-
1
-
-
48649104994
-
The O-linked N-acetylglucosamine modification in cellular signaling and the immune system
-
doi:10.1038/embor.2008.129. PubMed: 18617890
-
Golks A, Guerini D (2008) The O-linked N-acetylglucosamine modification in cellular signaling and the immune system. EMBO Rep 9: 748-753. doi:10.1038/embor.2008.129. PubMed: 18617890.
-
(2008)
EMBO Rep
, vol.9
, pp. 748-753
-
-
Golks, A.1
Guerini, D.2
-
2
-
-
77957269724
-
The O-GlcNAc modification: Three-dimensional structure, enzymology and the development of selective inhibitors to probe disease
-
doi:10.1042/BST0381179. PubMed: 20863281
-
Davies GJ, Martinez-Fleites C (2010) The O-GlcNAc modification: three-dimensional structure, enzymology and the development of selective inhibitors to probe disease. Biochem Soc Trans 38: 1179-1188. doi:10.1042/BST0381179. PubMed: 20863281.
-
(2010)
Biochem Soc Trans
, vol.38
, pp. 1179-1188
-
-
Davies, G.J.1
Martinez-Fleites, C.2
-
3
-
-
77949309755
-
Structural analyses of enzymes involved in the O-GlcNAc modification
-
doi:10.1016/j.bbagen.2009.07.019. PubMed: 19647042
-
Martinez-Fleites C, He Y, Davies GJ (2010) Structural analyses of enzymes involved in the O-GlcNAc modification. Biochim Biophys Acta. 1800: 122-133. doi:10.1016/j.bbagen.2009.07.019. PubMed: 19647042.
-
(2010)
Biochim Biophys Acta
, vol.1800
, pp. 122-133
-
-
Martinez-Fleites, C.1
He, Y.2
Davies, G.J.3
-
4
-
-
77951299059
-
Glycopeptide-specific monoclonal antibodies suggest new roles for OGlcNAc
-
PubMed: 20305658
-
Teo CF, Ingale S, Wolfert MA, Elsayed GA, Nöt LG et al. (2010) Glycopeptide-specific monoclonal antibodies suggest new roles for OGlcNAc. Nat Chem Biol 6: 338-343. PubMed: 20305658.
-
(2010)
Nat Chem Biol
, vol.6
, pp. 338-343
-
-
Teo, C.F.1
Ingale, S.2
Wolfert, M.A.3
Elsayed, G.A.4
Nöt, L.G.5
-
5
-
-
79959381299
-
Cross-talk between O-GlcNAc-ylation and phosphorylation: Roles in signaling, transcription, and chronic Disease
-
Hart GW, Slawson C, Ramirez-Correa G, Lagerlof O (2011) Cross-talk between O-GlcNAc-ylation and phosphorylation: roles in signaling, transcription, and chronic Disease. Annual Rev Biochem 80:6: 1-6.34.
-
(2011)
Annual Rev Biochem
, vol.80
, Issue.6
-
-
Hart, G.W.1
Slawson, C.2
Ramirez-Correa, G.3
Lagerlof, O.4
-
6
-
-
0034705030
-
The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny
-
DOI 10.1073/pnas.100471497
-
Shafi R, Iyer SP, Ellies LG, O'Donnell N, Marek KW et al. (2000) The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny. Proc Natl Acad Sci U S A 97: 5735-5739. doi:10.1073/pnas.100471497. PubMed: 1080198. (Pubitemid 30367467)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.11
, pp. 5735-5739
-
-
Shafi, R.1
Iyer, S.P.N.2
Ellies, L.G.3
O'Donnell, N.4
Marek, K.W.5
Chui, D.6
Hart, G.W.7
Marth, J.D.8
-
7
-
-
0842347416
-
Ogt-Dependent X-Chromosome-Linked Protein Glycosylation Is a Requisite Modification in Somatic Cell Function and Embryo Viability
-
DOI 10.1128/MCB.24.4.1680-1690.2004
-
O'Donnell N, Zachara NE, Hart GW, Marth JD (2004) OGT-dependent X-chromosome-linked protein glycosylation is a requisite modification in somatic cell function and embryo viability. Mol Cell Biol 24: 1680-1690. doi:10.1128/MCB.24.4.1680-1690.2004. PubMed: 14749383. (Pubitemid 38167089)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.4
, pp. 1680-1690
-
-
O'Donnell, N.1
Zachara, N.E.2
Hart, G.W.3
Marth, J.D.4
-
8
-
-
35348866703
-
O-GlcNAc modification in diabetes and Alzheimer's disease
-
DOI 10.1039/b704905f
-
Dias WB, Hart GW (2007) O-GlcNAc modification in diabetes and Alzheimer's disease. Mol Biosyst 3: 766-772. doi:10.1039/b704905f. PubMed: 17940659. (Pubitemid 47587186)
-
(2007)
Molecular BioSystems
, vol.3
, Issue.11
, pp. 766-772
-
-
Dias, W.B.1
Hart, G.W.2
-
9
-
-
70349270677
-
O-GlcNAc cycling: Implications for neuro-degenerative disorders
-
doi:10.1016/j.biocel.2009.03.008. PubMed: 19782947
-
Lazarus BD, Love DC, Hanover JA (2009) O-GlcNAc cycling: implications for neuro-degenerative disorders. Int J Biochem Cell Biol 41: 2134-2146. doi:10.1016/j.biocel.2009.03.008. PubMed: 19782947.
