Evaluation of the cytotoxicity of organic dust components on THP1 monocytes-derived macrophages using high content analysis

Environmental Toxicology

Volumn 29, Issue 3, 2014, Pages 310-319

  Ramery, Eve ^a,b   O'Brien, Peter J ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

High content analysis; LPS; Organic dust; Peptidoglycan; Toxicity; Zymosan

Indexed keywords

HIGH CONTENT ANALYSIS; LPS; ORGANIC DUST; PEPTIDOGLYCAN; TOXICITY; ZYMOSAN;

CELL LINE; DUST; HUMANS; LIPOPOLYSACCHARIDES; MACROPHAGES; OXIDATIVE STRESS; PEPTIDOGLYCAN; PHAGOCYTOSIS; PHAGOSOMES; RESPIRATORY BURST; ZYMOSAN;

EID: 84893722873     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.21759     Document Type: Article

References (40)

1. Alexis NE, Lay JC, Zeman K, Bennett WE, Peden DB, Soukup JM, Devlin RB, Becker S. 2006. Biological material on inhaled coarse fraction particulate matter activates airway phagocytes in vivo in healthy volunteers. J Allergy Clin Immunol 117:1396-1403.
2. Bassoe CF, Smith I, Sornes S, Halstensen A, Lehmann AK. 2000. Concurrent measurement of antigen- and antibody-dependent oxidative burst and phagocytosis in monocytes and neutrophils. Methods 21:203-220.
3. Calabrese EJ, Baldwin LA. 2003. Hormesis: The dose-response revolution. Ann Rev Pharmacol Toxicol 43:175-197.
4. Craig S, Lopez A, Hoskin D, Markham F. 2005. Meconium inhibits phagocytosis and stimulates respiratory burst in alveolar macrophages. Pediatric Res 57:813-818.
5. Downey GP, Botelho RJ, Butler JR, Moltyaner Y, Chien P, Schreiber AD, Grinstein S. 1999. Phagosomal maturation, acidification, and inhibition of bacterial growth in nonphagocytic cells transfected with FcγRIIA receptors. J Biol Chem 274:28436-28444.
6. Elbim C, Lizard G. 2009. Flow cytometric investigation of neutrophil oxidative burst and apoptosis in physiological and pathological situations. Cytometry. Part A: J Int Soc Anal Cytol 75:475-481.
7. Hiura TS, Kaszubowski MP, Li N, Nel AE. 1999. Chemicals in diesel exhaust particles generate reactive oxygen radicals and induce apoptosis in macrophages. J Immunol 163:5582-5591.
8. Huynh KK, Gershenzon E, Grinstein S. 2008. Cholesterol accumulation by macrophages impairs phagosome maturation. JBiol Chem 283:35745-35755.
9. Jolie R, Backstrom L, Gunderson P. 1998. Airborne contaminants and farmers health in swine farms with high and low prevalence of respiratory diseases in pigs. Annals Agricultural Environ Med 5:87-92.
10. Kreyling WG. 1992. Intracellular particle dissolution in alveolar macrophages. Environ Health Perspect 97:121-126.
11. Lieggi NT, Edvardsson A, O'Brien PJ. 2010. Translation of novel anti-cancer cytotoxicity biomarkers detected with high content analysis from an in vitro predictive model to an in vivo cell model. Toxicol In Vitro 24:2063-2071.
12. Lighty JS, Veranth JM, Sarofim AF. 2000. Combustion aerosols: Factors governing their size and composition and implications to human health. J Air Waste Manage Assoc 50:1565-1618; discussion 1619-1622.
13. Loew LM, Carrington W, Tuft RA, Fay FS. 1994. Physiological cytosolic Ca2+ transients evoke concurrent mitochondrial depolarizations. Proc Natl Acad Sci 91:12579-12583.
14. Miller FJ, Overton JH, Jaskot RH, Menzel DB. 1985. A model of the regional uptake of gaseous pollutants in the lung. I. The sensitivity of the uptake of ozone in the human lung to lower respiratory tract secretions and exercise. Toxicol Appl Pharmacol 79:11-27.
15. Morrow PE. 1988. Possible mechanisms to explain dust overloading of the lungs. Fundamental Appl Toxicol: Official J Soc Toxicol 10:369-384.
16. Müller-Suur C, Larsson K, Grunewald J. 2002. Organic dust-induced interleukin-12 production activates T- and natural killer cells. Eur Respiratory J 20:686-690.
17. Nicholls DG. 2004. Mitochondrial membrane potential and aging. Aging Cell 3:35-40.
18. O'Brien PJ, Domingos MC. 2010. Use of high content analysis in toxicologic clinical pathology for identification and monitoring of translational safety biomarkers. Int Drug Discov 5:50-55.
19. O'Brien PJ, Irwin W, Diaz D, Howard-Cofield E, Krejsa CM, Slaughter MR, Gao B, Kaludercic N, Angeline A, Bernardi P, Brain P, Hougham C. 2006. High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening. Arch Toxicol 80:580-604.
