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Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 4, 2014, Pages 1116-1121

Anilino-monoindolylmaleimides as potent and selective JAK3 inhibitors

(7) McDonnell, Mark E a Bian, Haiyan a Wrobel, Jay a Smith, Garry R a Liang, Shuguang b Ma, Haiching b Reitz, Allen B a

a Fox Chase Chemical Diversity Center Inc (United States)

b REACTION BIOLOGY CORPORATION (United States)

Author keywords

Anilino monoindolylmaleimide; JAK1 inhibitor; JAK2 selective inhibitor; JAK3 inhibitor; Rheumatoid arthritis

Indexed keywords

ANILINO-MONOINDOLYLMALEIMIDE; JAK1 INHIBITOR; JAK2 SELECTIVE INHIBITOR; JAK3 INHIBITOR; RHEUMATOID ARTHRITIS;

ANILINE COMPOUNDS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; JANUS KINASE 3; MALEIMIDES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84893725644 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2014.01.001 Document Type: Article

Times cited : (15)

References (25)

1
- 84864716411
- R. Fleischmann, J. Kremer, J. Cush, H. Schulze-Koops, C.A. Connell, J.D. Bradley, D. Gruben, G.V. Wallenstein, S.H. Zwillich, and S.K. Kanik N. Engl. J. Med. 367 2012 495
- (2012) N. Engl. J. Med. , vol.367 , pp. 495
- Fleischmann, R.¹ Kremer, J.² Cush, J.³ Schulze-Koops, H.⁴ Connell, C.A.⁵ Bradley, J.D.⁶ Gruben, D.⁷ Wallenstein, G.V.⁸ Zwillich, S.H.⁹ Kanik, S.K.¹⁰

2
- 84864703156
- R. van Vollenhoven, R. Fleischmann, S. Cohen, E. Lee, J.A. García Meijide, S. Wagner, S. Forejtova, S.H. Zwillich, D. Gruben, T. Koncz, G.V. Wallenstein, S. Krishnaswami, J.D. Bradley, and B. Wilkinson N. Engl. J. Med. 367 2012 508
- (2012) N. Engl. J. Med. , vol.367 , pp. 508
- Van Vollenhoven, R.¹ Fleischmann, R.² Cohen, S.³ Lee, E.⁴ García Meijide, J.A.⁵ Wagner, S.⁶ Forejtova, S.⁷ Zwillich, S.H.⁸ Gruben, D.⁹ Koncz, T.¹⁰ Wallenstein, G.V.¹¹ Krishnaswami, S.¹² Bradley, J.D.¹³ Wilkinson, B.¹⁴

3
- 84875910671
- R. van Vollenhoven Curr. Opin. Rheumatol. 25 2013 391
- (2013) Curr. Opin. Rheumatol. , vol.25 , pp. 391
- Van Vollenhoven, R.¹

4
- 78650362917
- M.E. Flanagan, T.A. Blumenkopf, W.H. Brissette, M.F. Brown, J.M. Casavant, C. Shang-Poa, J.L. Doty, E.A. Elliott, M.B. Fisher, M. Hines, C. Kent, E.M. Kudlacz, B.M. Lillie, K.S. Magnuson, S.P. McCurdy, M.J. Munchhof, B.D. Perry, P.S. Sawyer, T.J. Strelevitz, C. Subramanyam, J. Sun, D.A. Whipple, and P.S. Changelian J. Med. Chem. 53 2010 8468
- (2010) J. Med. Chem. , vol.53 , pp. 8468
- Flanagan, M.E.¹ Blumenkopf, T.A.² Brissette, W.H.³ Brown, M.F.⁴ Casavant, J.M.⁵ Shang-Poa, C.⁶ Doty, J.L.⁷ Elliott, E.A.⁸ Fisher, M.B.⁹ Hines, M.¹⁰ Kent, C.¹¹ Kudlacz, E.M.¹² Lillie, B.M.¹³ Magnuson, K.S.¹⁴ McCurdy, S.P.¹⁵ Munchhof, M.J.¹⁶ Perry, B.D.¹⁷ Sawyer, P.S.¹⁸ Strelevitz, T.J.¹⁹ Subramanyam, C.²⁰ more..

