메뉴 건너뛰기




Volumn 4 JAN, Issue , 2014, Pages

The potential and hurdles of targeted alpha therapy - clinical trials and beyond

Author keywords

Alpha emitters; Cancer; Dosimetry; Ovarian cancer; Radionuclide therapy; Targeted alpha therapy

Indexed keywords

ACTINIUM 225; ASTATINE 211; BISMUTH 212; BISMUTH 213; LEAD 212; LUTETIUM 177; MONOCLONAL ANTIBODY; RADIOISOTOPE; RADIUM CHLORIDE RA 223; TRASTUZUMAB;

EID: 84893690105     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2013.00324     Document Type: Review
Times cited : (144)

References (89)
  • 1
    • 79959428518 scopus 로고    scopus 로고
    • Protein targeting constructs in alpha therapy
    • doi:10.2174/1874471011104030197
    • Olafsen T, Elgqvist J, Wu AM. Protein targeting constructs in alpha therapy. Curr Radiopharm (2011) 4(3):197-213. doi:10.2174/1874471011104030197
    • (2011) Curr Radiopharm , vol.4 , Issue.3 , pp. 197-213
    • Olafsen, T.1    Elgqvist, J.2    Wu, A.M.3
  • 2
    • 79952687471 scopus 로고    scopus 로고
    • Cancer radioimmunotherapy
    • doi:10.2217/imt.10.114
    • Sharkey RM, Goldenberg DM. Cancer radioimmunotherapy. Immunotherapy (2011) 3(3):349-70. doi:10.2217/imt.10.114
    • (2011) Immunotherapy , vol.3 , Issue.3 , pp. 349-370
    • Sharkey, R.M.1    Goldenberg, D.M.2
  • 3
    • 84889589885 scopus 로고    scopus 로고
    • Peptide-based radiopharmaceuticals for targeted tumor therapy
    • Dong C, Liu Z, Wang F. Peptide-based radiopharmaceuticals for targeted tumor therapy. Curr Med Chem (2013) 21(1):139-52.
    • (2013) Curr Med Chem , vol.21 , Issue.1 , pp. 139-152
    • Dong, C.1    Liu, Z.2    Wang, F.3
  • 4
    • 77949895194 scopus 로고    scopus 로고
    • Preclinical and clinical studies of peptide receptor radionuclide therapy
    • doi:10.1053/j.semnuclmed.2009.12.001
    • Pool SE, Krenning EP, Koning GA, van Eijck CH, Teunissen JJ, Kam B, et al. Preclinical and clinical studies of peptide receptor radionuclide therapy. Semin Nucl Med (2010) 40(3):209-18. doi:10.1053/j.semnuclmed.2009.12.001
    • (2010) Semin Nucl Med , vol.40 , Issue.3 , pp. 209-218
    • Pool, S.E.1    Krenning, E.P.2    Koning, G.A.3    van Eijck, C.H.4    Teunissen, J.J.5    Kam, B.6
  • 5
    • 84891082821 scopus 로고    scopus 로고
    • Prospects in folate receptor-targeted radionuclide therapy.
    • doi:10.3389/fonc.2013.00249
    • Muller C, Schibli R. Prospects in folate receptor-targeted radionuclide therapy. Front Oncol (2013) 3:249. doi:10.3389/fonc.2013.00249
    • (2013) Front Oncol , vol.3 , pp. 249
    • Muller, C.1    Schibli, R.2
  • 6
    • 34248655131 scopus 로고    scopus 로고
    • Tunable pharmacokinetics: modifying the in vivo half-life of antibodies by directed mutagenesis of the Fc fragment
    • doi:10.1038/nprot.2006.322
    • Olafsen T, Kenanova VE, Wu AM. Tunable pharmacokinetics: modifying the in vivo half-life of antibodies by directed mutagenesis of the Fc fragment. Nat Protoc (2006) 1(4):2048-60. doi:10.1038/nprot.2006.322
    • (2006) Nat Protoc , vol.1 , Issue.4 , pp. 2048-2060
    • Olafsen, T.1    Kenanova, V.E.2    Wu, A.M.3
  • 7
    • 77954952365 scopus 로고    scopus 로고
    • Targeted alpha-radionuclide therapy of functionally critically located gliomas with 213Bi-DOTA-[Thi8, Met(O2)11]-substance P: a pilot trial
    • doi:10.1007/s00259-010-1385-5
    • Cordier D, Forrer F, Bruchertseifer F, Morgenstern A, Apostolidis C, Good S, et al. Targeted alpha-radionuclide therapy of functionally critically located gliomas with 213Bi-DOTA-[Thi8, Met(O2)11]-substance P: a pilot trial. Eur J Nucl Med Mol Imaging (2010) 37(7):1335-44. doi:10.1007/s00259-010-1385-5
    • (2010) Eur J Nucl Med Mol Imaging , vol.37 , Issue.7 , pp. 1335-1344
    • Cordier, D.1    Forrer, F.2    Bruchertseifer, F.3    Morgenstern, A.4    Apostolidis, C.5    Good, S.6
  • 8
    • 33745697736 scopus 로고    scopus 로고
    • Local targeting of malignant gliomas by the diffusible peptidic vector 1,4,7,10-tetraazacyclododecane-1-glutaric acid-4,7,10-triacetic acid-substance p
    • doi:10.1158/1078-0432.CCR-05-2820
    • Kneifel S, Cordier D, Good S, Ionescu MC, Ghaffari A, Hofer S, et al. Local targeting of malignant gliomas by the diffusible peptidic vector 1,4,7,10-tetraazacyclododecane-1-glutaric acid-4,7,10-triacetic acid-substance p. Clin Cancer Res (2006) 12(12):3843-50. doi:10.1158/1078-0432.CCR-05-2820
    • (2006) Clin Cancer Res , vol.12 , Issue.12 , pp. 3843-3850
    • Kneifel, S.1    Cordier, D.2    Good, S.3    Ionescu, M.C.4    Ghaffari, A.5    Hofer, S.6
  • 9
