2-ethylpyridine, a cigarette smoke component, causes mitochondrial damage in human retinal pigment epithelial cells in vitro

Indian Journal of Ophthalmology

Volumn 62, Issue 1, 2014, Pages 16-22

  Mansoor, S ^a,b   Gupta, N ^a,c   Falatoonzadeh, P ^a,d   Kuppermann, B D ^a   Kenney, M C ^a,e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Georgia Institute of Technology   (United States)

^c Lotus Eye Care Hospital   (India)

^d DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

2 ethylpyridine; apoptosis; ARPE 19 cells; cigarette smoke toxicant; mitochondrial membrane potential; reactive oxygen nitrogen species

Indexed keywords

2 ETHYLPYRIDINE; 2-ETHYLPYRIDINE; PYRIDINE DERIVATIVE;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL SURVIVAL; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; HUMAN; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; OXIDATIVE STRESS; PASSIVE SMOKING; PATHOLOGY; PIGMENT EPITHELIUM; RETINA MACULA DEGENERATION;

APOPTOSIS; CELL SURVIVAL; CELLS, CULTURED; HUMANS; MACULAR DEGENERATION; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; OXIDATIVE STRESS; PYRIDINES; RETINAL PIGMENT EPITHELIUM; TOBACCO SMOKE POLLUTION;

EID: 84893619056     PISSN: 03014738     EISSN: 19983689     Source Type: Journal    
DOI: 10.4103/0301-4738.126168     Document Type: Article

References (54)

