Pretreatment of Gymnema sylvestre revealed the protection against acetic acid-induced ulcerative colitis in rats

BMC Complementary and Alternative Medicine

Volumn 14, Issue , 2014, Pages

  Aleisa, Abdulaziz M ^a   Al Rejaie, Salim S ^a   Abuohashish, Hatem M ^a,b   Ola, Mohammed S ^c   Parmar, Mihir Y ^a   Ahmed, Mohammed M ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b IMAM ABDULRAHMAN BIN FAISAL UNIVERSITY   (Saudi Arabia)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Gymnema sylvestre; Inflammatory bowel diseases; Oxidative stress; Ulcerative colitis

Indexed keywords

ACETIC ACID; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CATALASE; GLUTATHIONE; INTERLEUKIN 1BETA; INTERLEUKIN 6; PLANT EXTRACT; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; CHEMICALLY INDUCED; COLITIS; COLITIS, ULCERATIVE; COLON; DRUG EFFECTS; GYMNEMA SYLVESTRE; MALE; METABOLISM; PHYTOTHERAPY; PLANT LEAF; WISTAR RAT;

ACETIC ACID; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; CATALASE; COLITIS; COLITIS, ULCERATIVE; COLON; GLUTATHIONE; GYMNEMA SYLVESTRE; INTERLEUKIN-1BETA; INTERLEUKIN-6; MALE; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; RATS, WISTAR; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84893678005     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-14-49     Document Type: Article

References (61)

