A large cohort study reveals the association of elevated peripheral blood lymphocyte-to-monocyte ratio with favorable prognosis in nasopharyngeal carcinoma

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Li, Jing ^a   Jiang, Rou ^a   Liu, Wen Sheng ^a   Liu, Qing ^a   Xu, Miao ^a   Feng, Qi Sheng ^a   Chen, Li Zhen ^a   Bei, Jin Xin ^a   Chen, Ming Yuan ^a   Zeng, Yi Xin ^a  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; COHORT STUDIES; FEMALE; HUMANS; LYMPHOCYTE COUNT; LYMPHOCYTES; MALE; MIDDLE AGED; MONOCYTES; MULTIVARIATE ANALYSIS; NASOPHARYNGEAL NEOPLASMS; PROGNOSIS; RETROSPECTIVE STUDIES;

EID: 84893558098     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0083069     Document Type: Article

References (53)

1. Wei WI, Sham JS (2005) Nasopharyngeal carcinoma. Lancet 365: 2041-2054. (Pubitemid 40812341)
2. Yu MC, Yuan JM (2002) Epidemiology of nasopharyngeal carcinoma. Semin Cancer Biol 12: 421-429. (Pubitemid 35370755)
3. Lee AW, Lau WH, Tung SY, Chua DT, Chappell R, et al. (2005) Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma: NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group. J Clin Oncol 23: 6966-6975.
4. McMillan DC (2009) Systemic inflammation, nutritional status and survival in patients with cancer. Curr Opin Clin Nutr Metab Care 12: 223-226.
5. Bruckner HW, Lavin PT, Plaxe SC, Storch JA, Livstone EM (1982) Absolute granulocyte, lymphocyte, and moncyte counts. Useful determinants of prognosis for patients with metastatic cancer of the stomach. JAMA 247: 1004-1006. (Pubitemid 12162304)
6. Sun D, Elson P, Liedtke M, Medeiros BC, Earl M, et al. (2012) Absolute lymphocyte count at day 28 independently predicts event-free and overall survival in adults with newly diagnosed acute lymphoblastic leukemia. Am J Hematol 87: 957-960.
7. Wilcox RA, Ristow K, Habermann TM, Inwards DJ, Micallef IN, et al. (2011) The absolute monocyte and lymphocyte prognostic score predicts survival and identifies high-risk patients in diffuse large-B-cell lymphoma. Leukemia 25: 1502-1509.
8. Chew V, Chen J, Lee D, Loh E, Lee J, et al. (2012) Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinoma. Gut 61: 427-438.
9. Koh YW, Kang HJ, Park C, Yoon DH, Kim S, et al. (2012) The ratio of the absolute lymphocyte count to the absolute monocyte count is associated with prognosis in Hodgkin's lymphoma: correlation with tumor-associated macrophages. Oncologist 17: 871-880.
10. Tibaldi C, Vasile E, Bernardini I, Orlandini C, Andreuccetti M, et al. (2008) Baseline elevated leukocyte count in peripheral blood is associated with poor survival in patients with advanced non-small cell lung cancer: a prognostic model. J Cancer Res Clin Oncol 134: 1143-1149.
11. Vijai J, Kirchhoff T, Schrader KA, Brown J, Dutra-Clarke AV, et al. (2013) Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies. PLoS Genet 9: e1003220.
12. Flavell KJ, Murray PG (2000) Hodgkin's disease and the Epstein-Barr virus. Mol Pathol 53: 262-269.
13. Cordes C, Tiemann M, Tiemann K, Knappe D, Hoffmann M, et al. (2011) Epstein-Barr virus-associated diffuse large B-cell lymphoma of the hypopharynx. B-ENT 7: 43-46.
14. Spratt DE, Lee N (2012) Current and emerging treatment options for nasopharyngeal carcinoma. Onco Targets Ther 5: 297-308.
15. Naranbhai V, Hill AV, Abdool KS, Naidoo K, Abdool KQ, et al. (2013) Ratio of Monocytes to Lymphocytes in Peripheral Blood Identifies Adults at Risk of Incident Tuberculosis Among HIV-Infected Adults Initiating Antiretroviral Therapy. J Infect Dis.
16. Katz MH (2011) Multivariable Analysis: A Practical Guide for Clinicians and Public Health Researchers (3rd editon).: Cambridge University Press. 95.
