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Volumn 8, Issue 12, 2013, Pages

Comparative efficacy and safety of deferoxamine, deferiprone and deferasirox on severe thalassemia: A meta-analysis of 16 randomized controlled trials

Author keywords

[No Author keywords available]

Indexed keywords

DEFERASIROX; DEFERIPRONE; DEFEROXAMINE; FERRITIN; IRON; BENZOIC ACID DERIVATIVE; IRON CHELATING AGENT; PYRIDONE DERIVATIVE; TRIAZOLE DERIVATIVE;

EID: 84893461706     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0082662     Document Type: Article
Times cited : (43)

References (38)
  • 1
    • 29744468347 scopus 로고    scopus 로고
    • Changing patterns of thalassemia worldwide
    • PubMed: 16339647
    • Vichinsky EP (2005) Changing patterns of thalassemia worldwide. Ann N Y Acad Sci 1054: 18-24. PubMed: 16339647.
    • (2005) Ann N Y Acad Sci , vol.1054 , pp. 18-24
    • Vichinsky, E.P.1
  • 2
    • 44949128064 scopus 로고    scopus 로고
    • Global epidemiology of haemoglobin disorders and derived service indicators
    • DOI 10.2471/BLT.06.036673
    • Modell B, Darlison M (2008) Global epidemiology of haemoglobin disorders and derived service indicators. Bull World Health Organ 86: 480-487. PubMed: 18568278. (Pubitemid 351821761)
    • (2008) Bulletin of the World Health Organization , vol.86 , Issue.6 , pp. 480-487
    • Modell, B.1    Darlison, M.2
  • 5
    • 84860555772 scopus 로고    scopus 로고
    • Effects of combined deferiprone with deferoxamine on right ventricular function in thalassaemia major
    • doi:10.1186/1532-429X-14-S1-P8. PubMed: 22277065
    • Alpendurada F, Smith GC, Carpenter JP, Nair SV, Tanner MA et al. (2012) Effects of combined deferiprone with deferoxamine on right ventricular function in thalassaemia major. J Cardiovasc Magn Reson 14: 8-8. doi:10.1186/1532-429X- 14-S1-P8. PubMed: 22277065.
    • (2012) J Cardiovasc Magn Reson , vol.14 , pp. 8-8
    • Alpendurada, F.1    Smith, G.C.2    Carpenter, J.P.3    Nair, S.V.4    Tanner, M.A.5
  • 7
    • 80053455572 scopus 로고    scopus 로고
    • Efficacy and safety of Iranian made Deferasirox (Osveral?) in Iranian major thalassemic patients with transfusional iron overload: A one year prospective multicentric open-label non-comparative study
    • Eshghi P, Molavi M, Farahmandinia Z (2011) Efficacy and safety of Iranian made Deferasirox (Osveral?) in Iranian major thalassemic patients with transfusional iron overload: A one year prospective multicentric open-label non-comparative study. Daru - Journal of Pharmaceutical Sciences.
    • (2011) Daru - Journal of Pharmaceutical Sciences
    • Eshghi, P.1    Molavi, M.2    Farahmandinia, Z.3
  • 9
    • 80755175417 scopus 로고    scopus 로고
    • Evaluation of cardiac iron load by cardiac magnetic resonance in thalassemia
    • doi:10.1007/s13312-011-0115-9. PubMed: 21169646
    • Merchant RH, Joshi A, Ahmed J, Krishnan P, Jankharia B (2011) Evaluation of cardiac iron load by cardiac magnetic resonance in thalassemia. Indian Pediatr 48: 697-701. doi:10.1007/s13312-011-0115-9. PubMed: 21169646.
    • (2011) Indian Pediatr , vol.48 , pp. 697-701
    • Merchant, R.H.1    Joshi, A.2    Ahmed, J.3    Krishnan, P.4    Jankharia, B.5
  • 11
    • 78651061167 scopus 로고    scopus 로고
    • Improved efficacy and tolerability of oral deferasirox by twice-daily dosing for patients with transfusion-dependent β-thalassemia
    • doi:10.1002/pbc.22826
    • Chang HH, Lu MY, Liao YM, Lin PC, Yang YL et al. (2011) Improved efficacy and tolerability of oral deferasirox by twice-daily dosing for patients with transfusion-dependent β-thalassemia. Pediatric Blood and Cancer 56: 420-424. doi:10.1002/pbc.22826.
