen J., Yellon D.M., Schulz R. Post-conditioning and protection from reperfusion injury: where do we standα Position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology. Cardiovasc Res 2010, 87:406-423.
46. Marzilli M., Morrone D., Guarini G. Post-conditioning. Heart Metab 2012, 54:20-24.
47. Moghimian M., Faghihi M., Karimian S.M., Imani A., Houshmand F., Azizi Y. Role of central oxytocin in stress-induced cardioprotection in ischemic-reperfused heart model. J Cardiol 2013, 61:79-86.
48. Hofmann U., Hu K., Walter F., Burkard N., Ertl G., Bauersachs J., Ritter O., Frantz S., Bonz A. Pharmacological pre and post-conditioning with the sphingosine-1-phosphate receptor modulator FTY720 after myocardial ischemia-reperfusion. Br J Pharmacol 2010, 160:1243-1251.
49. Bouhidel O.J., Cai L.H. Postconditioning with netrin-1 protects against myocardial ischemia-reperfusion injury via a DCC/ERK1/2/eNOS mechanism. Circulation 2011, 124:A17337.