Grading epithelial atypia in endoscopic ultrasound-guided fine-needle aspiration of intraductal papillary mucinous neoplasms: An international interobserver concordance study

Cancer Cytopathology

Volumn 121, Issue 12, 2013, Pages 729-736

  Pitman, Martha B ^a   Centeno, Barbara A ^b   Genevay, Muriel ^c   Fonseca, Ricardo ^d   Mino Kenudson, Mari ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^c Clinical Pathology   (Switzerland)

^d INSTITUTO PORTUGUÊS DE ONCOLOGIA DE LISBOA FRANCISCO GENTIL   (Portugal)

Author keywords

Cytology; Endoscopic ultrasound; Epithelial atypia; Fine needle aspiration; Interobserver; Intraductal papillary mucinous neoplasm; Pancreas; Variability

Indexed keywords

ARTICLE; CANCER GRADING; CONTROLLED STUDY; CYST FLUID; CYTODIAGNOSIS; DIAGNOSTIC TEST ACCURACY STUDY; ENDOSCOPIC ULTRASOUND GUIDED FINE NEEDLE BIOPSY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INTRADUCTAL PAPILLARY MUCINOUS TUMOR; OBSERVER VARIATION; PANCREAS ADENOCARCINOMA; PREDICTIVE VALUE; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; COHORT ANALYSIS; COLLOID CARCINOMA; COMPARATIVE STUDY; CYTOLOGY; ENDOSCOPIC ECHOGRAPHY; EPIDEMIOLOGY; EPITHELIUM ATYPIA; FEMALE; FINE-NEEDLE ASPIRATION; INTEROBSERVER; MALE; METHODOLOGY; PANCREAS; PANCREAS CARCINOMA; PANCREAS TUMOR; PATHOLOGY; PREOPERATIVE CARE; VARIABILITY; ADENOCARCINOMA, MUCINOUS; CARCINOMA, PANCREATIC DUCTAL; PANCREATIC NEOPLASMS; PROCEDURES;

CYTOLOGY; ENDOSCOPIC ULTRASOUND; EPITHELIAL ATYPIA; FINE-NEEDLE ASPIRATION; INTEROBSERVER; INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM; PANCREAS; VARIABILITY;

ADENOCARCINOMA, MUCINOUS; CARCINOMA, PANCREATIC DUCTAL; COHORT STUDIES; ENDOSCOPIC ULTRASOUND-GUIDED FINE NEEDLE ASPIRATION; FEMALE; HUMANS; MALE; NEOPLASM GRADING; OBSERVER VARIATION; PANCREATIC NEOPLASMS; PREOPERATIVE CARE; SAMPLING STUDIES; SENSITIVITY AND SPECIFICITY;

EID: 84893505889     PISSN: None     EISSN: 19346638     Source Type: Journal    
DOI: 10.1002/cncy.21334     Document Type: Article

References (55)

