Increased Toll-like receptor 5 expression indicates esophageal columnar dysplasia

Virchows Archiv

Volumn 464, Issue 1, 2014, Pages 11-18

  Helminen, Olli ^a,b   Huhta, Heikki ^a,b   Takala, Heikki ^a,b   Lehenkari, Petri P ^a,b   Saarnio, Juha ^a,b   Kauppila, Joonas H ^a,b   Karttunen, Tuomo J ^a,b  

^a UNIVERSITY OF OULU   (Finland)

^b OULU UNIVERSITY HOSPITAL   (Finland)

Author keywords

Barrett's esophagus; Columnar dysplasia; Columnar metaplasia; Esophageal adenocarcinoma; Immunohistochemistry; TLR5; Toll like receptor

Indexed keywords

BIOLOGICAL MARKER; TOLL LIKE RECEPTOR 5;

ADULT; AGED; ARTICLE; BARRETT ESOPHAGUS; CANCER PROGNOSIS; CANCER STAGING; CARCINOGENESIS; COLUMNAR EPITHELIUM; CONTROLLED STUDY; CYTOPLASM; DIAGNOSTIC TEST ACCURACY STUDY; DYSPLASIA; EPITHELIUM DYSPLASIA; ESOPHAGEAL ADENOCARCINOMA; ESOPHAGUS DYSPLASIA; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTESTINE METAPLASIA; MAJOR CLINICAL STUDY; MALE; METAPLASIA; MICROBIOME; MIDDLE AGED; PATHOGENESIS; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SQUAMOUS EPITHELIUM; STOMACH METAPLASIA;

EID: 84893641844     PISSN: 09456317     EISSN: 14322307     Source Type: Journal    
DOI: 10.1007/s00428-013-1505-2     Document Type: Article

References (34)