17. Shen GP, Xu FH, He F, Ruan HL, Cui C, et al. (2012) Pretreatment lifestyle behaviors as survival predictors for patients with nasopharyngeal carcinoma. PLoS One 7: e36515.
18. Tsai YD, Wang CP, Chen CY, Lin LW, Hwang TZ, et al. (2013) Pretreatment circulating monocyte count associated with poor prognosis in patients with oral cavity head and neck cancer. Head Neck.
19. Schmidt H, Bastholt L, Geertsen P, Christensen IJ, Larsen S, et al. (2005) Elevated neutrophil and monocyte counts in peripheral blood are associated with poor survival in patients with metastatic melanoma: a prognostic model. Br J Cancer 93: 273-278. (Pubitemid 43080028)
20. Wilcox RA, Ristow K, Habermann TM, Inwards DJ, Micallef IN, et al. (2012) The absolute monocyte count is associated with overall survival in patients newly diagnosed with follicular lymphoma. Leuk Lymphoma 53: 575-580.
21. Hussain SP, Aguilar F, Amstad P, Cerutti P (1994) Oxy-radical induced mutagenesis of hotspot codons 248 and 249 of the human p53 gene. Oncogene 9: 2277-2281. (Pubitemid 24228678)
22. Nakamura Y, Gindhart TD, Winterstein D, Tomita I, Seed JL, et al. (1988) Early superoxide dismutase-sensitive event promotes neoplastic transformation in mouse epidermal JB6 cells. Carcinogenesis 9: 203-207. (Pubitemid 18037980)
23. Salim AS (1993) The permissive role of oxygen-derived free radicals in the development of colonic cancer in the rat. A new theory for carcinogenesis. Int J Cancer 53: 1031-1035.
24. Licitra L, Bernier J, Cvitkovic E, Grandi C, Spinazze S, et al. (2003) Cancer of the nasopharynx. Crit Rev Oncol Hematol 45: 199-213.
25. Porrata LF, Inwards DJ, Ansell SM, Micallef IN, Johnston PB, et al. (2013) Day 100 Peripheral Blood Absolute Lymphocyte/Monocyte Ratio and Survival in Classical Hodgkin's Lymphoma Postautologous Peripheral Blood Hematopoietic Stem Cell Transplantation. Bone Marrow Res 2013: 658371.
26. Li ZM, Huang JJ, Xia Y, Sun J, Huang Y, et al. (2012) Blood lymphocyte-to-monocyte ratio identifies high-risk patients in diffuse large B-cell lymphoma treated with R-CHOP. PLoS One 7: e41658.
27. Porrata LF, Ristow K, Colgan JP, Habermann TM, Witzig TE, et al. (2012) Peripheral blood lymphocyte/monocyte ratio at diagnosis and survival in classical Hodgkin's lymphoma. Haematologica 97: 262-269.
28. Tse KP, Su WH, Chang KP, Tsang NM, Yu CJ, et al. (2009) Genome-wide association study reveals multiple nasopharyngeal carcinoma-associated loci within the HLA region at chromosome 6p21.3. Am J Hum Genet 85: 194-203.
29. Bei JX, Li Y, Jia WH, Feng BJ, Zhou G, et al. (2010) A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci. Nat Genet 42: 599-603.
30. Bishara S, Griffin M, Cargill A, Bali A, Gore ME, et al. (2008) Pre-treatment white blood cell subtypes as prognostic indicators in ovarian cancer. Eur J Obstet Gynecol Reprod Biol 138: 71-75. (Pubitemid 351608106)
31. Noh H, Eomm M, Han A (2013) Usefulness of pretreatment neutrophil to lymphocyte ratio in predicting disease-specific survival in breast cancer patients. J Breast Cancer 16: 55-59.
32. He JR, Shen GP, Ren ZF, Qin H, Cui C, et al. (2012) Pretreatment levels of peripheral neutrophils and lymphocytes as independent prognostic factors in patients with nasopharyngeal carcinoma. Head Neck 34: 1769-1776.
33. Saroha S, Uzzo RG, Plimack ER, Ruth K, Al-Saleem T (2013) Lymphopenia is an independent predictor of inferior outcome in clear cell renal carcinoma. J Urol 189: 454-461.
34. Fogar P, Sperti C, Basso D, Sanzari MC, Greco E, et al. (2006) Decreased total lymphocyte counts in pancreatic cancer: an index of adverse outcome. Pancreas 32: 22-28. (Pubitemid 41803643)
35. Sarraf KM, Belcher E, Raevsky E, Nicholson AG, Goldstraw P, et al. (2009) Neutrophil/lymphocyte ratio and its association with survival after complete resection in non-small cell lung cancer. J Thorac Cardiovasc Surg 137: 425-428.