    • 37649010802 scopus 로고    scopus 로고
    • Clinical experience with alpha-particle emitting 211At: treatment of recurrent brain tumor patients with 211At-labeled chimeric antitenascin monoclonal antibody 81C6
    • doi:10.2967/jnumed.107.046938
    • Zalutsky MR, Reardon DA, Akabani G, Coleman RE, Friedman AH, Friedman HS, et al. Clinical experience with alpha-particle emitting 211At: treatment of recurrent brain tumor patients with 211At-labeled chimeric antitenascin monoclonal antibody 81C6. J Nucl Med (2008) 49(1):30-8. doi:10.2967/jnumed.107.046938
    • (2008) J Nucl Med , vol.49 , Issue.1 , pp. 30-38
    • Zalutsky, M.R.1    Reardon, D.A.2    Akabani, G.3    Coleman, R.E.4    Friedman, A.H.5    Friedman, H.S.6
  • 10
    • 67650088549 scopus 로고    scopus 로고
    • Intraperitoneal alpha-particle radioimmunotherapy of ovarian cancer patients: pharmacokinetics and dosimetry of (211)At-MX35 F(ab')2-a phase I study
    • doi:10.2967/jnumed.109.062604
    • Andersson H, Cederkrantz E, Back T, Divgi C, Elgqvist J, Himmelman J, et al. Intraperitoneal alpha-particle radioimmunotherapy of ovarian cancer patients: pharmacokinetics and dosimetry of (211)At-MX35 F(ab')2-a phase I study. J Nucl Med (2009) 50(7):1153-60. doi:10.2967/jnumed.109.062604
    • (2009) J Nucl Med , vol.50 , Issue.7 , pp. 1153-1160
    • Andersson, H.1    Cederkrantz, E.2    Back, T.3    Divgi, C.4    Elgqvist, J.5    Himmelman, J.6
  • 11
    • 84890532810 scopus 로고    scopus 로고
    • Pharmacokinetics and imaging of (212)Pb-TCMC-Trastuzumab after intraperitoneal administration in ovarian cancer patients
    • doi:10.1089/cbr.2013.1531
    • Meredith RF, Torgue J, Azure MT, Shen S, Saddekni S, Banaga E, et al. Pharmacokinetics and imaging of (212)Pb-TCMC-Trastuzumab after intraperitoneal administration in ovarian cancer patients. Cancer Biother Radiopharm (2014) 29(1):12-7. doi:10.1089/cbr.2013.1531
    • (2014) Cancer Biother Radiopharm , vol.29 , Issue.1 , pp. 12-17
    • Meredith, R.F.1    Torgue, J.2    Azure, M.T.3    Shen, S.4    Saddekni, S.5    Banaga, E.6
  • 13
    • 78049456138 scopus 로고    scopus 로고
    • Sequential cytarabine and alpha-particle immunotherapy with bismuth-213-lintuzumab (HuM195) for acute myeloid leukemia
    • doi:10.1158/1078-0432.ccr-10-0382
    • Rosenblat TL, McDevitt MR, Mulford DA, Pandit-Taskar N, Divgi CR, Panageas KS, et al. Sequential cytarabine and alpha-particle immunotherapy with bismuth-213-lintuzumab (HuM195) for acute myeloid leukemia. Clin Cancer Res (2010) 16(21):5303-11. doi:10.1158/1078-0432.ccr-10-0382
    • (2010) Clin Cancer Res , vol.16 , Issue.21 , pp. 5303-5311
    • Rosenblat, T.L.1    McDevitt, M.R.2    Mulford, D.A.3    Pandit-Taskar, N.4    Divgi, C.R.5    Panageas, K.S.6
  • 14
    • 0032694040 scopus 로고    scopus 로고
    • Pharmacokinetics and dosimetry of an alpha-particle emitter labeled antibody: 213Bi-HuM195 (anti-CD33) in patients with leukemia
    • Sgouros G, Ballangrud AM, Jurcic JG, McDevitt MR, Humm JL, Erdi YE, et al. Pharmacokinetics and dosimetry of an alpha-particle emitter labeled antibody: 213Bi-HuM195 (anti-CD33) in patients with leukemia. J Nucl Med (1999) 40(11):1935-46.
    • (1999) J Nucl Med , vol.40 , Issue.11 , pp. 1935-1946
    • Sgouros, G.1    Ballangrud, A.M.2    Jurcic, J.G.3    McDevitt, M.R.4    Humm, J.L.5    Erdi, Y.E.6
  • 15
    • 84893672221 scopus 로고    scopus 로고
    • Memorial Sloan Kettering Cancer C, National Cancer Institute, Actinium Pharmaceuticals.
    • Targeted Atomic Nano-Generators (Actinium-225-Labeled Humanized Anti-CD33 Monoclonal Antibody HuM195) in Patients With Advanced Myeloid Malignancies. U.S. National Institutes of Health
    • Memorial Sloan Kettering Cancer C, National Cancer Institute, Actinium Pharmaceuticals. Targeted Atomic Nano-Generators (Actinium-225-Labeled Humanized Anti-CD33 Monoclonal Antibody HuM195) in Patients With Advanced Myeloid Malignancies. U.S. National Institutes of Health (2014).
    • (2014)
  • 16
    • 84893690222 scopus 로고    scopus 로고
    • M.D. Anderson Cancer Center, Actinium Pharmaceuticals. Low Dose Cytarabine and Lintuzumab-Ac225 in Older Patients.
    • U.S. National Institutes of Health
    • M.D. Anderson Cancer Center, Actinium Pharmaceuticals. Low Dose Cytarabine and Lintuzumab-Ac225 in Older Patients. U.S. National Institutes of Health (2015).
    • (2015)
  • 17
    • 84893638588 scopus 로고    scopus 로고
    • Alpha radioimmunotherapy of B-lineage non-Hodgkin's lymphoma using 213Bi-labeled anti-CD19-and anti-CD20-CHX-A"-DTPA conjugates.