1. Sood A, Midha V, Sood N, Bhatia AS, Avasthi G. Incidence and prevalence of ulcerative colitis in Punjab. North India. Gut 2003, 52(11):1587-1590.
2. Olden KW. Diagnosis of irritable bowel syndrome. Gastroenterology 2002, 122(6):1701-1714. 10.1053/gast.2002.33741, 12016433.
3. Nieto N, Torres MI, Rios A, Gil A. Dietary polyunsaturated fatty acids improve histological and biochemical alterations in rats with experimental ulcerative colitis. J Nutr 2002, 132(1):11-19.
4. Slamon ND, Pentreath VW. Antioxidant defense against antidepressants in C6 and 1321 N1 cells. Chem Biol Interact 2000, 127(3):181-199. 10.1016/S0009-2797(00)00172-1, 10967317.
5. Cetinkaya A, Bulbuloglu E, Kantarceken B, Ciralik H, Kurutas EB, Buyukbese MA, Gumusalan Y. Effects of L-carnitine on oxidant/antioxidant status in acetic acid-induced colitis. Dig Dis Sci 2006, 51(3):488-494. 10.1007/s10620-006-3160-9, 16614957.
6. Cetinkaya A, Bulbuloglu E, Kurutas EB, Ciralik H, Kantarceken B, Buyukbese MA. Beneficial effects of N-acetylcysteine on acetic acid-induced colitis in rats. Tohoku J Exp Med 2005, 206(2):131-139. 10.1620/tjem.206.131, 15888969.
7. Reiff C, Kelly D. Inflammatory bowel disease, gut bacteria and probiotic therapy. Int J Med Microbiol 2010, 300(1):25-33. 10.1016/j.ijmm.2009.08.004, 19800289.
8. Pavlick KP, Laroux FS, Fuseler J, Wolf RE, Gray L, Hoffman J, Grisham MB. Role of reactive metabolites of oxygen and nitrogen in inflammatory bowel disease. Free Radic Biol Med 2002, 33(3):311-322. 10.1016/S0891-5849(02)00853-5, 12126753.
9. Grisham MB. Oxidants and free radicals in inflammatory bowel disease. Lancet 1994, 344(8926):859-861. 10.1016/S0140-6736(94)92831-2, 7916405.
10. Tuzun A, Erdil A, Inal V, Aydin A, Bagci S, Yesilova Z, Sayal A, Karaeren N, Dagalp K. Oxidative stress and antioxidant capacity in patients with inflammatory bowel disease. Clin Biochem 2002, 35(7):569-572. 10.1016/S0009-9120(02)00361-2, 12493587.
11. Chang JC, Cohen RD. Medical management of severe ulcerative colitis. Gastroenterol Clin North Am 2004, 33(2):235-250. viii, 10.1016/j.gtc.2004.02.005, 15177536.
12. Kanetkar P, Singhal R, Kamat M. Gymnema sylvestre: A Memoir. J Clin Biochem Nutr 2007, 41(2):77-81. 10.3164/jcbn.2007010, 2170951, 18193099.
13. Daisy P, Eliza J, Mohamed Farook KA. A novel dihydroxy gymnemic triacetate isolated from Gymnema sylvestre possessing normoglycemic and hypolipidemic activity on STZ-induced diabetic rats. J Ethnopharmacol 2009, 126(2):339-344. 10.1016/j.jep.2009.08.018, 19703537.
14. Ramkumar KM, Ponmanickam P, Velayuthaprabhu S, Archunan G, Rajaguru P. Protective effect of Gymnema montanum against renal damage in experimental diabetic rats. Food Chem Toxicol 2009, 47(10):2516-2521. 10.1016/j.fct.2009.07.010, 19616598.
15. Grover JK, Yadav S, Vats V. Medicinal plants of India with anti-diabetic potential. J Ethnopharmacol 2002, 81(1):81-100. 10.1016/S0378-8741(02)00059-4, 12020931.
16. Ye WC, Zhang QW, Liu X, Che CT, Zhao SX. Oleanane saponins from Gymnema sylvestre. Phytochemistry 2000, 53(8):893-899. 10.1016/S0031-9422(99)00483-5, 10820799.
17. Surveswaran S, Cai YZ, Xing J, Corke H, Sun M. Antioxidant properties and principal phenolic phytochemicals of Indian medicinal plants from Asclepiadoideae and Periplocoideae. Nat Prod Res 2010, 24(3):206-221. 10.1080/14786410802228827, 20140800.
18. Trease EGaE, W.E Saponins and cardioactive drugs 1978, London: Bailiere Tindal, Textbook of Pharmacognosy, Trease EGaE, W.E.
19. Al-Rejaie SS, Abuohashish HM, Al-Enazi MM, Al-Assaf AH, Parmar MY, Ahmed MM. Protective effect of naringenin on acetic acid-induced ulcerative colitis in rats. World j gastroenterol WJG 2013, 19(34):5633-5644.
20. Koch TR, Yuan LX, Stryker SJ, Ratliff P, Telford GL, Opara EC. Total antioxidant capacity of colon in patients with chronic ulcerative colitis. Dig dis sci 2000, 45(9):1814-1819. 10.1023/A:1005517824877, 11052325.
21. Harputluoglu MM, Demirel U, Yucel N, Karadag N, Temel I, Firat S, Ara C, Aladag M, Karincaoglu M, Hilmioglu F. The effects of Gingko biloba extract on acetic acid-induced colitis in rats. Turk j gastroenterol off j Turk Soc Gastroenterol 2006, 17(3):177-182.
