-
1
-
-
1642588228
-
Pancreatic cancer
-
DOI 10.1016/S0140-6736(04)15841-8, PII S0140673604158418
-
Li D, Xie K, Wolff R and Abbruzzese JL: Pancreatic cancer. Lancet 363: 1049-1057, 2004. (Pubitemid 38410779)
-
(2004)
Lancet
, vol.363
, Issue.9414
, pp. 1049-1057
-
-
Li, D.1
Xie, K.2
Wolff, R.3
Abbruzzese, J.L.4
-
2
-
-
33646577163
-
Genetics and biology of pancreatic ductal adenocarcinoma
-
DOI 10.1101/gad.1415606
-
Hezel AF, Kimmelman AC, Stanger BZ, Bardeesy N and Depinho RA: Genetics and biology of pancreatic ductal adenocarcinoma. Genes Dev 20: 1218-1249, 2006. (Pubitemid 43727584)
-
(2006)
Genes and Development
, vol.20
, Issue.10
, pp. 1218-1249
-
-
Hezel, A.F.1
Kimmelman, A.C.2
Stanger, B.Z.3
Bardeesy, N.4
DePinho, R.A.5
-
3
-
-
0036883940
-
Pancreatic cancer biology and genetics
-
DOI 10.1038/nrc949
-
Bardeesy N and DePinho RA: Pancreatic cancer biology and genetics. Nat Rev Cancer 2: 897-909, 2002. (Pubitemid 37328891)
-
(2002)
Nature Reviews Cancer
, vol.2
, Issue.12
, pp. 897-909
-
-
Bardeesy, N.1
DePinho, R.A.2
-
4
-
-
0033577982
-
Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs
-
DOI 10.1056/NEJM199906173402407
-
Wolfe MM, Lichtenstein DR and Singh G: Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs. N Engl J Med 340: 1888-1899, 1999. (Pubitemid 29272670)
-
(1999)
New England Journal of Medicine
, vol.340
, Issue.24
, pp. 1888-1899
-
-
Wolfe, M.M.1
Lichtenstein, D.R.2
Singh, G.3
-
5
-
-
0033199017
-
Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: Growth inhibition by nonsteroidal anti-inflammatory drugs
-
Molina MA, Sitja-Arnau M, Lemoine MG, Frazier ML and Sinicrope FA: Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. Cancer Res 59: 4356-4362, 1999. (Pubitemid 29418754)
-
(1999)
Cancer Research
, vol.59
, Issue.17
, pp. 4356-4362
-
-
Molina, M.A.1
Sitja-Arnau, M.2
Lemoine, M.G.3
Frazier, M.L.4
Sinicrope, F.A.5
-
6
-
-
34250703218
-
Suppression of pancreatic tumor growth by combination chemotherapy with sulindac and LC-1 is associated with cyclin D1 inhibition in vivo
-
DOI 10.1158/1535-7163.MCT-06-0794
-
Yip-Schneider MT, Wu H, Ralstin M, Yiannoutsos C, Crooks PA, Neelakantan S, Noble S, Nakshatri H, Sweeney CJ and Schmidt CM: Suppression of pancreatic tumor growth by combination chemotherapy with sulindac and LC-1 is associated with cyclin D1 inhibition in vivo. Mol Cancer Ther 6: 1736-1744, 2007. (Pubitemid 46954050)
-
(2007)
Molecular Cancer Therapeutics
, vol.6
, Issue.6
, pp. 1736-1744
-
-
Yip-Schneider, M.T.1
Wu, H.2
Ralstin, M.3
Yiannoutsos, C.4
Crooks, P.A.5
Neelakantan, S.6
Noble, S.7
Nakshatri, H.8
Sweeney, C.J.9
Schmidt, C.M.10
-
7
-
-
18044376489
-
Parthenolide and sulindac cooperate to mediate growth suppression and inhibit the nuclear factor-kappaB pathway in pancreatic carcinoma cells
-
DOI 10.1158/1535-7163.MCT-04-0215
-
Yip-Schneider MT, Nakshatri H, Sweeney CJ, Marshall MS, Wiebke EA and Schmidt CM: Parthenolide and sulindac cooperate to mediate growth suppression and inhibit the nuclear factor-kappa B pathway in pancreatic carcinoma cells. Mol Cancer Ther 4: 587-594, 2005. (Pubitemid 40601840)
-
(2005)
Molecular Cancer Therapeutics
, vol.4
, Issue.4
, pp. 587-594
-
-
Yip-Schneider, M.T.1
Nakshatri, H.2
Sweeney, C.J.3
Marshall, M.S.4
Wiebke, E.A.5
Schmidt, C.M.6
-
8
-
-
0242349249
-
MEK Inhibition of Pancreatic Carcinoma Cells by U0126 and Its Effect in Combination with Sulindac
-
DOI 10.1097/00006676-200311000-00012
-
Yip-Schneider MT and Schmidt CM: MEK inhibition of pancreatic carcinoma cells by U0126 and its effect in combination with sulindac. Pancreas 7: 337-344, 2003. (Pubitemid 37337901)
-
(2003)
Pancreas
, vol.27
, Issue.4
, pp. 337-344
-
-
Yip-Schneider, M.T.1
Schmidt, C.M.2
-
9
-
-
78149248334
-
Phospho-sulindac (OXT-922) inhibits the growth of human colon cancer cell lines: A redox/polyamine-dependent effect
-
Huang L, Zhu C, Sun Y, Xie G, Mackenzie GG, Qiao G, Komninou D and Rigas B: Phospho-sulindac (OXT-922) inhibits the growth of human colon cancer cell lines: a redox/polyamine-dependent effect. Carcinogenesis 31: 1982-1990, 2010.