-
(2009)
Int J Biochem Cell Biol
, vol.41
, pp. 2134-2146
-
-
Lazarus, B.D.1
Love, D.C.2
Hanover, J.A.3
-
10
-
-
47649114560
-
A potent mechanism-inspired O-GlCNAcase inhibitor that blocks phosphorylation of Tau in vivo
-
doi:10.1038/nchembio.96. PubMed: 18587388
-
Yuzwa SA, Macauley MS, Heinonen JE, Shan X, Dennis RJ (2008) A potent mechanism-inspired O-GlCNAcase inhibitor that blocks phosphorylation of Tau in vivo. Nat Chem Biol 4: 483-490. doi:10.1038/nchembio.96. PubMed: 18587388.
-
(2008)
Nat Chem Biol
, vol.4
, pp. 483-490
-
-
Yuzwa, S.A.1
Macauley, M.S.2
Heinonen, J.E.3
Shan, X.4
Dennis, R.J.5
-
11
-
-
84858664547
-
Increasing O-GlcNAc slows neurodegeneration ald stabilizes tau against aggregation
-
doi:10.1038/nchembio.797. PubMed: 22366723
-
Yuzwa SA, Shan X, Macauley MS, Clark T, Skorobogatko Y et al. (2012) Increasing O-GlcNAc slows neurodegeneration ald stabilizes tau against aggregation. Nat Chem Biol 8: 393-399. doi:10.1038/nchembio.797. PubMed: 22366723.
-
(2012)
Nat Chem Biol
, vol.8
, pp. 393-399
-
-
Yuzwa, S.A.1
Shan, X.2
Macauley, M.S.3
Clark, T.4
Skorobogatko, Y.5
-
12
-
-
67349143998
-
Classification and basic pathology of Alzheimer 's Disease
-
Duyckaerts C, Delatour B, Potier MC (2008) Classification and basic pathology of Alzheimer 's Disease. Acta Neuropathol 118: 5-36.
-
(2008)
Acta Neuropathol
, vol.118
, pp. 5-36
-
-
Duyckaerts, C.1
Delatour, B.2
Potier, M.C.3
-
13
-
-
77956056008
-
Animal models reveal role for Tau phosphorylation in human disease
-
doi:10.1016/j.bbadis.2009.09.008. PubMed: 19751831
-
Götz J, Gladbach A, Pennanen L, van Eersel J, Schild A (2010) Animal models reveal role for Tau phosphorylation in human disease. Biochim Biophys Acta 1802: 860-871. doi:10.1016/j.bbadis.2009.09.008. PubMed: 19751831.