    • Proceedings of the 225th ACS National Meeting, Division of Nuclear Chemistry & Technology; 2003 March 23-27; New Orleans, LA, USA. Available from:
    • Heeger S, Moldenhauer G, Egerer G, Wesch H, Martin S, Nikula T, et al., editors. Alpha radioimmunotherapy of B-lineage non-Hodgkin's lymphoma using 213Bi-labeled anti-CD19-and anti-CD20-CHX-A"-DTPA conjugates. Proceedings of the 225th ACS National Meeting, Division of Nuclear Chemistry & Technology; 2003 March 23-27; New Orleans, LA, USA. (2003). Available from: http://oasys2.confex.com/acs/225nm/techprogram/P613172.HTM
    • (2003)
    • Heeger, S.1    Moldenhauer, G.2    Egerer, G.3    Wesch, H.4    Martin, S.5    Nikula, T.6
  • 18
    • 31144463014 scopus 로고    scopus 로고
    • Intralesional targeted alpha therapy for metastatic melanoma
    • doi:10.4161/cbt.4.12.2251
    • Allen BJ, Raja C, Rizvi S, Li Y, Tsui W, Graham P, et al. Intralesional targeted alpha therapy for metastatic melanoma. Cancer Biol Ther (2005) 4(12):1318-24. doi:10.4161/cbt.4.12.2251
    • (2005) Cancer Biol Ther , vol.4 , Issue.12 , pp. 1318-1324
    • Allen, B.J.1    Raja, C.2    Rizvi, S.3    Li, Y.4    Tsui, W.5    Graham, P.6
  • 19
    • 80053000534 scopus 로고    scopus 로고
    • Analysis of patient survival in a phase I trial of systemic targeted alpha-therapy for metastatic melanoma
    • doi:10.2217/imt.11.97
    • Allen BJ, Singla AA, Rizvi SM, Graham P, Bruchertseifer F, Apostolidis C, et al. Analysis of patient survival in a phase I trial of systemic targeted alpha-therapy for metastatic melanoma. Immunotherapy (2011) 3(9):1041-50. doi:10.2217/imt.11.97
    • (2011) Immunotherapy , vol.3 , Issue.9 , pp. 1041-1050
    • Allen, B.J.1    Singla, A.A.2    Rizvi, S.M.3    Graham, P.4    Bruchertseifer, F.5    Apostolidis, C.6
  • 20
    • 84880428467 scopus 로고    scopus 로고
    • Alpha emitter radium-223 and survival in metastatic prostate cancer
    • doi:10.1056/NEJMoa1213755
    • Parker C, Nilsson S, Heinrich D, Helle SI, O'Sullivan JM, Fossa SD, et al. Alpha emitter radium-223 and survival in metastatic prostate cancer. N Engl J Med (2013) 369(3):213-23. doi:10.1056/NEJMoa1213755
    • (2013) N Engl J Med , vol.369 , Issue.3 , pp. 213-223
    • Parker, C.1    Nilsson, S.2    Heinrich, D.3    Helle, S.I.4    O'Sullivan, J.M.5    Fossa, S.D.6
  • 21
    • 28844482277 scopus 로고    scopus 로고
    • Adjuvant chemotherapy in colorectal cancer: a joint analysis of randomised trials by the Nordic Gastrointestinal Tumour Adjuvant Therapy Group
    • doi:10.1080/02841860500355900
    • Glimelius B, Dahl O, Cedermark B, Jakobsen A, Bentzen SM, Starkhammar H, et al. Adjuvant chemotherapy in colorectal cancer: a joint analysis of randomised trials by the Nordic Gastrointestinal Tumour Adjuvant Therapy Group. Acta Oncol (2005) 44(8):904-12. doi:10.1080/02841860500355900
    • (2005) Acta Oncol , vol.44 , Issue.8 , pp. 904-912
    • Glimelius, B.1    Dahl, O.2    Cedermark, B.3    Jakobsen, A.4    Bentzen, S.M.5    Starkhammar, H.6
  • 22
    • 80052251168 scopus 로고    scopus 로고
    • Patient-specific alpha-particle dosimetry
    • doi:10.2174/1874471011104040329
    • Palm S, Elgqvist J, Jacobsson L. Patient-specific alpha-particle dosimetry. Curr Radiopharm (2011) 4(4):329-35. doi:10.2174/1874471011104040329
    • (2011) Curr Radiopharm , vol.4 , Issue.4 , pp. 329-335
    • Palm, S.1    Elgqvist, J.2    Jacobsson, L.3
  • 23
    • 9644262691 scopus 로고    scopus 로고
    • Radioiodine and 211At-labeled guanidinomethyl halobenzoyl octreotate conjugates: potential peptide radiotherapeutics for somatostatin receptor-positive cancers
    • doi:10.1016/j.peptides.2004.08.018
    • Vaidyanathan G, Boskovitz A, Shankar S, Zalutsky MR. Radioiodine and 211At-labeled guanidinomethyl halobenzoyl octreotate conjugates: potential peptide radiotherapeutics for somatostatin receptor-positive cancers. Peptides (2004) 25(12):2087-97. doi:10.1016/j.peptides.2004.08.018
    • (2004) Peptides , vol.25 , Issue.12 , pp. 2087-2097
    • Vaidyanathan, G.1    Boskovitz, A.2    Shankar, S.3    Zalutsky, M.R.4
  • 24
    • 0035300544 scopus 로고    scopus 로고
    • Highly specific tumor binding of a 213Bi-labeled monoclonal antibody against mutant E-cadherin suggests its usefulness for locoregional alpha-radioimmunotherapy of diffuse-type gastric cancer
    • Senekowitsch-Schmidtke R, Schuhmacher C, Becker KF, Nikula TK, Seidl C, Becker I, et al. Highly specific tumor binding of a 213Bi-labeled monoclonal antibody against mutant E-cadherin suggests its usefulness for locoregional alpha-radioimmunotherapy of diffuse-type gastric cancer. Cancer Res (2001) 61(7):2804-8.
    • (2001) Cancer Res , vol.61 , Issue.7 , pp. 2804-2808
    • Senekowitsch-Schmidtke, R.1    Schuhmacher, C.2    Becker, K.F.3    Nikula, T.K.4    Seidl, C.5    Becker, I.6
  • 25
    • 84903774685 scopus 로고    scopus 로고
    • Re-Treatment Safety of Radium-223 Dichloride in Castration-resistant Prostate Cancer With Bone Metastases.
    • U.S. National Institutes of Health
    • Bayer. Re-Treatment Safety of Radium-223 Dichloride in Castration-resistant Prostate Cancer With Bone Metastases. U.S. National Institutes of Health (2017).
    • Bayer1
  • 26
    • 84893647151 scopus 로고    scopus 로고
    • A Study of Alpharadin® With Docetaxel in Patients With Bone Metastasis From Castration-Resistant Prostate Cancer (CRPC).
    • U.S. National Institutes of Health
    • Algeta ASA, Bayer. A Study of Alpharadin® With Docetaxel in Patients With Bone Metastasis From Castration-Resistant Prostate Cancer (CRPC). U.S. National Institutes of Health (2014).
    • (2014)
    • Algeta, A.S.A.1    Bayer2
  • 29
    • 56449102606 scopus 로고    scopus 로고
    • Production of 230U/226Th for targeted alpha therapy via proton irradiation of 231Pa
    • doi:10.1021/ac801304c
    • Morgenstern A, Lebeda O, Stursa J, Bruchertseifer F, Capote R, McGinley J, et al. Production of 230U/226Th for targeted alpha therapy via proton irradiation of 231Pa. Anal Chem (2008) 80(22):8763-70. doi:10.1021/ac801304c
    • (2008) Anal Chem , vol.80 , Issue.22 , pp. 8763-8770
    • Morgenstern, A.1    Lebeda, O.2    Stursa, J.3    Bruchertseifer, F.4    Capote, R.5    McGinley, J.6
  • 30
    • 84876872396 scopus 로고    scopus 로고
    • Tumor growth of subcutaneous xenografts after repeated alpha-radioimmunotherapy with astatine-211: what absorbed dose is required to treat solid tumors with alpha emitters?
    • Bäck T, Chouin N, Lindegren S, Jensen H, Palm S, Albertsson P. Tumor growth of subcutaneous xenografts after repeated alpha-radioimmunotherapy with astatine-211: what absorbed dose is required to treat solid tumors with alpha emitters? Eur J Nucl Med Mol Imaging (2012) 39(Suppl 2):S324.
    • (2012) Eur J Nucl Med Mol Imaging , vol.39 , Issue.2
    • Bäck, T.1    Chouin, N.2    Lindegren, S.3    Jensen, H.4    Palm, S.5    Albertsson, P.6
  • 32
    • 0141525461 scopus 로고    scopus 로고
    • A systematic overview of radiation therapy effects in ovarian cancer.