1. Bhutani MS, Gupta V, Guha S, Gheonea DI, Saftoiu A. Pancreatic cyst fluid analysis-A review. J Gastrointestin Liver Dis. 2011;20: 175-180.
2. Chai SM, Herba K, Kumarasinghe MP, et al. Optimizing the multimodal approach to pancreatic cyst fluid diagnosis: developing a volume-based triage protocol. Cancer (Cancer Cytopathol). 2013; 121:86-100.
3. Cizginer S, Turner B, Bilge AR, Karaca C, Pitman MB, Brugge WR. Cyst fluid carcinoembryonic antigen is an accurate diagnostic marker of pancreatic mucinous cysts. Pancreas. 2011;40:1024-1028.
4. Khalid A, Zahid M, Finkelstein SD, et al. Pancreatic cyst fluid DNA analysis in evaluating pancreatic cysts: a report of the PANDA study. Gastrointest Endosc. 2009;69:1095-1102.
5. Linder JD, Geenen JE, Catalano MF. Cyst fluid analysis obtained by EUS-guided FNA in the evaluation of discrete cystic neoplasms of the pancreas: a prospective single-center experience. Gastrointest Endosc. 2006;64:697-702.
6. Park WG, Mascarenhas R, Palaez-Luna M, et al. Diagnostic performance of cyst fluid carcinoembryonic antigen and amylase in histologically confirmed pancreatic cysts. Pancreas. 2011;40:42-45.
7. Pitman MB, Yaeger KA, Brugge WR, Mino-Kenudson M. Prospective analysis of atypical epithelial cells as a high-risk cytologic feature for malignancy in pancreatic cysts. Cancer (Cancer Cytopathol). 2013;121:29-36.
8. Pitman MB, Brugge WR, Warshaw AL. The value of cyst fluid analysis in the pre-operative evaluation of pancreatic cysts. J Gastrointest Oncol. 2011;2:195-198.
9. Pitman MB, Michaels PJ, Deshpande V, Brugge WR, Bounds BC. Cytological and cyst fluid analysis of small ((< or 53 cm) branch duct intraductal papillary mucinous neoplasms adds value to patient management decisions Pancreatology. 2008; 8: 277-284
10. Ryu JK, Woo SM, Hwang JH, et al. Cyst fluid analysis for the differential diagnosis of pancreatic cysts. Diagn Cytopathol. 2004;31: 100-105.
11. van der Waaij LA, van Dullemen HM, Porte RJ. Cyst fluid analysis in the differential diagnosis of pancreatic cystic lesions: a pooled analysis. Gastrointest Endosc. 2005;62:383-389.
12. Buscaglia JM, Giday SA, Kantsevoy SV, et al. Patient-and cystrelated factors for improved prediction of malignancy within cystic lesions of the pancreas. Pancreatology. 2009;9:631-638.
13. Fernandez-del Castillo C, Targarona J, Thayer SP, Rattner DW, Brugge WR, Warshaw AL. Incidental pancreatic cysts: clinicopathologic characteristics and comparison with symptomatic patients. Arch Surg. 2003;138:427-423; discussion 433-424.
14. Ferrone CR, Correa-Gallego C, Warshaw AL, et al. Current trends in pancreatic cystic neoplasms. Arch Surg. 2009;144:448-454.
15. Lahav M, Maor Y, Avidan B, Novis B, Bar-Meir S. Nonsurgical management of asymptomatic incidental pancreatic cysts. Clin Gastroenterol Hepatol. 2007;5:813-817.
16. Sahani DV, Saokar A, Hahn PF, Brugge WR, Fernandez-Del Castillo C. Pancreatic cysts 3 cm or smaller: how aggressive should treatment be? Radiology. 2006;238:912-919.
17. Tanaka M, Chari S, Adsay V, et al. International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas. Pancreatology. 2006;6:17-32.
18. Tanaka M, Fernandez-del Castillo C, Adsay V, et al. International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas. Pancreatology. 2012;12:183-197.
19. Kim YH, Saini S, Sahani D, Hahn PF, Mueller PR, Auh YH. Imaging diagnosis of cystic pancreatic lesions: pseudocyst versus nonpseudocyst. Radiographics. 2005;25:761-785.
