Screening and determination of sibutramine in adulterated herbal slimming supplements by HPTLC-UV densitometry

Food Additives and Contaminants - Part A

Volumn 31, Issue 1, 2014, Pages 15-20

  Mathon, Caroline ^a,b   Ankli, Anita ^c   Reich, Eike ^c   Bieri, Stefan ^a   Christen, Philippe ^b  

^a The Official Food and Veterinary Control Authority of Geneva   (Switzerland)

^b UNIVERSITY OF GENEVA   (Switzerland)

^c CAMAG Laboratory   (Switzerland)

Author keywords

adulteration; densitogram; herbal slimming supplements; HPTLC; sibutramine; weight loss

Indexed keywords

SILICA GEL;

ADULTERATION; DENSITOGRAM; HERBAL SLIMMING SUPPLEMENTS; HPTLC; SIBUTRAMINE; WEIGHT LOSS;

SILICA;

METHANOL; SIBUTRAMINE; SILICA GEL; TOLUENE;

ARTICLE; CONTROLLED STUDY; DENSITOMETRY; DIET SUPPLEMENTATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; THIN LAYER CHROMATOGRAPHY; WEIGHT REDUCTION;

APPETITE DEPRESSANTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, THIN LAYER; CYCLOBUTANES; DENSITOMETRY; DIET, REDUCING; DIETARY SUPPLEMENTS; FOOD CONTAMINATION; FOOD SAFETY; HAZARD ANALYSIS AND CRITICAL CONTROL POINTS; HUMANS; LIMIT OF DETECTION; PLANT PREPARATIONS; TANDEM MASS SPECTROMETRY;

EID: 84893673710     PISSN: 19440049     EISSN: 14645122     Source Type: Journal    
DOI: 10.1080/19440049.2013.861934     Document Type: Article

References (24)

1. Ancuceanu R, Dinu M, Arama C. 2013. Weight loss food supplements: adulteration and multiple quality issues in two products of Chinese origin. Farmacia (Bucharest, Rom). 61:28-44.
2. Ariburnu E, Uludag MF, Yalcinkaya H, Yesilada E. 2012. Comparative determination of sibutramine as an adulterant in natural slimming products by HPLC and HPTLC densitometry. J Pharm Biomed Anal. 64-65:77-81.
3. Bland JM, Altman DG. 2012. Agreed statistics: Measurement method comparison. Anesthesiology. 116:182-185.
4. Bogusz MJ, Hassan H, Al-Enazi E, Ibrahim Z, Al-Tufail M. 2006. Application of LC-ESI-MS-MS for detection of synthetic adulterants in herbal remedies. J Pharm Biomed Anal. 41:554-564.
5. Chen Y, Zhao L, Lu F, Yu Y, Chai Y, Wu Y. 2009. Determination of synthetic drugs used to adulterate botanical dietary supplements using QTRAP LC-MS/MS. Food Addit Contam Part A. 26:595-603.
6. Cheng S-C, Huang M-Z, Shiea J. 2011. Thin layer chromatography/mass spectrometry. J Chromatogr A. 1218:2700-2711.
7. Cohen P, Benner C, McCormick D. 2012. Use of a pharmaceutically adulterated dietary supplement, Pai You Guo, among Brazilian-born women in the United States. J Gen Intern Med. 27:51-56.
8. Domenech-Carbo A, Martini M, Machado dCL, Viana C, Domenech-Carbo MT, Silva M. 2013. Screening of pharmacologic adulterant classes in herbal formulations using voltammetry of microparticles. J Pharm Biomed Anal. 74:194- 204.
9. European Medicines Agency. 2003. Committee for medicinal products for human use. Referral Sibutramine. CPMP/4514/02. London (UK): EMA.
10. European Medicines Agency. 2010. European Medicines Agency recommends suspension of marketing authorisations for sibutramine. Press release. EMA/39408/2010. London (UK): EMA.
11. [FDA] Food and Drug Administration. 2010. FDA drug safety communication: FDA recommends against the continued use of Meridia (sibutramine) [Internet]. 8 October 2010. [cited 2013 Nov 25]. Available from: http://www.fda.gov/Drugs/DrugSafety/ucm228746.htm
12. [FDA] Food and Drug Administration. 2011. Safety alerts for Human medical products, products with undeclared drug ingredients [Internet]. [cited 2013 Nov 25]. Available from: http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm238512.htm
13. [FDA] Food and Drug Administration. 2012. Safety alerts for Human medical products, products with undeclared drug ingredients [Internet]. [cited 2013 Nov 25]. Available from: http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm285497.htm
14. Kanan S, Abu-Yousef IA, Gunasekar C, Abdo N, Narasimhan S. 2009. Detection and quantification of synthetic drugs in herbal slimming formula. Eur J Sci Res. 34:348-357.
15. Kim JW, Kweon SJ, Park SK, Kim JY, Lee JH, Han KM, Cho S, Kim J, Han SY, Kim HJ, et al. 2013. Isolation and identification of a sibutramine analogue adulterated in slimming dietary supplements. Food Addit Contam: Part A. 30:1221-1229.
16. Kim SH, Lee J, Yoon T, Choi J, Choi D, Kim D, Kwon SW. 2009. Simultaneous determination of anti-diabetes/anti-obesity drugs by LC/PDA, and targeted analysis of sibutramine analog in dietary supplements by LC/MS/MS. Biomed Chromatogr. 23:1259-1265.
17. Lai K-C, Liu Y-C, Tseng M-C, Lin Y-L, Jer-Huei L. 2007. Isolation and identification of a sibutramine analogue in a healthy food for weight loss. J Food Drug Anal. 15:20-24.
18. Park S-r, Lee JG, Roh SH, Kim G, Kwon CH, Park HR, Kwon KS, Kim D, Kwon SW. 2012. Determination of PDE-5 inhibitors and appetite suppressants in adulterated dietary supplements using LC/PDA and LC/MS. Food Addit Contam Part B. 5:29-32.
19. Phattanawasin P, Sotanaphun U, Sukwattanasinit T, Akkarawaranthorn J, Kitchaiya S. 2012. Quantitative determination of sibutramine in adulterated herbal slimming formulations by TLC-image analysis method. Forensic Sci Int. 219:96-100.
20. Rebiere H, Guinot P, Civade C, Bonnet PA, Nicolas A. 2012. Detection of hazardous weight-loss substances in adulterated slimming formulations using ultra-high-pressure liquid chromatography with diode-array detection. Food Addit Contam Part A. 29:161-171.
21. Reich E, Schibli A. 2006. High-performance thin-layer chromatography for the analysis of medicinal plants. New York: Thieme Medical Publishers, INC.
22. Vaysse J, Balayssac S, Gilard V, Desoubdzanne D, Malet-Martino M, Martino R. 2010. Analysis of adulterated herbal medicines and dietary supplements marketed for weight loss by DOSY 1H-NMR. Food Addit Contam Part A. 27:903-916.
23. Wang H, Wu Y, Zhao Y, Sun W, Ding L, Guo B, Chen B. 2012. Rapid screening of illicit additives in weight loss dietary supplements with desorption corona beam ionisation (DCBI) mass spectrometry. Food Addit Contam Part A. 29:1194-1201.
24. Yuen YP, Lai CK, Poon WT, Ng SW, Chan AY, Mak TW. 2007. Adulteration of over-the-counter slimming products with pharmaceutical analogue--an emerging threat. Hong Kong Med J. 13:216-220.