    • doi:10.1080/02841860310014426
    • Einhorn N, Trope C, Ridderheim M, Boman K, Sorbe B, Cavallin-Stahl E. A systematic overview of radiation therapy effects in ovarian cancer. Acta Oncol (2003) 42(5-6):562-6. doi:10.1080/02841860310014426
    • (2003) Acta Oncol , vol.42 , Issue.5-6 , pp. 562-566
    • Einhorn, N.1    Trope, C.2    Ridderheim, M.3    Boman, K.4    Sorbe, B.5    Cavallin-Stahl, E.6
  • 34
    • 0041384504 scopus 로고    scopus 로고
    • Intraperitoneal radioactive phosphorus (32P) versus observation after negative second-look laparotomy for stage III ovarian carcinoma: a randomized trial of the Gynecologic Oncology Group
    • doi:10.1200/JCO.2003.11.018
    • Varia MA, Stehman FB, Bundy BN, Benda JA, Clarke-Pearson DL, Alvarez RD, et al. Intraperitoneal radioactive phosphorus (32P) versus observation after negative second-look laparotomy for stage III ovarian carcinoma: a randomized trial of the Gynecologic Oncology Group. J Clin Oncol (2003) 21(15):2849-55. doi:10.1200/JCO.2003.11.018
    • (2003) J Clin Oncol , vol.21 , Issue.15 , pp. 2849-2855
    • Varia, M.A.1    Stehman, F.B.2    Bundy, B.N.3    Benda, J.A.4    Clarke-Pearson, D.L.5    Alvarez, R.D.6
  • 35
    • 30044438368 scopus 로고    scopus 로고
    • Intraperitoneal cisplatin and paclitaxel in ovarian cancer
    • doi:10.1056/NEJMoa052985
    • Armstrong DK, Bundy B, Wenzel L, Huang HQ, Baergen R, Lele S, et al. Intraperitoneal cisplatin and paclitaxel in ovarian cancer. N Engl J Med (2006) 354(1):34-43. doi:10.1056/NEJMoa052985
    • (2006) N Engl J Med , vol.354 , Issue.1 , pp. 34-43
    • Armstrong, D.K.1    Bundy, B.2    Wenzel, L.3    Huang, H.Q.4    Baergen, R.5    Lele, S.6
  • 36
    • 84860794367 scopus 로고    scopus 로고
    • Intraperitoneal chemotherapy for the initial management of primary epithelial ovarian cancer.
    • CD005340. doi:10.1002/14651858.CD005340.pub3
    • Jaaback K, Johnson N, Lawrie TA. Intraperitoneal chemotherapy for the initial management of primary epithelial ovarian cancer. Cochrane Database Syst Rev (2011) 9(11):CD005340. doi:10.1002/14651858.CD005340.pub3
    • (2011) Cochrane Database Syst Rev , vol.9 , Issue.11
    • Jaaback, K.1    Johnson, N.2    Lawrie, T.A.3
  • 37
    • 0141456585 scopus 로고    scopus 로고
    • Astatine-211-labeled antibodies for treatment of disseminated ovarian cancer: an overview of results in an ovarian tumor model.
    • Andersson H, Elgqvist J, Horvath G, Hultborn R, Jacobsson L, Jensen H, et al. Astatine-211-labeled antibodies for treatment of disseminated ovarian cancer: an overview of results in an ovarian tumor model. Clin Cancer Res (2003) 9(10 Pt 2):3914S-21S.
    • (2003) Clin Cancer Res , vol.9 , Issue.10
    • Andersson, H.1    Elgqvist, J.2    Horvath, G.3    Hultborn, R.4    Jacobsson, L.5    Jensen, H.6
  • 38
    • 0023256856 scopus 로고
    • Localization of radioiodine conjugated to the monoclonal antibody HMFG2 in human ovarian carcinoma: assessment of intravenous and intraperitoneal routes of administration
    • Ward BG, Mather SJ, Hawkins LR, Crowther ME, Shepherd JH, Granowska M, et al. Localization of radioiodine conjugated to the monoclonal antibody HMFG2 in human ovarian carcinoma: assessment of intravenous and intraperitoneal routes of administration. Cancer Res (1987) 47(17):4719-23.
    • (1987) Cancer Res , vol.47 , Issue.17 , pp. 4719-4723
    • Ward, B.G.1    Mather, S.J.2    Hawkins, L.R.3    Crowther, M.E.4    Shepherd, J.H.5    Granowska, M.6
  • 39
    • 34247474805 scopus 로고    scopus 로고
    • Decreased intraperitoneal disease recurrence in epithelial ovarian cancer patients receiving intraperitoneal consolidation treatment with yttrium-90-labeled murine HMFG1 without improvement in overall survival
    • doi:10.1002/ijc.22663
    • Oei AL, Verheijen RH, Seiden MV, Benigno BB, Lopes A, Soper JT, et al. Decreased intraperitoneal disease recurrence in epithelial ovarian cancer patients receiving intraperitoneal consolidation treatment with yttrium-90-labeled murine HMFG1 without improvement in overall survival. Int J Cancer (2007) 120(12):2710-4. doi:10.1002/ijc.22663
    • (2007) Int J Cancer , vol.120 , Issue.12 , pp. 2710-2714
    • Oei, A.L.1    Verheijen, R.H.2    Seiden, M.V.3    Benigno, B.B.4    Lopes, A.5    Soper, J.T.6
  • 40
    • 33644834874 scopus 로고    scopus 로고
    • Phase III trial of intraperitoneal therapy with yttrium-90-labeled HMFG1 murine monoclonal antibody in patients with epithelial ovarian cancer after a surgically defined complete remission
    • doi:10.1200/jco.2005.02.5973
    • Verheijen RH, Massuger LF, Benigno BB, Epenetos AA, Lopes A, Soper JT, et al. Phase III trial of intraperitoneal therapy with yttrium-90-labeled HMFG1 murine monoclonal antibody in patients with epithelial ovarian cancer after a surgically defined complete remission. J Clin Oncol (2006) 24(4):571-8. doi:10.1200/jco.2005.02.5973
    • (2006) J Clin Oncol , vol.24 , Issue.4 , pp. 571-578
    • Verheijen, R.H.1    Massuger, L.F.2    Benigno, B.B.3    Epenetos, A.A.4    Lopes, A.5    Soper, J.T.6
  • 41
    • 1242344875 scopus 로고    scopus 로고
    • Microdosimetry of astatine-211 single-cell irradiation: role of daughter polonium-211 diffusion
    • doi:10.1118/1.1640951
    • Palm S, Humm JL, Rundqvist R, Jacobsson L. Microdosimetry of astatine-211 single-cell irradiation: role of daughter polonium-211 diffusion. Med Phys (2004) 31(2):218-25. doi:10.1118/1.1640951
    • (2004) Med Phys , vol.31 , Issue.2 , pp. 218-225
    • Palm, S.1    Humm, J.L.2    Rundqvist, R.3    Jacobsson, L.4
  • 43
    • 79959430516 scopus 로고    scopus 로고
    • Astatine-211: production and availability
    • doi:10.2174/1874471011104030177
    • Zalutsky MR, Pruszynski M. Astatine-211: production and availability. Curr Radiopharm (2011) 4(3):177-85. doi:10.2174/1874471011104030177
    • (2011) Curr Radiopharm , vol.4 , Issue.3 , pp. 177-185
    • Zalutsky, M.R.1    Pruszynski, M.2
  • 44
    • 84893684349 scopus 로고
    • International Commission on Radiological Protection.