    • (2011) Pediatric Blood and Cancer , vol.56 , pp. 420-424
    • Chang, H.H.1    Lu, M.Y.2    Liao, Y.M.3    Lin, P.C.4    Yang, Y.L.5
  • 13
    • 0942298725 scopus 로고    scopus 로고
    • Comparative efficacy of desferrioxamine, deferiprone and in combination on iron chelation in thalassemic children
    • PubMed: 14767084
    • Gomber S, Saxena R, Madan N (2004) Comparative efficacy of desferrioxamine, deferiprone and in combination on iron chelation in thalassemic children. Indian Pediatr 41: 21-28. PubMed: 14767084.
    • (2004) Indian Pediatr , vol.41 , pp. 21-28
    • Gomber, S.1    Saxena, R.2    Madan, N.3
  • 14
    • 33646387405 scopus 로고    scopus 로고
    • Randomized controlled trial of deferiprone or deferoxamine in beta-thalassemia major patients with asymptomatic myocardial siderosis
    • doi:10.1182/blood-2005-07-2948. PubMed: 16352815
    • Pennell DJ, Berdoukas V, Karagiorga M, Ladis V, Piga A et al. (2006) Randomized controlled trial of deferiprone or deferoxamine in beta-thalassemia major patients with asymptomatic myocardial siderosis. Blood 107: 3738-3744. doi:10.1182/blood-2005-07-2948. PubMed: 16352815.
    • (2006) Blood , vol.107 , pp. 3738-3744
    • Pennell, D.J.1    Berdoukas, V.2    Karagiorga, M.3    Ladis, V.4    Piga, A.5
  • 15
    • 44449104925 scopus 로고    scopus 로고
    • Iron chelation in thalassemia: Combined or monotherapy? The Egyptian experience
    • doi:10.1007/s00277-008-0471-2. PubMed: 18351337
    • El-Beshlawy A, Manz C, Naja M, Eltagui M, Tarabishi C et al. (2008) Iron chelation in thalassemia: combined or monotherapy? The Egyptian experience. Ann Hematol 87: 545-550. doi:10.1007/s00277-008-0471-2. PubMed: 18351337.
    • (2008) Ann Hematol , vol.87 , pp. 545-550
    • El-Beshlawy, A.1    Manz, C.2    Naja, M.3    Eltagui, M.4    Tarabishi, C.5
  • 17
    • 33745568162 scopus 로고    scopus 로고
    • A randomized controlled study evaluating the safety and efficacy of deferiprone treatment in thalassemia major patients from Hong Kong
    • doi:10.1080/03630260600642617. PubMed: 16798652
    • Ha SY, Chik KW, Ling SC, Lee AC, Luk CW et al. (2006) A randomized controlled study evaluating the safety and efficacy of deferiprone treatment in thalassemia major patients from Hong Kong. Hemoglobin 30: 263-274. doi:10.1080/03630260600642617. PubMed: 16798652.
    • (2006) Hemoglobin , vol.30 , pp. 263-274
    • Ha, S.Y.1    Chik, K.W.2    Ling, S.C.3    Lee, A.C.4    Luk, C.W.5
  • 19
    • 80053488289 scopus 로고    scopus 로고
    • Effect of deferiprone or deferoxamine on right ventricular function in thalassemia major patients with myocardial iron overload
    • doi:10.1186/1532-429X-13-S1-M1. PubMed: 21208447
    • Smith GC, Alpendurada F, Carpenter JP, Alam MH, Berdoukas V et al. (2011) Effect of deferiprone or deferoxamine on right ventricular function in thalassemia major patients with myocardial iron overload. Journal of Cardiovascular Magnetic Resonance 13: 1-7. doi:10.1186/1532-429X-13-S1-M1. PubMed: 21208447.
