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Volumn 118, Issue 1, 2014, Pages 1-8

Mouse models of glioblastoma: Lessons learned and questions to be answered

Author keywords

Gene expression; Glioblastoma; Mouse model; Preclinical; TCGA

Indexed keywords

NUCLEAR FACTOR I; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; RAS PROTEIN; VASCULOTROPIN RECEPTOR; VIRUS VECTOR;

EID: 84893683702     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-014-1401-x     Document Type: Review
Times cited : (23)

References (48)
  • 2
    • 49249112617 scopus 로고    scopus 로고
    • Cancer stem cells and glioma
    • doi:10.1038/ncpneuro0862
    • Das S, Srikanth M, Kessler JA (2008) Cancer stem cells and glioma. Nat Clin Pract Neurol 4:427-435. doi:10.1038/ncpneuro0862
    • (2008) Nat Clin Pract Neurol , vol.4 , pp. 427-435
    • Das, S.1    Srikanth, M.2    Kessler, J.A.3
  • 3
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • doi:10.1038/nature07385
    • Das S, Srikanth M, Kessler JA (2008) Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455:1061-1068. doi:10.1038/nature07385
    • (2008) Nature , vol.455 , pp. 1061-1068
    • Das, S.1    Srikanth, M.2    Kessler, J.A.3
  • 7
    • 38549123928 scopus 로고    scopus 로고
    • Cre activity causes widespread apoptosis and lethal anemia during embryonic development
    • DOI 10.1002/dvg.20353
    • Naiche LA, Papaioannou VE (2007) Cre activity causes widespread apoptosis and lethal anemia during embryonic development. Genesis 45:768-775. doi:10.1002/dvg.20353 (Pubitemid 351158379)
    • (2007) Genesis , vol.45 , Issue.12 , pp. 768-775
    • Naiche, L.A.1    Papaioannou, V.E.2
  • 8
    • 0026720075 scopus 로고
    • Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
    • Gossen M, Bujard H (1992) Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci USA 89:5547-5551
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 5547-5551
    • Gossen, M.1    Bujard, H.2
  • 9
    • 0034842640 scopus 로고    scopus 로고
    • Site- and time-specific gene targeting in the mouse
    • doi:10.1006/meth 2001.1159
    • Metzger D, Chambon P (2001) Site- and time-specific gene targeting in the mouse.Methods 24:71-80. doi:10.1006/meth 2001.1159
    • (2001) Methods , vol.24 , pp. 71-80
    • Metzger, D.1    Chambon, P.2
  • 11
    • 57849109837 scopus 로고    scopus 로고
    • Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model
    • doi:10.1016/j.ccr.2008.12.006
    • Alcantara Llaguno S, Chen J, Kwon CH, Jackson EL, Li Y, Burns DK, Alvarez-Buylla A, Parada LF (2009) Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model. Cancer Cell 15:45-56. doi:10.1016/j.ccr.2008.12.006
    • (2009) Cancer Cell , vol.15 , pp. 45-56
    • Alcantara Llaguno, S.1    Chen, J.2    Kwon, C.H.3    Jackson, E.L.4    Li, Y.5    Burns, D.K.6    Alvarez-Buylla, A.7    Parada, L.F.8
  • 13
    • 0142150950 scopus 로고    scopus 로고
    • Generation of transgenic mice using lentiviral vectors: A novel preclinical assessment of lectiviral vectors for gene therapy
    • DOI 10.1016/S1525-0016(03)00240-5
    • Ikawa M, Tanaka N, Kao WW, Verma IM (2003) Generation of transgenic mice using lentiviral vectors: a novel preclinical assessment of lentiviral vectors for gene therapy. Mol Ther 8:666-673 (Pubitemid 37321696)
    • (2003) Molecular Therapy , vol.8 , Issue.4 , pp. 666-673
    • Ikawa, M.1    Tanaka, N.2    Kao, W.W.-Y.3    Verma, I.M.4
  • 16
    • 70849122697 scopus 로고    scopus 로고
    • Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations
    • doi:10.1371/journal.pone.0007752
    • Brennan C, Momota H, Hambardzumyan D, Ozawa T, Tandon A, Pedraza A, Holland E (2009) Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations. PLoS ONE 4:e7752. doi:10.1371/journal.pone.0007752
    • (2009) PLoS ONE , vol.4
    • Brennan, C.1    Momota, H.2    Hambardzumyan, D.3    Ozawa, T.4    Tandon, A.5    Pedraza, A.6    Holland, E.7
  • 19
    • 0025196273 scopus 로고
    • Identification and characterization of transcript from the neurofibromatosis 1 region: The sequence and genomic structure of EVI2 and mapping of other transcripts
    • DOI 10.1016/0888-7543(90)90199-5
    • Cawthon RM, O'Connell P, Buchberg AM, Viskochil D, Weiss RB, Culver M, Stevens J, Jenkins NA, Copeland NG, White R (1990) Identification and characterization of transcripts from the neurofibromatosis 1 region: the sequence and genomic structure of EVI2 and mapping of other transcripts. Genomics 7:555-565 (Pubitemid 20244459)
    • (1990) Genomics , vol.7 , Issue.4 , pp. 555-565
    • Cawthon, R.M.1    O'Connel, P.2    Buchberg, A.M.3    Viskochil, W.D.R.B.4    Culver, M.5    Stevens, J.6    Jenkins, N.A.7    Copeland, N.G.8    White, R.9
  • 21
    • 0028307836 scopus 로고
    • Tumour predisposition in mice heterozygous for a targeted mutation in Nf1
    • DOI 10.1038/ng0794-353
    • Jacks T, Shih TS, Schmitt EM, Bronson RT, Bernards A, Weinberg RA (1994) Tumour predisposition in mice heterozygous for a targeted mutation in Nf1. Nat Genet 7:353-361. doi:10.1038/ng0794-353 (Pubitemid 24204410)
    • (1994) Nature Genetics , vol.7 , Issue.3 , pp. 353-361
    • Jacks, T.1    Shih, T.S.2    Schmitt, E.M.3    Bronson, R.T.4    Bernards, A.5    Weinberg, R.A.6
  • 22
    • 23644443053 scopus 로고    scopus 로고
    • Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma
    • DOI 10.1016/j.ccr.2005.07.004, PII S153561080500228X
    • Zhu Y, Guignard F, Zhao D, Liu L, Burns DK, Mason RP, Messing A, Parada LF (2005) Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell 8:119-130. doi:10.1016/j.ccr. 2005.07.004 (Pubitemid 41132741)
    • (2005) Cancer Cell , vol.8 , Issue.2 , pp. 119-130
    • Zhu, Y.1    Guignard, F.2    Zhao, D.3    Liu, L.4    Burns, D.K.5    Mason, R.P.6    Messing, A.7    Parada, L.F.8
  • 24
    • 0031465906 scopus 로고    scopus 로고
    • Proliferation of human malignant astrocytomas is dependent on Ras activation
    • Guha A, Feldkamp MM, Lau N, Boss G, Pawson A (1997) Proliferation of human malignant astrocytomas is dependent on Ras activation. Oncogene 15:2755-2765 (Pubitemid 28004565)
    • (1997) Oncogene , vol.15 , Issue.23 , pp. 2755-2765
    • Guha, A.1    Feldkamp, M.M.2    Lau, N.3    Boss, G.4    Pawson, A.5
  • 25
    • 0032418416 scopus 로고    scopus 로고
    • 1 cell-cycle arrest pathways to induce glioma-like lesions in mice
    • Holland EC, Hively WP, DePinho RA, Varmus HE (1998) A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice. Genes Dev 12:3675-3685 (Pubitemid 29019648)
    • (1998) Genes and Development , vol.12 , Issue.23 , pp. 3675-3685
    • Holland, E.C.1    Hively, W.P.2    DePinho, R.A.3    Varmus, H.E.4
  • 26
    • 0034020459 scopus 로고    scopus 로고
    • Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice
    • DOI 10.1038/75596
    • Holland EC, Celestino J, Dai C, Schaefer L, Sawaya RE, Fuller GN (2000) Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice. Nat Genet 25:55-57. doi:10.1038/75596 (Pubitemid 30257036)
