Low-grade dysplasia in barrett's esophagus: Overdiagnosed and underestimated

American Journal of Gastroenterology

Volumn 105, Issue 7, 2010, Pages 1523-1530

  Curvers, Wouter L ^a,h   Ten Kate, Fiebo J ^a,f,h   Krishnadath, Kausilia K ^a,h   Visser, Mike ^a,f   Elzer, Brenda ^a   Baak, Lubertus C ^b,h   Bohmer, Clarisse ^c,h   Mallant Hent, Rosalie C ^b,h   Van Oijen, Arnout ^d,h   Naber, Anton H ^b,h   Scholten, Pieter ^e,h   Busch, Olivier R ^a,f   Blaauwgeers, Harriët G T ^f   Meijer, Gerrit A ^f,g   Bergman, Jacques J G H M ^a,f,h  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b Onze Lieve Vrouwe Gasthuis ^*  (Netherlands)

^c Afdeling Verloskunde en Gynaecologie   (Netherlands)

^d Medisch Centrum Alkmaar   (Netherlands)

^e ONZE LIEVE VROUWE GASTHUIS   (Netherlands)

^f Integraal Kankercentrum Amsterdam   (Netherlands)

^g VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^h Amsterdam Gastroenterological Association   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; BARRETT ESOPHAGUS; CLINICAL TRIAL; COHORT ANALYSIS; CONSENSUS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DYSPLASIA; ENDOSCOPIC SURGERY; ENDOSCOPY; FEMALE; FOLLOW UP; HIGH GRADE DYSPLASIA; HISTOPATHOLOGY; HUMAN; INDEFINITE FOR DYSPLASIA; LOW GRADE DYSPLASIA; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OUTCOME ASSESSMENT; PATHOLOGIST; PRIORITY JOURNAL; PROSPECTIVE STUDY; RADIOFREQUENCY ABLATION; REVIEW;

BARRETT ESOPHAGUS; DISEASE PROGRESSION; ESOPHAGEAL NEOPLASMS; ESOPHAGOSCOPY; FEMALE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; NETHERLANDS; POPULATION SURVEILLANCE; PRECANCEROUS CONDITIONS; PROSPECTIVE STUDIES; REGISTRIES; RETROSPECTIVE STUDIES; RISK ASSESSMENT;

EID: 77954424898     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1038/ajg.2010.171     Document Type: Review

References (47)

