Identification of axon-enriched MicroRNAs localized to growth cones of cortical neurons

Developmental Neurobiology

Volumn 74, Issue 3, 2014, Pages 397-406

  Sasaki, Yukio ^a,b,c   Gross, Christina ^a   Xing, Lei ^a   Goshima, Yoshio ^b   Bassell, Gary J ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YOKOHAMA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

Axon; Growth cone; MicroRNA

Indexed keywords

MICRORNA; MICRORNA 16; MICRORNA 17 5P; MICRORNA 181A; MICRORNA 192; MICRORNA 212; MICRORNA 324 3P; MICRORNA 361; MICRORNA 382; MICRORNA 532; MICRORNA 676; MICRORNA 685; MICRORNA 709; MICRORNA 720; RIBONUCLEASE P; RNA INDUCED SILENCING COMPLEX; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN REGION; CELL DENSITY; FLUORESCENCE IN SITU HYBRIDIZATION; GROWTH CONE; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NERVE CELL CULTURE; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA TRANSLATION;

AXON; GROWTH CONE; MICRORNA;

ANIMALS; AXONS; CELL CULTURE TECHNIQUES; CELLS, CULTURED; CEREBRAL CORTEX; CYTOPLASMIC GRANULES; GROWTH CONES; HIPPOCAMPUS; IMMUNOPRECIPITATION; IN SITU HYBRIDIZATION, FLUORESCENCE; MICE; MICRORNAS; NEURONS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA-INDUCED SILENCING COMPLEX;

EID: 84893717200     PISSN: 19328451     EISSN: 10974695     Source Type: Journal    
DOI: 10.1002/dneu.22113     Document Type: Article

References (32)

