-
1
-
-
84879129926
-
Leucine-Rich Repeat Kinase 2 (LRRK2)-Deficient Rats Exhibit Renal Tubule Injury and Perturbations in Metabolic and Immunological Homeostasis
-
doi:10.1371/journal.pone.0066164. PubMed: 23799078. PONE-D-13-08292 . PII
-
Ness D, Ren Z, Gardai S, Sharpnack D, Johnson VJ et al. (2013) Leucine-Rich Repeat Kinase 2 (LRRK2)-Deficient Rats Exhibit Renal Tubule Injury and Perturbations in Metabolic and Immunological Homeostasis. PLOS ONE 8: e66164. doi:10.1371/journal.pone.0066164. PubMed: 23799078. PONE-D-13-08292 . PII.
-
(2013)
PLOS ONE
, vol.8
-
-
Ness, D.1
Ren, Z.2
Gardai, S.3
Sharpnack, D.4
Johnson, V.J.5
-
2
-
-
66949152096
-
Parkinson's disease
-
doi:10.1016/S0140-6736(09)60492-X. PubMed: 19524782
-
Lees AJ, Hardy J, Revesz T (2009) Parkinson's disease. Lancet 373: 2055-2066. doi:10.1016/S0140-6736(09)60492-X. PubMed: 19524782.
-
(2009)
Lancet
, vol.373
, pp. 2055-2066
-
-
Lees, A.J.1
Hardy, J.2
Revesz, T.3
-
3
-
-
68649123354
-
Revelations and revolutions in the understanding of Parkinson's disease
-
doi:10.1016/j.bbadis.2009.06.001. PubMed: 19539178
-
Dawson TM, Moore DJ, West AB (2009) Revelations and revolutions in the understanding of Parkinson's disease. Biochim Biophys Acta 1792: 585-586. doi:10.1016/j.bbadis.2009.06.001. PubMed: 19539178.
-
(2009)
Biochim Biophys Acta
, vol.1792
, pp. 585-586
-
-
Dawson, T.M.1
Moore, D.J.2
West, A.B.3
-
4
-
-
32544432029
-
Non-motor symptoms of Parkinson's disease: Diagnosis and management
-
DOI 10.1016/S1474-4422(06)70373-8, PII S1474442206703738
-
Chaudhuri KR, Healy DG, Schapira AH (2006) Non-motor symptoms of Parkinson's disease: diagnosis and management. Lancet Neurol 5: 235-245. doi:10.1016/S1474-4422(06)70373-8. PubMed: 16488379. (Pubitemid 43238347)
-
(2006)
Lancet Neurology
, vol.5
, Issue.3
, pp. 235-245
-
-
Chaudhuri, K.R.1
Healy, D.G.2
Schapira, A.H.V.3
-
5
-
-
0030744876
-
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
-
DOI 10.1126/science.276.5321.2045
-
Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A et al. (1997) Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276: 2045-2047. doi:10.1126/science.276.5321.2045. PubMed: 9197268. (Pubitemid 27443610)
-
(1997)
Science
, vol.276
, Issue.5321
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
Lavedan, C.2
Leroy, E.3
Ide, S.E.4
Dehejia, A.5
Dutra, A.6
Pike, B.7
Root, H.8
Rubenstein, J.9
Boyer, R.10
Stenroos, E.S.11
Chandrasekharappa, S.12
Athanassiadou, A.13
Papapetropoulos, T.14
Johnson, W.G.15
Lazzarini, A.M.16
Duvoisin, R.C.17
Di, I.G.18
Golbe, L.I.19
Nussbaum, R.L.20
more..
-
6
-
-
0030768929
-
Genetics of Parkinson's disease
-
DOI 10.1093/hmg/6.10.1687
-
Nussbaum RL, Polymeropoulos MH (1997) Genetics of Parkinson's disease. Hum Mol Genet 6: 1687-1691. doi:10.1093/hmg/6.10.1687. PubMed: 9300660. (Pubitemid 27401611)
-
(1997)
Human Molecular Genetics
, vol.6
, Issue.10 REV. ISS.
