Skin temperature: Its role in thermoregulation

Acta Physiologica

Volumn 210, Issue 3, 2014, Pages 498-507

  Romanovsky, A A ^a  

^a ST JOSEPH'S HOSPITAL AND MEDICAL CENTER   (United States)

Author keywords

Auxiliary feedback; Body temperature; Feedforward; Thermopharmacology; TPRV1; TRPM8

Indexed keywords

TRANSIENT RECEPTOR POTENTIAL CHANNEL;

BODY TEMPERATURE; BROWN ADIPOSE TISSUE; ENVIRONMENT; ENVIRONMENTAL TEMPERATURE; EXTERNAL AUDITORY CANAL; GLABROUS SKIN; HEAT EXCHANGE; HEAT TRANSFER; HUMAN; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; RESPONSE TIME; REVIEW; SKIN TEMPERATURE; THERMORECEPTOR; THERMOREGULATION; VASOMOTOR REFLEX;

ANIMALS; BODY TEMPERATURE REGULATION; HUMANS; SKIN TEMPERATURE;

EID: 84893474696     PISSN: 17481708     EISSN: 17481716     Source Type: Journal    
DOI: 10.1111/apha.12231     Document Type: Review

References (67)

1. Almeida, M.C., Steiner, A.A., Branco, L.G. & Romanovsky, A.A. 2006. Cold-seeking behavior as a thermoregulatory strategy in systemic inflammation. Eur J Neurosci 23, 3359-3367.
2. Almeida, M.C., Hew-Butler, T., Soriano, R.N., Rao, S., Wang, W., Wang, J., Tamayo, N., Oliveira, D.L., Nucci, T.B., Aryal, P., Garami, A., Bautista, D., Gavva, N.R. & Romanovsky, A.A. 2012. Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J Neurosci 32, 2086-2099.
3. Aschoff, J. & Wever, R. 1958. Kern und Schale im Waermehaushalt des Menschen. Naturwissenschaften 45, 477-485.
4. Bandell, M., Macpherson, L.J. & Patapoutian, A. 2007. From chills to chilis: mechanisms for thermosensation and chemesthesis via thermoTRPs. Curr Opin Neurobiol 17, 490-497.
5. Bautista, D.M., Siemens, J., Glazer, J.M., Tsuruda, P.R., Basbaum, A.I., Stucky, C.L., Jordt, S.E. & Julius, D. 2007. The menthol receptor TRPM8 is the principal detector of environmental cold. Nature 448, 204-208.
6. Bligh, J. 1966. The thermosensitivity of the hypothalamus and thermoregulation in mammals. Biol Rev Camb Philos Soc 41, 317-368.
7. Boulant, J.A. 2006. Counterpoint: heat-induced membrane depolarization of hypothalamic neurons: an unlikely mechanism of central thermosensitivity. Am J Physiol 290, R1481-R1484.
8. Bratincsak, A. & Palkovits, M. 2005. Evidence that peripheral rather than intracranial thermal signals induce thermoregulation. Neuroscience 135, 525-532.
9. Cabanac, M. 1995. Human Selective Brain Cooling. R.G. Landes, Austin, TX.
10. del Camino, D., Murphy, S., Heiry, M., Barrett, L.B., Earley, T.J., Cook, C.A., Petrus, M.J., Zhao, M., D'Amours, M., Deering, N. 2010. TRPA1 contributes to cold hypersensitivity. J Neurosci 30, 15165-15174.
11. Caterina, M.J. 2007. Transient receptor potential ion channels as participants in thermosensation and thermoregulation. Am J Physiol 292, R64-R76.
12. Chen, J. & Kym, P.R. 2009. TRPA1: the species difference. J Gen Physiol 133, 623-625.
13. Chen, J., Joshi, S.K., DiDomenico, S., Perner, R.J., Mikusa, J.P., Gauvin, D.M., Seqreti, J.A., Han, P., Zhang, X.F., Niforatos, W. 2011. Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation. Pain 152, 1165-1172.
14. Craig, A.D. 2002. How do you feel? Interoception: the sense of the physiological condition of the body. Nat Rev Neurosci 3, 655-666.
15. Doufas, A.G., Wadhwa, A., Lin, C.M., Shah, Y.M., Hanni, K. & Sessler, D.I. 2003. Neither arm nor face warming reduces the shivering threshold in unanesthetized humans. Stroke 34, 1736-1740.
16. Fealey, R.D. 2013. Interoception and autonomic nervous system reflexes thermoregulation. Handb Clin Neurol 117, 79-88.
17. Flouris, A.D. 2011. Functional architecture of behavioural thermoregulation. Eur J Appl Physiol 111, 1-8.
18. Garami, A., Shimansky, Y.P., Pakai, E., Oliveira, D.L., Gavva, N.R. & Romanovsky, A.A. 2010. Contributions of different modes of TRPV1 activation to TRPV1 antagonist-induced hyperthermia. J Neurosci 30, 1435-1440.
19. Gavva, N.R., Treanor, J.J., Garami, A., Fang, L., Surapaneni, S., Akrami, A., Alvarez, F., Bak, A., Darling, M., Gore, A. et al. 2008. Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans. Pain 136, 202-210.