20. Orrenius S, Nicotera P. 1994. The calcium ion and cell death. J Neural Transmission. Supplementum 43:1-11.
21. Orrenius S, McCabe MJJr, Nicotera P. 1992. Ca(2+)-dependent mechanisms of cytotoxicity and programmed cell death. Toxicol Lett 64:357-364.
22. Park EK, Jung HS, Yang HI, Yoo MC, Kim C, Kim KS. 2007. Optimized THP-1 differentiation is required for the detection of responses to weak stimuli. Inflammation Res. [et al.] 56:45-50.
23. Pirie RS, Collie DD, Dixon PM, McGorum BC. 2002a. Evaluation of nebulised hay dust suspensions (HDS) for the diagnosis and investigation of heaves. II. Effects of inhaled HDS on control and heaves horses. Equine Veterinary J 34:337-342.
24. Pirie RS, McLachlan G, McGorum BC. 2002b. Evaluation of nebulised hay dust suspensions (HDS) for the diagnosis and investigation of heaves. I. Preparation and composition of HDS. Equine Veterinary J 34:332-336.
25. Poole JA, Alexis NE, Parks C, MacInnes AK, Gentry-Nielsen MJ, Fey PD, Larsson L, Allen-Gipson D, Von Essen SG, Romberger DJ. 2008. Repetitive organic dust exposure in vitro impairs macrophage differentiation and function. J Allergy Clin Immunol 122:375-82, 382 e1-4.
26. Renwick LC, Donaldson K, Clouter A. 2001. Impairment of alveolar macrophage phagocytosis by ultrafine particles. Toxicol Appl Pharmacol 172:119-127.
27. Reynolds JE, Li J, Eastman A. 1996. Detection of apoptosis by flow cytometry of cells simultaneously stained for intracellular pH (carboxy SNARF-1) and membrane permeability (Hoechst 33342). Cytometry 25:349-357.
28. Romberger DJ, Bodlak V, Von Essen SG, Mathisen T, Wyatt TA. 2002. Hog barn dust extract stimulates IL-8 and IL-6 release in human bronchial epithelial cells via PKC activation. J Appl Physiol 93:289-296.
29. Rye HS, Yue S, Wemmer DE, Quesada MA, Haugland RP, Mathies RA, Glazer AN. 1992. Stable fluorescent complexes of double-stranded DNA with bis-intercalating asymmetric cyanine dyes: properties and applications. Nucleic Acids Res 20:2803-2812.
30. Seagrave J, McDonald JD, Mauderly JL. 2005. In vitro versus in vivo exposure to combustion emissions. Exp Toxicol Pathol 57(Suppl 1):233-238.
31. Sebastian A, Pehrson C, Larsson L. 2006. Elevated concentrations of endotoxin in indoor air due to cigarette smoking. J Environ Monitoring JEM 8:519-522.
32. Sigsgaard T, Bonefeld-J{circled division slash}rgensen EC, Hoffmann HJ, B{circled division slash}nl{circled division slash}kke J, Krüger T. 2005b. Microbial cell wall agents as an occupational hazard. Toxicol Appl Pharmacol 207(Suppl 1):310-319.
33. Simonen-Jokinen T, Pirie RS, McGorum BC, Maisi P. 2005. Effect of composition and different fractions of hay dust suspension on inflammation in lungs of heaves-affected horses: MMP-9 and MMP-2 as indicators of tissue destruction. Equine Veterinary J 37:412-417.
34. Steinberg BE, Scott CC, Grinstein S. 2007. High-throughput assays of phagocytosis, phagosome maturation, and bacterial invasion. Am J Physiol-Cell Physiol 292:C945-C952.
35. Tao F, Kobzik L. 2002. Lung macrophage-epithelial cell interactions amplify particle-mediated cytokine release. Am J Respiratory Cell Mol Biol 26:499-505.
36. Uhing RJ, Adams DO. 1989. Molecular events in the activation of murine macrophages. Agents Actions 26(1-2):9-14.
37. Van Furth R, Hirsch JG, Fedorko ME. 1970. Morphology and peroxidase cytochemistry of mouse promonocytes, monocytes, and macrophages. J Exp Med 132:794-812.
38. Veranth JM, Reilly CA, Veranth MM, Moss TA, Langelier CR, Lanza DL, Yost GS. 2004. Inflammatory cytokines and cell death in BEAS-2B lung cells treated with soil dust, lipopolysaccharide, and surface-modified particles. Toxicol Sci 82:88-96.
39. Von Essen S, Romberger D. 2003. The respiratory inflammatory response to the swine confinement building environment: the adaptation to respiratory exposures in the chronically exposed worker. J Agricultural Safety Health 9:185-196.
40. Yin XJ, Dong CC, Ma JY, Roberts JR, Antonini JM, Ma JK. 2007. Suppression of phagocytic and bactericidal functions of rat alveolar macrophages by the organic component of diesel exhaust particles. J Toxicol Environ Health Part A 70:820-828.