1. Hawkins BS, Bird A, Klein R, West SK. Epidemiology of age-related macular degeneration. Mol Vis 1999;5:26.
2. Friedman DS, O'Colmain BJ, Muñoz B, Tomany SC, McCarty C, de Jong PT, et al. Prevalence of age-related macular degeneration in the United States. Arch Ophthalmol 2004;122:564-72.
3. Uka J, Tamura H, Kobayashi T, Yamane K, Kawakami H, Minamoto A, et al. No association of complement factor H gene polymorphism and age-related macular degeneration in the Japanese population. Retina 2006;26:985-7.
4. Tezel TH, Bora NS, Kaplan HJ. Pathogenesis of age-related macular degeneration. Trends Mol Med 2004;10:417-20.
5. Cai J, Nelson KC, Wu M, Sternberg P Jr, Jones DP. Oxidative damage and protection of the RPE. Prog Retin Eye Res 2000;19:205-21.
6. Klein R, Klein BE, Linton KL, DeMets DL. The Beaver Dam Eye Study: The relation of age-related maculopathy to smoking. Am J Epidemiol 1993;137:190-200.
7. Schmidt S, Hauser MA, Scott WK, Postel EA, Agarwal A, Gallins P, et al. Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration. Am J Hum Genet 2006;78:852-64.
8. Klein R, Knudtson MD, Cruickshanks KJ, Klein BE. Further observations on the association between smoking and the long-term incidence and progression of age-related macular degeneration: The Beaver Dam Eye Study. Arch Ophthalmol 2008;126:115-21.
9. Ishibashi T, Patterson R, Ohnishi Y, Inomata H, Ryan SJ. Formation of drusen in the human eye. Am J Ophthalmol 1986;101:342-53.
10. Young RW. Pathophysiology of age-related macular degeneration. Surv Ophthalmol 1987;31:291-306.
11. Dunaief JL, Dentchev T, Ying GS, Milam AH. The role of apoptosis in age-related macular degeneration. Arch Ophthalmol 2002;120:1435-42.
12. Yu AL, Birke K, Burger J, Welge-Lussen U. Biological effects of cigarette smoke in cultured human retinal pigment epithelial cells. PLoS One 2012;7:e48501.
13. Melkonian G, Eckelhoefer H, Wu M, Wang Y, Tong C, Riveles K, et al. Growth and angiogenesis are inhibited in vivo in developing tissues by pyrazine and its derivatives. Toxicol Sci 2003;75:393-401.
14. Ji L, Melkonian G, Riveles K, Talbot P. Identification of pyridine compounds in cigarette smoke solution that inhibit growth of the chick chorioallantoic membrane. Toxicol Sci 2002;69:217-25.
15. Hove EL, Hardin JO. Effect of vitamins E, B12 and folacin on CCL4 toxicity and protein utilization in rats. Proc Soc Exp Biol Med 1951;77:502-5.
16. Hove EL. The relation of pyridine toxicity in rats to dietary vitamin E. J Nutr 1953;50:361-71.
17. Wu SC, Liu M. In vitro assessment of reproductive toxicity of cigarette smoke and deleterious consequences of maternal exposure to its constituents. Biol Res 2012;45:101-9.
18. Dam H. Relationship of vitamin E deficiency to tissue peroxides. Ann N Y Acad Sci 1949;52:195-210.
19. Riveles K, Iv M, Arey J, Talbot P. Pyridines in cigarette smoke inhibit hamster oviductal functioning in picomolar doses. Reprod Toxicol 2003;17:191-202.
20. Yu R, Wu M, Lin S, Talbot P. Cigarette smoke toxicants alter growth and survival of cultured mammalian cells. Toxicol Sci 2006;93:82-95.
21. Dunn KC, Marmorstein AD, Bonilha VL, Rodriguez-Boulan E, Giordano F, Hjelmeland LM. Use of the ARPE-19 cell line as a model of RPE polarity: Basolateral secretion of FGF5. Invest Ophthalmol Vis Sci 1998;39:2744-9.
22. Dunn KC, Aotaki-Keen AE, Putkey FR, Hjelmeland LM. ARPE-19, a human retinal pigment epithelial cell line with differentiated properties. Exp Eye Res 1996;62:155-69.
23. Sharma A, Patil JA, Gramajo AL, Seigel GM, Kuppermann BD, Kenney CM. Effects of hydroquinone on retinal and vascular cells in vitro. Indian J Ophthalmol 2012;60:189-93.
24. Pesonen M, Pasanen M, Loikkanen J, Naukkarinen A, Hemmilä M, Seulanto H, et al. Chloropicrin induces endoplasmic reticulum stress in human retinal pigment epithelial cells. Toxicol Lett 2012;211:239-45.
25. Sharma A, Neekhra A, Gramajo AL, Patil J, Chwa M, Kuppermann BD, et al. Effects of Benzo (e) Pyrene, a toxic component of cigarette smoke, on human retinal pigment epithelial cells in vitro. Invest Ophthalmol Vis Sci 2008;49:5111-7.
26. Narayanan R, Kenney MC, Kamjoo S, Trinh TH, Seigel GM, Resende GP, et al. Trypan blue: Effect on retinal pigment epithelial and neurosensory retinal cells. Invest Ophthalmol Vis Sci 2005;46:304-9.
27. Chwa M, Atilano SR, Reddy V, Jordan N, Kim DW, Kenney MC. Increased stress-induced generation of reactive oxygen species and apoptosis in human keratoconus fibroblasts. Invest Ophthalmol Vis Sci 2006;47:1902-10.