-
(2010)
Biochim Biophys Acta
, vol.1802
, pp. 860-871
-
-
Götz, J.1
Gladbach, A.2
Pennanen, L.3
Van Eersel, J.4
Schild, A.5
-
14
-
-
77957872827
-
Modeling of Tau-mediated synaptic and neuronal degeneration in Alzheimer's disease
-
pii, 2010: 573138. PubMed: 20862366
-
Jaworski T, Kügler S, Van Leuven F (2010) Modeling of Tau-mediated synaptic and neuronal degeneration in Alzheimer's disease. Int J Alzheimer Dis pii, 2010: 573138. PubMed: 20862366
-
(2010)
Int J Alzheimer Dis
-
-
Jaworski, T.1
Kügler, S.2
Van Leuven, F.3
-
16
-
-
10544236116
-
The microtubule-associated protein tau is extensively modified with O- linked N-acetylglucosamine
-
DOI 10.1074/jbc.271.46.28741
-
Arnold CS, Johnson GV, Cole RN, Dong DL, Lee M et al. (1996) The microtubule-associated protein Tau is extensively modified with Olinked N-acetylglucosamine. J Biol Chem 271: 28741-28744. doi:10.1074/jbc.271.46.28741. PubMed: 8910513. (Pubitemid 26382566)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.46
, pp. 28741-28744
-
-
Shane, A.C.1
Johnson, G.V.W.2
Cole, R.N.3
Dong, D.L.-Y.4
Lee, M.5
Hart, G.W.6
-
17
-
-
0029815467
-
Glycosylation of microtubule-associated protein tau: An abnormal posttranslational modification in Alzheimer's disease
-
DOI 10.1038/nm0896-871
-
Wang JZ, Grundke-Iqbal I, Iqbal K (1996) Glycosylation of microtubule-associated protein Tau: an abnormal post-translational modification in Alzheimer's disease. Nat Med 2: 871-875. doi:10.1038/nm0896-871. PubMed: 8705855. (Pubitemid 26296756)
-
(1996)
Nature Medicine
, vol.2
, Issue.8
, pp. 871-875
-
-
Wang, J.-Z.1
Grundke-Iqbal, I.2
Iqbal, K.3
-
18
-
-
79954437580
-
Mapping O-GlcNAc modification sites on Tau and generation of a site-specific O-GlcNAc Tau antibody
-
doi:10.1007/s00726-010-0705-1. PubMed: 20706749
-
Yuzwa SA, Yadav AK, Skorobogatko Y, Clark T, Vosseller K et al. (2011) Mapping O-GlcNAc modification sites on Tau and generation of a site-specific O-GlcNAc Tau antibody. Amino Acids. 40: 857-868. doi:10.1007/s00726-010-0705-1. PubMed: 20706749.
-
(2011)
Amino Acids
, vol.40
, pp. 857-868
-
-
Yuzwa, S.A.1
Yadav, A.K.2
Skorobogatko, Y.3
Clark, T.4
Vosseller, K.5
-
19
-
-
50949099668
-
O-GlcNAc-ylation modulates the self-aggregation ability of the fourth microtubule-binding repeat of Tau
-
doi:10.1016/j.bbrc.2008.07.101. PubMed: 18671940
-
Yu CH, Si T, Wu WH, Hu J, Du JT et al. (2008) O-GlcNAc-ylation modulates the self-aggregation ability of the fourth microtubule-binding repeat of Tau. Biochem Biophys Res Commun 375: 59-62. doi:10.1016/j.bbrc.2008.07.101. PubMed: 18671940.
-
(2008)
Biochem Biophys Res Commun
, vol.375
, pp. 59-62
-
-
Yu, C.H.1
Si, T.2
Wu, W.H.3
Hu, J.4
Du, J.T.5
-
20
-
-
73649112749
-
Dysregulation of insulin signaling, glucose transporters, O-GlcNAc-ylation and phosphorylation of Tau and neurofilaments in the brain
-
doi:10.2353/ajpath.2009.090157. PubMed: 19815707
-
Deng Y, Li B, Iqbal K, Grundke-Iqbal I, Gong CX (2009) Dysregulation of insulin signaling, glucose transporters, O-GlcNAc-ylation and phosphorylation of Tau and neurofilaments in the brain.Am J Pathol 175: 2089-2098. doi:10.2353/ajpath.2009.090157. PubMed: 19815707.
