-
1
-
-
0035725868
-
Practical management of iron overload
-
Porter JB. Practical management of iron overload. Br J Haematol 2001;115:239-52.
-
(2001)
Br J Haematol
, vol.115
, pp. 239-252
-
-
Porter, J.B.1
-
4
-
-
0018866090
-
Serum ferritin, liver iron stores, and liver histology in children with thalassemia
-
deVirgiliis S, Sanna G, Cornacchia G, et al. Serum ferritin, liver iron stores, and liver histology in children with thalassemia. Arch Dis Child 1980;55:43-5.
-
(1980)
Arch Dis Child
, vol.55
, pp. 43-45
-
-
Virgiliis, S.1
Sanna, G.2
Cornacchia, G.3
-
5
-
-
0036976639
-
Thalassemia: Current approach to an old disease
-
Lo L, Singer ST. Thalassemia: current approach to an old disease. Pediatr Clin North Am 2002;49:1165-91.
-
(2002)
Pediatr Clin North Am
, vol.49
, pp. 1165-1191
-
-
Lo, L.1
Singer, S.T.2
-
6
-
-
0036431540
-
Monitoring chelation therapy to achieve optimal outcome in the treatment of beta-thalassemia
-
Porter JB, Davis BA. Monitoring chelation therapy to achieve optimal outcome in the treatment of beta-thalassemia. Best Pract Res Clin Haematol 2002;15:329-68.
-
(2002)
Best Pract Res Clin Haematol
, vol.15
, pp. 329-368
-
-
Porter, J.B.1
Davis, B.A.2
-
7
-
-
0020465049
-
Magnetic-susceptibility measurement of human iron stores
-
Brittenham GM, Farrell DE, Harris JW, et al. Magnetic-susceptibility measurement of human iron stores. N Engl J Med 1982;307:1671-5.
-
(1982)
N Engl J Med
, vol.307
, pp. 1671-1675
-
-
Brittenham, G.M.1
Farrell, D.E.2
Harris, J.W.3
-
8
-
-
0031001278
-
Iron-chelating therapy and the treatment of thalassemia
-
Olivieri NF, Brittenham GM. Iron-chelating therapy and the treatment of thalassemia. Blood 1997;89:739-61.
-
(1997)
Blood
, vol.89
, pp. 739-761
-
-
Olivieri, N.F.1
Brittenham, G.M.2
-
9
-
-
0033536288
-
The beta-thalassemias
-
Olivieri NF. The beta-thalassemias. N Engl J Med 1999;341:99-109.
-
(1999)
N Engl J Med
, vol.341
, pp. 99-109
-
-
Olivieri, N.F.1
-
12
-
-
10744230223
-
Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: A randomized, double-blind, placebo-controlled, dose-escalation trial
-
Nisbet-Brown E, Olivieri NF, Giardina PJ, et al. Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: a randomized, double-blind, placebo-controlled, dose-escalation trial. Lancet 2003;361:1597-602.
-
(2003)
Lancet
, vol.361
, pp. 1597-1602
-
-
Nisbet-Brown, E.1
Olivieri, N.F.2
Giardina, P.J.3
-
13
-
-
33745112221
-
-
Jan
-
National Horizon Scanning Center. Deferasirox (ICL670) for iron overload. Jan 2005. www.pcpoh.bham.ac.uk/publichealth/horizon (accessed 2005 Jun 20).
-
(2005)
Deferasirox (ICL670) for Iron Overload
-
-
-
14
-
-
0037906104
-
Safety, tolerability, and pharmacokinetics of ICL670, a new orally active iron-chelating agent in patients with transfusion-dependent iron overload due to β-thalassemia
-
Galanello R, Piga A, Alberti D, et al. Safety, tolerability, and pharmacokinetics of ICL670, a new orally active iron-chelating agent in patients with transfusion-dependent iron overload due to β-thalassemia. J Clin Pharmacol 2003;43:565-72.
-
(2003)
J Clin Pharmacol
, vol.43
, pp. 565-572
-
-
Galanello, R.1
Piga, A.2
Alberti, D.3
-
15
-
-
33745062600
-
-
East Hanover, NJ: Novartis Pharmaceuticals, November
-
Package insert. Exjade (deferasirox). East Hanover, NJ: Novartis Pharmaceuticals, November 2005.