-
(2010)
Carcinogenesis
, vol.31
, pp. 1982-1990
-
-
Huang, L.1
Zhu, C.2
Sun, Y.3
Xie, G.4
Mackenzie, G.G.5
Qiao, G.6
Komninou, D.7
Rigas, B.8
-
10
-
-
77957350899
-
Phosphosulindac (OXT-328), a novel sulindac derivative, is safe and effective in colon cancer prevention in mice
-
Mackenzie GG, Sun Y, Huang L, Xie G, Ouyang N, Gupta RC, Johnson F, Komninou D, Kopelovich L and Rigas B: Phosphosulindac (OXT-328), a novel sulindac derivative, is safe and effective in colon cancer prevention in mice. Gastroenterology 139: 1320-1332, 2010.
-
(2010)
Gastroenterology
, vol.139
, pp. 1320-1332
-
-
Mackenzie, G.G.1
Sun, Y.2
Huang, L.3
Xie, G.4
Ouyang, N.5
Gupta, R.C.6
Johnson, F.7
Komninou, D.8
Kopelovich, L.9
Rigas, B.10
-
11
-
-
84863257781
-
The metabolism and pharmacokinetics of phosphosulindac (OXT-328) and the effect of difluoromethylornithine
-
Xie G, Nie T, Mackenzie GG, Sun Y, Huang L, Ouyang N, Alston N, Zhu C, Murray OT, Constantinides PP, Kopelovich L and Rigas B: The metabolism and pharmacokinetics of phosphosulindac (OXT-328) and the effect of difluoromethylornithine. Br J Pharmacol 165: 2152-2166, 2012.
-
(2012)
Br J Pharmacol
, vol.165
, pp. 2152-2166
-
-
Xie, G.1
Nie, T.2
Mackenzie, G.G.3
Sun, Y.4
Huang, L.5
Ouyang, N.6
Alston, N.7
Zhu, C.8
Murray, O.T.9
Constantinides, P.P.10
Kopelovich, L.11
Rigas, B.12
-
12
-
-
77956175013
-
NFAT, immunity and cancer: A transcription factor comes of age
-
Muller MR and Rao A: NFAT, immunity and cancer: a transcription factor comes of age. Nat Rev Immunol 10: 645-656, 2010.
-
(2010)
Nat Rev Immunol
, vol.10
, pp. 645-656
-
-
Muller, M.R.1
Rao, A.2
-
13
-
-
70350514636
-
NFAT proteins: Emerging roles in cancer progression
-
Mancini M and Toker A: NFAT proteins: emerging roles in cancer progression. Nat Rev Cancer 9: 810-820, 2009.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 810-820
-
-
Mancini, M.1
Toker, A.2
-
14
-
-
84862080324
-
Resistance to ABT-737 in activated T lymphocytes: Molecular mechanisms and reversibility by inhibition of the calcineurin-NFAT pathway
-
Cippa PE, Kraus AK, Lindenmeyer MT, Chen J, Guimezanes A, Bardwell PD, Wekerle T, Wuthrich RP and Fehr T: Resistance to ABT-737 in activated T lymphocytes: molecular mechanisms and reversibility by inhibition of the calcineurin-NFAT pathway. Cell Death Dis 3: e299, 2012.
-
(2012)
Cell Death Dis
, vol.3
-
-
Cippa, P.E.1
Kraus, A.K.2
Lindenmeyer, M.T.3
Chen, J.4
Guimezanes, A.5
Bardwell, P.D.6
Wekerle, T.7
Wuthrich, R.P.8
Fehr, T.9
-
15
-
-
77954299059
-
+ leukemia cells upon inhibition of Bcr-Abl
-
+ leukemia cells upon inhibition of Bcr-Abl. Cancer Cell 18: 74-87, 2010.
-
(2010)
Cancer Cell
, vol.18
, pp. 74-87
-
-
Gregory, M.A.1
Phang, T.L.2
Neviani, P.3
Alvarez-Calderon, F.4
Eide, C.A.5
O'Hare, T.6
Zaberezhnyy, V.7
Williams, R.T.8
Druker, B.J.9
Perrotti, D.10
Degregori, J.11
-
16
-
-
54249105017
-
The thioredoxin system mediates redox-induced cell death in human colon cancer cells: Implications for the mechanism of action of anticancer agents
-
Sun Y and Rigas B: The thioredoxin system mediates redox-induced cell death in human colon cancer cells: implications for the mechanism of action of anticancer agents. Cancer Res 68: 8269-8277, 2008.
