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Volumn 2, Issue 1, 2013, Pages

Reduced cilia frequencies in human renal cell carcinomas versus neighboring parenchymal tissue

Author keywords

Chromophobe RCC; Cilia; Clear cell renal cell carcinoma; Histology; Kidney; Oncocytoma; Papillary RCC

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; ALPHA TUBULIN; KI 67 ANTIGEN; PERICENTRIN;

EID: 84893719988     PISSN: None     EISSN: 20462530     Source Type: Journal    
DOI: 10.1186/2046-2530-2-2     Document Type: Article
Times cited : (67)

References (41)
  • 1
    • 33746891890 scopus 로고    scopus 로고
    • The primary cilium as the cell's antenna: signaling at a sensory organelle
    • 10.1126/science.1124534, 16888132
    • Singla V. The primary cilium as the cell's antenna: signaling at a sensory organelle. Science 2006, 313:629-633. 10.1126/science.1124534, 16888132.
    • (2006) Science , vol.313 , pp. 629-633
    • Singla, V.1
  • 2
    • 84855460847 scopus 로고    scopus 로고
    • Cilia in vertebrate development and disease
    • 10.1242/dev.050054, 3275291, 22223675
    • Oh EC, Katsanis N. Cilia in vertebrate development and disease. Development 2012, 139:443-448. 10.1242/dev.050054, 3275291, 22223675.
    • (2012) Development , vol.139 , pp. 443-448
    • Oh, E.C.1    Katsanis, N.2
  • 4
    • 80052446941 scopus 로고    scopus 로고
    • Ciliopathies: an expanding disease spectrum
    • 10.1007/s00467-010-1731-7, 3098370, 21210154
    • Waters AM, Beales PL. Ciliopathies: an expanding disease spectrum. Pediatr Nephrol 2011, 26:1039-1056. 10.1007/s00467-010-1731-7, 3098370, 21210154.
    • (2011) Pediatr Nephrol , vol.26 , pp. 1039-1056
    • Waters, A.M.1    Beales, P.L.2
  • 5
    • 79551587194 scopus 로고    scopus 로고
    • Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia
    • 10.1101/gad.2008011, 3034894, 21289065
    • Wallingford JB, Mitchell B. Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia. Genes Dev 2011, 25:201-213. 10.1101/gad.2008011, 3034894, 21289065.
    • (2011) Genes Dev , vol.25 , pp. 201-213
    • Wallingford, J.B.1    Mitchell, B.2
  • 6
    • 65449129588 scopus 로고    scopus 로고
    • 2009 update on the classification of renal epithelial tumors in adults
    • 10.1111/j.1442-2042.2009.02302.x, 19453547
    • Lopez-Beltran A, Carrasco JC, Cheng L, Scarpelli M, Kirkali Z, Montironi R. 2009 update on the classification of renal epithelial tumors in adults. Int J Urol 2009, 16:432-443. 10.1111/j.1442-2042.2009.02302.x, 19453547.
    • (2009) Int J Urol , vol.16 , pp. 432-443
    • Lopez-Beltran, A.1    Carrasco, J.C.2    Cheng, L.3    Scarpelli, M.4    Kirkali, Z.5    Montironi, R.6
  • 8
    • 77953857889 scopus 로고    scopus 로고
    • Molecular pathology of chromophobe renal cell carcinoma: a review
    • 10.1111/j.1442-2042.2010.02558.x, 20590942
    • Yusenko MV. Molecular pathology of chromophobe renal cell carcinoma: a review. Int J Urol 2010, 17:592-600. 10.1111/j.1442-2042.2010.02558.x, 20590942.
    • (2010) Int J Urol , vol.17 , pp. 592-600
    • Yusenko, M.V.1
  • 9
    • 77953816103 scopus 로고    scopus 로고
    • Molecular pathology of renal oncocytoma: a review
    • 10.1111/j.1442-2042.2010.02574.x, 20590944
    • Yusenko MV. Molecular pathology of renal oncocytoma: a review. Int J Urol 2010, 17:602-612. 10.1111/j.1442-2042.2010.02574.x, 20590944.
    • (2010) Int J Urol , vol.17 , pp. 602-612
    • Yusenko, M.V.1
  • 10
    • 56049120376 scopus 로고    scopus 로고
    • All along the watchtower: is the cilium a tumor suppressor organelle?