    • (2000) Nature Genetics , vol.25 , Issue.1 , pp. 55-57
    • Holland, E.C.1    Celestino, J.2    Dai, C.3    Schaefer, L.4    Sawaya, R.E.5    Fuller, G.N.6
  • 27
    • 0035328722 scopus 로고    scopus 로고
    • Astrocyte-specific expression of activated p21-ras results in malignant astrocytoma formation in a transgenic mouse model of human gliomas
    • Ding H, Roncari L, Shannon P, Wu X, Lau N, Karaskova J, Gutmann DH, Squire JA, Nagy A, Guha A (2001) Astrocytespecific expression of activated p21-ras results in malignant astrocytoma formation in a transgenic mouse model of human gliomas. Cancer Res 61:3826-3836 (Pubitemid 32695000)
    • (2001) Cancer Research , vol.61 , Issue.9 , pp. 3826-3836
    • Ding, H.1    Roncari, L.2    Shannon, P.3    Wu, X.4    Lau, N.5    Karaskova, J.6    Gutmann, D.H.7    Squire, J.A.8    Nagy, A.9    Guha, A.10
  • 28
    • 44149090296 scopus 로고    scopus 로고
    • Role of platelet-derived growth factors in physiology and medicine
    • DOI 10.1101/gad.1653708
    • Andrae J, Gallini R, Betsholtz C (2008) Role of platelet-derived growth factors in physiology and medicine. Genes Dev 22:1276-1312. doi:10.1101/gad. 1653708 (Pubitemid 351717519)
    • (2008) Genes and Development , vol.22 , Issue.10 , pp. 1276-1312
    • Andrae, J.1    Gallini, R.2    Betsholtz, C.3
  • 30
    • 0032401819 scopus 로고    scopus 로고
    • Induction of brain tumors in mice using a recombinant platelet-derived growth factor B-chain retrovirus
    • Uhrbom L, Hesselager G, Nister M, Westermark B (1998) Induction of brain tumors in mice using a recombinant platelet-derived growth factor B-chain retrovirus. Cancer Res 58:5275-5279 (Pubitemid 28551098)
    • (1998) Cancer Research , vol.58 , Issue.23 , pp. 5275-5279
    • Uhrbom, L.1    Hesselager, G.2    Nister, M.3    Westermark, B.4
  • 31
    • 0028911678 scopus 로고
    • Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop
    • Guha A, Dashner K, Black PM, Wagner JA, Stiles CD (1995) Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop. Int J Cancer 60:168-173
    • (1995) Int J Cancer , vol.60 , pp. 168-173
    • Guha, A.1    Dashner, K.2    Black, P.M.3    Wagner, J.A.4    Stiles, C.D.5
  • 32
    • 0035425048 scopus 로고    scopus 로고
    • PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas from and oligoastrocytomas neural progenitors and astrocytes in vivo
    • DOI 10.1101/gad.903001
    • Dai C, Celestino JC, Okada Y, Louis DN, Fuller GN, Holland EC (2001) PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo. Genes Dev 15:1913-1925. doi:10.1101/gad.903001 (Pubitemid 32738621)
    • (2001) Genes and Development , vol.15 , Issue.15 , pp. 1913-1925
    • Dai, C.1    Celestino, J.C.2    Okada, Y.3    Louis, D.N.4    Fuller, G.N.5    Holland, E.C.6
  • 33
    • 0042591478 scopus 로고    scopus 로고
    • Complementary effects of platelet-derived growth factor autocrine stimulation and p53 or INK4a-Arf deletion in a mouse glioma model
    • Hesselager G, Uhrbom L, Westermark B, Nister M (2003) Complementary effects of platelet-derived growth factor autocrine stimulation and p53 or Ink4a-Arf deletion in a mouse glioma model. Cancer Res 63:4305-4309 (Pubitemid 36950994)
    • (2003) Cancer Research , vol.63 , Issue.15 , pp. 4305-4309
    • Hesselager, G.1    Uhrbom, L.2    Westermark, B.3    Nister, M.4
  • 34
    • 34648834721 scopus 로고    scopus 로고
    • Loss of Arf causes tumor progression of PDGFB-induced oligodendroglioma