    • (2011) Journal of Cardiovascular Magnetic Resonance , vol.13 , pp. 1-7
    • Smith, G.C.1    Alpendurada, F.2    Carpenter, J.P.3    Alam, M.H.4    Berdoukas, V.5
  • 20
    • 37049033278 scopus 로고    scopus 로고
    • A randomized controlled 1-year study of daily deferiprone plus twice weekly desferoxamine compared with daily deferiprone monotherapy in patients with thalassemia major
    • DOI 10.3324/haematol.11414
    • Aydinok Y, Ulger Z, Nart D, Terzi A, Cetiner N et al. (2007) A randomized controlled 1-year study of daily deferiprone plus twice weekly desferrioxamine compared with daily deferiprone monotherapy in patients with thalassemia major. Haematologica 92: 1599-1606. doi:10.3324/haematol.11414. PubMed: 18055982. (Pubitemid 350248238)
    • (2007) Haematologica , vol.92 , Issue.12 , pp. 1599-1606
    • Aydinok, Y.1    Ulger, Z.2    Nart, D.3    Terzi, A.4    Cetiner, N.5    Ellis, G.6    Zimmermann, A.7    Manz, C.8
  • 21
    • 0038472463 scopus 로고    scopus 로고
    • Safety monitoring of cardiac and hepatic systems in β-thalassemia patients with chelating treatment in Taiwan*
    • doi:10.1034/j.1600-0609.2003.00071.x. PubMed: 12756022
    • Peng CT, Chow KC, Chen JH, Chiang YP, Lin TY et al. (2003) Safety monitoring of cardiac and hepatic systems in β-thalassemia patients with chelating treatment in Taiwan*. Eur J Haematol 70: 392-397. doi:10.1034/j.1600-0609.2003.00071.x. PubMed: 12756022.
    • (2003) Eur J Haematol , vol.70 , pp. 392-397
    • Peng, C.T.1    Chow, K.C.2    Chen, J.H.3    Chiang, Y.P.4    Lin, T.Y.5
  • 23
    • 33646414765 scopus 로고    scopus 로고
    • A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with β-thalassemia
    • doi:10.1182/blood-2005-08-3430. PubMed: 16352812
    • Cappellini MD, Cohen A, Piga A, Bejaoui M, Perrotta S et al. (2006) A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with β-thalassemia. Blood 107: 3455-3462. doi:10.1182/blood-2005- 08-3430. PubMed: 16352812.
    • (2006) Blood , vol.107 , pp. 3455-3462
    • Cappellini, M.D.1    Cohen, A.2    Piga, A.3    Bejaoui, M.4    Perrotta, S.5
  • 24
    • 0242584372 scopus 로고    scopus 로고
    • Comparison between desferrioxamine and combined therapy with desferrioxamine and deferiprone in iron overloaded thalassaemia patients
    • DOI 10.1046/j.1365-2141.2003.04240.x
    • Mourad FH, Hoffbrand AV, Sheikh-Taha M, Koussa S, Khoriaty AI et al. (2003) Comparison between desferrioxamine and combined therapy with desferrioxamine and deferiprone in iron overloaded thalassaemia patients. Br J Haematol 121: 187-189. doi:10.1046/j.1365-2141.2003.04240.x. PubMed: 12670352. (Pubitemid 36461288)
    • (2003) British Journal of Haematology , vol.121 , Issue.1 , pp. 187-189
    • Mourad, F.H.1    Hoffbrand, A.V.2    Sheikh-Taha, M.3    Koussa, S.4    Khoriaty, A.I.5    Taher, A.6
  • 25
    • 34247103036 scopus 로고    scopus 로고
    • A randomized, placebo-controlled, double-blind trial of the effect of combined therapy with deferoxamine and deferiprone on myocardial iron in thalassemia major using cardiovascular magnetic resonance
    • DOI 10.1161/CIRCULATIONAHA.106.648790
    • Tanner MA, Galanello R, Dessi C, Smith GC, Westwood MA et al. (2007) A randomized, placebo-controlled, double-blind trial of the effect of combined therapy with deferoxamine and deferiprone on myocardial iron in thalassemia major using cardiovascular magnetic resonance. Circulation 115: 1876-1884. doi:10.1161/CIRCULATIONAHA.106.648790. PubMed: 17372174. (Pubitemid 46598901)
    • (2007) Circulation , vol.115 , Issue.14 , pp. 1876-1884
    • Tanner, M.A.1    Galanello, R.2    Dessi, C.3    Smith, G.C.4    Westwood, M.A.5    Agus, A.6    Roughton, M.7    Assomull, R.8    Nair, S.V.9    Walker, J.M.10    Pennell, D.J.11
  • 26
    • 84859576452 scopus 로고    scopus 로고
    • Observational study comparing long-term safety and efficacy of Deferasirox with Desferrioxamine therapy in chelation-naive children with transfusional iron overload
    • doi:10.1111/j.1600-0609.2012.01769.x. PubMed: 22335829
    • Aydinok Y, Unal S, Oymak Y, Vergin C, Türker ZD et al. (2012) Observational study comparing long-term safety and efficacy of Deferasirox with Desferrioxamine therapy in chelation-naive children with transfusional iron overload. Eur J Haematol 88: 431-438. doi:10.1111/j.1600-0609.2012.01769.x. PubMed: 22335829.