    • Committee 4. Report of Committee IV on Evaluation of Radiation Doses to Body Tissues from International Contamination Due to Occupational Exposure. 1st ed. Oxford: Pergamon
    • International Commission on Radiological Protection. Committee 4. Report of Committee IV on Evaluation of Radiation Doses to Body Tissues from International Contamination Due to Occupational Exposure. 1st ed. Oxford: Pergamon (1968). 94 p.
    • (1968) , pp. 94
  • 45
    • 0014277509 scopus 로고
    • A formalism for calculation of absorbed dose from radionuclides
    • doi:10.1088/0031-9155/13/2/306
    • Loevinger R, Berman M. A formalism for calculation of absorbed dose from radionuclides. Phys Med Biol (1968) 13(2):205-17. doi:10.1088/0031-9155/13/2/306
    • (1968) Phys Med Biol , vol.13 , Issue.2 , pp. 205-217
    • Loevinger, R.1    Berman, M.2
  • 46
    • 62449175592 scopus 로고    scopus 로고
    • MIRD pamphlet no. 21: a generalized schema for radiopharmaceutical dosimetry - standardization of nomenclature.
    • doi:10.2967/jnumed.108.056036
    • Bolch WE, Eckerman KF, Sgouros G, Thomas SR. MIRD pamphlet no. 21: a generalized schema for radiopharmaceutical dosimetry - standardization of nomenclature. J Nucl Med (2009) 50(3):477-84. doi:10.2967/jnumed.108.056036
    • (2009) J Nucl Med , vol.50 , Issue.3 , pp. 477-484
    • Bolch, W.E.1    Eckerman, K.F.2    Sgouros, G.3    Thomas, S.R.4
  • 47
    • 75749110617 scopus 로고    scopus 로고
    • MIRD pamphlet no. 22 (abridged): radiobiology and dosimetry of alpha-particle emitters for targeted radionuclide therapy.
    • doi:10.2967/jnumed.108.058651
    • Sgouros G, Roeske JC, McDevitt MR, Palm S, Allen BJ, Fisher DR, et al. MIRD pamphlet no. 22 (abridged): radiobiology and dosimetry of alpha-particle emitters for targeted radionuclide therapy. J Nucl Med (2010) 51(2):311-28. doi:10.2967/jnumed.108.058651
    • (2010) J Nucl Med , vol.51 , Issue.2 , pp. 311-328
    • Sgouros, G.1    Roeske, J.C.2    McDevitt, M.R.3    Palm, S.4    Allen, B.J.5    Fisher, D.R.6
  • 48
    • 33746707858 scopus 로고    scopus 로고
    • High-linear energy transfer irradiation targeted to skeletal metastases by the alpha-emitter 223Ra: adjuvant or alternative to conventional modalities?
    • doi:10.1158/1078-0432.CCR-06-0841
    • Bruland OS, Nilsson S, Fisher DR, Larsen RH. High-linear energy transfer irradiation targeted to skeletal metastases by the alpha-emitter 223Ra: adjuvant or alternative to conventional modalities? Clin Cancer Res (2006) 12(20 Pt 2):6250s-7s. doi:10.1158/1078-0432.CCR-06-0841
    • (2006) Clin Cancer Res , vol.12 , Issue.20
    • Bruland, O.S.1    Nilsson, S.2    Fisher, D.R.3    Larsen, R.H.4
  • 49
    • 0036301356 scopus 로고    scopus 로고
    • An activity quantification method based on registration of CT and whole-body scintillation camera images, with application to 131I
    • Sjogreen K, Ljungberg M, Strand SE. An activity quantification method based on registration of CT and whole-body scintillation camera images, with application to 131I. J Nucl Med (2002) 43(7):972-82.
    • (2002) J Nucl Med , vol.43 , Issue.7 , pp. 972-982
    • Sjogreen, K.1    Ljungberg, M.2    Strand, S.E.3
  • 50
    • 79959437613 scopus 로고    scopus 로고
    • Alpha-particle microdosimetry
    • doi:10.2174/1874471011104030266
    • Chouin N, Bardies M. Alpha-particle microdosimetry. Curr Radiopharm (2011) 4(3):266-80. doi:10.2174/1874471011104030266
    • (2011) Curr Radiopharm , vol.4 , Issue.3 , pp. 266-280
    • Chouin, N.1    Bardies, M.2
  • 51
    • 0001427396 scopus 로고
    • A device for the measurement of dose as a function of specific ionization
    • doi:10.1148/64.3.404
    • Rossi HH, Rosenzweig W. A device for the measurement of dose as a function of specific ionization. Radiology (1955) 64(3):404-11. doi:10.1148/64.3.404
    • (1955) Radiology , vol.64 , Issue.3 , pp. 404-411
    • Rossi, H.H.1    Rosenzweig, W.2
  • 53
    • 0026044529 scopus 로고
    • Radiobiology of alpha particles. III. Cell inactivation by alpha-particle traversals of the cell nucleus.
    • doi:10.2307/3578139
    • Raju MR, Eisen Y, Carpenter S, Inkret WC. Radiobiology of alpha particles. III. Cell inactivation by alpha-particle traversals of the cell nucleus. Radiat Res (1991) 128(2):204-9. doi:10.2307/3578139
    • (1991) Radiat Res , vol.128 , Issue.2 , pp. 204-209
    • Raju, M.R.1    Eisen, Y.2    Carpenter, S.3    Inkret, W.C.4
  • 54
    • 0031658476 scopus 로고    scopus 로고
    • Survival and DNA damage in Chinese hamster V79 cells exposed to alpha particles emitted by DNA-incorporated astatine-211
    • doi:10.2307/3579974
    • Walicka MA, Vaidyanathan G, Zalutsky MR, Adelstein SJ, Kassis AI. Survival and DNA damage in Chinese hamster V79 cells exposed to alpha particles emitted by DNA-incorporated astatine-211. Radiat Res (1998) 150(3):263-8. doi:10.2307/3579974
    • (1998) Radiat Res , vol.150 , Issue.3 , pp. 263-268
    • Walicka, M.A.1    Vaidyanathan, G.2    Zalutsky, M.R.3    Adelstein, S.J.4    Kassis, A.I.5
  • 55
    • 0011057882 scopus 로고
    • Impairment of the proliferative capacity of human cells in culture by alpha-particles with differing linear-energy transfer.
    • doi:10.1080/09553006414550561
    • Barendsen GW. Impairment of the proliferative capacity of human cells in culture by alpha-particles with differing linear-energy transfer. Int J Radiat Biol Relat Stud Phys Chem Med (1964) 8:453-66. doi:10.1080/09553006414550561
    • (1964) Int J Radiat Biol Relat Stud Phys Chem Med , vol.8 , pp. 453-466
    • Barendsen, G.W.1
  • 56
    • 0011832878 scopus 로고
    • Effects of different ionizing radiations on human cells in tissue culture. I. Irradiation techniques and dosimetry.