    • Mans DA, Voest EE, Giles RH. All along the watchtower: is the cilium a tumor suppressor organelle?. Biochim Biophys Acta 2008, 1786:114-125.
    • (2008) Biochim Biophys Acta , vol.1786 , pp. 114-125
    • Mans, D.A.1    Voest, E.E.2    Giles, R.H.3
  • 13
    • 73649132239 scopus 로고    scopus 로고
    • Renal cystic diseases and renal neoplasms: a mini-review
    • Bonsib SM. Renal cystic diseases and renal neoplasms: a mini-review. Clin J Am Soc of Nephrol 2009, 4:1998-2007.
    • (2009) Clin J Am Soc of Nephrol , vol.4 , pp. 1998-2007
    • Bonsib, S.M.1
  • 17
    • 80155184068 scopus 로고    scopus 로고
    • Generation of a mouse model of Von Hippel-Lindau kidney disease leading to renal cancers by expression of a constitutively active mutant of HIF1
    • 10.1158/0008-5472.CAN-11-1745, 3214086, 21908555
    • Fu L, Wang G, Shevchuk MM, Nanus DM, Gudas LJ. Generation of a mouse model of Von Hippel-Lindau kidney disease leading to renal cancers by expression of a constitutively active mutant of HIF1. Cancer Res 2011, 71:6848-6856. 10.1158/0008-5472.CAN-11-1745, 3214086, 21908555.
    • (2011) Cancer Res , vol.71 , pp. 6848-6856
    • Fu, L.1    Wang, G.2    Shevchuk, M.M.3    Nanus, D.M.4    Gudas, L.J.5
  • 18
    • 26444570008 scopus 로고    scopus 로고
    • A mouse model of tuberous sclerosis 1 showing background specific early post-natal mortality and metastatic renal cell carcinoma
    • 10.1093/hmg/ddi190, 15888477
    • Wilson C, Idziaszczyk S, Parry L, Guy C, Griffiths DF, Lazda E, Bayne RA, Smith AJ, Sampson JR, Cheadle JP. A mouse model of tuberous sclerosis 1 showing background specific early post-natal mortality and metastatic renal cell carcinoma. Hum Mol Genet 2005, 14:1839-1850. 10.1093/hmg/ddi190, 15888477.
    • (2005) Hum Mol Genet , vol.14 , pp. 1839-1850
    • Wilson, C.1    Idziaszczyk, S.2    Parry, L.3    Guy, C.4    Griffiths, D.F.5    Lazda, E.6    Bayne, R.A.7    Smith, A.J.8    Sampson, J.R.9    Cheadle, J.P.10
  • 21
    • 80053553994 scopus 로고    scopus 로고
    • The centrosome cycle: centriole biogenesis, duplication and inherent asymmetries
    • 10.1038/ncb2345, 21968988
    • Nigg EA, Stearns T. The centrosome cycle: centriole biogenesis, duplication and inherent asymmetries. Nat Cell Biol 2011, 13:1154-1160. 10.1038/ncb2345, 21968988.
    • (2011) Nat Cell Biol , vol.13 , pp. 1154-1160
    • Nigg, E.A.1    Stearns, T.2
  • 22
    • 58149159900 scopus 로고    scopus 로고
    • Sporadic clear cell renal cell carcinoma but not the papillary type is characterized by severely reduced frequency of primary cilia
    • Schraml P, Frew IJ, Thoma CR, Boysen G, Struckmann K, Krek W, Moch H. Sporadic clear cell renal cell carcinoma but not the papillary type is characterized by severely reduced frequency of primary cilia. Mod Pathol 2008, 22:31-36.
    • (2008) Mod Pathol , vol.22 , pp. 31-36
    • Schraml, P.1    Frew, I.J.2    Thoma, C.R.3    Boysen, G.4    Struckmann, K.5    Krek, W.6    Moch, H.7
  • 24
    • 34648840210 scopus 로고    scopus 로고
    • Immunofluorescence on proteinase XXIV-digested paraffin sections
    • van der Ven K, Nguyen TQ, Goldschmeding R. Immunofluorescence on proteinase XXIV-digested paraffin sections. Kidney Int 2007, 72:896.
    • (2007) Kidney Int , vol.72 , pp. 896
    • van der Ven, K.1    Nguyen, T.Q.2    Goldschmeding, R.3
  • 25
    • 84906329851 scopus 로고    scopus 로고
    • Aperio ImageScope
    • Aperio ImageScope.http://www.aperio.com.
