High-grade atypical epithelial cells in pancreatic mucinous cysts are a more accurate predictor of malignancy than "positive" cytology

Cancer Cytopathology

Volumn 118, Issue 6, 2010, Pages 434-440

  Pitman, Martha Bishop ^a   Genevay, Muriel ^a,b   Yaeger, Kurt ^a,c   Chebib, Ivan ^a,d   Turner, Brian G ^a   Mino Kenudson, Mari ^a   Brugge, William R ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^c LAFAYETTE COLLEGE   (United States)

^d FOOTHILLS HOSPITAL   (Canada)

Author keywords

Cytology; Intraductal papillary mucinous neoplasm; Mucinous cystic neoplasm; Mucinous cysts; Pancreas

Indexed keywords

ADULT; AGED; ARTICLE; EPITHELIUM CELL; FEMALE; HUMAN; MALE; MIDDLE AGED; NEEDLE BIOPSY; PANCREAS CYST; PANCREAS TUMOR; PATHOLOGY;

ADULT; AGED; BIOPSY, FINE-NEEDLE; EPITHELIAL CELLS; FEMALE; HUMANS; MALE; MIDDLE AGED; PANCREATIC CYST; PANCREATIC NEOPLASMS;

EID: 79952199737     PISSN: None     EISSN: 19346638     Source Type: Journal    
DOI: 10.1002/cncy.20118     Document Type: Article

References (20)

1. Crippa S, Salvia R, Warshaw AL, et al. Mucinous cystic neoplasm of the pancreas is not an aggressive entity: lessons from 163 resected patients. Ann Surg. 2008;247:571-579.
2. Scheiman JM. Management of cystic lesions of the pancreas. J Gastrointest Surg. 2008;12:405-407.
3. Liao T, Velanovich V. Asymptomatic pancreatic cysts: a decision analysis approach to observation versus resection. Pancreas. 2007;35:243-248.
4. Ferrone CR, Correa-Gallego C, Warshaw AL, et al. Current trends in pancreatic cystic neoplasms. Arch Surg. 2009;144:448-454.
5. Sahani DV, Lin DJ, Venkatesan AM, et al. Multidisciplinary approach to diagnosis and management of intraductal papillary mucinous neoplasms of the pancreas. Clin Gastroenterol Hepatol. 2009;7:259-269.
6. Hruban RH, Pitman MB, Klimstra DS. Tumors of the pancreas. In: Atlas of Tumor Pathology. 4th series. Fascicle 6. Washington, DC: American Registry of Pathology, Armed Forces Institutes of Pathology; 2007.
7. Sohn TA, Yeo CJ, Cameron JL, et al. Intraductal papillary mucinous neoplasms of the pancreas: an updated experience. Ann Surg. 2004;239:788-797; discussion 797-799.
8. Serikawa M, Sasaki T, Fujimoto Y, Kuwahara K, Chayama K. Management of intraductal papillary-mucinous neoplasm of the pancreas: treatment strategy based on morphologic classification. J Clin Gastroenterol. 2006;40:856-862.
9. Fujino Y, Suzuki Y, Yoshikawa T, et al. Outcomes of surgery for intraductal papillary mucinous neoplasms of the pancreas. World J Surg. 2006;30:1909-1914; discussion 1915.
10. Okabayashi T, Kobayashi M, Nishimori I, et al. Clinicopathological features and medical management of intraductal papillary mucinous neoplasms. J Gastroenterol Hepatol. 2006; 21:462-467.
11. Tanaka M, Chari S, Adsay V, et al. International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas. Pancreatology. 2006;6:17-32.
12. Michaels PJ, Brachtel EF, Bounds BC, Brugge WR, Pitman MB. Intraductal papillary mucinous neoplasm of the pancreas: cytologic features predict histologic grade. Cancer (Cancer Cytopathol). 2006;108:163-173.
13. Pitman MB, Michaels PJ, Deshpande V, Brugge WR, Bounds BC. Cytological and cyst fluid analysis of small (< or = 3 cm) branch duct intraductal papillary mucinous neoplasms adds value to patient management decisions. Pancreatology. 2008;8:277-284.
14. Shen J, Brugge WR, Dimaio CJ, Pitman MB. Molecular analysis of pancreatic cyst fluid: a comparative analysis with current practice of diagnosis. Cancer (Cancer Cytopathol). 2009;117:217-227.
15. Nagle J, Wilbur DC, Pitman MD. Cytomorphology of gastric and duodenal epithelium and reactivity to B72.3: a baseline for comparison to pancreatic neoplasms aspirated by EUS-FNAB. Diagn Cytopathol. 2005;33:381-386.
16. Robins DB, Katz RL, Evans DB, Atkinson EN, Green L. Fine needle aspiration of the pancreas. In quest of accuracy. Acta Cytol. 1995;39:1-10.
17. Pitman MB, Deshpande V. Endoscopic ultrasound-guided fine needle aspiration cytology of the pancreas: a morphological and multimodal approach to the diagnosis of solid and cystic mass lesions. Cytopathology. 2007;18:331-347.
18. Pitman MB. Cytology of the pancreas. In: Gray W, Kocjan G, eds. Diagnostic Cytopathology. London: Churchill Livingstone; 2010:333-366.
19. Nawgiri RS, Nagle JA, Wilbur DC, Pitman MB. Cytomorphology and B72.3 labeling of benign and malignant ductal epithelium in pancreatic lesions compared to gastrointestinal epithelium. Diagn Cytopathol. 2007;35:300-305.
20. Adsay NV, Merati K, Basturk O, et al. Pathologically and biologically distinct types of epithelium in intraductal papillary mucinous neoplasms: delineation of an "intestinal" pathway of carcinogenesis in the pancreas. Am J Surg Pathol. 2004;28:839-848.