5
- 84864994569
- A. Kontzias, A. Kotlyar, A. Laurence, P. Changelian, and J.J. O'Shea Curr. Opin. Pharmacol. 12 2012 464
- (2012) Curr. Opin. Pharmacol. , vol.12 , pp. 464
- Kontzias, A.¹ Kotlyar, A.² Laurence, A.³ Changelian, P.⁴ O'Shea, J.J.⁵

6
- 3543141120
- J.J. O'Shea, M. Pesu, D.C. Borie, and P.S. Changelian Nat. Rev. Drug Disc. 3 2004 555
- (2004) Nat. Rev. Drug Disc. , vol.3 , pp. 555
- O'Shea, J.J.¹ Pesu, M.² Borie, D.C.³ Changelian, P.S.⁴

7
- 77955363826
- T.H. Lin, M. Hegen, E. Quadros, C.L. Nickerson-Nutter, K.C. Appell, A.G. Cole, Y. Shao, S. Tam, M. Ohlmeyer, B. Wang, D.G. Goodwin, E.F. Kimble, J. Quintero, M. Gao, P. Symanowicz, C. Wrocklage, J. Lussier, S.H. Schelling, A.G. Hewet, D. Xuan, R. Krykbaev, J. Togias, X. Xu, R. Harrison, T. Mansour, M. Collins, J.D. Clark, M.L. Webb, and K.J. Seidl Arthritis Rheum. 62 2010 2283
- (2010) Arthritis Rheum. , vol.62 , pp. 2283
- Lin, T.H.¹ Hegen, M.² Quadros, E.³ Nickerson-Nutter, C.L.⁴ Appell, K.C.⁵ Cole, A.G.⁶ Shao, Y.⁷ Tam, S.⁸ Ohlmeyer, M.⁹ Wang, B.¹⁰ Goodwin, D.G.¹¹ Kimble, E.F.¹² Quintero, J.¹³ Gao, M.¹⁴ Symanowicz, P.¹⁵ Wrocklage, C.¹⁶ Lussier, J.¹⁷ Schelling, S.H.¹⁸ Hewet, A.G.¹⁹ Xuan, D.²⁰ more..

8
- 79953043687
- C. Haan, C. Rolvering, F. Raulf, M. Kapp, P. Druckes, G. Thoma, I. Behrmann, and H.-G. Zerwes Chem. Biol. 18 2011 314
- (2011) Chem. Biol. , vol.18 , pp. 314
- Haan, C.¹ Rolvering, C.² Raulf, F.³ Kapp, M.⁴ Druckes, P.⁵ Thoma, G.⁶ Behrmann, I.⁷ Zerwes, H.-G.⁸

9
- 33846900700
- M.P. Clark, K.M. George, R.G. Bookland, J. Chen, S.K. Laughlin, K.D. Thakur, W. Lee, J.R. Davis, E.J. Cabrera, T.A. Brugel, J.C. VanRens, M.J. Laufersweiler, J.A. Maier, M.P. Sabat, A. Golebiowski, V. Easwaran, M.E. Webster, B. Dea, and G. Zhang Bioorg. Med. Chem. Lett. 17 2007 1250
- (2007) Bioorg. Med. Chem. Lett. , vol.17 , pp. 1250
- Clark, M.P.¹ George, K.M.² Bookland, R.G.³ Chen, J.⁴ Laughlin, S.K.⁵ Thakur, K.D.⁶ Lee, W.⁷ Davis, J.R.⁸ Cabrera, E.J.⁹ Brugel, T.A.¹⁰ Vanrens, J.C.¹¹ Laufersweiler, M.J.¹² Maier, J.A.¹³ Sabat, M.P.¹⁴ Golebiowski, A.¹⁵ Easwaran, V.¹⁶ Webster, M.E.¹⁷ Dea, B.¹⁸ Zhang, G.¹⁹

10
- 84876149586
- S. Jaime-Figueroa, J. De Vicente, J. Hermann, A. Jahangir, S. Jin, A. Kuglstatter, S.M. Lynch, J. Menke, L. Niu, V. Patel, A. Shao, M. Soth, M.D. Vu, and C. Yee Bioorg. Med. Chem. Lett. 23 2013 2522
- (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 2522
- Jaime-Figueroa, S.¹ De Vicente, J.² Hermann, J.³ Jahangir, A.⁴ Jin, S.⁵ Kuglstatter, A.⁶ Lynch, S.M.⁷ Menke, J.⁸ Niu, L.⁹ Patel, V.¹⁰ Shao, A.¹¹ Soth, M.¹² Vu, M.D.¹³ Yee, C.¹⁴