  • 26
    • 49449100251 scopus 로고    scopus 로고
    • Building it up and taking it down: the regulation of vertebrate ciliogenesis
    • 10.1002/dvdy.21540, 3304540, 18435467
    • Santos N, Reiter JF. Building it up and taking it down: the regulation of vertebrate ciliogenesis. Dev Dyn 2008, 237:1972-1981. 10.1002/dvdy.21540, 3304540, 18435467.
    • (2008) Dev Dyn , vol.237 , pp. 1972-1981
    • Santos, N.1    Reiter, J.F.2
  • 27
    • 80855139808 scopus 로고    scopus 로고
    • Primary cilium depletion typifies cutaneous melanoma in situ and malignant melanoma
    • 10.1371/journal.pone.0027410, 3214062, 22096570
    • Kim J, Dabiri S, Seeley ES. Primary cilium depletion typifies cutaneous melanoma in situ and malignant melanoma. PLoS ONE 2011, 6:e27410. 10.1371/journal.pone.0027410, 3214062, 22096570.
    • (2011) PLoS ONE , vol.6
    • Kim, J.1    Dabiri, S.2    Seeley, E.S.3
  • 28
    • 58349099851 scopus 로고    scopus 로고
    • Pancreatic cancer and precursor pancreatic intraepithelial neoplasia lesions are devoid of primary cilia
    • 10.1158/0008-5472.CAN-08-1290, 2629528, 19147554
    • Seeley ES, Carrière C, Goetze T, Longnecker DS, Korc M. Pancreatic cancer and precursor pancreatic intraepithelial neoplasia lesions are devoid of primary cilia. Cancer Res 2009, 69:422-430. 10.1158/0008-5472.CAN-08-1290, 2629528, 19147554.
    • (2009) Cancer Res , vol.69 , pp. 422-430
    • Seeley, E.S.1    Carrière, C.2    Goetze, T.3    Longnecker, D.S.4    Korc, M.5
  • 29
  • 30
    • 69949166247 scopus 로고    scopus 로고
    • Dual and opposing roles of primary cilia in medulloblastoma development
    • 10.1038/nm.2020, 2771737, 19701203
    • Han Y-G, Kim HJ, Dlugosz AA, Ellison DW, Gilbertson RJ, Alvarez-Buylla A. Dual and opposing roles of primary cilia in medulloblastoma development. Nat Med 2009, 15:1062-1065. 10.1038/nm.2020, 2771737, 19701203.
    • (2009) Nat Med , vol.15 , pp. 1062-1065
    • Han, Y.-G.1    Kim, H.J.2    Dlugosz, A.A.3    Ellison, D.W.4    Gilbertson, R.J.5    Alvarez-Buylla, A.6
  • 31
    • 34548684136 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2
    • 10.1016/j.febslet.2007.08.050, 17825299
    • Lolkema MP, Mans DA, Snijckers CM, van Noort M, van Beest M, Voest EE, Giles RH. The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2. FEBS Letters 2007, 581:4571-4576. 10.1016/j.febslet.2007.08.050, 17825299.
    • (2007) FEBS Letters , vol.581 , pp. 4571-4576
    • Lolkema, M.P.1    Mans, D.A.2    Snijckers, C.M.3    van Noort, M.4    van Beest, M.5    Voest, E.E.6    Giles, R.H.7
  • 32
    • 47049090632 scopus 로고    scopus 로고
    • PVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation
    • 10.1038/emboj.2008.96, 2435131, 18497742
    • Frew IJ, Thoma CR, Georgiev S, Minola A, Hitz M, Montani M, Moch H, Krek W. pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation. EMBO J 2008, 27:1747-1757. 10.1038/emboj.2008.96, 2435131, 18497742.
    • (2008) EMBO J , vol.27 , pp. 1747-1757
    • Frew, I.J.1    Thoma, C.R.2    Georgiev, S.3    Minola, A.4    Hitz, M.5    Montani, M.6    Moch, H.7    Krek, W.8
  • 33
    • 34548220593 scopus 로고    scopus 로고
    • The VHL tumor suppressor: riding tandem with GSK3beta in primary cilium maintenance
    • 10.4161/cc.6.15.4518, 17671433
    • Thoma CRC, Frew IJI, Krek WW. The VHL tumor suppressor: riding tandem with GSK3beta in primary cilium maintenance. Cell Cycle 2007, 6:1809-1813. 10.4161/cc.6.15.4518, 17671433.
