Purinergic 2X receptors play a role in evoking the exercise pressor reflex in rats with peripheral artery insufficiency

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 306, Issue 3, 2014, Pages

  Stone, Audrey J ^a   Yamauchi, Katsuya ^a   Kaufman, Marc P ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

, methylene ATP; Autonomic nervous system; PPADS; Renal sympathetic activity; Thin fiber muscle afferents

Indexed keywords

ALPHA,BETA METHYLENEADENOSINE TRIPHOSPHATE; PURINERGIC P2X RECEPTOR; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL CIRCULATION; ARTERY LIGATION; ARTICLE; EXERCISE; FEMORAL ARTERY; HEART RATE; MALE; MECHANORECEPTOR; NERVE POTENTIAL; NONHUMAN; PERIPHERAL ISCHEMIA; PRESSOR RESPONSE; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; RAT; SYMPATHETIC NERVE;

AUTONOMIC NERVOUS SYSTEM; PPADS; RENAL SYMPATHETIC ACTIVITY; THIN FIBER MUSCLE AFFERENTS; Α,Β-METHYLENE ATP;

ADENOSINE TRIPHOSPHATE; ANIMALS; BLOOD PRESSURE; FEMORAL ARTERY; HINDLIMB; MALE; MUSCLE CONTRACTION; MUSCLE, SKELETAL; PHYSICAL EXERTION; PURINERGIC P2X RECEPTOR AGONISTS; PURINERGIC P2X RECEPTOR ANTAGONISTS; PYRIDOXAL PHOSPHATE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2X; REFLEX;

EID: 84893371016     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00762.2013     Document Type: Article

References (47)

