Integron mediated multidrug resistance in extended spectrum beta-lactamase producing clinical isolates of Klebsiella pneumoniae

Brazilian Journal of Microbiology

Volumn 44, Issue 3, 2013, Pages 849-854

  Mobarak Qamsari, Maryam ^a   Ashayeri Panah, Mitra ^a   Eftekhar, Freshteh ^a   Feizabadi, Mohammad Mehdi ^b  

^a SHAHID BEHESHTI UNIVERSITY   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Extended spectrum lactamase; Integron; Klebsiella pneumoniae; Multiple antibiotic resistance

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIAL DNA; BETA LACTAMASE;

DRUG EFFECTS; ENZYMOLOGY; GENETICS; HOSPITAL; HUMAN; INTEGRON; IRAN; ISOLATION AND PURIFICATION; KLEBSIELLA INFECTION; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MULTIDRUG RESISTANCE; POLYMERASE CHAIN REACTION; SECRETION (PROCESS);

ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; DNA, BACTERIAL; DRUG RESISTANCE, MULTIPLE, BACTERIAL; HOSPITALS; HUMANS; INTEGRONS; IRAN; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; POLYMERASE CHAIN REACTION;

EID: 84893526035     PISSN: 15178382     EISSN: 16784405     Source Type: Journal    
DOI: 10.1590/S1517-83822013000300028     Document Type: Article

References (24)

1. Bhattacharjee A, Sen MR, Prakash P, Gaur A, Anupurba S, Nath G (2010) Observation on integron carriage among clinical isolates of Klebsiella pneumoniae producing extended spectrum - lactamases. Ind J Med Microbiol 28:207-210.
2. Brisse S, Grimont F, Grimont PAD (2006) The genus Klebsiella. In: Dworkin M, Falkow, S., Rosenberg, E., Schleifer, K.H., Stackebrandt, E. (eds). The Prokaryotes: a handbook on the biology of bacteria. Berlin, Springer-Verlag, 6:159-196.
3. Cambray G, Guerout AM, Mazel D (2010) Integrons. Annu Rev Genet 44:141-166.
4. Clinical and Laboratory Standards Institute (2011). Performance Standards for Antimicrobial Susceptibility Testing; Twenty-First Informational Supplement. M100-S21, 30(1). Clinical and Laboratory Standards Institute, Wayne, PA.
5. Correia M, Boavida F, Grosso F, Salgado MJ, Lito LM (2003) Molecular characterization of a new class 3 integron in Klebsiella pneumoniae. Antimicrob Agents Chemother 47:2838-2843.
6. Drieux L, Brossier F, Sougakoff W, Jarlier V (2008) Phenotypic detection of extended-spectrum β- lactamase production in Enterobacteriaceae: review and bench guide. Clin Microbiol Infect 14:90-103.
7. El-Najjar NG, Farah MJ, Hashwa FA, Tokajian ST (2010) Antibiotic resistance patterns and sequencing of class I integron from uropathogenic Escherichia coli in Lebanon. Lett Appl Microbiol 51:456-461.
8. Fluit AC, Schmitz FJ (2004) Resistance integrons and super-integrons. Clin Microbiol Infect 10:272-288.
9. Goldstein C, Lee MD, Sanchez S, Hudson C, Phillips B, Register B, Grady M, Liebert C, Summers AO, White DG, Maurer JJ (2001) Incidence of class 1 and 2 integrases in clinical and commensal bacteria from livestock, companion animals, and exotics. Antimicrob Agents Chemother 45:723-726.
10. Hall RM, Collis CM (1995) Mobile gene cassettes and integrons: capture and spread of genes by site-specific recombination. Mol Microbiol 15:593-600.
11. Hall RM (1997) Mobile gene cassettes and integrons: moving antibiotic resistance genes in Gram-negative bacteria. CIBA Found Symp 207:192-205.
12. Jones LA, Mclver CJ, Rawlinson WD, White PA (2003) Polymerase chain reaction screening for integrons can be used to complement resistance surveillance programs. Commun Dis Intel 27:103-110.
13. Leverstein-van Hall MA, Paauw A, Box ATA, Blok HEM, Verhoef J, Fluit AC (2002) Presence of integron-associated resistance in the community is widespread and contributes to multidrug resistance in the hospital. J Clin Microbiol 40:3038-3040.
14. Levesque C, Piche L, Larose C, Roy pH (1995) PCR mapping of integrons reveals several novel combinations of resistance genes. Antimicrob Agents Chemother 39:185-191.
15. Machado E, Ferreira J, Novais A, Peixe L, Cantón R, Baquero F, Coque TM (2007) Preservation of integron types among Enterobacteriaceae producing extended-spectrum - lactamases in a Spanish hospital over a 15-year period (1988 to 2003). Antimicrob Agents Chemother 51:2201-2204.
16. Machado E, Cantón R, Baquero F, Galán JC, Rollán A, Peixe L, Coque TM (2005) Integron content of extended spectrum β- lactamase producing Escherichia coli strains over 12 years in a single hospital in Madrid, Spain. Antimicrob Agents Chemother 49:1823-1829.
17. Martinez-Freijo P, Fluit AC, Schmitz FJ, Grek VSC, Verhoef J, Jones ME (1998) Class I integrons in Gram-negative isolates from different European hospitals and association with decreased susceptibility to multiple antibiotic compounds. J Antimicrob Chemother 42:689-696.
18. Paterson DL, Bonomo RA (2005) Extended-spectrum - lactamases: a clinical update. Clin Microbiol Rev 18:657-686.
19. Podschun R, Ullmann U (1998) Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin Microbiol Rev 11:589-603.
20. Ramirez MS, Pineiro S, Centron D (2010) Novel insights about class 2 integrons from experimental and genomic epidemiology. Antimicrob Agents Chemother 54:699-706.
21. Rao AN, Barlow M, Clark LA, Boring JR, Tenover FC, McGowan JE (2006) Class 1 integrons in resistant Escherichia coli and Klebsiella spp., US Hospitals. Emerg Infect Dis 12:1011-1014.
22. Stokes HW, Hall RM (1989) A novel family of potentially mobile DNA elements encoding site-specific gene-integration functions: Integrons. Mol Microbiol 3:1669-1683.
23. White PA, McIver CJ, Rawlinson WD (2001) Integrons and gene cassettes in the Enterobacteriaceae. Antimicrob Agents Chemother 45:2658-2661.
24. Yao F, Quian Y, Chen S, Wang P, Huang Y (2007) Incidence of extended spectrum - lactamases and characterization of integrons in extended spectrum-lactamase producing Klebsiella pneumoniae isolated in Shantou, China. Acta Biochim Biophys Sin 39:527-532.