, pp. 1687-1691
-
-
Nussbaum, R.L.1
Polymeropoulos, M.H.2
-
7
-
-
8844233579
-
Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology
-
DOI 10.1016/j.neuron.2004.11.005, PII S0896627304007202
-
Zimprich A, Biskup S, Leitner P, Lichtner P, Farrer M et al. (2004) Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron 44: 601-607. doi:10.1016/j.neuron.2004.11.005. PubMed: 15541309. (Pubitemid 39531225)
-
(2004)
Neuron
, vol.44
, Issue.4
, pp. 601-607
-
-
Zimprich, A.1
Biskup, S.2
Leitner, P.3
Lichtner, P.4
Farrer, M.5
Lincoln, S.6
Kachergus, J.7
Hulihan, M.8
Uitti, R.J.9
Calne, D.B.10
Stoessl, A.J.11
Pfeiffer, R.F.12
Patenge, N.13
Carbajal, I.C.14
Vieregge, P.15
Asmus, F.16
Muller-Myhsok, B.17
Dickson, D.W.18
Meitinger, T.19
Strom, T.M.20
Wszolek, Z.K.21
Gasser, T.22
more..
-
8
-
-
31344439221
-
LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews [14]
-
DOI 10.1056/NEJMc055509
-
Ozelius LJ, Senthil G, Saunders-Pullman R, Ohmann E, Deligtisch A et al. (2006) LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews. N Engl J Med 354: 424-425. doi:10.1056/NEJMc055509. PubMed: 16436782. (Pubitemid 43145083)
-
(2006)
New England Journal of Medicine
, vol.354
, Issue.4
, pp. 424-425
-
-
Ozelius, L.J.1
Senthil, G.2
Saunders-Pullman, R.3
Ohmann, E.4
Deligtisch, A.5
Tagliati, M.6
Hunt, A.L.7
Klein, C.8
Henick, B.9
Hailpern, S.M.10
Lipton, R.B.11
Soto-Valencia, J.12
Risch, N.13
Bressman, S.B.14
-
9
-
-
33847751421
-
Screening for Lrrk2 G2019S and clinical comparison of Tunisian and North American Caucasian Parkinson's disease families
-
DOI 10.1002/mds.21180
-
Ishihara L, Gibson RA, Warren L, Amouri R, Lyons K et al. (2007) Screening for Lrrk2 G2019S and clinical comparison of Tunisian and North American Caucasian Parkinson's disease families. Mov Disord 22: 55-61. doi:10.1002/mds.21180. PubMed: 17115391. (Pubitemid 46382673)
-
(2007)
Movement Disorders
, vol.22
, Issue.1
, pp. 55-61
-
-
Ishihara, L.1
Gibson, R.A.2
Warren, L.3
Amouri, R.4
Lyons, K.5
Wielinski, C.6
Hunter, C.7
Swartz, J.E.8
Elango, R.9
Akkari, P.A.10
Leppert, D.11
Surh, L.12
Reeves, K.H.13
Thomas, S.14
Ragone, L.15
Hattori, N.16
Pahwa, R.17
Jankovic, J.18
Nance, M.19
Freeman, A.20
Gouider-Khouja, N.21
Kefi, M.22
Zouari, M.23
Sassi, S.B.24
Yahmed, S.B.25
El E.-Fayeche, G.26
Middleton, L.27
Burn, D.J.28
Watts, R.L.29
Hentati, F.30
more..
-
10
-
-
48949092066
-
Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease
-
doi:10.1002/ana.21405. PubMed: 18412265
-
Ross OA, Wu YR, Lee MC, Funayama M, Chen ML et al. (2008) Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease. Ann Neurol 64: 88-92. doi:10.1002/ana.21405. PubMed: 18412265.
-
(2008)
Ann Neurol
, vol.64
, pp. 88-92
-
-
Ross, O.A.1
Wu, Y.R.2
Lee, M.C.3
Funayama, M.4
Chen, M.L.5
-
11
-
-
78649389313
-
The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease
-
doi:10.1038/nrn2935. PubMed: 21088684
-
Cookson MR (2010) The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease. Nat Rev Neurosci 11: 791-797. doi:10.1038/nrn2935. PubMed: 21088684.
-
(2010)
Nat Rev Neurosci
, vol.11
, pp. 791-797
-
-
Cookson, M.R.1
-
12
-
-
28044460070
-
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
-
DOI 10.1073/pnas.0507360102
-
West AB, Moore DJ, Biskup S, Bugayenko A, Smith WW et al. (2005) Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity. Proc Natl Acad Sci U S A 102: 16842-16847. doi:10.1073/pnas.0507360102. PubMed: 16269541. (Pubitemid 41688864)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.46
, pp. 16842-16847
-
-
West, A.B.1
Moore, D.J.2
Biskup, S.3
Bugayenko, A.4
Smith, W.W.5
Ross, C.A.6
Dawson, V.L.7
Dawson, T.M.8
-
13
-
-
84857285604
-
Is inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease?