20. Sahani DV, Kadavigere R, Blake M, Fernandez-Del Castillo C, Lauwers GY, Hahn PF. Intraductal papillary mucinous neoplasm of pancreas: multi-detector row CT with 2D curved reformations-correlation with MRCP. Radiology. 2006;238:560-569.
21. Sahani DV, Kadavigere R, Saokar A, Fernandez-del Castillo C, Brugge WR, Hahn PF. Cystic pancreatic lesions: a simple imagingbased classification system for guiding management. Radiographics. 2005;25:1471-1484.
22. Sahani DV, Miller JC, del Castillo CF, Brugge WR, Thrall JH, Lee SI. Cystic pancreatic lesions: classification and management. J Am Coll Radiol. 2009;6:376-380.
23. Shah AA, Sainani NI, Kambadakone AR, et al. Predictive value of multi-detector computed tomography for accurate diagnosis of serous cystadenoma: radiologic-pathologic correlation. World J Gastroenterol. 2009;15:2739-2747.
24. Pongpornsup S, Piyapittayanan S, Charoensak A. MDCT imaging findings for characterization pancreatic cystic lesion: differentiation between benign and malignant pattern. J Med Assoc Thai. 2011;94: 369-378.
25. Lee HJ, Kim MJ, Choi JY, Hong HS, Kim KA. Relative accuracy of CT and MRI in the differentiation of benign from malignant pancreatic cystic lesions. Clin Radiol. 2011;66:315-321.
26. Kim YC, Choi JY, Chung YE, et al. Comparison of MRI and endoscopic ultrasound in the characterization of pancreatic cystic lesions. AJR Am J Roentgenol. 2010;195:947-952.
27. Sainani NI, Saokar A, Deshpande V, Fernandez-del Castillo C, Hahn P, Sahani DV. Comparative performance of MDCT and MRI with MR cholangiopancreatography in characterizing small pancreatic cysts. AJR Am J Roentgenol. 2009;193:722-731.
28. Fisher WE, Hodges SE, Yagnik V, et al. Accuracy of CT in predicting malignant potential of cystic pancreatic neoplasms. HPB (Oxford). 2008;10:483-490.
29. Chaudhari VV, Raman SS, Vuong NL, et al. Pancreatic cystic lesions: discrimination accuracy based on clinical data and highresolution computed tomographic features. J Comput Assist Tomogr. 2008;32:757-763.
30. D'Onofrio M, Megibow AJ, Faccioli N, et al. Comparison of contrast-enhanced sonography and MRI in displaying anatomic features of cystic pancreatic masses. AJR Am J Roentgenol. 2007; 189:1435-1442.
31. Katz DS, Friedel DM, Kho D, Georgiou N, Hines JJ. Relative accuracy of CT and MRI for characterization of cystic pancreatic masses. AJR Am J Roentgenol. 2007;189:657-661.
32. Shimizu M, Hirokawa M, Manabe T, et al. Cytologic findings in noninvasive intraductal papillary-mucinous carcinoma of the pancreas: a report of 2 cases. Acta Cytol. 1999;43:243-246.
33. Stelow EB, Stanley MW, Bardales RH, et al. Intraductal papillarymucinous neoplasm of the pancreas. The findings and limitations of cytologic samples obtained by endoscopic ultrasound-guided fine-needle aspiration. Am J Clin Pathol. 2003;120:398-404.
34. Sole M, Iglesias C, Fernandez-Esparrach G, Colomo L, Pellise M, Gines A. Fine-needle aspiration cytology of intraductal papillary mucinous tumors of the pancreas. Cancer. 2005;105:298-303.
35. Salla C, Chatzipantelis P, Konstantinou P, et al. Endoscopic ultrasound-guided fine-needle aspiration cytology in the diagnosis of intraductal papillary mucinous neoplasms of the pancreas. A study of 8 cases. JOP. 2007;8:715-724.
36. Layfield LJ, Cramer H. Fine-needle aspiration cytology of intraductal papillary-mucinous tumors: a retrospective analysis. Diagn Cytopathol. 2005;32:16-20.
37. Emerson RE, Randolph ML, Cramer HM. Endoscopic ultrasoundguided fine-needle aspiration cytology diagnosis of intraductal papillary mucinous neoplasm of the pancreas is highly predictive of pancreatic neoplasia. Diagn Cytopathol. 2006;34:457-462.