    • DOI 10.1038/sj.onc.1210455, PII 1210455
    • Tchougounova E, Kastemar M, Brasater D, Holland EC, Westermark B, Uhrbom L (2007) Loss of Arf causes tumor progression of PDGFB-induced oligodendroglioma. Oncogene 26:6289-6296. doi:10.1038/sj.onc.1210455 (Pubitemid 47462106)
    • (2007) Oncogene , vol.26 , Issue.43 , pp. 6289-6296
    • Tchougounova, E.1    Kastemar, M.2    Brasater, D.3    Holland, E.C.4    Westermark, B.5    Uhrbom, L.6
  • 35
    • 69649103118 scopus 로고    scopus 로고
    • GFAP promoter driven transgenic expression of PDGFB in the mouse brain leads to glioblastoma in a Trp53 null background
    • doi:10.1002/glia.20837
    • Hede SM, Hansson I, Afink GB, Eriksson A, Nazarenko I, Andrae J, Genove G, Westermark B, Nister M (2009) GFAP promoter driven transgenic expression of PDGFB in the mouse brain leads to glioblastoma in a Trp53 null background. Glia 57:1143-1153. doi:10.1002/glia.20837
    • (2009) Glia , vol.57 , pp. 1143-1153
    • Hede, S.M.1    Hansson, I.2    Afink, G.B.3    Eriksson, A.4    Nazarenko, I.5    Andrae, J.6    Genove, G.7    Westermark, B.8    Nister, M.9
  • 36
    • 79956361405 scopus 로고    scopus 로고
    • Glioblastoma models reveal the connection between adult glial progenitors and the proneural phenotype
    • doi:10.1371/journal.pone.0020041
    • Lei L, Sonabend AM, Guarnieri P, Soderquist C, Ludwig T, Rosenfeld S, Bruce JN, Canoll P (2011) Glioblastoma models reveal the connection between adult glial progenitors and the proneural phenotype. PLoS ONE 6:e20041. doi:10.1371/journal.pone.0020041
    • (2011) PLoS ONE , vol.6
    • Lei, L.1    Sonabend, A.M.2    Guarnieri, P.3    Soderquist, C.4    Ludwig, T.5    Rosenfeld, S.6    Bruce, J.N.7    Canoll, P.8
  • 37
    • 33745880884 scopus 로고    scopus 로고
    • PDGFRalpha-Positive B Cells Are Neural Stem Cells in the Adult SVZ that Form Glioma-like Growths in Response to Increased PDGF Signaling
    • DOI 10.1016/j.neuron.2006.06.012, PII S0896627306004661
    • Jackson EL, Garcia-Verdugo JM, Gil-Perotin S, Roy M, Quinones-Hinojosa A, VandenBerg S, Alvarez-Buylla A (2006) PDGFR alpha-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling. Neuron 51:187-199. doi:10.1016/j.neuron.2006.06.012 (Pubitemid 44063617)
    • (2006) Neuron , vol.51 , Issue.2 , pp. 187-199
    • Jackson, E.L.1    Garcia-Verdugo, J.M.2    Gil-Perotin, S.3    Roy, M.4    Quinones-Hinojosa, A.5    VandenBerg, S.6    Alvarez-Buylla, A.7
  • 39
    • 0035824396 scopus 로고    scopus 로고
    • Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo
    • doi:10. 1126/science.1065518
    • Groszer M, Erickson R, Scripture-Adams DD, Lesche R, Trumpp A, Zack JA, Kornblum HI, Liu X, Wu H (2001) Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science 294:2186-2189. doi:10. 1126/science.1065518
    • (2001) Science , vol.294 , pp. 2186-2189
    • Groszer, M.1    Erickson, R.2    Scripture-Adams, D.D.3    Lesche, R.4    Trumpp, A.5    Zack, J.A.6    Kornblum, H.I.7    Liu, X.8    Wu, H.9
  • 40
    • 84860162767 scopus 로고    scopus 로고
    • Pten deletion in adult hippocampal neural stem/progenitor cells causes cellular abnormalities and alters neurogenesis
    • doi:10.1523/JNEUROSCI.5462-11.2012
    • Amiri A, Cho W, Zhou J, Birnbaum SG, Sinton CM, McKay RM, Parada LF (2012) Pten deletion in adult hippocampal neural stem/progenitor cells causes cellular abnormalities and alters neurogenesis. J Neurosci 32:5880-5890. doi:10.1523/JNEUROSCI.5462-11.2012
    • (2012) J Neurosci , vol.32 , pp. 5880-5890