-
1741-7015-10-20. PubMed: 22361010. PII; 10.1186/1741-7015-10-20 [doi]. PubMed: 22361010
-
Rudenko IN, Chia R, Cookson MR, Rudenko IN, Chia R, et al. (2012) Is inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease? BMC Med 10: 20: 1741-7015-10-20. PubMed: 22361010. PII];10.1186/1741-7015-10-20 [doi]. PubMed: 22361010.
-
(2012)
BMC Med
, vol.10
, pp. 20
-
-
Rudenko, I.N.1
Chia, R.2
Cookson, M.R.3
Rudenko, I.N.4
Chia, R.5
-
14
-
-
77953090478
-
Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice
-
doi: 10.1073/pnas.1004676107. PubMed: 20457918
-
Tong Y, Yamaguchi H, Giaime E, Boyle S, Kopan R et al. (2010) Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proc Natl Acad Sci U S A 107: 9879-9884. doi: 10.1073/pnas.1004676107. PubMed: 20457918.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 9879-9884
-
-
Tong, Y.1
Yamaguchi, H.2
Giaime, E.3
Boyle, S.4
Kopan, R.5
-
15
-
-
84863294414
-
Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway
-
doi: 10.1186/1750-1326-7-2. PubMed: 22230652
-
Tong Y, Giaime E, Yamaguchi H, Ichimura T, Liu Y et al. (2012) Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway. Mol Neurodegener 7: 2. doi: 10.1186/1750-1326-7-2. PubMed: 22230652.
-
(2012)
Mol Neurodegener
, vol.7
, pp. 2
-
-
Tong, Y.1
Giaime, E.2
Yamaguchi, H.3
Ichimura, T.4
Liu, Y.5
-
16
-
-
80053968304
-
LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice
-
Herzig MC, Kolly C, Persohn E, Theil D, Schweizer T et al. (2011) LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice. Hum: Mol Genet .
-
(2011)
Hum: Mol Genet
-
-
Herzig, M.C.1
Kolly, C.2
Persohn, E.3
Theil, D.4
Schweizer, T.5
-
17
-
-
84861552733
-
LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors
-
doi:10.1186/1750-1326-7-S1-L25. PubMed: 22647713
-
Hinkle KM, Yue M, Behrouz B, Dächsel JC, Lincoln SJ et al. (2012) LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors. Mol Neurodegener 7: 25. doi:10.1186/1750-1326-7-S1-L25. PubMed: 22647713.
-
(2012)
Mol Neurodegener
, vol.7
, pp. 25
-
-
Hinkle, K.M.1
Yue, M.2
Behrouz, B.3
Dächsel, J.C.4
Lincoln, S.J.5
-
19
-
-
0041303853
-
A fast histochemical staining method to identify hyaline droplets in the rat kidney
-
VX2XE18QTDXJ6MME . PII
-
de Rijk EP, Ravesloot WT, Wijnands Y, van EE (2003) A fast histochemical staining method to identify hyaline droplets in the rat kidney. Toxicol Pathol 31: 462-464. VX2XE18QTDXJ6MME . PII.
-
(2003)
Toxicol Pathol
, vol.31
, pp. 462-464
-
-
De Rijk, E.P.1
Ravesloot, W.T.2
Wijnands, Y.3
Van, E.E.4
-
20
-
-
33846471307
-
LAMP proteins are required for fusion of lysosomes with phagosomes
-
doi:10.1038/sj.emboj.7601511. PubMed: 17245426. 7601511 . PII;Retrieved onpublished at whilst December year 1111 from . doi:10.1038/sj.emboj.7601511
-
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P et al. (2007) LAMP proteins are required for fusion of lysosomes with phagosomes. EMBO J 26: 313-324. doi:10.1038/sj.emboj.7601511. PubMed: 17245426. 7601511 . PII;Retrieved onpublished at whilst December year 1111 from . doi:10.1038/sj.emboj.7601511
-
(2007)
EMBO J
, vol.26
, pp. 313-324
-
-
Huynh, K.K.1
Eskelinen, E.L.2
Scott, C.C.3
Malevanets, A.4
Saftig, P.5
-
21
-
-
0037341547
-
Measurement of tubular enzymuria facilitates early detection of acute renal impairment in the intensive care unit
-
DOI 10.1093/ndt/18.3.543
-