    • doi:10.2307/3570858
    • Barendsen GW, Beusker TL. Effects of different ionizing radiations on human cells in tissue culture. I. Irradiation techniques and dosimetry. Radiat Res (1960) 13:832-40. doi:10.2307/3570858
    • (1960) Radiat Res , vol.13 , pp. 832-840
    • Barendsen, G.W.1    Beusker, T.L.2
  • 57
    • 84961060184 scopus 로고
    • Effects of different radiations on human cells in tissue culture. II. Biological experiments.
    • doi:10.2307/3570859
    • Barendsen GW, Beusker TL, Vergroesen AJ, Budke L. Effects of different radiations on human cells in tissue culture. II. Biological experiments. Radiat Res (1960) 13:841-9. doi:10.2307/3570859
    • (1960) Radiat Res , vol.13 , pp. 841-849
    • Barendsen, G.W.1    Beusker, T.L.2    Vergroesen, A.J.3    Budke, L.4
  • 58
    • 80155146078 scopus 로고
    • Effects of different ionizing radiations on human cells in tissue culture. IV. Modification of radiation damage.
    • doi:10.2307/3571569
    • Barendsen GW, Walter HM. Effects of different ionizing radiations on human cells in tissue culture. IV. Modification of radiation damage. Radiat Res (1964) 21:314-29. doi:10.2307/3571569
    • (1964) Radiat Res , vol.21 , pp. 314-329
    • Barendsen, G.W.1    Walter, H.M.2
  • 59
    • 84873775089 scopus 로고
    • Effects of different ionizing radiations on human cells in tissue culture. III. Experiments with cyclotron-accelerated alpha-particles and deuterons.
    • doi:10.2307/3571430
    • Barendsen GW, Walter HM, Fowler JF, Bewley DK. Effects of different ionizing radiations on human cells in tissue culture. III. Experiments with cyclotron-accelerated alpha-particles and deuterons. Radiat Res (1963) 18:106-19. doi:10.2307/3571430
    • (1963) Radiat Res , vol.18 , pp. 106-119
    • Barendsen, G.W.1    Walter, H.M.2    Fowler, J.F.3    Bewley, D.K.4
  • 60
    • 0027465168 scopus 로고
    • Radiobiology of alpha particles. IV. Cell inactivation by alpha particles of energies 0.4-3.5 MeV.
    • doi:10.2307/3578212
    • Raju MR, Eisen Y, Carpenter S, Jarrett K, Harvey WF. Radiobiology of alpha particles. IV. Cell inactivation by alpha particles of energies 0.4-3.5 MeV. Radiat Res (1993) 133(3):289-96. doi:10.2307/3578212
    • (1993) Radiat Res , vol.133 , Issue.3 , pp. 289-296
    • Raju, M.R.1    Eisen, Y.2    Carpenter, S.3    Jarrett, K.4    Harvey, W.F.5
  • 61
    • 79956197636 scopus 로고    scopus 로고
    • Delayed repair of radiation induced clustered DNA damage: friend or foe?
    • doi:10.1016/j.mrfmmm.2010.11.003
    • Eccles LJ, O'Neill P, Lomax ME. Delayed repair of radiation induced clustered DNA damage: friend or foe? Mutat Res (2011) 711(1-2):134-41. doi:10.1016/j.mrfmmm.2010.11.003
    • (2011) Mutat Res , vol.711 , Issue.1-2 , pp. 134-141
    • Eccles, L.J.1    O'Neill, P.2    Lomax, M.E.3
  • 62
    • 2542637919 scopus 로고    scopus 로고
    • Processing of clustered DNA damage generates additional double-strand breaks in mammalian cells post-irradiation
    • doi:10.1093/nar/gkh306
    • Gulston M, de Lara C, Jenner T, Davis E, O'Neill P. Processing of clustered DNA damage generates additional double-strand breaks in mammalian cells post-irradiation. Nucleic Acids Res (2004) 32(4):1602-9. doi:10.1093/nar/gkh306
    • (2004) Nucleic Acids Res , vol.32 , Issue.4 , pp. 1602-1609
    • Gulston, M.1    de Lara, C.2    Jenner, T.3    Davis, E.4    O'Neill, P.5
  • 64
    • 0025333874 scopus 로고
    • Radiobiological aspects of low dose rates in radioimmunotherapy
    • doi:10.1016/0360-3016(90)90467-X
    • Fowler JF. Radiobiological aspects of low dose rates in radioimmunotherapy. Int J Radiat Oncol Biol Phys (1990) 18(5):1261-9. doi:10.1016/0360-3016(90)90467-X
    • (1990) Int J Radiat Oncol Biol Phys , vol.18 , Issue.5 , pp. 1261-1269
    • Fowler, J.F.1
  • 65
    • 3242717082 scopus 로고    scopus 로고
    • Radiobiology of radioimmunotherapy: targeting CD20 B-cell antigen in non-Hodgkin's lymphoma
    • doi:10.1016/j.ijrobp.2004.02.065
    • Hernandez MC, Knox SJ. Radiobiology of radioimmunotherapy: targeting CD20 B-cell antigen in non-Hodgkin's lymphoma. Int J Radiat Oncol Biol Phys (2004) 59(5):1274-87. doi:10.1016/j.ijrobp.2004.02.065
    • (2004) Int J Radiat Oncol Biol Phys , vol.59 , Issue.5 , pp. 1274-1287
    • Hernandez, M.C.1    Knox, S.J.2
  • 66
    • 84876724320 scopus 로고    scopus 로고
    • Apoptosis and p53 are not involved in the anti-tumor efficacy of (1)(2)(5)I-labeled monoclonal antibodies targeting the cell membrane
    • doi:10.1016/j.nucmedbio.2013.02.001
    • Paillas S, Boudousq V, Piron B, Kersual N, Bardies M, Chouin N, et al. Apoptosis and p53 are not involved in the anti-tumor efficacy of (1)(2)(5)I-labeled monoclonal antibodies targeting the cell membrane. Nucl Med Biol (2013) 40(4):471-80. doi:10.1016/j.nucmedbio.2013.02.001
    • (2013) Nucl Med Biol , vol.40 , Issue.4 , pp. 471-480
    • Paillas, S.1    Boudousq, V.2    Piron, B.3    Kersual, N.4    Bardies, M.5    Chouin, N.6
  • 67
    • 0026743080 scopus 로고
    • Quantitative comparison of radiolabeled antibody therapy and external beam radiotherapy in the treatment of human glioma xenografts
    • doi:10.1016/0360-3016(92)91029-M
    • Williams JA, Edwards JA, Dillehay LE. Quantitative comparison of radiolabeled antibody therapy and external beam radiotherapy in the treatment of human glioma xenografts. Int J Radiat Oncol Biol Phys (1992) 24(1):111-7. doi:10.1016/0360-3016(92)91029-M
    • (1992) Int J Radiat Oncol Biol Phys , vol.24 , Issue.1 , pp. 111-117