22. Kannan N, Guruvayoorappan C. Protective effect of Bauhinia tomentosa on acetic acid induced ulcerative colitis by regulating antioxidant and inflammatory mediators. Int immunopharmacol 2013, 16(1):57-66. 10.1016/j.intimp.2013.03.008, 23538025.
23. Mousavizadeh K, Rahimian R, Fakhfouri G, Aslani FS, Ghafourifar P. Anti-inflammatory effects of 5-HT receptor antagonist, tropisetron on experimental colitis in rats. Eur J Clin Invest 2009, 39(5):375-383. 10.1111/j.1365-2362.2009.02102.x, 19302562.
24. Popov SV, Markov PA, Nikitina IR, Petrishev S, Smirnov V, Ovodov YS. Preventive effect of a pectic polysaccharide of the common cranberry Vaccinium oxycoccos L. on acetic acid-induced colitis in mice. World J Gastroenterol 2006, 12(41):6646-6651.
25. Sedlak J, Lindsay RH. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem 1968, 25(1):192-205.
26. Kono Y. Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. Arch Biochem Biophys 1978, 186(1):189-195. 10.1016/0003-9861(78)90479-4, 24422.
27. Aebi H. Catalase. Methods in enzymatic analysis 1974, 674-684. New York: Verlag Chemie-Academic Press, Bergmeyer, 2.
28. Bregman A. Laboratory Investigation and Cell Biology 1983, New York: John Wiley and Sons.
29. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951, 193(1):265-275.
30. Hartmann RM, Morgan Martins MI, Tieppo J, Fillmann HS, Marroni NP. Effect of Boswellia serrata on antioxidant status in an experimental model of colitis rats induced by acetic acid. Dig Dis Sci 2012, 57(8):2038-2044. 10.1007/s10620-012-2134-3, 22451119.
31. El-Abhar HS, Hammad LN, Gawad HS. Modulating effect of ginger extract on rats with ulcerative colitis. J Ethnopharmacol 2008, 118(3):367-372. 10.1016/j.jep.2008.04.026, 18571884.
32. Duerr RH. Update on the genetics of inflammatory bowel disease. J Clin Gastroenterol 2003, 37(5):358-367. 10.1097/00004836-200311000-00003, 14564181.
33. Al-Rejaie SS, Abuohashish HM, Ahmed MM, Aleisa AM, Alkhamees O. Possible biochemical effects following inhibition of ethanol-induced gastric mucosa damage by Gymnema sylvestre in male Wistar albino rats. Pharm Biol 2012, 50(12):1542-1550. 10.3109/13880209.2012.694894, 22978267.
34. Sands BE. Therapy of inflammatory bowel disease. Gastroenterology 2000, 118(2 Suppl 1):S68-82.
35. Langmead L, Dawson C, Hawkins C, Banna N, Loo S, Rampton DS. Antioxidant effects of herbal therapies used by patients with inflammatory bowel disease: an in vitro study. Aliment Pharmacol Ther 2002, 16(2):197-205. 10.1046/j.1365-2036.2002.01157.x, 11860402.
36. Button LA, Roberts SE, Goldacre MJ, Akbari A, Rodgers SE, Williams JG. Hospitalized prevalence and 5-year mortality for IBD: record linkage study. World J Gastroenterol 2010, 16(4):431-438. 10.3748/wjg.v16.i4.431, 2811794, 20101767.
37. Grisham MB, Yamada T. Neutrophils, nitrogen oxides, and inflammatory bowel disease. Ann N Y Acad Sci 1992, 664:103-115. 10.1111/j.1749-6632.1992.tb39753.x, 1456643.
38. Sartor RB. Cytokines in intestinal inflammation: pathophysiological and clinical considerations. Gastroenterology 1994, 106(2):533-539.
39. Elson CO, Sartor RB, Tennyson GS, Riddell RH. Experimental models of inflammatory bowel disease. Gastroenterology 1995, 109(4):1344-1367. 10.1016/0016-5085(95)90599-5, 7557106.
40. Bertevello PL, Logullo AF, Nonogaki S, Campos FM, Chiferi V, Alves CC, Torrinhas RS, Gama-Rodrigues JJ, Waitzberg DL. Immunohistochemical assessment of mucosal cytokine profile in acetic acid experimental colitis. Clinics (Sao Paulo) 2005, 60(4):277-286.
41. Stucchi A, Reed K, O'Brien M, Cerda S, Andrews C, Gower A, Bushell K, Amar S, Leeman S, Becker J. A new transcription factor that regulates TNF-alpha gene expression, LITAF, is increased in intestinal tissues from patients with CD and UC. Inflamm Bowel Dis 2006, 12(7):581-587. 10.1097/01.MIB.0000225338.14356.d5, 16804395.
42. Tahan G, Aytac E, Aytekin H, Gunduz F, Dogusoy G, Aydin S, Tahan V, Uzun H. Vitamin E has a dual effect of anti-inflammatory and antioxidant activities in acetic acid-induced ulcerative colitis in rats. Can J Surg 2011, 54(5):333-338. 10.1503/cjs.013610, 3195661, 21933527.
