Structure-based design of irreversible human KAT II inhibitors: Discovery of new potency-enhancing interactions

ACS Medicinal Chemistry Letters

Volumn 4, Issue 1, 2013, Pages 37-40

  Tuttle, Jamison B ^a,b   Anderson, Marie ^a   Bechle, Bruce M ^a   Campbell, Brian M ^a   Chang, Cheng ^a   Dounay, Amy B ^a   Evrard, Edelweiss ^a   Fonseca, Kari R ^a   Gan, Xinmin ^a   Ghosh, Somraj ^a   Horner, Weldon ^a   James, Larry C ^a   Kim, Ji Young ^a   McAllister, Laura A ^a   Pandit, Jayvardhan ^a   Parikh, Vinod D ^a   Rago, Brian J ^a   Salafia, Michelle A ^a   Strick, Christine A ^a   Zawadzke, Laura E ^a   Verhoest, Patrick R ^a   more..

^a PFIZER INC   (United States)

^b not available   (United States)

Author keywords

aryl hydrocarbon receptor; dose response modeling; hydroxamic acid; in vivo microdialysis; irreversible inhibition; kynurenic acid; kynurenine amino transferase; schizophrenia

Indexed keywords

AMINOTRANSFERASE INHIBITOR; HYDROXAMIC ACID DERIVATIVE; KYNURENINE AMINOTRANSFERASE; KYNURENINE AMINOTRANSFERASE II; KYNURENINE AMINOTRANSFERASE II INHIBITOR; UNCLASSIFIED DRUG;

AREA UNDER THE CURVE; ARTICLE; BRAIN; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BRAIN LEVEL; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; ENZYME ACTIVITY; HUMAN; IC 50; IN VIVO STUDY; PHARMACODYNAMICS; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; X RAY CRYSTALLOGRAPHY;

EID: 84872285323     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml300237v     Document Type: Article

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