11
- 84872312946
- M. Soth, J.C. Hermann, C. Yee, M. Alam, J.W. Barnett, P. Berry, M.F. Browner, K. Frank, S. Frauchiger, S. Harris, Y. He, M. Hekmat-Nejad, T. Hendricks, R. Henningsen, R. Hilgenkamp, H. Ho, A. Hoffman, P.-I. Hsu, D.-Q. Hu, A. Itano, S. Jaime-Figueroa, A. Jahangir, S. Jin, A. Kuglstatter, A.K. Kutach, C. Liao, S. Lynch, J. Menke, L. Niu, V. Patel, A. Railkar, D. Roy, A. Shao, D. Shaw, S. Steiner, Y. Sun, S.-L. Tan, S. Wang, and M.D. Vu J. Med. Chem. 56 2013 345
- (2013) J. Med. Chem. , vol.56 , pp. 345
- Soth, M.¹ Hermann, J.C.² Yee, C.³ Alam, M.⁴ Barnett, J.W.⁵ Berry, P.⁶ Browner, M.F.⁷ Frank, K.⁸ Frauchiger, S.⁹ Harris, S.¹⁰ He, Y.¹¹ Hekmat-Nejad, M.¹² Hendricks, T.¹³ Henningsen, R.¹⁴ Hilgenkamp, R.¹⁵ Ho, H.¹⁶ Hoffman, A.¹⁷ Hsu, P.-I.¹⁸ Hu, D.-Q.¹⁹ Itano, A.²⁰ more..

12
- 84876155897
- S.M. Lynch, J. DeVicente, J.C. Hermann, S. Jaime-Figueroa, S. Jin, A. Kuglstatter, H. Li, A. Lovey, J. Menke, L. Niu, V. Patel, D. Roy, M. Soth, S. Steiner, P. Tivitmahaisoon, M.D. Vu, and C. Yee Bioorg. Med. Chem. Lett. 23 2013 2793
- (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 2793
- Lynch, S.M.¹ Devicente, J.² Hermann, J.C.³ Jaime-Figueroa, S.⁴ Jin, S.⁵ Kuglstatter, A.⁶ Li, H.⁷ Lovey, A.⁸ Menke, J.⁹ Niu, L.¹⁰ Patel, V.¹¹ Roy, D.¹² Soth, M.¹³ Steiner, S.¹⁴ Tivitmahaisoon, P.¹⁵ Vu, M.D.¹⁶ Yee, C.¹⁷

13
- 78651070500
- G. Thoma, F. Nuninger, R. Falchetto, E. Hermes, G.A. Tavares, E. Vangrevelinghe, and H.-G. Zerwes J. Med. Chem. 54 2011 284
- (2011) J. Med. Chem. , vol.54 , pp. 284
- Thoma, G.¹ Nuninger, F.² Falchetto, R.³ Hermes, E.⁴ Tavares, G.A.⁵ Vangrevelinghe, E.⁶ Zerwes, H.-G.⁷

14
- 84870239048
- S. Labadie, P.S. Dragovich, K. Barrett, W. Blair, P. Bergeron, C. Chang, G. Deshmukh, C. Eigenbrot, N. Ghilardi, P. Gibbons, C.A. Hurley, A. Johnson, J.R. Kenny, P.B. Kohli, J.J. Kulagowski, M. Liimatta, R. Mendonca, J.M. Murray, R. Pulk, S. Shia, M. Steffek, S. Ubhayakar, M. Ultsch, A. van Abbema, S. Ward, and M. Zak Bioorg. Med. Chem. Lett. 22 2012 7627
- (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 7627
- Labadie, S.¹ Dragovich, P.S.² Barrett, K.³ Blair, W.⁴ Bergeron, P.⁵ Chang, C.⁶ Deshmukh, G.⁷ Eigenbrot, C.⁸ Ghilardi, N.⁹ Gibbons, P.¹⁰ Hurley, C.A.¹¹ Johnson, A.¹² Kenny, J.R.¹³ Kohli, P.B.¹⁴ Kulagowski, J.J.¹⁵ Liimatta, M.¹⁶ Mendonca, R.¹⁷ Murray, J.M.¹⁸ Pulk, R.¹⁹ Shia, S.²⁰ more..