-
(2009)
Am J Pathol
, vol.175
, pp. 2089-2098
-
-
Deng, Y.1
Li, B.2
Iqbal, K.3
Grundke-Iqbal, I.4
Gong, C.X.5
-
21
-
-
79954538679
-
Identification of O-GlcNAc sites within peptides of the Tau protein and their impact on phosphorylation
-
doi:10.1039/c0mb00337a. PubMed: 21327254
-
Smet-Nocca C, Broncel M, Wieruszeski JM, Tokarski C, Hanoulle X et al. (2011) Identification of O-GlcNAc sites within peptides of the Tau protein and their impact on phosphorylation. Mol Biosyst 7: 1420-1429. doi:10.1039/ c0mb00337a. PubMed: 21327254.
-
(2011)
Mol Biosyst
, vol.7
, pp. 1420-1429
-
-
Smet-Nocca, C.1
Broncel, M.2
Wieruszeski, J.M.3
Tokarski, C.4
Hanoulle, X.5
-
22
-
-
13644268449
-
Changed conformation of mutant tau-P301L underlies the moribund tauopathy, absent in progressive, nonlethal axonopathy of tau-4R/2N transgenic mice
-
DOI 10.1074/jbc.M409876200
-
Terwel D, Lasrado R, Snauwaert J, Vandeweert E, Van Haesendonck C et al. (2005) Changed conformation of mutant Tau.P301L mice underlies the moribund tauopathy, absent in progressive, nonlethal axonopathy of Tau-4R/2N transgenic mice. J Biol Chem 280: 3963-3973. PubMed: 15509565. (Pubitemid 40227485)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.5
, pp. 3963-3973
-
-
Terwel, D.1
Lasrado, R.2
Snauwaert, J.3
Vandeweert, E.4
Van Haesendonck, C.5
Borghgraef, P.6
Van Leuven, F.7
-
23
-
-
33645454579
-
Improved long-term potentiation and memory in young Tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy
-
doi:10.1523/JNEUROSCI.5425-05.2006. PubMed: 16571759
-
Boekhoorn K, Terwel D, Biemans B, Borghgraef P, Wiegert O et al. (2006) Improved long-term potentiation and memory in young Tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy. J Neurosci 26: 3514-3523. doi:10.1523/JNEUROSCI.5425-05.2006. PubMed: 16571759.
-
(2006)
J Neurosci
, vol.26
, pp. 3514-3523
-
-
Boekhoorn, K.1
Terwel, D.2
Biemans, B.3
Borghgraef, P.4
Wiegert, O.5
-
24
-
-
40449098952
-
Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice
-
DOI 10.2353/ajpath.2008.070904
-
Terwel D, Muyllaert D, Dewachter I, Borghgraef P, Croes S et al. (2008) Amyloid activates GSK3beta to aggravate neuronal tauopathy in bigenic mice. Am J Pathol 172: 786-798. doi:10.2353/ajpath.2008.070904. PubMed: 18258852. (Pubitemid 351354550)
-
(2008)
American Journal of Pathology
, vol.172
, Issue.3
, pp. 786-798
-
-
Terwel, D.1
Muyllaert, D.2
Dewachter, I.3
Borghgraef, P.4
Croes, S.5
Devijver, H.6
Van Leuven, F.7
-
25
-
-
76149113615
-
Upper Airway Dysfunction of Tau.P301L Mice correlates with tauopathy in Mid-brain and Ponto-Medullary brainstem Nuclei
-
doi:10.1523/JNEUROSCI.5261-09.2010. PubMed: 20130190
-
Dutschmann M, Menuet C, Stettner GM, Gestreau C, Borghgraef P et al. (2010) Upper Airway Dysfunction of Tau.P301L Mice correlates with tauopathy in Mid-brain and Ponto-Medullary brainstem Nuclei. J-Neuroscience 30: 1810-1821. doi:10.1523/JNEUROSCI.5261-09.2010. PubMed: 20130190.
-
(2010)
J-Neuroscience
, vol.30
, pp. 1810-1821
-
-
Dutschmann, M.1
Menuet, C.2
Stettner, G.M.3
Gestreau, C.4
Borghgraef, P.5
-
26
-
-
80052352120
-
Raphé tauopathy alters serotonin metabolism and breathing activity in terminal Tau.P301L mice: Possible implications for Tauopathies and Alzheimer's disease
-
doi:10.1016/j.resp.2011.06.030. PubMed: 21763469
-
Menuet C, Borghgraef P, Matarazzo V, Gielis L, Lajard AM et al. (2011) Raphé tauopathy alters serotonin metabolism and breathing activity in terminal Tau.P301L mice: possible implications for Tauopathies and Alzheimer's disease. Respir Physiol Neurobiol 178: 290-303. doi:10.1016/j.resp.2011.06.030. PubMed: 21763469.
