Wild blueberry consumption affects aortic vascular function in the obese Zucker rat

Applied Physiology, Nutrition and Metabolism

Volumn 39, Issue 2, 2014, Pages 255-261

  Vendrame, Stefano ^a   Kristo, Aleksandra S ^a   Schuschke, Dale A ^b   Klimis Zacas, Dorothy ^a  

^a UNIVERSITY OF MAINE   (United States)

^b University of Louisville School of Medicine   (United States)

Author keywords

Anthocyanins; Endothelial dysfunction; Metabolic syndrome; Nitric oxide; Vasoconstriction; Vasorelaxation

Indexed keywords

ANIMAL; AORTA; BLUEBERRY; MALE; OBESITY; PATHOPHYSIOLOGY; RAT; VASOCONSTRICTION; VASODILATATION; ZUCKER RAT;

ANIMALS; AORTA; BLUEBERRY PLANT; MALE; OBESITY; RATS; RATS, ZUCKER; VASOCONSTRICTION; VASODILATION;

EID: 84893405075     PISSN: 17155312     EISSN: 17155320     Source Type: Journal    
DOI: 10.1139/apnm-2013-0249     Document Type: Article

References (31)

1. Andrews, T. J., Laight, D. W., Anggård, E. E., and Carrier, M. J. 2000. Investigation of endothelial hyperreactivity in the obese Zucker rat in-situ: reversal by vitamin E. J. Pharm. Pharmacol. 52 (1): 83-86. doi:10.1211/0022357001773544. PMID:10716607.
2. Auguet, M., Delaflotte, S., and Braquet, P. 1989. Increased influence of endothelium in obese Zucker rat aorta. J. Pharm. Pharmacol. 41 (12): 861-864. doi:10.1111/j.2042-7158.1989.tb06389.x. PMID:2576451.
3. De Artiñano, A., and Castro, M. 2009. Experimental rat models to study the metabolic syndrome. Br. J. Nutr. 9: 1246-1253. doi:10.1017/S0007114509990729. PMID:19631025.
4. Del Bo', C., Kristo, A. S., Kalea, A. Z., Ciappellano, S., Riso, P., Porrini, M., and Klimis-Zacas, D. 2012. The temporal effect of a wild blueberry (Vaccinium angustifolium)-enriched diet on vasomotor tone in the Sprague-Dawley rat. Nutr. Metab. Cardiovasc. Dis. 22 (2): 127-132. doi:10.1016/j.numecd.2010.05.004. PMID:20709513.
5. Häkkinen, S. H., and Törrönen, A. R. 1999. Screening of selected flavonoids and phenolic acids in 19 berries. Food Res. Int. 32: 345-353. doi:10.1016/S0963-9969(99)00095-2.
6. Institoris, A., Snipes, J. A., Katakam, P. V., Domoki, F., Boda, K., Bari, F., and Busija, D. W. 2011. Impaired vascular responses of insulin-resistant rats after mild subarachnoid hemorrhage. Am. J. Physiol. Heart Circ. Physiol. 300 (6): H2080-H2087. doi:10.1152/ajpheart.01169.2010. PMID:21421821.
7. Kalea, A. Z., Lamari, F. N., Theocharis, A. D., Cordopatis, P., Schuschke, D. A., Karamanos, N. K., and Klimis-Zacas, D. J. 2006. Wild blueberry (Vaccinium angustifolium) consumption affects the composition and structure of glycosaminoglycans in Sprague-Dawley rat aorta. J. Nutr. Biochem. 17 (2): 109-116. doi:10.1016/j.jnutbio.2005.05.015. PMID:16111874.
8. Kalea, A. Z., Clark, K., Schuschke, D. A., and Klimis-Zacas, D. J. 2009. Vascular reactivity is affected by dietary consumption of wild blueberries in the Sprague-Dawley rat. J. Med. Food, 12 (1): 21-28. doi:10.1089/jmf.2008.0078. PMID:19298192.