    • (2012) Eur J Haematol , vol.88 , pp. 431-438
    • Aydinok, Y.1    Unal, S.2    Oymak, Y.3    Vergin, C.4    Türker, Z.D.5
  • 27
    • 33748783066 scopus 로고    scopus 로고
    • A prospective randomized controlled trial on the safety and efficacy of alternating deferoxamine and deferiprone in the treatment of iron overload in patients with thalassemia
    • %@ 0390-6078
    • Galanello R, Kattamis A, Piga A, Fischer R, Leoni G, et al. (2006) A prospective randomized controlled trial on the safety and efficacy of alternating deferoxamine and deferiprone in the treatment of iron overload in patients with thalassemia. Haematologica 91: 1241-1243 %@ 0390-6078
    • (2006) Haematologica , vol.91 , pp. 1241-1243
    • Galanello, R.1    Kattamis, A.2    Piga, A.3    Fischer, R.4    Leoni, G.5
  • 28
    • 79957483630 scopus 로고    scopus 로고
    • Sequential alternating deferiprone and deferoxamine treatment compared to deferiprone monotherapy: Main findings and clinical follow-up of a large multicenter randomized clinical trial in -thalassemia major patients
    • doi: 10.3109/03630269.2011.570674. PubMed: 21599433
    • Pantalone GR, Maggio A, Vitrano A, Capra M, Cuccia L et al. (2011) Sequential alternating deferiprone and deferoxamine treatment compared to deferiprone monotherapy: main findings and clinical follow-up of a large multicenter randomized clinical trial in -thalassemia major patients. Hemoglobin 35: 206-216. doi: 10.3109/03630269.2011.570674. PubMed: 21599433.
    • (2011) Hemoglobin , vol.35 , pp. 206-216
    • Pantalone, G.R.1    Maggio, A.2    Vitrano, A.3    Capra, M.4    Cuccia, L.5
  • 29
    • 63149177947 scopus 로고    scopus 로고
    • Long-term sequential deferiprone-deferoxamine versus deferiprone alone for thalassaemia major patients: A randomized clinical trial
    • doi:10.1111/j.1365-2141.2009.07609.x. PubMed: 19236376
    • Maggio A, Vitrano A, Capra M, Cuccia L, Gagliardotto F et al. (2009) Long-term sequential deferiprone-deferoxamine versus deferiprone alone for thalassaemia major patients: a randomized clinical trial. Br J Haematol 145: 245-254. doi:10.1111/j.1365-2141.2009.07609.x. PubMed: 19236376.
    • (2009) Br J Haematol , vol.145 , pp. 245-254
    • Maggio, A.1    Vitrano, A.2    Capra, M.3    Cuccia, L.4    Gagliardotto, F.5
  • 30
    • 84864932660 scopus 로고    scopus 로고
    • Cardiac iron removal and functional cardiac improvement by different iron chelation regimens in thalassemia major patients
    • doi:10.1007/s00277-012-1480-8. PubMed: 22572843
    • Cassinerio E, Roghi A, Pedrotti P, Brevi F, Zanaboni L et al. (2012) Cardiac iron removal and functional cardiac improvement by different iron chelation regimens in thalassemia major patients. Ann Hematol 91: 1443-1449. doi:10.1007/s00277-012-1480-8. PubMed: 22572843.