15
- 84863109520
- J.J. Kulagowski, W. Blair, R.J. Bull, C. Chang, G. Deshmukh, H.J. Dyke, C. Eigenbrot, N. Ghilardi, P. Gibbons, T.K. Harrison, P.R. Hewitt, M. Liimatta, C.A. Hurley, A. Johnson, T. Johnson, J.R. Kenny, P.B. Kohli, R.J. Maxey, R. Mendonca, K. Mortara, J. Murray, R. Narukulla, S. Shia, M. Steffek, S. Ubhayakar, M. Ultsch, A. van Abbema, S.I. Ward, N. Waszkowycz, and M. Zak J. Med. Chem. 55 2012 5901
- (2012) J. Med. Chem. , vol.55 , pp. 5901
- Kulagowski, J.J.¹ Blair, W.² Bull, R.J.³ Chang, C.⁴ Deshmukh, G.⁵ Dyke, H.J.⁶ Eigenbrot, C.⁷ Ghilardi, N.⁸ Gibbons, P.⁹ Harrison, T.K.¹⁰ Hewitt, P.R.¹¹ Liimatta, M.¹² Hurley, C.A.¹³ Johnson, A.¹⁴ Johnson, T.¹⁵ Kenny, J.R.¹⁶ Kohli, P.B.¹⁷ Maxey, R.J.¹⁸ Mendonca, R.¹⁹ Mortara, K.²⁰ more..

16
- 84863822923
- M. Zak, R. Mendonca, M. Balazs, K. Barrett, P. Bergeron, W.S. Blair, C. Chang, G. Deshmukh, J. DeVoss, P.S. Dragovich, C. Eigenbrot, N. Ghilardi, P. Gibbons, S. Gradl, C. Hamman, E.J. Hanan, E. Harstad, P.R. Hewitt, C.A. Hurley, T. Jin, A. Johnson, T. Johnson, J.R. Kenny, M.F.T. Koehler, P.B. Kohli, J.J. Kulagowski, S. Labadie, J. Liao, M. Liimatta, Z. Lin, P.J. Lupardus, R.J. Maxey, J.M. Murray, R. Pulk, M. Rodriguez, S. Savage, S. Shia, M. Steffek, S. Ubhayakar, M. Ultsch, A. van Abbema, S.I. Ward, L. Xiao, and Y. Xiao J. Med. Chem. 55 2012 6176
- (2012) J. Med. Chem. , vol.55 , pp. 6176
- Zak, M.¹ Mendonca, R.² Balazs, M.³ Barrett, K.⁴ Bergeron, P.⁵ Blair, W.S.⁶ Chang, C.⁷ Deshmukh, G.⁸ Devoss, J.⁹ Dragovich, P.S.¹⁰ Eigenbrot, C.¹¹ Ghilardi, N.¹² Gibbons, P.¹³ Gradl, S.¹⁴ Hamman, C.¹⁵ Hanan, E.J.¹⁶ Harstad, E.¹⁷ Hewitt, P.R.¹⁸ Hurley, C.A.¹⁹ Jin, T.²⁰ more..

17
- 84878114913
- C.A. Hurley, W.S. Blair, R.J. Bull, C. Chang, P.H. Crackett, G. Deshmukh, H.J. Dyke, R. Fong, N. Ghilardi, P. Gibbons, P.R. Hewitt, A. Johnson, T. Johnson, J.R. Kenny, P.B. Kohli, J.J. Kulagowski, M. Liimatta, P.J. Lupardus, R.J. Maxey, R. Mendonca, R. Narukulla, R. Pulk, S. Ubhayakar, A. van Abbema, S.I. Ward, B. Waszkowycz, and M. Zak Bioorg. Med. Chem. Lett. 23 2013 3592
- (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 3592
- Hurley, C.A.¹ Blair, W.S.² Bull, R.J.³ Chang, C.⁴ Crackett, P.H.⁵ Deshmukh, G.⁶ Dyke, H.J.⁷ Fong, R.⁸ Ghilardi, N.⁹ Gibbons, P.¹⁰ Hewitt, P.R.¹¹ Johnson, A.¹² Johnson, T.¹³ Kenny, J.R.¹⁴ Kohli, P.B.¹⁵ Kulagowski, J.J.¹⁶ Liimatta, M.¹⁷ Lupardus, P.J.¹⁸ Maxey, R.J.¹⁹ Mendonca, R.²⁰ more..