    • Williams, J.A.1    Edwards, J.A.2    Dillehay, L.E.3
  • 68
    • 0038756812 scopus 로고
    • Lethal mutations and cell death
    • doi:10.1088/0031-9155/8/4/301
    • Alper T. Lethal mutations and cell death. Phys Med Biol (1963) 66:365-85. doi:10.1088/0031-9155/8/4/301
    • (1963) Phys Med Biol , vol.66 , pp. 365-385
    • Alper, T.1
  • 69
    • 0028287960 scopus 로고
    • Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis
    • doi:10.1084/jem.180.2.525
    • Haimovitz-Friedman A, Kan CC, Ehleiter D, Persaud RS, McLoughlin M, Fuks Z, et al. Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. J Exp Med (1994) 180(2):525-35. doi:10.1084/jem.180.2.525
    • (1994) J Exp Med , vol.180 , Issue.2 , pp. 525-535
    • Haimovitz-Friedman, A.1    Kan, C.C.2    Ehleiter, D.3    Persaud, R.S.4    McLoughlin, M.5    Fuks, Z.6
  • 70
    • 70449728439 scopus 로고    scopus 로고
    • Membrane-dependent bystander effect contributes to amplification of the response to alpha-particle irradiation in targeted and nontargeted cells
    • doi:10.1016/j.ijrobp.2009.07.014
    • Hanot M, Hoarau J, Carriere M, Angulo JF, Khodja H. Membrane-dependent bystander effect contributes to amplification of the response to alpha-particle irradiation in targeted and nontargeted cells. Int J Radiat Oncol Biol Phys (2009) 75(4):1247-53. doi:10.1016/j.ijrobp.2009.07.014
    • (2009) Int J Radiat Oncol Biol Phys , vol.75 , Issue.4 , pp. 1247-1253
    • Hanot, M.1    Hoarau, J.2    Carriere, M.3    Angulo, J.F.4    Khodja, H.5
  • 71
    • 79953784615 scopus 로고    scopus 로고
    • In vivo space radiation-induced non-targeted responses: late effects on molecular signaling in mitochondria
    • doi:10.2174/1874467211104020106
    • Jain MR, Li M, Chen W, Liu T, de Toledo SM, Pandey BN, et al. In vivo space radiation-induced non-targeted responses: late effects on molecular signaling in mitochondria. Curr Mol Pharmacol (2011) 4(2):106-14. doi:10.2174/1874467211104020106
    • (2011) Curr Mol Pharmacol , vol.4 , Issue.2 , pp. 106-114
    • Jain, M.R.1    Li, M.2    Chen, W.3    Liu, T.4    de Toledo, S.M.5    Pandey, B.N.6
  • 72
    • 49249116990 scopus 로고    scopus 로고
    • Cell membrane is a more sensitive target than cytoplasm to dense ionization produced by auger electrons
    • doi:10.1667/RR1359.1
    • Pouget JP, Santoro L, Raymond L, Chouin N, Bardies M, Bascoul-Mollevi C, et al. Cell membrane is a more sensitive target than cytoplasm to dense ionization produced by auger electrons. Radiat Res (2008) 170(2):192-200. doi:10.1667/RR1359.1
    • (2008) Radiat Res , vol.170 , Issue.2 , pp. 192-200
    • Pouget, J.P.1    Santoro, L.2    Raymond, L.3    Chouin, N.4    Bardies, M.5    Bascoul-Mollevi, C.6
  • 73
    • 34147190965 scopus 로고    scopus 로고
    • Radiation-induced cell signaling: inside-out and outside-in
    • doi:10.1158/1535-7163.MCT-06-0596
    • Valerie K, Yacoub A, Hagan MP, Curiel DT, Fisher PB, Grant S, et al. Radiation-induced cell signaling: inside-out and outside-in. Mol Cancer Ther (2007) 6(3):789-801. doi:10.1158/1535-7163.MCT-06-0596
    • (2007) Mol Cancer Ther , vol.6 , Issue.3 , pp. 789-801
    • Valerie, K.1    Yacoub, A.2    Hagan, M.P.3    Curiel, D.T.4    Fisher, P.B.5    Grant, S.6
  • 74
    • 67349262052 scopus 로고    scopus 로고
    • Mitochondrial dysfunction resulting from loss of cytochrome c impairs radiation-induced bystander effect
    • doi:10.1038/sj.bjc.6605087
    • Yang G, Wu L, Chen S, Zhu L, Huang P, Tong L, et al. Mitochondrial dysfunction resulting from loss of cytochrome c impairs radiation-induced bystander effect. Br J Cancer (2009) 100(12):1912-6. doi:10.1038/sj.bjc.6605087
    • (2009) Br J Cancer , vol.100 , Issue.12 , pp. 1912-1916
    • Yang, G.1    Wu, L.2    Chen, S.3    Zhu, L.4    Huang, P.5    Tong, L.6
  • 75
    • 84885799432 scopus 로고    scopus 로고
    • Radiotherapy effects on anti-tumor immunity: implications for cancer treatment.
    • doi:10.3389/fonc.2013.00128
    • Demaria S, Formenti SC. Radiotherapy effects on anti-tumor immunity: implications for cancer treatment. Front Oncol (2013) 3:128. doi:10.3389/fonc.2013.00128
    • (2013) Front Oncol , vol.3 , pp. 128
    • Demaria, S.1    Formenti, S.C.2
  • 76
    • 84875039618 scopus 로고    scopus 로고
    • Combining radiotherapy and cancer immunotherapy: a paradigm shift
    • doi:10.1093/jnci/djs629
    • Formenti SC, Demaria S. Combining radiotherapy and cancer immunotherapy: a paradigm shift. J Natl Cancer Inst (2013) 105(4):256-65. doi:10.1093/jnci/djs629
    • (2013) J Natl Cancer Inst , vol.105 , Issue.4 , pp. 256-265
    • Formenti, S.C.1    Demaria, S.2
  • 77
    • 84876273134 scopus 로고    scopus 로고
    • The influence of p53 functions on radiation-induced inflammatory bystander-type signaling in murine bone marrow
    • doi:10.1667/RR3158.2
    • Lorimore SA, Rastogi S, Mukherjee D, Coates PJ, Wright EG. The influence of p53 functions on radiation-induced inflammatory bystander-type signaling in murine bone marrow. Radiat Res (2013) 179(4):406-15. doi:10.1667/RR3158.2
    • (2013) Radiat Res , vol.179 , Issue.4 , pp. 406-415
    • Lorimore, S.A.1    Rastogi, S.2    Mukherjee, D.3    Coates, P.J.4    Wright, E.G.5
  • 78
    • 0037361745 scopus 로고    scopus 로고
    • Pretargeted radioimmunotherapy of cancer: progress step by step
    • Boerman OC, van Schaijk FG, Oyen WJ, Corstens FH. Pretargeted radioimmunotherapy of cancer: progress step by step. J Nucl Med (2003) 44(3):400-11.