Westhuyzen J, Endre ZH, Reece G, Reith DM, Saltissi D et al. (2003) Measurement of tubular enzymuria facilitates early detection of acute renal impairment in the intensive care unit. Nephrol Dial Transplant 18: 543-551. doi:10.1093/ndt/18.3.543. PubMed: 12584277. (Pubitemid 36305660)
-
(2003)
Nephrology Dialysis Transplantation
, vol.18
, Issue.3
, pp. 543-551
-
-
Westhuyzen, J.1
Endre, Z.H.2
Reece, G.3
Reith, D.M.4
Saltissi, D.5
Morgan, T.J.6
-
22
-
-
70350453660
-
Differences in immunolocalization of Kim-1, RPA-1, and RPA-2 in kidneys of gentamicin-, cisplatin-, and valproic acid-treated rats: Potential role of iNOS and nitrotyrosine
-
doi:10.1177/0192623309339605. PubMed: 19535489. 0192623309339605 . PII;Retrieved onpublished at whilst December year 1111 from . doi:10.1177/0192623309339605
-
Zhang J, Goering PL, Espandiari P, Shaw M, Bonventre JV et al. (2009) Differences in immunolocalization of Kim-1, RPA-1, and RPA-2 in kidneys of gentamicin-, cisplatin-, and valproic acid-treated rats: potential role of iNOS and nitrotyrosine. Toxicol Pathol 37: 629-643. doi:10.1177/0192623309339605. PubMed: 19535489. 0192623309339605 . PII;Retrieved onpublished at whilst December year 1111 from . doi:10.1177/0192623309339605
-
(2009)
Toxicol Pathol
, vol.37
, pp. 629-643
-
-
Zhang, J.1
Goering, P.L.2
Espandiari, P.3
Shaw, M.4
Bonventre, J.V.5
-
23
-
-
84858017005
-
Effects of subthalamic nucleus lesions and stimulation upon corticostriatal afferents in the 6-hydroxydopamine-lesioned rat
-
doi:10.1371/journal.pone.0032919. PubMed: 22427909. PONE-D-11-23644 . PII
-
Walker RH, Moore C, Davies G, Dirling LB, Koch RJ et al. (2012) Effects of subthalamic nucleus lesions and stimulation upon corticostriatal afferents in the 6-hydroxydopamine-lesioned rat. PLOS ONE 7: e32919. doi:10.1371/journal. pone.0032919. PubMed: 22427909. PONE-D-11-23644 . PII.
-
(2012)
PLOS ONE
, vol.7
-
-
Walker, R.H.1
Moore, C.2
Davies, G.3
Dirling, L.B.4
Koch, R.J.5
-
24
-
-
1842563805
-
A contemporary overview of chronic progressive nephropathy in the laboratory rat, and its significance for human risk assessment
-
doi: 10.1080/01926230490422574. PubMed: 15200155. JQ0P52PF3Q195GCE . PII
-
Hard GC, Khan KN (2004) A contemporary overview of chronic progressive nephropathy in the laboratory rat, and its significance for human risk assessment. Toxicol Pathol 32: 171-180. doi: 10.1080/01926230490422574. PubMed: 15200155. JQ0P52PF3Q195GCE . PII.
-
(2004)
Toxicol Pathol
, vol.32
, pp. 171-180
-
-
Hard, G.C.1
Khan, K.N.2
-
26
-
-
0017618338
-
Aldose reductase and sorbitol dehydrogenase distribution in rat kidney
-
Corder CN, Collins JG, Brannan TS, Sharma J (1977) Aldose reductase and sorbitol dehydrogenase distribution in rat kidney. J Histochem Cytochem 25: 1-8. doi:10.1177/25.1.401844. PubMed: 401844. (Pubitemid 8034870)
-
(1977)
Journal of Histochemistry and Cytochemistry
, vol.25
, Issue.1
, pp. 1-8
-
-
Corder, C.N.1
Collins, J.G.2
Brannan, T.S.3
Sharma, J.4
-
27
-
-
84888181176
-
LRRK2 secretion in exosomes is regulated by 14-3-3
-
MedlinePgn: PubMed: 23886663. PII; 10.1093/hmg/ddt346 [doi]. PubMed: 23886663
-
Fraser KB, Moehle MS, Daher JP, Webber PJ, Williams JY et al. (2013) LRRK2 secretion in exosomes is regulated by 14-3-3. Hum Mol Genet DDT346: ([MedlinePgn:]) PubMed: 23886663. PII];10.1093/hmg/ddt346 [doi]. PubMed: 23886663.
-
(2013)
Hum Mol Genet DDT
, vol.346
-
-
Fraser, K.B.1
Moehle, M.S.2
Daher, J.P.3
Webber, P.J.4
Williams, J.Y.5
|