Structural basis for substrate specificity in ArnB. A key enzyme in the polymyxin resistance pathway of gram-negative bacteria

Biochemistry

Volumn 53, Issue 4, 2014, Pages 796-805

  Lee, Myeongseon ^a   Sousa, Marcelo C ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL COLONIZATION; CATIONIC ANTIMICROBIAL PEPTIDES; GRAM-NEGATIVE BACTERIA; MODIFICATION MECHANISM; NEGATIVELY CHARGED; SPECIFIC INHIBITORS; SUBSTRATE SPECIFICITY; UDP-GLUCURONIC ACID;

BIOCHEMISTRY; CATALYSIS; PATIENT TREATMENT;

BACTERIA;

4 AMINO 4 DEOXY LEVO ARABINOSE; 4 AMINO 4 DEOXYARABINOSE; ALDIMINE; AMINOTRANSFERASE; BACTERIAL ENZYME; BACTERIAL PROTEIN; CATIONIC ANTIMICROBIAL PEPTIDE; COLISTIN; IMINE; LIPID A; PEPTIDE; PHOSPHATE; POLYMYXIN; PROTEIN ARNB; PYRIDOXAL 5 PHOSPHATE; SOLVENT; SUGAR NUCLEOTIDE; UNCLASSIFIED DRUG; URACIL; URIDINE DERIVATIVE; URIDINE DIPHOSPHATE; URIDINE DIPHOSPHATE RIBOSE;

ANTIBIOTIC RESISTANCE; ARTICLE; CATALYSIS; CATALYST; CHEMICAL MODIFICATION; COMPLEX FORMATION; CONFORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYSTIC FIBROSIS; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; GRAM NEGATIVE BACTERIUM; HUMAN; LIPOGENESIS; NONHUMAN; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN STRUCTURE; PSEUDOMONAS; SALMONELLA;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, BACTERIAL; MODELS, MOLECULAR; MUTATION; POLYMYXINS; PROTEIN CONFORMATION; PYRIDOXAL PHOSPHATE; SALMONELLA TYPHIMURIUM; SUBSTRATE SPECIFICITY; TRANSAMINASES; URIDINE DIPHOSPHATE SUGARS;

EID: 84893695827     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi4015677     Document Type: Article

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