Eradication of hepatitis C virus could improve immunological status and pyoderma gangrenosum-like lesions

Hepatology Research

Volumn 44, Issue 2, 2014, Pages 238-245

  Kondo, Yasuteru ^a   Iwata, Tomoaki ^a   Haga, Takahiro ^a   Kimura, Osamu ^a   Ninomiya, Masashi ^a   Kakazu, Eiji ^a   Kogure, Takayuki ^a   Morosawa, Tatsuki ^a   Aiba, Setsuya ^a   Shimosegawa, Tooru ^a  

^a TOHOKU UNIVERSITY HOSPITAL   (Japan)

Author keywords

CD19; CD4; Extrahepatic diseases; Hepatitis C virus; T helper 17

Indexed keywords

CD19 ANTIGEN; CD4 ANTIGEN; CRYOGLOBULIN; CYCLOSPORIN; INTERLEUKIN 17; INTERLEUKIN 21; INTERLEUKIN 23; INTERLEUKIN 28B; PEGINTERFERON ALPHA2B; RIBAVIRIN; VIRUS RNA;

ANTIVIRAL THERAPY; ARTICLE; B LYMPHOCYTE; CASE REPORT; CD19+ B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DISEASE ACTIVITY; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOSUPPRESSIVE TREATMENT; IMMUNOTHERAPY; LYMPHOID CELL; NONHUMAN; PRIORITY JOURNAL; PYODERMA GANGRENOSUM; TH17 CELL; TREATMENT OUTCOME; VIRAL CLEARANCE;

EID: 84893510100     PISSN: 13866346     EISSN: 1872034X     Source Type: Journal    
DOI: 10.1111/hepr.12102     Document Type: Article

References (22)

1. Alter MJ, Kruszon-Moran D, Nainan OV etal. The prevalence of hepatitis C virus infection in the United States, 1988 through 1994. N Engl J Med 1999; 341: 556-562.
2. Kondo Y, Kobayashi K, Kobayashi T etal. Distribution of the HLA class I allele in chronic hepatitis C and its association with serum ALT level in chronic hepatitis C. Tohoku J Exp Med 2003; 201: 109-117.
3. Machida K, Kondo Y, Huang JY etal. Hepatitis C virus (HCV)-induced immunoglobulin hypermutation reduces the affinity and neutralizing activities of antibodies against HCV envelope protein. J Virol 2008; 82: 6711-6720.
4. Kondo Y, Machida K, Liu HM etal. Hepatitis C virus infection of T cells inhibits proliferation and enhances fas-mediated apoptosis by down-regulating the expression of CD44 splicing variant 6. J Infect Dis 2009; 199: 726-736.
5. Kondo Y, Ueno Y, Shimosegawa T. Dysfunction of immune systems and host genetic factors in hepatitis C virus infection with persistent normal ALT. Hepat Res Treat 2011; 2011: 713216.
6. + cells and affect their proliferation and IFN-gamma secretion activity. J Gastroenterol 2011; 46: 232-241.
7. Kondo Y, Ueno Y, Shimosegawa T. Biological significance of HCV in various kinds of lymphoid cells. Int J Microbiol 2012; 2012: 647581.
8. Saadoun D, Landau DA, Calabrese LH, Cacoub PP. Hepatitis C-associated mixed cryoglobulinaemia: a crossroad between autoimmunity and lymphoproliferation. Rheumatology 2007; 46: 1234-1242.
9. Sansonno D, Tucci FA, Lauletta G etal. Hepatitis C virus productive infection in mononuclear cells from patients with cryoglobulinaemia. Clin Exp Immunol 2007; 147: 241-248.
10. Simula MP, Caggiari L, Gloghini A, De Re V. HCV-related immunocytoma and type II mixed cryoglobulinemia-associated autoantigens. Ann N Y Acad Sci 2007; 1110: 121-130.
11. Harati A, Brockmeyer NH, Altmeyer P, Kreuter A. Skin disorders in association with monoclonal gammopathies. Eur J Med Res 2005; 10: 93-104.
12. Crowson AN, Nuovo G, Ferri C, Magro CM. The dermatopathologic manifestations of hepatitis C infection: a clinical, histological, and molecular assessment of 35 cases. Hum Pathol 2003; 34: 573-579.
13. Kondo Y, Sung VM, Machida K, Liu M, Lai MM. Hepatitis C virus infects T cells and affects interferon-gamma signaling in T cell lines. Virology 2007; 361: 161-173.
14. Kondo Y, Ueno Y, Wakui Y etal. Rapid reduction of hepatitis C virus-Core protein in the peripheral blood improve the immunological response in chronic hepatitis C patients. Hepatol Res 2011; 41: 1153-1168.
15. Manns MP, Rambusch EG. Autoimmunity and extrahepatic manifestations in hepatitis C virus infection. J Hepatol 1999; 31 (Suppl 1): 39-42.
16. Ferri C, Antonelli A, Mascia MT etal. HCV-related autoimmune and neoplastic disorders: the HCV syndrome. Dig Liver Dis 2007; 39 (Suppl 1): S13-21.
17. Laochumroonvorapong P, DiCostanzo DP, Wu H, Srinivasan K, Abusamieh M, Levy H. Disseminated histoplasmosis presenting as pyoderma gangrenosum-like lesions in a patient with acquired immunodeficiency syndrome. Int J Dermatol 2001; 40: 518-521.
18. Namazi MR, Kerchner KR, Pichardo RO. Essential type II mixed cryoglobulinemia causing pyoderma gangrenosum-like ulcers. ScientificWorldJournal 2008; 8: 228.
19. Kondo Y, Ueno Y, Machida K etal. Hcv-core protein could induce th17 commitment by enhancing the stat-3 signaling. Hepatology 2011; 54: 1332A-A.
20. Guo ZX, Chen ZP, Zheng CL etal. The role of Th17 cells in adult patients with chronic idiopathic thrombocytopenic purpura. Eur J Haematol 2009; 82: 488-489.
21. Zhao L, Tang Y, You Z etal. Interleukin-17 contributes to the pathogenesis of autoimmune hepatitis through inducing hepatic interleukin-6 expression. PLoS ONE 2011; 6: e18909.
22. Pan HF, Leng RX, Feng CC etal. Expression profiles of Th17 pathway related genes in human systemic lupus erythematosus. Mol Biol Rep 2013; 40: 391-399.