-
(2008)
Cancer Res
, vol.68
, pp. 8269-8277
-
-
Sun, Y.1
Rigas, B.2
-
17
-
-
33646268630
-
Nitric oxide-donating aspirin prevents pancreatic cancer in a hamster tumor model
-
Ouyang N, Williams JL, Tsioulias GJ, Gao J, Iatropoulos MJ, Kopelovich L, Kashfi K and Rigas B: Nitric oxide-donating aspirin prevents pancreatic cancer in a hamster tumor model. Cancer Res 66: 4503-4511, 2006.
-
(2006)
Cancer Res
, vol.66
, pp. 4503-4511
-
-
Ouyang, N.1
Williams, J.L.2
Tsioulias, G.J.3
Gao, J.4
Iatropoulos, M.J.5
Kopelovich, L.6
Kashfi, K.7
Rigas, B.8
-
18
-
-
80052179488
-
Oxidative stress mediates through apoptosis the anticancer effect of phosphononsteroidal anti-inflammatory drugs: Implications for the role of oxidative stress in the action of anticancer agents
-
Sun Y, Huang L, Mackenzie GG and Rigas B: Oxidative stress mediates through apoptosis the anticancer effect of phosphononsteroidal anti-inflammatory drugs: implications for the role of oxidative stress in the action of anticancer agents. J Pharmacol Exp Ther 338: 775-783, 2011.
-
(2011)
J Pharmacol Exp Ther
, vol.338
, pp. 775-783
-
-
Sun, Y.1
Huang, L.2
Mackenzie, G.G.3
Rigas, B.4
-
19
-
-
84860875508
-
Phospho-ibuprofen (MDC-917) incorporated in nanocarriers: Anti-cancer activity in vitro and in vivo
-
Nie T, Wong CC, Alston N, Aro P, Constantinides PP and Rigas B: Phospho-ibuprofen (MDC-917) incorporated in nanocarriers: Anti-cancer activity in vitro and in vivo. Br J Pharmacol 166: 991-1001, 2011.
-
(2011)
Br J Pharmacol
, vol.166
, pp. 991-1001
-
-
Nie, T.1
Wong, C.C.2
Alston, N.3
Aro, P.4
Constantinides, P.P.5
Rigas, B.6
-
20
-
-
33747616250
-
2+/calcineurin signaling pathway
-
DOI 10.1038/sj.emboj.7601246, PII 7601246
-
Buchholz M, Schatz A, Wagner M, Michl P, Linhart T, Adler G, Gress TM and Ellenrieder V: Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway. EMBO J 25: 3714-3724, 2006. (Pubitemid 44264881)
-
(2006)
EMBO Journal
, vol.25
, Issue.15
, pp. 3714-3724
-
-
Buchholz, M.1
Schatz, A.2
Wagner, M.3
Michl, P.4
Linhart, T.5
Adler, G.6
Gress, T.M.7
Ellenrieder, V.8
-
21
-
-
15744397205
-
Expression and function of the nuclear factor of activated T cells in colon carcinoma cells: Involvement in the regulation of cyclooxygenase-2
-
DOI 10.1074/jbc.M413076200
-
Duque J, Fresno M and Iniguez MA: Expression and function of the nuclear factor of activated T cells in colon carcinoma cells: involvement in the regulation of cyclooxygenase-2. J Biol Chem 280: 8686-8693, 2005. (Pubitemid 40409556)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.10
, pp. 8686-8693
-
-
Duque, J.1
Fresno, M.2
Iniguez, M.A.3
-
22
-
-
0036297295
-
Chemical induction of cellular antioxidants affords marked protection against oxidative injury in vascular smooth muscle cells
-
DOI 10.1006/bbrc.2002.6614
-
Cao Z and Li Y: Chemical induction of cellular antioxidants affords marked protection against oxidative injury in vascular smooth muscle cells. Biochem Biophys Res Commun 292: 50-57, 2002. (Pubitemid 34687327)
-
(2002)
Biochemical and Biophysical Research Communications
, vol.292
, Issue.1
, pp. 50-57
-
-
Cao, Z.1
Li, Y.2
-
23
-
-
0141483523
-
Transcriptional regulation by calcium, calcineurin, and NFAT
-
DOI 10.1101/gad.1102703
-
Hogan PG, Chen L, Nardone J and Rao A: Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev 17: 2205-2232, 2003. (Pubitemid 37128637)
-
(2003)
Genes and Development
, vol.17
, Issue.18
, pp. 2205-2232
-
-
Hogan, P.G.1
Chen, L.2
Nardone, J.3
Rao, A.4
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