1. Shaheen N J, Crosby M A, Bozym sk i E M et al.Is there publication bias in the reporting of cancer risk in Barrett's esophagus? Gastroenterology 2000;119:333-338
2. Gillison E W, Powell J, McConkey C C et al. Surgical workload and outcome af er res ection for carcinoma of the o esophagus and cardia. Br J Surg 2002; 89:344-348
3. Liu JF, Wang Q Z, Hou J. Su rgical tre atm en t fo r can cer o f th e o eso p h agu s and gastric cardia in Hebei, China. Br J Surg 2004; 91:90-98
4. Hameeteman W, Tytgat G N, Houth of H J et al. Barrett's esophagus:development of dysplasia and adenocarcinoma. Gastroenterology 1989; 96:1249-1256
5. Haggitt RC. Pathology of Barrett's esophagus. J Gastrointest Surg 2000;4:117-118
6. Hornick JL, Odze RD. Neoplastic precursor lesions in Barrett's esophagus. Gastroenterol Clin North Am 2007;36:775-96, v.
7. Koppert L B, Wijnhoven B P, van D H et al. The molecular biology of esophageal adenocarcinoma. J Surg Oncol 2005;92:169-190
8. Schlemper R J, Riddell R H, Kato Y et al. TeVienna classif cation of gastrointestinal epithelial neoplasia. Gut 2000; 47:251-255
9. Wang KK, Sampliner RE. Updated guidelines 2008 for the diagnosis, surveillance and therapy of Barrett's esophagus. Am J Gastroenterol 2008;103:788-797
10. Hirota WK, Zuckerman MJ, Adler DG et al. ASGE guideline: The role of endoscopy in the surveillance of premalignant conditions of the upper GI tract. Gastrointest Endosc 2006;63:570-580
11. Schnell T G, Sontag SJ, Chejfec G et al.Long-term n o n su rgical m an age-ment of Barrett's esophagus with high-grade dysplasia. Gastroenterology 2001;120:1607-1619
12. Conio M, Blanchi S, Lapertosa G et al. Long-term endoscopic surveillance of patients with Barrett's esophagus. Incidence of dysplasia and adenocarcinoma: A prospective study. Am J Gastroenterol 2003; 98:1931-1939
13. Sharma P, Falk G W, West o n A P et al. Dysplasia and cancerinalarge multicenter cohort of patients with Barrett's esophagus. Clin Gastroenterol Hepatol 2006;4:566-572
14. Montgomery E, Goldblum JR, Greenson JK et al.Dysplasiaasapredic-tive marker for invasive carcinoma in Barrett esophagus: A follow-up study based on 138 cases from a diagnostic variability study. Hum Pathol 2001;32:379-388
15. Skacel M, Petras R E, Gramlich T L et al. The diagnosis of low-grade dysplasia in Barrett's esophagus and its implications for disease progression. Am J Gastroenterol 2000;95:3383-3387
16. Sharma P. Low-grade dysplasia in Barrett's esophagus. Gastroenterology 2004;127:1233-1238
17. Alikhan M, Rex D, Khan A et al. Variable pathologic interpretation of columnar lined esophagus by general pathologists in community practice. Gastrointest Endosc 1999;50:23-26 (Pubitemid 29323284)
18. Montgomery E, Bronner MP, Goldblum JR et al. Reproducibility of the diagnosis of dysplasia in Barrett esophagus: A reafrmation. Hum Pathol 2001;32:368-378
19. Vieth M. Low-gradedysplasia in Barrett's esophagus\-an innocent bystander? Contra. Endoscopy 2007;39:647-649
20. Casparie M, Tiebosch A T, Burger G et al. Pathology databanking and biobanking in TeNetherlands, a central role for PALGA, the nationwide histopathology and cytopathology data network and archive. Cell Oncol 2007;29:19-24.
21. Kerkhof M, van D H, Steyerberg E W et al. Grading of dysplasia in Barrett's oesophagus:substantial interobserver variation between general and gastrointestinal pathologists. Histopathology 2007;50:920-927
22. Oferhaus G J, ten Kate F J, Baak J P et al. Comprehensive Cancer Centre Amsterdam Barrett Advisory Committee:frst results. Neth J Med 2001;58:3-8.
23. Reid B J, Haggitt R C, Rubin C E et al. Observer variation in the diagnosis of dysplasia in Barrett's esophagus. Hum Pathol 1988; 19:166-178
24. Peters F P, Brakenhof K P, Curvers W L et al. Histologic evaluation of resection specimens obtained at 293 endoscopic resections in Barrett's esophagus. Gastrointest Endosc 2008; 67:604-609
25. van Sandick JW, van Lanschot JB, van Felius L et al. Intestinalmet aplasia of the esophagus or esophagogastric junction:evidence of distinct clinical, pathologic, and histochemical staining features. Am J Clin Pathol 2002;117:117-125