43. Otani T, Yamaguchi K, Scherl E, Du B, Tai HH, Greifer M, Petrovic L, Daikoku T, Dey SK, Subbaramaiah K, et al. Levels of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase are reduced in inflammatory bowel disease: evidence for involvement of TNF-alpha. Am J Physiol Gastrointest Liver Physiol 2006, 290(2):G361-368. 10.1152/ajpgi.00348.2005, 16195422.
44. Park MY, Ji GE, Sung MK. Dietary kaempferol suppresses inflammation of dextran sulfate sodium-induced colitis in mice. Dig Dis Sci 2012, 57(2):355-363. 10.1007/s10620-011-1883-8, 21901258.
45. Diwan PV, Margaret I, Ramakrishna S. Influence of Gymnema sylvestre on inflammation. InflammoPharmacology 1995, 3(3):271-277.
46. Jitender KM, Manvi F, Alagawadi K, Noolvi M. Evaluation of anti-inflammatory activity of Gymnema sylvestre leaves extract in rats. IJGP 2008, 2(2):114-115.
47. Hamalainen M, Nieminen R, Vuorela P, Heinonen M, Moilanen E. Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediators Inflamm 2007, 2007:45673. 2220047, 18274639.
48. Raso GM, Meli R, Di Carlo G, Pacilio M, Di Carlo R. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1. Life Sci 2001, 68(8):921-931. 10.1016/S0024-3205(00)00999-1, 11213362.
49. Patel MA, Patel PK, Patel MB. Effects of ethanol extract of Ficus bengalensis (bark) on inflammatory bowel disease. Indian J Pharmacol 2010, 42(4):214-218. 10.4103/0253-7613.68420, 2941610, 20927245.
50. Narushima S, Spitz DR, Oberley LW, Toyokuni S, Miyata T, Gunnett CA, Buettner GR, Zhang J, Ismail H, Lynch RG, et al. Evidence for oxidative stress in NSAID-induced colitis in IL10-/- mice. Free Radic Biol Med 2003, 34(9):1153-1166. 10.1016/S0891-5849(03)00065-0, 12706496.
51. Droge W. Free radicals in the physiological control of cell function. Physiol Rev 2002, 82(1):47-95.
52. Pravda J. Radical induction theory of ulcerative colitis. World J Gastroenterol 2005, 11(16):2371-2384.
53. Bitiren M, Karakilcik AZ, Zerin M, Ozardali I, Selek S, Nazligul Y, Ozgonul A, Musa D, Uzunkoy A. Protective effects of selenium and vitamin E combination on experimental colitis in blood plasma and colon of rats. Biol Trace Elem Res 2010, 136(1):87-95. 10.1007/s12011-009-8518-3, 19774348.
54. Ademoglu E, Erbil Y, Tam B, Barbaros U, Ilhan E, Olgac V, Mutlu-Turkoglu U. Do vitamin E and selenium have beneficial effects on trinitrobenzenesulfonic acid-induced experimental colitis. Dig Dis Sci 2004, 49(1):102-108.
55. Yu BP. Cellular defenses against damage from reactive oxygen species. Physiol Rev 1994, 74(1):139-162.
56. Cai DJ, Zhao Y, Glasier J, Cullen D, Barnes S, Turner CH, Wastney M, Weaver CM. Comparative effect of soy protein, soy isoflavones, and 17beta-estradiol on bone metabolism in adult ovariectomized rats. J Bone Miner Res 2005, 20(5):828-839.
57. Preuss HG, Jarrell ST, Scheckenbach R, Lieberman S, Anderson RA. Comparative effects of chromium, vanadium and gymnema sylvestre on sugar-induced blood pressure elevations in SHR. J Am Coll Nutr 1998, 17(2):116-123. 10.1080/07315724.1998.10718736, 9550454.
58. Kang MH, Lee MS, Choi MK, Min KS, Shibamoto T. Hypoglycemic activity of Gymnema sylvestre extracts on oxidative stress and antioxidant status in diabetic rats. J Agric Food Chem 2012, 60(10):2517-2524. 10.1021/jf205086b, 22360666.
59. Kumar V, Bhandari U, Tripathi CD, Khanna G. Evaluation of antiobesity and cardioprotective effect of Gymnema sylvestre extract in murine model. Indian J Pharmacol 2012, 44(5):607-613. 10.4103/0253-7613.100387, 3480794, 23112423.
60. Sharma K, Singh U, Vats S, Priyadarsini K, Bhatia A, Kamal R. Evaluation of evidenced-based radioprotective efficacy of Gymnema sylvestre leaves in mice brain. J Environ Pathol Toxicol Oncol 2009, 28(4):311-323. 10.1615/JEnvironPatholToxicolOncol.v28.i4.60, 20102328.
61. Rachh PR, Patel SR, Hirpara HV, Rupareliya MT, Rachh MR, Bhargava AS, Patel NM, Modi DC. In vitro evaluation of antioxidant activity of Gymnema sylvestre R. BR leaf extract Rom J Biol 2009, 54(2):141-148.