    • (2003) J Nucl Med , vol.44 , Issue.3 , pp. 400-411
    • Boerman, O.C.1    van Schaijk, F.G.2    Oyen, W.J.3    Corstens, F.H.4
  • 79
    • 33846549106 scopus 로고    scopus 로고
    • Advances in cancer therapy with radiolabeled monoclonal antibodies
    • Goldenberg DM, Sharkey RM. Advances in cancer therapy with radiolabeled monoclonal antibodies. Q J Nucl Med Mol Imaging (2006) 50(4):248-64.
    • (2006) Q J Nucl Med Mol Imaging , vol.50 , Issue.4 , pp. 248-264
    • Goldenberg, D.M.1    Sharkey, R.M.2
  • 80
    • 0023841413 scopus 로고
    • Pre-targeted immunoscintigraphy of murine tumors with indium-111-labeled bifunctional haptens
    • Goodwin DA, Meares CF, McCall MJ, McTigue M, Chaovapong W. Pre-targeted immunoscintigraphy of murine tumors with indium-111-labeled bifunctional haptens. J Nucl Med (1988) 29(2):226-34.
    • (1988) J Nucl Med , vol.29 , Issue.2 , pp. 226-234
    • Goodwin, D.A.1    Meares, C.F.2    McCall, M.J.3    McTigue, M.4    Chaovapong, W.5
  • 83
    • 79960684246 scopus 로고    scopus 로고
    • Anti-CD45 pretargeted radioimmunotherapy using bismuth-213: high rates of complete remission and long-term survival in a mouse myeloid leukemia xenograft model
    • doi:10.1182/blood-2011-04-347039
    • Pagel JM, Kenoyer AL, Back T, Hamlin DK, Wilbur DS, Fisher DR, et al. Anti-CD45 pretargeted radioimmunotherapy using bismuth-213: high rates of complete remission and long-term survival in a mouse myeloid leukemia xenograft model. Blood (2011) 118(3):703-11. doi:10.1182/blood-2011-04-347039
    • (2011) Blood , vol.118 , Issue.3 , pp. 703-711
    • Pagel, J.M.1    Kenoyer, A.L.2    Back, T.3    Hamlin, D.K.4    Wilbur, D.S.5    Fisher, D.R.6
  • 84
    • 78549263790 scopus 로고    scopus 로고
    • Conventional and pretargeted radioimmunotherapy using bismuth-213 to target and treat non-Hodgkin lymphomas expressing CD20: a preclinical model toward optimal consolidation therapy to eradicate minimal residual disease
    • doi:10.1182/blood-2010-05-282327
    • Park SI, Shenoi J, Pagel JM, Hamlin DK, Wilbur DS, Orgun N, et al. Conventional and pretargeted radioimmunotherapy using bismuth-213 to target and treat non-Hodgkin lymphomas expressing CD20: a preclinical model toward optimal consolidation therapy to eradicate minimal residual disease. Blood (2010) 116(20):4231-9. doi:10.1182/blood-2010-05-282327
    • (2010) Blood , vol.116 , Issue.20 , pp. 4231-4239
    • Park, S.I.1    Shenoi, J.2    Pagel, J.M.3    Hamlin, D.K.4    Wilbur, D.S.5    Orgun, N.6
  • 85
    • 0037452667 scopus 로고    scopus 로고
    • Pretarget radiotherapy with an anti-CD25 antibody-streptavidin fusion protein was effective in therapy of leukemia/lymphoma xenografts
    • doi:10.1073/pnas.0437788100
    • Zhang M, Zhang Z, Garmestani K, Schultz J, Axworthy DB, Goldman CK, et al. Pretarget radiotherapy with an anti-CD25 antibody-streptavidin fusion protein was effective in therapy of leukemia/lymphoma xenografts. Proc Natl Acad Sci USA (2003) 100(4):1891-5. doi:10.1073/pnas.0437788100
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.4 , pp. 1891-1895
    • Zhang, M.1    Zhang, Z.2    Garmestani, K.3    Schultz, J.4    Axworthy, D.B.5    Goldman, C.K.6
  • 86
    • 84874755179 scopus 로고    scopus 로고
    • Comparison of (211)At-PRIT and (211)At-RIT of ovarian microtumors in a nude mouse model
    • doi:10.1089/cbr.2012.1281
    • Frost SH, Back T, Chouin N, Hultborn R, Jacobsson L, Elgqvist J, et al. Comparison of (211)At-PRIT and (211)At-RIT of ovarian microtumors in a nude mouse model. Cancer Biother Radiopharm (2013) 28(2):108-14. doi:10.1089/cbr.2012.1281
    • (2013) Cancer Biother Radiopharm , vol.28 , Issue.2 , pp. 108-114
    • Frost, S.H.1    Back, T.2    Chouin, N.3    Hultborn, R.4    Jacobsson, L.5    Elgqvist, J.6
  • 87
    • 33751234490 scopus 로고    scopus 로고
    • Fractionated radioimmunotherapy of intraperitoneally growing ovarian cancer in nude mice with 211At-MX35 F(ab')2: therapeutic efficacy and myelotoxicity
    • doi:10.1016/j.nucmedbio.2006.07.009
    • Elgqvist J, Andersson H, Back T, Claesson I, Hultborn R, Jensen H, et al. Fractionated radioimmunotherapy of intraperitoneally growing ovarian cancer in nude mice with 211At-MX35 F(ab')2: therapeutic efficacy and myelotoxicity. Nucl Med Biol (2006) 33(8):1065-72. doi:10.1016/j.nucmedbio.2006.07.009
    • (2006) Nucl Med Biol , vol.33 , Issue.8 , pp. 1065-1072
    • Elgqvist, J.1    Andersson, H.2    Back, T.3    Claesson, I.4    Hultborn, R.5    Jensen, H.6
  • 88
    • 84883300098 scopus 로고    scopus 로고
    • Advances in anticancer radiopharmaceuticals
    • doi:10.1016/j.clon.2013.06.004
    • Jackson MR, Falzone N, Vallis KA. Advances in anticancer radiopharmaceuticals. Clin Oncol (2013) 25(10):604-9. doi:10.1016/j.clon.2013.06.004
    • (2013) Clin Oncol , vol.25 , Issue.10 , pp. 604-609
    • Jackson, M.R.1    Falzone, N.2    Vallis, K.A.3
  • 89
    • 84871919395 scopus 로고    scopus 로고
    • Options to meet the future global demand of radionuclides for radionuclide therapy
    • doi:10.1016/j.nucmedbio.2012.09.007
    • Das T, Pillai MR. Options to meet the future global demand of radionuclides for radionuclide therapy. Nucl Med Biol (2013) 40(1):23-32. doi:10.1016/j.nucmedbio.2012.09.007
    • (2013) Nucl Med Biol , vol.40 , Issue.1 , pp. 23-32
    • Das, T.1    Pillai, M.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.