26. Polkowski W, Meijer G A, Baak JP et al. Reproducibility of p53 and Ki-67 immunoquantitation in Barrett's esophagus. Anal Quant Cytol Histol 1997;19:246-254
27. Polkowski W, Baak JP, van Lanschot JJ et al.Clinical decision making in Barrett's oesophagus can be supported by computerized immunoquan-titation and morphometry of features associated with proliferation and diferentiation. J Pathol 1998;184:161-168
28. Baak JP, ten Kate F J, Oferhaus G J et al. Routine morphometrical analysis can improve reproducibility of dysplasia grade in Barrett's oesophagus surveillance biopsies. J Clin Pathol 2002; 55:910-916
29. Kaplan E, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457-481
30. Mantel N. Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 1966;50:163-170
31. Gondrie JJ, Pouw R E, Sonderm eijer C M et al. E f ective treatment of early Barrett's neoplasia with stepwise circumferential and focal ablation using the HALO system. Endoscopy 2008;40:370-379
32. Gondrie JJ, Pouw R E, Sonderm eijer C M et al. Stepwise circumferential and focal ablation of Barrett's esophagus with high-grade dysplasia:results of the f rst prospective ser ies of 11 patients. Endoscopy 2008; 40:359-369
33. O 'Connor JB, Falk G W, Richter JE. The incidence of adenocarcinoma and dysplasia in Barrett's esophagus:report on the Cleveland Clinic Barrett's Esophagus Registry. Am J Gastroenterol 1999;94:2037-2042
34. Reid B J, Levine D S, Longton G et al. Predictors of progression to cancer in Barrett's esophagus:baseline histology and f ow cytometry identify low-and high-risk patient subsets. Am J Gastroenterol 2000;95:1669-1676
35. Weston A P, Banerjee SK, Sharma P et al. p53 protein overexpression in low grade dysplasia (LGD) in Barrett's esophagus:immunohistochemical marker predictive of progression. Am J Gastroenterol 2001;96:1355-1362
36. Dulai G S, Shekelle P G, Jensen D M et al. Dysplasia and risk of further neoplastic progression in a regional Veterans Administration Barrett's cohort. Am J Gastroenterol 2005;100:775-783
37. Vieth M, Schuber t B, Lang -Schwarz K et al. Frequency of Barrett's neoplasia af er initial negative endoscopy with biopsy: A long-term histopathological follow-up study. Endoscopy 2006;38:1201-1205
38. Srivastava A, Hornick JL, Li X et al. Extent of low-grade dysplasia is a risk factor for the development of esophageal adenocarcinoma in Barrett's esophagus. Am J Gastroenterol 2007; 102:483-493
39. Lim C H, Treanor D, Dixon M F et al. Low-grade dysplasia in Barrett's esophagus has a high risk of progression. Endoscopy 2007;39:581-587
40. Vieth M, Stolte M. Barrett's esophagus and neoplasia:data from the Bayreuth Barrett's archive. Gastroenterology 2002; 122:590-591
41. Pech O, Vieth M, Schmitz D et al. Conclusions from the histological diag- nosis of low-grade intraepithelial neoplasia in Barrett's oesophagus. Scand J Gastroenterol 2007;42:682-688
42. Ofman JJ, Lew in K, Ramers C et al. The economic impact of the diagnosis of dysplasia in Barrett's esophagus. Am J Gastroenterol 2000; 95:2946-2952
43. Provenzale D, Schmitt C, Wong JB. Barrett's esophagus: A new look at sur- veillance based on emerging estimates of cancer risk. Am J Gastroenterol 1999;94:2043-2053
44. Inadomi JM, Sampliner R, Lagergren J et al. Screening and surveillance for Barrett esophagus in high-risk groups: A cost-utility analysis. Ann Intern Med 2003;138:176-186
45. Shaheen N J, Green B, Medapalli R K et al. The perception of cancer risk in patients with prevalent Barrett's esophagus enrolled in an endoscopic surveillance program. Gastroenterology 2005;129:429-436
46. Shaheen N J, Wolfsen H C, Hawes R H et al. Impact of Barrett's esophagus containing dysplasia on patient quality of life:interim results of a randomized, sham-controlled trial of Radiofrequency ablation (AIM dysplasia trial). Gastroenterology 2008;134:A323.
47. Curvers W L, Bansal A, Sharma P et al. Endoscopic work-up of early Barrett's neoplasia. Endoscopy 2008;40:1000-1007