20. Hausfater, P., Zhao, Y., Defrenne, S., Bonnet, P. & Riou, B. 2008. Cutaneous infrared thermometry for detecting febrile patients. Emerg Infect Dis 14, 1255-1258.
21. Hensel, H. 1974. Thermoreceptors. Annu Rev Physiol 36, 233-249.
22. Huckaba, C.E., Downey, J.A. & Darling, R.C. 1971. A feedback-feedforward mechanism describing the interaction of central and peripheral signals in human thermoregulation. Int J Biometeorol 15, 141-145.
23. Jessen, C. 1981. Independent clamps of peripheral and central temperatures and their effects on heat production in the goat. J Physiol 311, 11-22.
24. Jessen, C. 1985. Thermal afferents in the control of body temperature. Pharmacol Ther 28, 107-134.
25. Jordt, S.E., McKemy, D.D. & Julius, D. 2003. Lessons from peppers and peppermint: the molecular logic of thermosensation. Curr Opin Neurobiol 13, 487-492.
26. Kanosue, K., Crawshaw, L.I., Nagashima, K. & Yoda, T. 2010. Concepts to utilize in describing thermoregulation and neurophysiological evidence for how the system works. Eur J Appl Physiol 109, 5-11.
27. Katz-Sidlow, R.J., Rowberry, J.P. & Ho, M. 2009. Fever determination in young infants: prevalence and accuracy of parental palpation. Pediatr Emerg Care 25, 12-14.
28. Kitzing, J., Behling, K., Bleichert, A., Scarperi, M. & Scarperi, S. 1972. Antriebe und effektorische Massnahmen der Thermoregulation bei Ruhe und waehrend koerperlicher Arbeit. Int Z Angew Physiol 30, 119-131.
29. Knowlton, W.M., Daniels, R.L., Palkar, R., McCoy, D.D. & McKemy, D.D. 2011. Pharmacological blockade of TRPM8 ion channels alters cold and cold pain responses in mice. PLoS One 6, e25894.
30. Kondo, N., Yanagimoto, S., Nishiyasu, T. & Crandall, C.G. 2003. Effects of muscle metaboreceptor stimulation on cutaneous blood flow from glabrous and nonglabrous skin in mildly heated humans. J Appl Physiol 94, 1829-1835.
31. Loftus, R. 1968. The response of the antennal cold receptor of Periplaneta americana to rapid temperature changes and to steady temperature. Z Vgl Physiol 59, 413-455.
32. Marks, A., Vianna, D.M. & Carrive, P. 2009. Nonshivering thermogenesis without interscapular brown adipose tissue involvement during conditioned fear in the rat. Am J Physiol 296, R1239-R1247.
33. McAllen, R.M., Farrell, M., Johnson, J.M., Trevaks, D., Cole, L., McKinley, M.J., Jackson, G., Denton, D.A. & Egan, G.F. 2006. Human medullary responses to cooling and rewarming the skin: a functional MRI study. Proc Natl Acad Sci USA 103, 809-813.
34. McCaffrey, T.V., Wurster, R.D., Jacobs, H.K., Euler, D.E. & Geis, G.S. 1979. Role of skin temperature in the control of sweating. J Appl Physiol Respir Environ Exerc Physiol 47, 591-597.
35. Mercer, J.B. & Simon, E. 1984. A comparison between total body thermosensitivity and local thermosensitivity in mammals and birds. Pflugers Arch 400, 228-234.
36. Nadel, E.R., Mitchell, J.W. & Stolwijk, J.A. 1973. Differential thermal sensitivity in the human skin. Pflugers Arch 340, 71-76.
37. Nagasaka, T., Cabanac, M., Hirata, K. & Nunomura, T. 1987. Control of local heat gain by vasomotor response of the hand. J Appl Physiol 63, 1335-1338.
38. Nakamura, K. 2011. Central circuitries for body temperature regulation and fever. Am J Physiol 301, R1207-R1228.
39. Nakamura, K. & Morrison, S.F. 2007. Central efferent pathways mediating skin cooling-evoked sympathetic thermogenesis in brown adipose tissue. Am J Physiol 292, R127-R136.
40. Nakamura, K. & Morrison, S.F. 2008. A thermosensory pathway that controls body temperature. Nat Neurosci 11, 62-71.
41. Nakamura, K. & Morrison, S.F. 2010. A thermosensory pathway mediating heat-defense responses. Proc Natl Acad Sci USA 107, 8848-8853.
42. Nakamura, M., Yoda, T., Crawshaw, L.I., Kasuga, M., Uchida, Y., Tokizawa, K., Nagashima, K. & Kanosue, K. 2013. Relative importance of different surface regions for thermal comfort in humans. Eur J Appl Physiol 113, 63-76.
43. Nilius, B., Appendino, G. & Owsianik, G. 2012. The transient receptor potential channel TRPA1: from gene to pathophysiology. Pflugers Arch 464, 425-458.
44. Okazawa, M., Takao, K., Hori, A., Shiraki, T., Matsumura, K. & Kobayashi, S. 2002. Ionic basis of cold receptors acting as thermostats. J Neurosci 22, 3994-4001.