    • (2012) Ann Hematol , vol.91 , pp. 1443-1449
    • Cassinerio, E.1    Roghi, A.2    Pedrotti, P.3    Brevi, F.4    Zanaboni, L.5
  • 32
    • 0344689355 scopus 로고    scopus 로고
    • Estimates of the effect on hepatic iron of oral deferiprone compared with subcutaneous desferrioxamine for treatment of iron overload in thalassemia major: A systematic review
    • %@ 1471-2326
    • Caro JJ, Huybrechts KF, Green TC (2002) Estimates of the effect on hepatic iron of oral deferiprone compared with subcutaneous desferrioxamine for treatment of iron overload in thalassemia major: a systematic review. BMC blood disorders 2: 4 %@ 1471-2326
    • (2002) BMC Blood Disorders , vol.2 , pp. 4
    • Caro, J.J.1    Huybrechts, K.F.2    Green, T.C.3
  • 33
    • 33745101113 scopus 로고    scopus 로고
    • Deferasirox--an oral agent for chronic iron overload
    • doi:10.1345/aph.1G566. PubMed: 16735647
    • Vanorden HE, Hagemann TM (2006) Deferasirox--an oral agent for chronic iron overload. Ann Pharmacother 40: 1110-1117. doi:10.1345/aph.1G566. PubMed: 16735647.
    • (2006) Ann Pharmacother , vol.40 , pp. 1110-1117
    • Vanorden, H.E.1    Hagemann, T.M.2
  • 34
    • 44249127965 scopus 로고    scopus 로고
    • Influence of iron chelators on myocardial iron and cardiac function in transfusion-dependent thalassaemia: A systematic review and meta-analysis
    • DOI 10.1111/j.1365-2141.2008.07122.x
    • Mamtani M, Kulkarni H (2008) Influence of iron chelators on myocardial iron and cardiac function in transfusion-dependent thalassaemia: a systematic review and meta-analysis. Br J Haematol 141: 882-890. doi:10.1111/j.1365-2141. 2008.07122.x. PubMed: 18355381. (Pubitemid 351724860)
    • (2008) British Journal of Haematology , vol.141 , Issue.6 , pp. 882-890
    • Mamtani, M.1    Kulkarni, H.2
  • 35
    • 77953779950 scopus 로고    scopus 로고
    • The effect of deferasirox on cardiac iron in thalassemia major: Impact of total body iron stores
    • doi:10.1182/blood-2009-11-250308. PubMed: 20421452
    • Wood JC, Kang BP, Thompson A, Giardina P, Harmatz P et al. (2010) The effect of deferasirox on cardiac iron in thalassemia major: impact of total body iron stores. Blood 116: 537-543. doi:10.1182/blood-2009-11-250308. PubMed: 20421452.
    • (2010) Blood , vol.116 , pp. 537-543
    • Wood, J.C.1    Kang, B.P.2    Thompson, A.3    Giardina, P.4    Harmatz, P.5
  • 36
    • 77649296214 scopus 로고    scopus 로고
    • Deferasirox (Exjade®) significantly improves cardiac T2*in heavily iron-overloaded patients with β-thalassemia major
    • doi:10.1007/s00277-009-0838-z. PubMed: 19798501
    • Pathare A, Taher A, Daar S (2010) Deferasirox (Exjade®) significantly improves cardiac T2*in heavily iron-overloaded patients with β-thalassemia major. Ann Hematol 89: 405-409. doi:10.1007/s00277-009-0838- z. PubMed: 19798501.
    • (2010) Ann Hematol , vol.89 , pp. 405-409
    • Pathare, A.1    Taher, A.2    Daar, S.3
  • 37
    • 77950617863 scopus 로고    scopus 로고
    • Efficacy of deferasirox in reducing and preventing cardiac iron overload in beta-thalassemia
    • doi:10.1182/blood-2009-04-217455. PubMed: 19996412
    • Pennell DJ, Porter JB, Cappellini MD, El-Beshlawy A, Chan LL et al. (2010) Efficacy of deferasirox in reducing and preventing cardiac iron overload in beta-thalassemia. Blood 115: 2364-2371. doi:10.1182/blood-2009-04-217455. PubMed: 19996412.
    • (2010) Blood , vol.115 , pp. 2364-2371
    • Pennell, D.J.1    Porter, J.B.2    Cappellini, M.D.3    El-Beshlawy, A.4    Chan, L.L.5
  • 38
    • 84864373876 scopus 로고    scopus 로고
    • Limitations of Meta-Analyses
    • PubMed: 21360019
    • Green D (2012) Limitations of Meta-Analyses. J Autism Dev Disord, 42: 1-2. PubMed: 21360019.
    • (2012) J Autism Dev Disord , vol.42 , pp. 1-2
    • Green, D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.