Prospective analysis of atypical epithelial cells as a high-risk cytologic feature for malignancy in pancreatic cysts

Cancer Cytopathology

Volumn 121, Issue 1, 2013, Pages 29-36

  Pitman, Martha B ^a   Yaeger, Kurt A ^a   Brugge, William R ^a   Mino Kenudson, Mari ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Atypical epithelial cells; Cytology; Endoscopic ultrasound; Fine needle aspiration biopsy; Intraductal papillary mucinous neoplasm; Mucinous cysts; Pancreas

Indexed keywords

AMYLASE; CARCINOEMBRYONIC ANTIGEN;

ADOLESCENT; ADULT; AGED; ARTICLE; ATYPICAL EPITHELIUM CELL; CELL NUCLEUS; CONTROLLED STUDY; CYST FLUID; CYTOLOGY; CYTOPLASM; DIAGNOSTIC ACCURACY; DYSPLASIA; ENDOSCOPIC ULTRASOUND GUIDED FINE NEEDLE BIOPSY; EPITHELIUM CELL; FALSE NEGATIVE RESULT; FEMALE; FINE NEEDLE ASPIRATION BIOPSY; HIGH RISK POPULATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; INVASIVE CARCINOMA; MAJOR CLINICAL STUDY; MALE; MALIGNANT NEOPLASTIC DISEASE; MUCINOUS CYSTIC NEOPLASM; PANCREAS ADENOCARCINOMA; PANCREAS CYST; PANCREATICODUODENECTOMY; PRIORITY JOURNAL; PSEUDOCYST; CYTODIAGNOSIS; ENDOSCOPIC ECHOGRAPHY; EVALUATION; PANCREAS TUMOR; PATHOLOGY; PREDICTIVE VALUE; PROSPECTIVE STUDY; RISK; SENSITIVITY AND SPECIFICITY;

BIOPSY, FINE-NEEDLE; CYTODIAGNOSIS; ENDOSONOGRAPHY; EPITHELIAL CELLS; HUMANS; PANCREATIC CYST; PANCREATIC NEOPLASMS; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; RISK; SENSITIVITY AND SPECIFICITY;

MLCS; MLOWN;

EID: 84874740180     PISSN: None     EISSN: 19346638     Source Type: Journal    
DOI: 10.1002/cncy.21242     Document Type: Article

References (22)

1. Brugge WR. Role of endoscopic ultrasound in the diagnosis of cystic lesions of the pancreas. Pancreatology. 2001;1:637-640. (Pubitemid 33674960)
2. Brugge WR. Evaluation of pancreatic cystic lesions with EUS. Gastrointest Endosc. 2004;59:698-707. (Pubitemid 38609705)
3. Brugge WR, Lewandrowski K, Lee-Lewandrowski E, et al. Diagnosis of pancreatic cystic neoplasms: a report of the Cooperative Pancreatic Cyst Study. Gastroenterology. 2004;126:1330-1336. (Pubitemid 38552797)
4. Pitman MB, Lewandrowski K, Shen J, et al. Pancreatic cysts: preoperative diagnosis and clinical management. Cancer (Cancer Cytopathol). 2010;118:1-13.
5. Polkowski M, Larghi A, Weynand B, et al. Learning, techniques, and complications of endoscopic ultrasound (EUS)-guided sampling in gastroenterology: European Society of Gastrointestinal Endoscopy (ESGE) technical guideline. Endoscopy. 2012;44:190-206.
6. Yamao K, Yanagisawa A, Takahashi K, et al. Clinicopathological features and prognosis of mucinous cystic neoplasm with ovariantype stroma: a multi-institutional study of the Japan pancreas society. Pancreas. 2011;40:67-71.
7. Hirooka Y, Goto H, Itoh A, et al. Case of intraductal papillary mucinous tumor in which endosonography-guided fine-needle aspiration biopsy caused dissemination. J Gastroenterol Hepatol. 2003;18:1323-1324. (Pubitemid 37464012)
8. Tanaka M, Fernandez-del Castillo C, Adsay V, et al. International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas. Pancreatology. 2012;12:183-197.
9. Kang MJ, Jang JY, Kim SJ, et al. Cyst growth rate predicts malignancy in patients with branch duct intraductal papillary mucinous neoplasms. Clin Gastroenterol Hepatol. 2011;9:87-93.
10. Levy P, Jouannaud V, O'Toole D, et al. Natural history of intraductal papillary mucinous tumors of the pancreas: actuarial risk of malignancy. Clin Gastroenterol Hepatol. 2006;4:460-468.
11. Tanaka M, Chari S, Adsay V, et al. International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas. Pancreatology. 2006;6:17-32.
12. Michaels PJ, Brachtel EF, Bounds BC, et al. Intraductal papillary mucinous neoplasm (IPMN) of the pancreas: cytohistologic analysis and correlation with histologic grade. Cancer (Cancer Cytopathol). 2006;108:163-173.
13. Pitman MB, Michaels PJ, Deshpande V, et al. Cytological and cyst fluid analysis of small (3 cm) branch duct intraductal papillary mucinous neoplasms adds value to patient management decisions. Pancreatology. 2008;8:277-284. (Pubitemid 351832481)
14. Pitman MB, Genevay M, Yaeger K, et al. High-grade atypical epithelial cells in pancreatic mucinous cysts are a more accurate predictor of malignancy than "positive" cytology. Cancer (Cancer Cytopathol). 2010;118:434-440.
15. Genevay M, Mino-Kenudson M, Yaeger K, et al. Cytology adds value to imaging studies for risk assessment of malignancy in pancreatic mucinous cysts. Ann Surg. 2011;254:977-983.
16. Schmidt CM, White PB, Waters JA, et al. Intraductal papillary mucinous neoplasms: predictors of malignant and invasive pathology. Ann Surg. 2007;246:644-651; discussion 651-654. (Pubitemid 47480616)
17. Wiesenauer CA, Schmidt CM, Cummings OW, et al. Preoperative predictors of malignancy in pancreatic intraductal papillary mucinous neoplasms. Arch Surg. 2003;138:610-617; discussion 617-618.
18. Nagle J, Wilbur DC, Pitman MD. The cytomorphology of gastric and duodenal epithelium and reactivity to B72.3: a baseline for comparison to pancreatic neoplasms aspirated by EUS-FNAB. Diagn Cytopathol. 2005;33:381-386. (Pubitemid 41780457)
19. Nawgiri RS, Nagle JA, Wilbur DC, et al. Cytomorphology and B72.3 labeling of benign and malignant ductal epithelium in pancreatic lesions compared to gastrointestinal epithelium. Diagn Cytopathol. 2007;35:300-305. (Pubitemid 46652565)
20. Hruban RH, Pitman MB, Klimstra DS. Tumors of the Pancreas. Atlas of Tumor Pathology, 4th series, fascicle 6. Washington, DC: American Registry of Pathology, Armed Forces Institutes of Pathology; 2007.
21. de Jong K, van Hooft JE, Nio CY, et al. Accuracy of preoperative workup in a prospective series of surgically resected cystic pancreatic lesions. Scand J Gastroenterol. 2012;8-9:1056-1063.
22. Cizginer S, Turner B, Bilge AR, et al. Cyst fluid carcinoembryonic antigen is an accurate diagnostic marker of pancreatic mucinous cysts. Pancreas. 2011;40:1024-1028.