36. Rabinowich H, Cohen R, Bruderman I, Steiner Z, Klajman A (1987) Functional analysis of mononuclear cells infiltrating into tumors: lysis of autologous human tumor cells by cultured infiltrating lymphocytes. Cancer Res 47: 173-177. (Pubitemid 17002118)
37. Dworacki G, Meidenbauer N, Kuss I, Hoffmann TK, Gooding W, et al. (2001) Decreased zeta chain expression and apoptosis in CD3+ peripheral blood T lymphocytes of patients with melanoma. Clin Cancer Res 7: 947s-957s. (Pubitemid 33600950)
38. Youn JI, Collazo M, Shalova IN, Biswas SK, Gabrilovich DI (2012) Characterization of the nature of granulocytic myeloid-derived suppressor cells in tumor-bearing mice. J Leukoc Biol 91: 167-181.
39. Apetoh L, Ghiringhelli F, Tesniere A, Obeid M, Ortiz C, et al. (2007) Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med 13: 1050-1059. (Pubitemid 47517504)
40. Kryczek I, Banerjee M, Cheng P, Vatan L, Szeliga W, et al. (2009) Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments. Blood 114: 1141-1149.
41. Stojanovic I, Cvjeticanin T, Lazaroski S, Stosic-Grujicic S, Miljkovic D (2009) Macrophage migration inhibitory factor stimulates interleukin-17 expression and production in lymph node cells. Immunology 126: 74-83.
42. Li J, Mo HY, Xiong G, Zhang L, He J, et al. (2012) Tumor microenvironment macrophage inhibitory factor directs the accumulation of interleukin-17- producing tumor-infiltrating lymphocytes and predicts favorable survival in nasopharyngeal carcinoma patients. J Biol Chem 287: 35484-35495.
43. Lenz G, Wright G, Dave SS, Xiao W, Powell J, et al. (2008) Stromal gene signatures in large-B-cell lymphomas. N Engl J Med 359: 2313-2323.
44. Huang JJ, Li YJ, Xia Y, Wang Y, Wei WX, et al. (2013) Prognostic significance of peripheral monocyte count in patients with extranodal natural killer/T-cell lymphoma. BMC Cancer 13: 222.
45. Hase S, Weinitschke K, Fischer K, Fornara P, Hoda R, et al. (2011) Monitoring peri-operative immune suppression in renal cancer patients. Oncol Rep 25: 1455-1464.
46. Torisu-Itakura H, Lee JH, Huynh Y, Ye X, Essner R, et al. (2007) Monocyte-derived IL-10 expression predicts prognosis of stage IV melanoma patients. J Immunother 30: 831-838. (Pubitemid 350295362)
47. Anand M, Chodda SK, Parikh PM, Nadkarni JS (1998) Abnormal levels of proinflammatory cytokines in serum and monocyte cultures from patients with chronic myeloid leukemia in different stages, and their role in prognosis. Hematol Oncol 16: 143-154.
48. Pollard JW (2004) Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer 4: 71-78.
49. Hefler L, Tempfer C, Heinze G, Mayerhofer K, Breitenecker G, et al. (1999) Monocyte chemoattractant protein-1 serum levels in ovarian cancer patients. Br J Cancer 81: 855-859. (Pubitemid 29504697)
50. Laughter AH, Twomey JJ (1977) Suppression of lymphoproliferation by high concentrations of normal human mononuclear leukocytes. J Immunol 119: 173-179. (Pubitemid 8141134)
51. Goodwin JS, Bankhurst AD, Messner RP (1977) Suppression of human T-cell mitogenesis by prostaglandin. Existence of a prostaglandin-producing suppressor cell. J Exp Med 146: 1719-1734. (Pubitemid 8245453)
52. Goodwin JS, Messner RP, Bankhurst AD, Peake GT, Saiki JH, et al. (1977) Prostaglandin-producing suppressor cells in Hodgkin's disease. N Engl J Med 297: 963-968. (Pubitemid 8218825)
53. Han T, Takita H (1980) Indomethacin-mediated enhancement of lymphocyte response to mitogens in healthy subjects and lung cancer patients. Cancer 46: 2416-2420. (Pubitemid 11253701)