The miR-17/106-p38 axis is a key regulator of the neurogenic-to-gliogenic transition in developing neural stem/progenitor cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 4, 2014, Pages 1604-1609

  Naka Kaneda, Hayato ^a,b   Nakamura, Shiho ^a,b   Igarashi, Mana ^a,c   Aoi, Hisashi ^d   Kanki, Hiroaki ^b   Tsuyama, Jun ^b   Tsutsumi, Shuichi ^e   Aburatani, Hiroyuki ^e   Shimazaki, Takuya ^b   Okano, Hideyuki ^b  

^a RIKEN Center for Integrative Medical Sciences   (Japan)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c Biwako Kusatsu Campus Research Organization of Social Sciences   (United States)

^d RITSUMEIKAN UNIVERSITY   (Japan)

^e UNIVERSITY OF TOKYO   (Japan)

Author keywords

Differentiation; Fate determination; Glia; Neural development; Neurogenesis

Indexed keywords

MICRORNA; MICRORNA 106; MICRORNA 17; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; GENE; GFAP GENE; GLIA CELL; MAPK14 GENE; MOUSE; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; STEM CELL;

DIFFERENTIATION; FATE DETERMINATION; GLIA; NEURAL DEVELOPMENT; NEUROGENESIS;

ANIMALS; BASE SEQUENCE; CELL DIFFERENTIATION; GLIAL FIBRILLARY ACIDIC PROTEIN; MICE; MICE, INBRED ICR; MICRORNAS; NEURAL STEM CELLS; NEUROGLIA; NEURONS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROMOTER REGIONS, GENETIC; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84893386176     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1315567111     Document Type: Article

References (28)

1. Okano H (2010) Neural stem cells and strategies for the regeneration of the central nervous system. Proc Jpn Acad, Ser B, Phys Biol Sci 86(4):438-450.
2. Nori S, et al. (2011) Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice. Proc Natl Acad Sci USA 108(40):16825-16830.
3. Naka H, Nakamura S, Shimazaki T, Okano H (2008) Requirement for COUP-TFI and II in the temporal specification of neural stem cells in CNS development. Nat Neurosci 11(9):1014-1023.
4. Shen Q, et al. (2006) The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells. Nat Neurosci 9(6):743-751.
5. He L, et al. (2005) A microRNA polycistron as a potential human oncogene. Nature 435(7043):828-833.
6. Ventura A, et al. (2008) Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell 132(5):875-886.
7. Concepcion CP, Bonetti C, Ventura A (2012) The microRNA-17-92 family of microRNA clusters in development and disease. Cancer J 18(3):262-267.
8. Kawaguchi A, et al. (2001) Nestin-EGFP transgenic mice: Visualization of the self-renewal and multipotency of CNS stem cells. Mol Cell Neurosci 17(2):259-273.
9. Roy A, et al. (2012) Onecut transcription factors act upstream of Isl1 to regulate spinal motoneuron diversification. Development 139(17):3109-3119.
10. Koblar SA, et al. (1998) Neural precursor differentiation into astrocytes requires signaling through the leukemia inhibitory factor receptor. Proc Natl Acad Sci USA 95(6): 3178-3181.
11. Nakashima K, et al. (1999) Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300. Science 284(5413):479-482.
12. Nakashima K, et al. (2001) BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis. Proc Natl Acad Sci USA 98(10):5868-5873.
13. Takizawa T, et al. (2001) DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain. Dev Cell 1(6):749-758.
14. Li W, Cogswell CA, LoTurco JJ (1998) Neuronal differentiation of precursors in the neocortical ventricular zone is triggered by BMP. J Neurosci 18(21):8853-8862.
15. Haraguchi T, Ozaki Y, Iba H (2009) Vectors expressing efficient RNA decoys achieve the long-term suppression of specific microRNA activity in mammalian cells. Nucleic Acids Res 37(6):e43.
16. Barnabé-Heider F, et al. (2005) Evidence that embryonic neurons regulate the onset of cortical gliogenesis via cardiotrophin-1. Neuron 48(2):253-265.
17. Schmid RS, et al. (2003) Neuregulin 1-erbB2 signaling is required for the establishment of radial glia and their transformation into astrocytes in cerebral cortex. Proc Natl Acad Sci USA 100(7):4251-4256.
18. Sardi SP, Murtie J, Koirala S, Patten BA, Corfas G (2006) Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain. Cell 127(1):185-197.
19. Gauthier AS, et al. (2007) Control of CNS cell-fate decisions by SHP-2 and its dysregulation in Noonan syndrome. Neuron 54(2):245-262.
20. Grillari J, Hackl M, Grillari-Voglauer R (2010) miR-17-92 cluster: Ups and downs in cancer and aging. Biogerontology 11(4):501-506.
21. Yang Y, Chaerkady R, Beer MA, Mendell JT, Pandey A (2009) Identification of miR-21 targets in breast cancer cells using a quantitative proteomic approach. Proteomics 9(5):1374-1384.
22. Cahoy JD, et al. (2008) A transcriptome database for astrocytes, neurons, and oligodendrocytes: A new resource for understanding brain development and function. J Neurosci 28(1):264-278.
23. Xiao C, et al. (2008) Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes. Nat Immunol 9(4):405-414.
24. Bian S, et al. (2013) MicroRNA cluster miR-17-92 regulates neural stem cell expansion and transition to intermediate progenitors in the developing mouse neocortex. Cell Rep 3(5):1398-1406.
25. Hirabayashi Y, et al. (2009) Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition. Neuron 63(5):600-613.
26. Hanashima C, Li SC, Shen L, Lai E, Fishell G (2004) Foxg1 suppresses early cortical cell fate. Science 303(5654):56-59.
27. Saito A, et al. (2012) Unfolded protein response, activated by OASIS family transcription factors, promotes astrocyte differentiation. Nat Commun 3:967.
28. Li X, et al. (2012) MEK Is a Key Regulator of Gliogenesis in the Developing Brain. Neuron 75(6):1035-1050.