9. Kalea, A. Z., Clark, K., Schuschke, D. A., Kristo, A. S., and Klimis-Zacas, D. J. 2010. Dietary enrichment with wild blueberries (Vaccinium angustifolium) affects the vascular reactivity in the aorta of young spontaneously hypertensive rats. J. Nutr. Biochem. 21 (1): 14-22. doi:10.1016/j.jnutbio.2008.09.005. PMID:19157824.
10. Kristo, A. S., Kalea, A. Z., Schuschke, D. A., and Klimis-Zacas, D. J. 2010. A wild blueberry-enriched diet (Vaccinium angustifolium) improves vascular tone in the adult spontaneously hypertensive rat. J. Agric. Food Chem. 58 (22): 11600-11605. doi:10.1021/jf101839u. PMID:20964405.
11. Kristo, A. S., Malavaki, C. J., Lamari, F. N., Karamanos, N. K., and Klimis-Zacas, D. 2012. Wild blueberry (V. angustifolium)-enriched diets alter aortic glycosaminoglycan profile in the spontaneously hypertensive rat. J. Nutr. Biochem. 23 (8): 961-965. doi:10.1016/j.jnutbio.2011.05.002. PMID:21925856.
12. Landberg, R., Naidoo, N., and van Dam, R. M. 2012. Diet and endothelial function: from individual components to dietary patterns. Curr. Opin. Lipidol. 23 (2): 147-55. doi:10.1097/MOL.0b013e328351123a. PMID:22327611.
13. Liang, Y. C., Huang, Y. T., Tsai, S. H., Lin-Shiau, S. Y., Chen, C. F., and Lin, J. K. 1999. Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages. Carcinogenesis, 20 (10): 1945-1952. doi:10.1093/carcin/20.10.1945. PMID:10506109.
14. Livak, K. J., and Schmittgen, T. D. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the Delta Delta CT method. Methods, 25: 402-408. doi:10.1006/meth.2001.1262. PMID:11846609.
15. Marti, C. N., Gheorghiade, M., Kalogeropoulos, A. P., Georgiopoulou, V. V., Quyyumi, A. A., and Butler, J. 2012. Endothelial dysfunction, arterial stiffness, and heart failure. J. Am. Coll. Cardiol. 60 (16): 1455-1469. doi:10.1016/j.jacc.2011.11.082. PMID:22999723.
16. Mollace, V., Muscoli, C., Masini, E., Cuzzocrea, S., and Salvemini, D. 2005. Modulation of prostaglandin biosynthesis by nitric oxide and nitric oxide donors. Pharmacol. Rev. 57 (2): 217-252. doi:10.1124/pr.57.2.1. PMID:15914468.
17. Moncada, S., and Higgs, A. 1993. The L-arginine-nitric oxide pathway. N. Engl. J. Med. 329 (27): 2002-2012. doi:10.1056/NEJM199312303292706. PMID:7504210.
18. Moral-Sanz, J., Menendez, C., Moreno, L., Moreno, E., Cogolludo, A., and Perez-Vizcaino, F. 2011. Pulmonary arterial dysfunction in insulin resistant obese Zucker rats. Respir. Res. 12: 51. doi:10.1186/1465-9921-12-51. PMID:21513515.
19. Norton, C., Kalea, A. Z., Harris, P. D., and Klimis-Zacas, D. J. 2005. Wild blueberryrich diets affect the contractile machinery of the vascular smooth muscle in the Sprague-Dawley rat. J. Med. Food, 8 (1): 8-13. doi:10.1089/jmf.2005.8.8. PMID:15857202.
20. Oltman, C. L., Richou, L. L., Davidson, E. P., Coppey, L. J., Lund, D. D., and Yorek, M. A. 2006. Progression of coronary and mesenteric vascular dysfunction in Zucker obese and Zucker diabetic fatty rats. Am. J. Physiol. Heart Circ. Physiol. 291 (4): H1780-H1787. doi:10.1152/ajpheart.01297.2005. PMID:16714356.