-
(2011)
Respir Physiol Neurobiol
, vol.178
, pp. 290-303
-
-
Menuet, C.1
Borghgraef, P.2
Matarazzo, V.3
Gielis, L.4
Lajard, A.M.5
-
27
-
-
0035152814
-
Neurotrophins are required for nerve growth during development
-
PubMed: 11135642
-
Tucker KL, Meyer M, Barde YA (2001) Neurotrophins are required for nerve growth during development. Nat Neurosci 4: 29-37. PubMed: 11135642.
-
(2001)
Nat Neurosci
, vol.4
, pp. 29-37
-
-
Tucker, K.L.1
Meyer, M.2
Barde, Y.A.3
-
28
-
-
79851508769
-
Iminosugars past, present and future: Medicines for tomorrow
-
doi:10.1016/j.drudis.2010.08.017. PubMed: 20817006
-
Horne G, Wilson FX, Tinsley J, Williams DH, Storer R (2011) Iminosugars past, present and future: medicines for tomorrow. Drug Discov Today. 16: 107-118. doi:10.1016/j.drudis.2010.08.017. PubMed: 20817006.
-
(2011)
Drug Discov Today
, vol.16
, pp. 107-118
-
-
Horne, G.1
Wilson, F.X.2
Tinsley, J.3
Williams, D.H.4
Storer, R.5
-
29
-
-
0037117511
-
Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes
-
DOI 10.1073/pnas.072072399
-
Vosseller K, Wells L, Lane MD, Hart GW (2002) Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes. Proc Natl Acad Sci U S A 99: 5313-5318. doi:10.1073/pnas.072072399. PubMed: 11959983. (Pubitemid 34411545)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.8
, pp. 5313-5318
-
-
Vosseller, K.1
Wells, L.2
Lane, M.D.3
Hart, G.W.4
-
30
-
-
78649894035
-
Olinked beta-N-acetylglucosamine (O-GlcNAc) regulates stress-induced heat shock protein expression in a GSK-3beta-dependent manner
-
doi:10.1074/jbc.M110.131102. PubMed: 20926391
-
Kazemi Z, Chang H, Haserodt S, McKen C, Zachara NE (2010) Olinked beta-N-acetylglucosamine (O-GlcNAc) regulates stress-induced heat shock protein expression in a GSK-3beta-dependent manner. J Biol Chem 285: 39096-39107. doi:10.1074/jbc.M110.131102. PubMed: 20926391.
-
(2010)
J Biol Chem
, vol.285
, pp. 39096-39107
-
-
Kazemi, Z.1
Chang, H.2
Haserodt, S.3
McKen, C.4
Zachara, N.E.5
-
31
-
-
79959924071
-
Down-regulation of β-N-acetyl-D-glucosaminidase increases Akt1 activity in thyroid anaplastic cancer cells
-
PubMed: 21637923
-
Krześlak A, Jóźwiak P, Lipińska A (2011) Down-regulation of β-N-acetyl-D-glucosaminidase increases Akt1 activity in thyroid anaplastic cancer cells. Oncol Rep 26: 743-749. PubMed: 21637923.
-
(2011)
Oncol Rep
, vol.26
, pp. 743-749
-
-
Krześlak, A.1
Jóźwiak, P.2
Lipińska, A.3
-
32
-
-
58649120835
-
In vivo modulation of O-GlcNAc levels regulates hippocampal synaptic plasticity through interplay with phosphorylation
-
PubMed: 19004831
-
Tallent MK, Varghis N, Skorobogatko Y, Hernandez-Cuebas L, Whelan K et al. (2009) In vivo modulation of O-GlcNAc levels regulates hippocampal synaptic plasticity through interplay with phosphorylation. J Biol Chem 284: 174-181. PubMed: 19004831.
-
(2009)
J Biol Chem
, vol.284
, pp. 174-181
-
-
Tallent, M.K.1
Varghis, N.2
Skorobogatko, Y.3
Hernandez-Cuebas, L.4
Whelan, K.5
|