28. Chen CS, Gee KR. Redox-dependent trafficking of 2, 3, 4, 5, 6-pentafluorodihydrotetramethylrosamine, a novel fluorogenic indicator of cellular oxidative activity. Free Radic Biol Med 2000;28:1266-78.
29. Métivier D, Dallaporta B, Zamzami N, Larochette N, Susin SA, Marzo I, et al. Cytofluorometric detection of mitochondrial alterations in early CD95/Fas/APO-1-triggered apoptosis of Jurkat T lymphoma cells. Comparison of seven mitochondrion-specific fluorochromes. Immunol Lett 1998;61:157-63.
30. Rottenberg H, Wu S. Quantitative assay by flow cytometry of the mitochondrial membrane potential in intact cells. Biochim Biophys Acta 1998;1404:393-404.
31. Rao P, Suzuki R, Mizobuchi S, Yamaguchi T, Sasaguri S. Bilirubin exhibits a novel anti-cancer effect on human adenocarcinoma. Biochem Biophys Res Commun 2006;342:1279-83.
32. Kulshreshtha NP, Moldoveanu SC. Analysis of pyridines in mainstream cigarette smoke. J Chromatogr A 2003;985:303-12.
33. Dempsey DA, Benowitz NL. Risks and benefits of nicotine to aid smoking cessation in pregnancy. Drug Saf 2001;24:277-322.
34. Chakravarthy U, Augood C, Bentham GC, de Jong PT, Rahu M, Seland J, et al. Cigarette smoking and age-related macular degeneration in the EUREYE Study. Ophthalmology 2007;114:1157-63.
35. Vinding T, Appleyard M, Nyboe J, Jensen G. Risk factor analysis for atrophic and exudative age-related macular degeneration. An epidemiological study of 1000 aged individuals. Acta Ophthalmol (Copenh) 1992;70:66-72.
36. Vingerling JR, Hofman A, Grobbee DE, de Jong PT. Age-related macular degeneration and smoking. The Rotterdam Study. Arch Ophthalmol 1996;114:1193-6.
37. Smith W, Mitchell P, Leeder SR. Smoking and age-related maculopathy. The Blue Mountains Eye Study. Arch Ophthalmol 1996;114:1518-23.
38. Seddon JM, Willett WC, Speizer FE, Hankinson SE. A prospective study of cigarette smoking and age-related macular degeneration in women. JAMA 1996;276:1141-6.
39. Christen WG, Glynn RJ, Manson JE, Ajani UA, Buring JE. A prospective study of cigarette smoking and risk of age-related macular degeneration in men. JAMA 1996;276:1147-51.
40. Patil AJ, Gramajo AL, Sharma A, Chwa M, Seigel GM, Kuppermann BD, et al. Effects of benzo (e) pyrene on the retinal neurosensory cells and human microvascular endothelial cells in vitro. Curr Eye Res 2009;34:672-82.
41. Bertram KM, Baglole CJ, Phipps RP, Libby RT. Molecular regulation of cigarette smoke induced-oxidative stress in human retinal pigment epithelial cells: Implications for age-related macular degeneration. Am J Physiol Cell Physiol 2009;297:C1200-10.
42. Richter C. Oxidative stress, mitochondria, and apoptosis. Restor Neurol Neurosci 1998;12:59-62.
43. Jia L, Liu Z, Sun L, Miller SS, Ames BN, Cotman CW, et al. Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: Protection by (R)-alpha-lipoic acid. Invest Ophthalmol Vis Sci 2007;48:339-48.
44. Mansoor S, Gupta N, Luczy-Bachman G, Limb GA, Kuppermann BD, Kenney MC. Protective effects of memantine and epicatechin on catechol-induced toxicity on Müller cells in vitro. Toxicology 2010;271:107-14.
45. Pons M, Marin-Castaño ME. Cigarette smoke-related hydroquinone dysregulates MCP-1, VEGF and PEDF expression in retinal pigment epithelium in vitro and in vivo. PLoS One 2011;6:e16722.
46. Tritschler HJ, Packer L, Medori R. Oxidative stress and mitochondrial dysfunction in neurodegeneration. Biochem Mol Biol Int 1994;34:169-81.
47. Yakes FM, Van Houten B. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc Natl Acad Sci USA 1997;94:514-9.
48. Udar N, Atilano SR, Memarzadeh M, Boyer DS, Chwa M, Lu S, et al. Mitochondrial DNA haplogroups associated with age-related macular degeneration. Invest Ophthalmol Vis Sci 2009;50:2966-74.
49. Karunadharma PP, Nordgaard CL, Olsen TW, Ferrington DA. Mitochondrial DNA damage as a potential mechanism for age-related macular degeneration. Invest Ophthalmol Vis Sci 2010;51:5470-9.
50. Melov S, Coskun PE, Wallace DC. Mouse models of mitochondrial disease, oxidative stress, and senescence. Mutat Res 1999;434:233-42.
51. Delhalle S, Duvoix A, Schnekenburger M, Morceau F, Dicato M, Diederich M. An introduction to the molecular mechanisms of apoptosis. Ann N Y Acad Sci 2003;1010:1-8.
52. Kroemer G. Mitochondrial control of apoptosis: An introduction. Biochem Biophys Res Commun 2003;304:433-5.
53. Ozgen U, Savaan S, Buck S, Ravindranath Y. Comparison of DiOC (6)(3) uptake and annexin V labeling for quantification of apoptosis in leukemia cells and non-malignant T lymphocytes from children. Cytometry 2000;42:74-8.
54. Zoratti M, Szabò I. The mitochondrial permeability transition. Biochim Biophys Acta 1995;1241:139-76.