21. Picchi, A., Gao, X., Belmadani, S., Potter, B. J., Focardi, M., Chilian, W. M., and Zhang, C. 2006. Tumor necrosis factor-alpha induces endothelial dysfunction in the prediabetic metabolic syndrome. Circ. Res. 99 (1): 69-77. doi:10.1161/01.RES.0000229685.37402.80. PMID:16741160.
22. Prasad, H., Ryan, D. A., Celzo, M. F., and Stapleton, D. 2012. Metabolic syndrome: definition and therapeutic implications. Postgrad. Med. 124 (1): 21-30. doi:10.3810/pgm.2012.01.2514. PMID:22314111.
23. Rodriguez-Mateos, A., Ishisaka, A., Mawatari, K., Vidal-Diez, A., Spencer, J. P., and Terao, J. 2013. Blueberry intervention improves vascular reactivity and lowers blood pressure in high-fat-, high-cholesterol-fed rats. Br. J. Nutr. 109 (10): 1746-1754. doi:10.1017/S0007114512003911. PMID:23046999.
24. Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Benjamin, E. J., Berry, J. D., Borden, W. B., et al. 2012. Heart disease and stroke statistics-2012 update: a report from the American Heart Association. Circulation, 125 (1): e2-e220. doi:10.1161/CIR.0b013e31823ac046. PMID:22179539.
25. Romanko, O. P., and Stepp, D. W. 2005. Reduced constrictor reactivity balances impaired vasodilation in the mesenteric circulation of the obese Zucker rat. Am. J. Physiol. Heart Circ. Physiol. 289 (5): H2097-H2102. doi:10.1152/ajpheart.00213.2005. PMID:15951349.
26. Sánchez, A., Contreras, C., Martínez, P., Villalba, N., Benedito, S., García-Sacristán, A., et al. 2010. Enhanced cyclooxygenase 2-mediated vasorelaxation in coronary arteries from insulin-resistant obese Zucker rats. Atherosclerosis, 213 (2): 392-399. doi:10.1016/j.atherosclerosis.2010.09.022. PMID:20956003.
27. Subramanian, R., and MacLeod, K. M. 2003. Age-dependent changes in blood pressure and arterial reactivity in obese Zucker rats. Eur. J. Pharmacol. 477 (2): 143-152. doi:10.1016/j.ejphar.2003.08.003. PMID:14519418.
28. Vanhoutte, P. M. 2003. Endothelial control of vasomotor function: from health to coronary disease. Circ. J. 67 (7): 572-575. doi:10.1253/circj.67.572. PMID:12845177.
29. Vendrame, S., Daugherty, A., Kristo, A. S., Riso, P., and Klimis-Zacas, D. 2013. Wild blueberry (Vaccinium angustifolium) consumption improves inflammatory status in the obese Zucker rat model of the metabolic syndrome. J. Nutr. Biochem. 24 (8): 1508-1512. doi:10.1016/j.jnutbio.2012.12.010. PMID:23465589.
30. Vessières, E., Belin de Chantemèle, E. J., Toutain, B., Guihot, A. L., Jardel, A., Loufrani, L., and Henrion, D. 2010. Cyclooxygenase-2 inhibition restored endothelium-mediated relaxation in old obese zucker rat mesenteric arteries. Front. Physiol. 1: 145. doi:10.3389/fphys.2010.00145. PMID:21423385.
31. Villalba, N., Martínez, P., Bríones, A. M., Sánchez, A., Salaíces, M., García-Sacristán, A., et al. 2009. Differential structural and functional changes in penile and coronary arteries from obese Zucker rats. Am. J. Physiol. Heart Circ. Physiol. 297 (2): H696-H707. doi:10.1152/ajpheart.01308.2008. PMID:19542483.