1. Bassell GJ, Kelic S. 2004. Binding proteins for mRNA localization and local translation, and their dysfunction in genetic neurological disease. Curr Opin Neurobiol 14:574-581.
2. Bassell GJ, Warren ST. 2008. Fragile X syndrome: Loss of local mRNA regulation alters synaptic development and function. Neuron 60:201-214.
3. Bramham CR, Wells DG. 2007. Dendritic mRNA: Transport, translation and function. Nat Rev Neurosci 8:776-789.
4. Bushati N, Cohen SM. 2007. MicroRNA functions. Annu Rev Cell Dev Biol 23:175-205.
5. Dajas-Bailador F, Bonev B, Garcez P, Stanley P, Guillemot F, Papalopulu N. 2012. MicroRNA-9 regulates axon extension and branching by targeting Map1b in mouse cortical neurons. Nat Neurosci 15:697-699.
6. Davis TH, Cuellar TL, Koch SM, Barker AJ, Harfe BD, McManus MT, Ullian EM. 2008. Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus. J Neurosci 28:4322-4330.
7. Eulalio A, Huntzinger E, Izaurralde E. 2008. Getting to the root of miRNA-mediated gene silencing. Cell 132:9-14.
8. Fabian MR, Sonenberg N, Filipowicz W. 2010. Regulation of mRNA translation and stability by microRNAs. Annu Rev Biochem 79:351-379.
9. Fruhbeis C, Frohlich D, Kramer-Albers EM. 2012. Emerging roles of exosomes in neuron-glia communication. Front Physiol 3:119.
10. Ghildiyal M, Zamore PD. 2009. Small silencing RNAs: An expanding universe. Nat Rev Genet 10:94-108.
11. Han L, Wen Z, Lynn RC, Baudet ML, Holt CE, Sasaki Y, Bassell GJ, et al. 2011. Regulation of chemotropic guidance of nerve growth cones by microRNA. Mol Brain 4:40.
12. Hengst U, Cox LJ, Macosko EZ, Jaffrey SR. 2006. Functional and selective RNA interference in developing axons and growth cones. J Neurosci 26:5727-5732.
13. Kleiman R, Banker G, Steward O. 1994. Development of subcellular mRNA compartmentation in hippocampal neurons in culture. J Neurosci 14:1130-1140.
14. Kye MJ, Liu T, Levy SF, Xu NL, Groves BB, Bonneau R, Lao K, et al. 2007. Somatodendritic microRNAs identified by laser capture and multiplex RT-PCR. RNA 13:1224-1234.
15. Lin AC, Holt CE. 2007. Local translation and directional steering in axons. EMBO J 26:3729-3736.
16. Martin KC, Ephrussi A. 2009. mRNA localization: Gene expression in the spatial dimension. Cell 136:719-730.
17. Muddashetty RS, Kelic S, Gross C, Xu M, Bassell GJ. 2007. Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome. J Neurosci 27:5338-5348.
18. Muddashetty RS, Nalavadi VC, Gross C, Yao X, Xing L, Laur O, Warren ST, et al. 2011. Reversible inhibition of PSD-95 mRNA translation by miR-125a, FMRP phosphorylation, and mGluR signaling. Mol Cell 42:673-688.
19. Murashov AK, Chintalgattu V, Islamov RR, Lever TE, Pak ES, Sierpinski PL, Katwa LC, et al. 2007. RNAi pathway is functional in peripheral nerve axons. FASEB J 21:656-670.
20. Natera-Naranjo O, Aschrafi A, Gioio AE, Kaplan BB. 2010. Identification and quantitative analyses of microRNAs located in the distal axons of sympathetic neurons. RNA 16:1516-1529.
21. Piper M, Holt C. 2004. RNA translation in axons. Annu Rev Cell Dev Biol 20:505-523.
22. Richter JD. 2007. CPEB: A life in translation. Trends Biochem Sci 32:279-285.
23. Ro S, Park C, Jin J, Sanders KM, Yan W. 2006. A PCR-based method for detection and quantification of small RNAs. Biochem Biophys Res Commun 351:756-763.
24. Sasaki Y, Welshhans K, Wen Z, Yao J, Xu M, Goshima Y, Zheng JQ, et al. 2010. Phosphorylation of zipcode binding protein 1 is required for brain-derived neurotrophic factor signaling of local β-actin synthesis and growth cone turning. J Neurosci 30:9349-9358.
25. Schratt GM, Tuebing F, Nigh EA, Kane CG, Sabatini ME, Kiebler M, Greenberg ME. 2006. A brain-specific microRNA regulates dendritic spine development. Nature 439:283-289.
26. Steward O, Schuman EM. 2001. Protein synthesis at synaptic sites on dendrites. Ann Rev Neurosci 24:299-325.
27. Sutton MA, Schuman EM. 2006. Dendritic protein synthesis, synaptic plasticity, and memory. Cell 127:49-58.
28. Taylor AM, Berchtold NC, Perreau VM, Tu CH, Li Jeon N, Cotman CW. 2009. Axonal mRNA in uninjured and regenerating cortical mammalian axons. J Neurosci 29:4697-4707.
29. Vester B, Wengel J. 2004. LNA (locked nucleic acid): High-affinity targeting of complementary RNA and DNA. Biochemistry 43:13233-13241.
30. Wu D, Raafat A, Pak E, Clemens S, Murashov AK. 2012. Dicer-microRNA pathway is critical for peripheral nerve regeneration and functional recovery in vivo and regenerative axonogenesis in vitro. Exp Neurol 233:555-565.
31. Zhang Y, Ueno Y, Liu XS, Buller B, Wang X, Chopp M, Zhang ZG. 2013. The microRNA-17-92 cluster enhances axonal outgrowth in embryonic cortical neurons. J Neurosci 33:6885-6894.
32. Zivraj KH, Tung YC, Piper M, Gumy L, Fawcett JW, Yeo GS, Holt CE. 2010. Subcellular profiling reveals distinct and developmentally regulated repertoire of growth cone mRNAs. J Neurosci 30:15464-15478.