1. Takeda K, Akira S (2007) Toll-like receptors. Curr Protoc Immunol. doi: 10.1002/0471142735.im1412s77
2. Kumar H, Kawai T, Akira S (2011) Pathogen recognition by the innate immune system. Int Rev Immunol 30:16-34
3. Akira S, Takeda K (2004) Toll-like receptor signalling. Nat Rev Immunol 4:499-511
4. Moresco EM, LaVine D, Beutler B (2011) Toll-like receptors. Curr Biol 21:R488-R493
5. Liew FY, Xu D, Brint EK, O'Neill LA (2005) Negative regulation of Toll-like receptor-mediated immune responses. Nat Rev Immunol 5:446-458
6. Huang B, Zhao J, Li H, He KL, Chen Y, Chen SH, Mayer L, Unkeless JC, Xiong H (2005) Toll-like receptors on tumor cells facilitate evasion of immune surveillance. Cancer Res 65:5009-5014
7. Pimentel-Nunes P, Afonso L, Lopes P, Roncon-Albuquerque R Jr, Goncalves N, Henrique R, Moreira-Dias L, Leite-Moreira AF, Dinis-Ribeiro M (2011) Increased expression of Toll-like receptors (TLR) 2, 4 and 5 in gastric dysplasia. Pathol Oncol Res 17:677-683
8. Kauppila JH, Takala H, Selander KS, Lehenkari PP, Saarnio J, Karttunen TJ (2011) Increased Toll-like receptor 9 expression indicates adverse prognosis in oesophageal adenocarcinoma. Histopathology 59:643-649
9. Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, Eng JK, Akira S, Underhill DM, Aderem A (2001) The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 410:1099-1103
10. Schmausser B, Andrulis M, Endrich S, Lee SK, Josenhans C, Muller-Hermelink HK, Eck M (2004) Expression and subcellular distribution of Toll-like receptors TLR4, TLR5 and TLR9 on the gastric epithelium in Helicobacter pylori infection. Clin Exp Immunol 136:521-526
11. Park JH, Yoon HE, Kim DJ, Kim SA, Ahn SG, Yoon JH (2011) Toll-like receptor 5 activation promotes migration and invasion of salivary gland adenocarcinoma. J Oral Pathol Med 40:187-193
12. Kauppila JH, Mattila AE, Karttunen TJ, Salo T (2013) Toll-like receptor 5 (TLR5) expression is a novel predictive marker for recurrence and survival in squamous cell carcinoma of the tongue. Br J Cancer 108(3):638-43
13. Jones RM, Sloane VM, Wu H, Luo L, Kumar A, Kumar MV, Gewirtz AT, Neish AS (2011) Flagellin administration protects gut mucosal tissue from irradiation-induced apoptosis via MKP-7 activity. Gut 60:648-657
14. Kim WY, Lee JW, Choi JJ, Choi CH, Kim TJ, Kim BG, Song SY, Bae DS (2008) Increased expression of Toll-like receptor 5 during progression of cervical neoplasia. Int J Gynecol Cancer 18:300-305
15. Pohl H, Welch HG (2005) The role of overdiagnosis and reclassification in the marked increase of esophageal adenocarcinoma incidence. J Natl Cancer Inst 97:142-146
16. Pei Z, Bini EJ, Yang L, Zhou M, Francois F, Blaser MJ (2004) Bacterial biota in the human distal esophagus. Proc Natl Acad Sci U S A 101:4250-4255
17. Yang L, Lu X, Nossa CW, Francois F, Peek RM, Pei Z (2009) Inflammation and intestinal metaplasia of the distal esophagus are associated with alterations in the microbiome. Gastroenterology 137:588-597
18. Pei Z, Yang L, Peek RM Jr, Levine SM, Pride DT, Blaser MJ (2005) Bacterial biota in reflux esophagitis and Barrett's esophagus. World J Gastroenterol 11:7277-7283
19. Odze RD (2009) Barrett esophagus: histology and pathology for the clinician. Nat Rev Gastroenterol Hepatol 6:478-490
20. Reid BJ, Haggitt RC, Rubin CE, Roth G, Surawicz CM, Van Belle G, Lewin K, Weinstein WM, Antonioli DA, Goldman H (1988) Observer variation in the diagnosis of dysplasia in Barrett's esophagus. Hum Pathol 19:166-178
21. Baker BS, Ovigne JM, Powles AV, Corcoran S, Fry L (2003) Normal keratinocytes express Toll-like receptors (TLRs) 1, 2 and 5: modulation of TLR expression in chronic plaque psoriasis. Br J Dermatol 148:670-679
22. Takala H, Kauppila JH, Soini Y, Selander KS, Vuopala KS, Lehenkari PP, Saarnio J, Karttunen TJ (2011) Toll-like receptor 9 is a novel biomarker for esophageal squamous cell dysplasia and squamous cell carcinoma progression. J Innate Immun 3:631-638
23. Yang L, Francois F, Pei Z (2012) Molecular pathways: pathogenesis and clinical implications of microbiome alteration in esophagitis and Barrett esophagus. Clin Cancer Res 18:2138-2144
24. Mullin JM, Valenzano MC, Trembeth S, Allegretti PD, Verrecchio JJ, Schmidt JD, Jain V, Meddings JB, Mercogliano G, Thornton JJ (2006) Transepithelial leak in Barrett's esophagus. Dig Dis Sci 51:2326-2336
25. Ormsby AH, Petras RE, Henricks WH, Rice TW, Rybicki LA, Richter JE, Goldblum JR (2002) Observer variation in the diagnosis of superficial oesophageal adenocarcinoma. Gut 51:671-676
26. Kerkhof M, van Dekken H, Steyerberg EW, Meijer GA, Mulder AH, de Bruine A, Driessen A, ten Kate FJ, Kusters JG, Kuipers EJ, Siersema PD, CYBAR study group (2007) Grading of dysplasia in Barrett's oesophagus: substantial interobserver variation between general and gastrointestinal pathologists. Histopathology 50:920-927
27. Curvers WL, ten Kate FJ, Krishnadath KK, Visser M, Elzer B, Baak LC, Bohmer C, Mallant-Hent RC, van Oijen A, Naber AH, Scholten P, Busch OR, Blaauwgeers HG, Meijer GA, Bergman JJ (2010) Low-grade dysplasia in Barrett's esophagus: overdiagnosed and underestimated. Am J Gastroenterol 105:1523-1530
28. Skacel M, Petras RE, Gramlich TL, Sigel JE, Richter JE, Goldblum JR (2000) The diagnosis of low-grade dysplasia in Barrett's esophagus and its implications for disease progression. Am J Gastroenterol 95:3383-3387
29. Srivastava A, Hornick JL, Li X, Blount PL, Sanchez CA, Cowan DS, Ayub K, Maley CC, Reid BJ, Odze RD (2007) Extent of low-grade dysplasia is a risk factor for the development of esophageal adenocarcinoma in Barrett's esophagus. Am J Gastroenterol 102:483-493, quiz 694
30. Bennett C, Vakil N, Bergman J, Harrison R, Odze R, Vieth M, Sanders S, Gay L, Pech O, Longcroft-Wheaton G, Romero Y, Inadomi J, Tack J, Corley DA, Manner H, Green S, Al Dulaimi D, Ali H, Allum B, Anderson M, Curtis H, Falk G, Fennerty MB, Fullarton G, Krishnadath K, Meltzer SJ, Armstrong D, Ganz R, Cengia G, Going JJ, Goldblum J, Gordon C, Grabsch H, Haigh C, Hongo M, Johnston D, Forbes-Young R, Kay E, Kaye P, Lerut T, Lovat LB, Lundell L, Mairs P, Shimoda T, Spechler S, Sontag S, Malfertheiner P, Murray I, Nanji M, Poller D, Ragunath K, Regula J, Cestari R, Shepherd N, Singh R, Stein HJ, Talley NJ, Galmiche JP, Tham TC, Watson P, Yerian L, Rugge M, Rice TW, Hart J, Gittens S, Hewin D, Hochberger J, Kahrilas P, Preston S, Sampliner R, Sharma P, Stuart R, Wang K, Waxman I, Abley C, Loft D, Penman I, Shaheen NJ, Chak A, Davies G, Dunn L, Falck-Ytter Y, Decaestecker J, Bhandari P, Ell C, Griffin SM, Attwood S, Barr H, Allen J, Ferguson MK, Moayyedi P, Jankowski JA (2012) Consensus statements for management of Barrett's dysplasia and early-stage esophageal adenocarcinoma, based on a Delphi process. Gastroenterology 143:336-346
31. Cai Z, Sanchez A, Shi Z, Zhang T, Liu M, Zhang D (2011) Activation of Toll-like receptor 5 on breast cancer cells by flagellin suppresses cell proliferation and tumor growth. Cancer Res 71:2466-2475
32. Rhee SH, Im E, Pothoulakis C (2008) Toll-like receptor 5 engagement modulates tumor development and growth in a mouse xenograft model of human colon cancer. Gastroenterology 135:518-528
33. Song EJ, Kang MJ, Kim YS, Kim SM, Lee SE, Kim CH, Kim DJ, Park JH (2011) Flagellin promotes the proliferation of gastric cancer cells via the Toll-like receptor 5. Int J Mol Med 28:115-119
34. Yu L, Wang L, Chen S (2012) Exogenous or endogenous Toll-like receptor ligands: which is the MVP in tumorigenesis? Cell Mol Life Sci 69:935-949