-
(2005)
Package Insert. Exjade (Deferasirox)
-
-
-
17
-
-
0035865702
-
ICL670: A new synthetic oral chelator: Evaluation in hypertransfused rats with selective radioiron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture
-
Hershko C, Konijin AM, Nick HP, et al. ICL670: a new synthetic oral chelator: evaluation in hypertransfused rats with selective radioiron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture. Blood 2001;97:1115-22.
-
(2001)
Blood
, vol.97
, pp. 1115-1122
-
-
Hershko, C.1
Konijin, A.M.2
Nick, H.P.3
-
18
-
-
0033761055
-
Chelator-induced iron excretion in iron-overloaded marmosets
-
Sergejew T, Forgiarini P, Schnebli HP. Chelator-induced iron excretion in iron-overloaded marmosets. Br J Haematol 2000;110:985-92.
-
(2000)
Br J Haematol
, vol.110
, pp. 985-992
-
-
Sergejew, T.1
Forgiarini, P.2
Schnebli, H.P.3
-
19
-
-
14544276809
-
Iron-chelating therapy with the new oral agent ICL670 (Exjade)
-
Cappellini M. Iron-chelating therapy with the new oral agent ICL670 (Exjade). Best Pract Res Clin Haematol 2005;18:289-98.
-
(2005)
Best Pract Res Clin Haematol
, vol.18
, pp. 289-298
-
-
Cappellini, M.1
-
21
-
-
0012773702
-
Phase II study of oral chelator ICL670 in thalassemia patients with transfusional iron overload: Efficacy, safety, pharmacokinetics and pharmacodynamics after 6 months of therapy
-
Piga A, Galanello R, Cappellini MD, et al. Phase II study of oral chelator ICL670 in thalassemia patients with transfusional iron overload: efficacy, safety, pharmacokinetics and pharmacodynamics after 6 months of therapy (abstract). Blood 2002;100:5a.
-
(2002)
Blood
, vol.100
-
-
Piga, A.1
Galanello, R.2
Cappellini, M.D.3
-
22
-
-
27644547811
-
A Phase II study with ICL670 (Exjade), a once-daily oral iron chelator, in patients with various tranfusion-dependent anemias and iron overload
-
Porter J, Vichinsky E, Rose C, et al. A Phase II study with ICL670 (Exjade), a once-daily oral iron chelator, in patients with various tranfusion-dependent anemias and iron overload (abstract). Blood 2004;104:3193.
-
(2004)
Blood
, vol.104
, pp. 3193
-
-
Porter, J.1
Vichinsky, E.2
Rose, C.3
-
23
-
-
33745099982
-
The efficacy and tolerability of ICL670, a once-daily oral iron chelator, in patients with myelodysplastic syndrome (MDS) and iron overload
-
Gattermann N, Cazzola M, Greenberg P, et al. The efficacy and tolerability of ICL670, a once-daily oral iron chelator, in patients with myelodysplastic syndrome (MDS) and iron overload (abstract). Leuk Res 2005;29(suppl 1):S67.
-
(2005)
Leuk Res
, vol.29
, Issue.SUPPL. 1
-
-
Gattermann, N.1
Cazzola, M.2
Greenberg, P.3
-
24
-
-
27644456657
-
Phase III evaluation of once-daily, oral therapy with ICL670 (Exjade) versus deferoxamine in patients with β-thalassemia and transfusional hemosiderosis (abstract)
-
Cappellini M, Bejaoui M, Perrotta S, et al. Phase III evaluation of once-daily, oral therapy with ICL670 (Exjade) versus deferoxamine in patients with β-thalassemia and transfusional hemosiderosis (abstract). Blood 2004;104:3619.
-
(2004)
Blood
, vol.104
, pp. 3619
-
-
Cappellini, M.1
Bejaoui, M.2
Perrotta, S.3
-
26
-
-
27744518242
-
Once-daily treatment with the oral iron chelator ICL670 (Exjade): Results of a Phase II study in pediatric patients with β-thalassemia major
-
Piga A, Galanello R, Foschini ML, et al. Once-daily treatment with the oral iron chelator ICL670 (Exjade): results of a Phase II study in pediatric patients with β-thalassemia major (abstract). Blood 2004;104:3614.
-
(2004)
Blood
, vol.104
, pp. 3614
-
-
Piga, A.1
Galanello, R.2
Foschini, M.L.3
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