45. Partridge, L.D. & Partridge, L.D. 1992. The Nervous System: Its Function and Its Interaction with the World. MIT Press, Cambridge, MA.
46. Pogorzala, L.A., Mishra, S.K. & Hoon, M.A. 2013. The cellular code for mammalian thermosensation. J Neurosci 33, 5533-5541.
47. Preti, D., Szallasi, A. & Patacchini, R. 2012. TRP channels as therapeutic targets in airway disorders: a patent review. Expert Opin Ther Pat 22, 663-695.
48. Roberts, W.W. 1988. Differential thermosensor control of thermoregulatory grooming, locomotion, and relaxed postural extension. Ann N Y Acad Sci 525, 363-734.
49. Romanovsky, A.A. 2007a. Temperature regulation. Chapter 23. In: O. Petersen (ed.) Lecture Notes on Human Physiology, 5th edn. Blackwell, Oxford.
50. Romanovsky, A.A. 2007b. Thermoregulation: some concepts have changed. Functional architecture of the thermoregulatory system. Am J Physiol 292, R37-R46.
51. Romanovsky, A.A., Quint, P.A., Benikova, Y. & Kiesow, L.A. 1997. A difference of 5 degrees C between ear and rectal temperatures in a febrile patient. Am J Emerg Med 15, 383-385.
52. Romanovsky, A.A., Ivanov, A.I. & Shimansky, Y.P. 2002. Selected contribution: ambient temperature for experiments in rats: a new method for determining the zone of thermal neutrality. J Appl Physiol 92, 2667-2679.
53. Romanovsky, A.A., Almeida, M.C., Garami, A., Steiner, A.A., Norman, M.H., Morrison, S.F., Nakamura, K., Burmeister, J.J. & Nucci, T.B. 2009. The transient receptor potential vanilloid-1 channel in thermoregulation: a thermosensor it is not. Pharmacol Rev 61, 228-261.
54. Saad, A.R., Stephens, D.P., Bennett, L.A., Charkoudian, N., Kosiba, W.A. & Johnson, J.M. 2001. Influence of isometric exercise on blood flow and sweating in glabrous and nonglabrous human skin. J Appl Physiol 91, 2487-2492.
55. Sakurada, S., Shido, O., Fujikake, K. & Nagasaka, T. 1993. Relationship between body core and peripheral temperatures at the onset of thermoregulatory responses in rats. Jpn J Physiol 43, 659-667.
56. Savage, M.V. & Brengelmann, G.L. 1996. Control of skin blood flow in the neutral zone of human body temperature regulation. J Appl Physiol 80, 1249-1257.
57. Sessler, D.I. & Sessler, A.M. 1998. Experimental determination of heat flow parameters during induction of general anesthesia. Anesthesiology 89, 657-665.
58. Slepchuk, N.A. & Ivanov, K.P. 1992. [The temperature gradient values in the skin and their significance for thermoregulation]. Fiziol Zh SSSR Im I M Sechenova 78, 80-84.
59. Steiner, A.A., Turek, V.F., Almeida, M.C., Burmeister, J.J., Oliveira, D.L., Roberts, J.L., Bannon, A.W., Norman, M.H., Louis, J.C., Treanor, J.J., Gavva, N.R. & Romanovsky, A.A. 2007. Nonthermal activation of transient receptor potential vanilloid-1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors. J Neurosci 27, 7459-7468.
60. Stevens, J.C. & Choo, K.K. 1998. Temperature sensitivity of the body surface over the life span. Somatosens Mot Res 15, 13-28.
61. Story, G.M., Peier, A.M., Reeve, A.J., Eid, S.R., Mosbacher, J., Hricik, T.R., Earley, T.J., Hergarden, A.C., Andersson, D.A., Hwang, S.W., McIntyre, P., Jeqla, T., Bevan, S. & Patapoutian, A. 2003. ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 112, 819-829.
62. Szekely, M. & Szelenyi, Z. 1979. Endotoxin fever in the rat. Acta Physiol Acad Sci Hung 53, 265-277.
63. Tanaka, M., Owens, N.C., Nagashima, K., Kanosue, K. & McAllen, R.M. 2006. Reflex activation of rat fusimotor neurons by body surface cooling, and its dependence on the medullary raphe. J Physiol 572, 569-583.
64. Tanaka, M., Ootsuka, Y., McKinley, M.J. & McAllen, R.M. 2007. Independent vasomotor control of rat tail and proximal hairy skin. J Physiol 582, 421-433.
65. Vianna, D.M. & Carrive, P. 2005. Changes in cutaneous and body temperature during and after conditioned fear to context in the rat. Eur J Neurosci 21, 2505-2512.
66. Werner, J. 1979. The concept of regulation for human body temperature. J Therm Biol 5, 75-82.
67. Werner, J. 2010. System properties, feedback control and effector coordination of human temperature regulation. Eur J Appl Physiol 109, 13-25.