    • (2007) Cell Cycle , vol.6 , pp. 1809-1813
    • Thoma, C.R.C.1    Frew, I.J.I.2    Krek, W.W.3
  • 34
    • 84885955126 scopus 로고    scopus 로고
    • Birt-Hogg-Dubé: tumour suppressor function and signalling dynamics central to folliculin
    • [Epub ahead of print]
    • Tee AR, Pause A. Birt-Hogg-Dubé: tumour suppressor function and signalling dynamics central to folliculin. Fam Cancer 2012, [Epub ahead of print].
    • (2012) Fam Cancer
    • Tee, A.R.1    Pause, A.2
  • 35
    • 84906329838 scopus 로고    scopus 로고
    • 3D renal modeling classifies BHD as a ciliopathy, possibly responsive to treatment with PTC124
    • Basten SG, Haidari K, Slaats G, van Steensel M, Giles R. 3D renal modeling classifies BHD as a ciliopathy, possibly responsive to treatment with PTC124. Cilia 2012, (Suppl 1):82.
    • (2012) Cilia , Issue.SUPPL. 1 , pp. 82
    • Basten, S.G.1    Haidari, K.2    Slaats, G.3    van Steensel, M.4    Giles, R.5
  • 36
    • 57649243069 scopus 로고    scopus 로고
    • The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway
    • 10.1093/hmg/ddn325, 2644647, 18845692
    • Hartman TR, Liu D, Zilfou JT, Robb V, Morrison T, Watnick T, Henske EP. The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway. Hum Mol Genet 2008, 18:151-163. 10.1093/hmg/ddn325, 2644647, 18845692.
    • (2008) Hum Mol Genet , vol.18 , pp. 151-163
    • Hartman, T.R.1    Liu, D.2    Zilfou, J.T.3    Robb, V.4    Morrison, T.5    Watnick, T.6    Henske, E.P.7
  • 37
    • 77952263737 scopus 로고    scopus 로고
    • The genetic basis of kidney cancer: a metabolic disease
    • 10.1038/nrurol.2010.47, 2929006, 20448661
    • Linehan WM, Srinivasan R, Schmidt LS. The genetic basis of kidney cancer: a metabolic disease. Nat Rev Urol 2010, 7:277-285. 10.1038/nrurol.2010.47, 2929006, 20448661.
    • (2010) Nat Rev Urol , vol.7 , pp. 277-285
    • Linehan, W.M.1    Srinivasan, R.2    Schmidt, L.S.3
  • 38
    • 0036718539 scopus 로고    scopus 로고
    • Molecular basis of the VHL hereditary cancer syndrome
    • 10.1038/nrc885, 12209156
    • Kaelin WG. Molecular basis of the VHL hereditary cancer syndrome. Nat Rev Cancer 2002, 2:673-682. 10.1038/nrc885, 12209156.
    • (2002) Nat Rev Cancer , vol.2 , pp. 673-682
    • Kaelin, W.G.1
  • 39
    • 84863116083 scopus 로고    scopus 로고
    • Target-of-rapamycin complex 1 (Torc1) signaling modulates cilia size and function through protein synthesis regulation
    • Yuan S, Li J, Diener DR, Choma MA, Rosenbaum JL, Sun Z. Target-of-rapamycin complex 1 (Torc1) signaling modulates cilia size and function through protein synthesis regulation. Proc Natl Acad of Sci USA 2012, 109:2021-2026.
    • (2012) Proc Natl Acad of Sci USA , vol.109 , pp. 2021-2026
    • Yuan, S.1    Li, J.2    Diener, D.R.3    Choma, M.A.4    Rosenbaum, J.L.5    Sun, Z.6
  • 41
    • 84860536549 scopus 로고    scopus 로고
    • Molecular pathways: the role of primary cilia in cancer progression and therapeutics with a focus on hedgehog signaling
    • 10.1158/1078-0432.CCR-11-0755, 22415315
    • Hassounah NB, Bunch TA, McDermott KM. Molecular pathways: the role of primary cilia in cancer progression and therapeutics with a focus on hedgehog signaling. Clin Cancer Res 2012, 18:2429-2435. 10.1158/1078-0432.CCR-11-0755, 22415315.
    • (2012) Clin Cancer Res , vol.18 , pp. 2429-2435
    • Hassounah, N.B.1    Bunch, T.A.2    McDermott, K.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.