38. Michaels PJ, Brachtel EF, Bounds BC, Brugge WR, Pitman MB. Intraductal papillary mucinous neoplasm (IPMN) of the pancreas: cytohistologic analysis and correlation with histologic grade. Cancer (Cancer Cytopathol). 2006;108:163-173.
39. Nakaizumi A, Tatsuta M, Uehara H, et al. Cytologic examination of pure pancreatic juice in the diagnosis of pancreatic carcinoma. The endoscopic retrograde intraductal catheter aspiration cytologic technique. Cancer. 1992;70:2610-2614.
40. Nakaizumi A, Tatsuta M, Uehara H, et al. Effectiveness of the cytologic examination of pure pancreatic juice in the diagnosis of early neoplasia of the pancreas. Cancer. 1995;76:750-757.
41. Pitman MB, Genevay M, Yaeger K, et al. High-grade atypical epithelial cells in pancreatic mucinous cysts are a more accurate predictor of malignancy than "positive" cytology. Cancer (Cancer Cytopathol). 2010;118:434-440.
42. Landis J, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33:159-174.
43. Hruban RH, Pitman MB, Klimstra DS. Tumors of the pancreas. In: Atlas of Tumor Pathology. 4th Series. Fascicle 6. Washington, DC: American Registry of Pathology; Armed Forces Institutes of Pathology; 2007.
44. Adsay NV, Merati K, Basturk O, et al. Pathologically and biologically distinct types of epithelium in intraductal papillary mucinous neoplasms: delineation of an "intestinal" pathway of carcinogenesis in the pancreas. Am J Surg Pathol. 2004;28:839-848.
45. Mino-Kenudson M, Fernandez-Del Castillo C, Baba Y, et al. Prognosis of invasive intraductal papillary mucinous neoplasm depends on histological and precursor epithelial subtypes. Gut. 2011;60: 1712-1720.
46. Furukawa T, Hatori T, Fujita I, et al. Prognostic relevance of morphological types of intraductal papillary mucinous neoplasms of the pancreas. Gut. 2011;60:509-516.
47. Fritz S, Klauss M, Bergmann F, et al. Small (Sendai negative) branch-duct IPMNs: not harmless. Ann Surg. 2012;256:313-320.
48. Wong J, Weber J, Centeno BA, et al. High-grade dysplasia and adenocarcinoma are frequent in side-branch intraductal papillary mucinous neoplasm measuring less than 3 cm on endoscopic ultrasound. J Gastrointest Surg. 2013;17:78-84; discussion 84-85.
49. Pelaez-Luna M, Chari ST, Smyrk TC, et al. Do consensus indications for resection in branch duct intraductal papillary mucinous neoplasm predict malignancy? A study of 147 patients. Am J Gastroenterol. 2007;102:1759-1764.
50. Tang RS, Weinberg B, Dawson DW, et al. Evaluation of the guidelines for management of pancreatic branch-duct intraductal papillary mucinous neoplasm. Clin Gastroenterol Hepatol. 2008;6: 815-819; quiz 719.
51. Woo SM, Ryu JK, Lee SH, Yoon WJ, Kim YT, Yoon YB. Branch duct intraductal papillary mucinous neoplasms in a retrospective series of 190 patients. Br J Surg. 2009;96:405-411.
52. Wu R, Yoon WJ, Brugge W, Mino-Kenudson M, Pitman M. Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) contributes to a triple negative test in preoperative screening of pancreatic cysts. J Am Soc Cytopathol. 2012;1(suppl 103):186-A.
53. Genevay M, Mino-Kenudson M, Yaeger K, et al. Cytology adds value to imaging studies for risk assessment of malignancy in pancreatic mucinous cysts. Ann Surg. 2011;254:977-983.
54. Schmidt CM, White PB, Waters JA, et al. Intraductal papillary mucinous neoplasms: predictors of malignant and invasive pathology. Ann Surg. 2007;246:644-651; discussion 651-644.
55. Wiesenauer CA, Schmidt CM, Cummings OW, et al. Preoperative predictors of malignancy in pancreatic intraductal papillary mucinous neoplasms. Arch Surg. 2003;138:610-617; discussion 617-618.