18
- 78449283839
- J.P. Malerich, J.S. Lam, B. Hart, R.M. Fine, B. Klebansky, M.J. Tanga, and A. D'Andrea Bioorg. Med. Chem. Lett. 22 2010 7454
- (2010) Bioorg. Med. Chem. Lett. , vol.22 , pp. 7454
- Malerich, J.P.¹ Lam, J.S.² Hart, B.³ Fine, R.M.⁴ Klebansky, B.⁵ Tanga, M.J.⁶ D'Andrea, A.⁷

19
- 80054958188
- J. Lim, B. Taoka, R.D. Otte, K. Spencer, C.J. Dinsmore, M.D. Altman, C. Chan, C. Rosenstein, S. Sharma, H.-P. Su, A.A. Szewczak, L. Xu, H. Yin, J. Zugay-Murphy, C.G. Marshall, and J.R. Young J. Med. Chem. 54 2011 7334
- (2011) J. Med. Chem. , vol.54 , pp. 7334
- Lim, J.¹ Taoka, B.² Otte, R.D.³ Spencer, K.⁴ Dinsmore, C.J.⁵ Altman, M.D.⁶ Chan, C.⁷ Rosenstein, C.⁸ Sharma, S.⁹ Su, H.-P.¹⁰ Szewczak, A.A.¹¹ Xu, L.¹² Yin, H.¹³ Zugay-Murphy, J.¹⁴ Marshall, C.G.¹⁵ Young, J.R.¹⁶

20
- 84055211821
- L.B. Schenkel, X. Huang, A. Cheng, H.L. Deak, E. Doherty, R. Emkey, Y. Gu, H. Gunaydin, J.L. Kim, J. Lee, R. Loberg, P. Olivieri, J. Pistillo, J. Tang, Q. Wan, H.-L. Wang, S.-W. Wang, M.C. Wells, B. Wu, V. Yu, L. Liu, and S. Geuns-Meyer J. Med. Chem. 54 2011 8440
- (2011) J. Med. Chem. , vol.54 , pp. 8440
- Schenkel, L.B.¹ Huang, X.² Cheng, A.³ Deak, H.L.⁴ Doherty, E.⁵ Emkey, R.⁶ Gu, Y.⁷ Gunaydin, H.⁸ Kim, J.L.⁹ Lee, J.¹⁰ Loberg, R.¹¹ Olivieri, P.¹² Pistillo, J.¹³ Tang, J.¹⁴ Wan, Q.¹⁵ Wang, H.-L.¹⁶ Wang, S.-W.¹⁷ Wells, M.C.¹⁸ Wu, B.¹⁹ Yu, V.²⁰ Liu, L.²¹ Geuns-Meyer, S.²² more..

21
- 80755125565
- T. Anastassiadis, S.W. Deacon, K. Devarajan, H. Ma, and J.R. Peterson Nat. Biotechnol. 29 2011 1039
- (2011) Nat. Biotechnol. , vol.29 , pp. 1039
- Anastassiadis, T.¹ Deacon, S.W.² Devarajan, K.³ Ma, H.⁴ Peterson, J.R.⁵

22
- 4544285673
- M. Tanaka, S. Sagawa, J.-I. Hoshi, F. Shimoma, I. Matsuda, K. Sakoda, T. Sasase, M. Shindo, and T. Inaba Bioorg. Med. Chem. Lett. 14 2004 5171
- (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 5171
- Tanaka, M.¹ Sagawa, S.² Hoshi, J.-I.³ Shimoma, F.⁴ Matsuda, I.⁵ Sakoda, K.⁶ Sasase, T.⁷ Shindo, M.⁸ Inaba, T.⁹

23
- 17044402190
- M. Schlosser, C. Bobbio, and T. Rausis J. Org. Chem. 70 2005 2494
- (2005) J. Org. Chem. , vol.70 , pp. 2494
- Schlosser, M.¹ Bobbio, C.² Rausis, T.³

24
- 72149129175
- M.D. Wendt, and A.R. Kunzer Tetrahedron Lett. 51 2010 641
- (2010) Tetrahedron Lett. , vol.51 , pp. 641
- Wendt, M.D.¹ Kunzer, A.R.²

25
- 33947644070
- A. Shafir, P.A. Lichtor, and S.L. Buchwald J. Am. Chem. Soc. 129 2007 3490
- (2007) J. Am. Chem. Soc. , vol.129 , pp. 3490
- Shafir, A.¹ Lichtor, P.A.² Buchwald, S.L.³

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