    • Amiri, A.1    Cho, W.2    Zhou, J.3    Birnbaum, S.G.4    Sinton, C.M.5    McKay, R.M.6    Parada, L.F.7
  • 41
    • 60849117508 scopus 로고    scopus 로고
    • PTEN/PI3 K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells
    • doi:10.1016/j.stem.2009.01.007
    • Bleau A-M, Hambardzumyan D, Ozawa T, Fomchenko EI, Huse JT, Brennan CW, Holland EC (2009) PTEN/PI3 K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells. Stem Cell 4:226-235. doi:10.1016/j.stem.2009.01.007
    • (2009) Stem Cell , vol.4 , pp. 226-235
    • Bleau, A.-M.1    Hambardzumyan, D.2    Ozawa, T.3    Fomchenko, E.I.4    Huse, J.T.5    Brennan, C.W.6    Holland, E.C.7
  • 42
    • 0036490954 scopus 로고    scopus 로고
    • Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation
    • DOI 10.1016/S1535-6108(02)00029-6
    • Xiao A, Wu H, Pandolfi PP, Louis DN, Van Dyke T (2002) Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation. Cancer Cell 1:157-168 (Pubitemid 41039162)
    • (2002) Cancer Cell , vol.1 , Issue.2 , pp. 157-168
    • Xiao, A.1    Wu, H.2    Pandolfi, P.P.3    Louis, D.N.4    Van Dyke, T.5
  • 43
    • 20444484560 scopus 로고    scopus 로고
    • Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation
    • DOI 10.1158/0008-5472.CAN-04-3902
    • Xiao A, Yin C, Yang C, Di Cristofano A, Pandolfi PP, Van Dyke T (2005) Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation. Cancer Res 65:5172-5180. doi:10.1158/0008-5472.CAN-04-3902 (Pubitemid 40827326)
    • (2005) Cancer Research , vol.65 , Issue.12 , pp. 5172-5180
    • Xiao, A.1    Yin, C.2    Yang, C.3    Di, C.A.4    Pandolfi, P.P.5    Van Dyke, T.6
  • 44
    • 65649142176 scopus 로고    scopus 로고
    • Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model
    • doi:10.1016/j.ccr.2009.04.001
    • Wang Y, Yang J, Zheng H, Tomasek GJ, Zhang P, McKeever PE, Lee EY, Zhu Y (2009) Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model. Cancer Cell 15:514-526. doi:10.1016/j.ccr.2009.04.001
    • (2009) Cancer Cell , vol.15 , pp. 514-526
    • Wang, Y.1    Yang, J.2    Zheng, H.3    Tomasek, G.J.4    Zhang, P.5    McKeever, P.E.6    Lee, E.Y.7    Zhu, Y.8
  • 45
    • 34247329362 scopus 로고    scopus 로고
    • p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM
    • DOI 10.1038/ncb1571, PII NCB1571
    • Song H, Hollstein M, Xu Y (2007) p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM. Nat Cell Biol 9:573-580. doi:10.1038/ncb1571 (Pubitemid 46696539)
    • (2007) Nature Cell Biology , vol.9 , Issue.5 , pp. 573-580
    • Song, H.1    Hollstein, M.2    Xu, Y.3
  • 46
    • 84855551714 scopus 로고    scopus 로고
    • Links between mutant p53 and genomic instability
    • doi:10.1002/jcb.23400
    • Hanel W, Moll UM (2012) Links between mutant p53 and genomic instability. J Cell Biochem 113:433-439. doi:10.1002/jcb.23400
    • (2012) J Cell Biochem , vol.113 , pp. 433-439
    • Hanel, W.1    Moll, U.M.2
  • 47
    • 0027379865 scopus 로고
    • An analysis of variation in expression of neurofibromatosis (NF) type 1 (NF1): Evidence for modifying genes
    • Easton DF, Ponder MA, Huson SM, Ponder BA (1993) An analysis of variation in expression of neurofibromatosis (NF) type 1 (NF1): evidence for modifying genes. Am J Hum Genet 53:305-313 (Pubitemid 23308924)
    • (1993) American Journal of Human Genetics , vol.53 , Issue.2 , pp. 305-313
    • Easton, D.F.1    Ponder, M.A.2    Huson, S.M.3    Ponder, B.A.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.