1. Baccelli G, Reggiani P, Mattioli A, Corbellini E, Garducci S, Catalano M. The exercise pressor reflex and changes in radial arterial pressure and heart rate during walking in patients with arteriosclerosis obliterans. Angiology 50: 361-374, 1999.
2. Bradbury EJ, Burnstock G, McMahon SB. The expression of P2X3 purinoreceptors in sensory neurons: effects of axotomy and glial-derived neurotrophic factor. Mol Cell Neurosci 12: 256-268, 1998.
3. 2-purinoreceptor? Gen Pharmacol 16: 433-440, 1985.
4. Cook SP, Vulchanova L, Hargreaves KM, Elde R, McCleskey EW. Distinct ATP receptors on pain-sensing and stretch-sensing neurons. Nature 387: 505-508, 1997.
5. Coote JH, Hilton SM, Perez-Gonzalez JF. The reflex nature of the pressor response to muscular exercise. J Physiol 215: 789-804, 1971.
6. Cui J, Leuenberger UA, Blaha C, King NC, Sinoway LI. Effect of P2 receptor blockade with pyridoxine on sympathetic response to exercise pressor reflex in humans. J Physiol 589: 685-695, 2011.
7. Demolombe S, Escande D. ATP-binding cassette proteins as targets for drug discovery. Trends Pharmacol Sci 17: 273-275, 1996.
8. Gever JR, Cockayne DA, Dillon MP, Burnstock G, Ford AP. Pharmacology of P2X channels. Pflügers Arch 452: 513-537, 2006.
9. Hanna RL, Hayes SG, Kaufman MP. α, β-Methylene ATP elicits a reflex pressor response arising from muscle in decerebrate cats. J Appl Physiol 93: 834-841, 2002.
10. Hanna RL, Kaufman MP. Role played by purinergic receptors on muscle afferents in evoking the exercise pressor reflex. J Appl Physiol 94: 1437-1445, 2003.
11. Hanna RL, Kaufman MP. Activation of thin-fiber muscle afferents by a P2X agonist in cats. J Appl Physiol 96: 1166-1169, 2004.
12. Hayes SG, Kaufman MP. Gadolinium attenuates exercise pressor reflex in cats. Am J Physiol Heart Circ Physiol 280: H2153-H2161, 2001.
13. Hayes SG, Kindig AE, Kaufman MP. Comparison between the effect of static contraction and tendon stretch on the discharge of group III and IV muscle afferents. J Appl Physiol 99: 1891-1896, 2005.
14. Hayes SG, McCord JL, Kaufman MP. Role played by P2X and P2Y receptors in evoking the muscle chemoreflex. J Appl Physiol 104: 538-541, 2008.
15. Hayes SG, McCord JL, Koba S, Kaufman MP. Gadolinium inhibits group III but not group IV muscle afferent responses to dynamic exercise. J Physiol 587: 873-882, 2009.
16. Kaufman MP. The exercise pressor reflex in animals. Exp Physiol 97: 51-58, 2012.
17. Kaufman MP, Longhurst JC, Rybicki KJ, Wallach JH, Mitchell JH. Effects of static muscular contraction on impulse activity of groups III and IV afferents in cats. J Appl Physiol 55: 105-112, 1983.
18. Kaufman MP, Rybicki KJ, Waldrop TG, Ordway GA. Effect of ischemia on responses of group III and IV afferents to contraction. J Appl Physiol 57: 644-650, 1984.
19. Kindig AE, Hayes SG, Hanna RL, Kaufman MP. P2 antagonist PPADS attenuates responses of thin fiber afferents to static contraction and tendon stretch. Am J Physiol Heart Circ Physiol 290: H1214-H1219, 2006.
20. Kindig AE, Hayes SG, Kaufman MP. Blockade of purinergic 2 receptors attenuates the mechanoreceptor component of the exercise pressor reflex. Am J Physiol Heart Circ Physiol 293: H2995-H3000, 2007.
21. Lambrecht G. Agonists and antagonists acting at P2X receptors: selectivity profiles and functional implications. Naunyn Schmiedeberg Arch Pharmacol 362: 340-350, 2000.
22. Li J, Gao Z, Kehoe V, Xing J, King N, Sinoway L. Interstitial adenosine triphosphate modulates muscle afferent nerve-mediated pressor reflex. Muscle Nerve 38: 972-977, 2008.
23. Li J, King NC, Sinoway LI. ATP concentrations and muscle tension increase linearly with muscle contraction. J Appl Physiol 95: 577-583, 2003.
24. Li J, Sinoway LI. ATP stimulates chemically sensitive and sensitizes mechanically sensitive afferents. Am J Physiol Heart Circ Physiol 283: H2636-H2643, 2002.
25. Liu J, Li JD, Lu J, Xing J, Li J. Contribution of nerve growth factor to upregulation of P2X3 expression in DRG neurons of rats with femoral artery occlusion. Am J Physiol Heart Circ Physiol 301: H1070-H1079, 2011.
26. MacLean DA, Saltin B, Radegran G, Sinoway L. Femoral arterial injection of adenosine in humans elevates MSNA via central but not peripheral mechanisms. J Appl Physiol 83: 1045-1053, 1997.
27. MacLean DA, Vickery LM, Sinoway L. Elevated interstitial adenosine concentrations do not activate the muscle reflex. Am J Physiol Heart Circ Physiol 280: H546-H553, 2001.
28. McCloskey DI, Mitchell JH. Reflex cardiovascular and respiratory responses originating in exercising muscle. J Physiol 224: 173-186, 1972.
29. McCord JL, Tsuchimochi H, Kaufman MP. P2X2/3 and P2X3 receptors contribute to the metaboreceptor component of the exercise pressor reflex in decerebrated cats. J Appl Physiol 109: 1416-1423, 2010.
30. Mense S, Meyer H. Bradykinin-induced modulation of the response behavior of different types of feline group III and IV muscle receptors. J Physiol 398: 49-63, 1988.
31. Mense S, Stahnke M. Responses in muscle afferent fibers of slow conduction velocity to contractions and ischemia in the cat. J Physiol 342: 383-397, 1983.
32. Mo FM. Ballard HJ. The effect of systemic hypoxia on interstitial and blood adenosine, AMP, ADP, and ATP in dog skeletal muscle. J Physiol 536: 593-603, 2001.
33. Prior BM, Lloyd PG, Ren J, Li H, Yang HT, Laughlin MH, Terjung RL. Time course of changes in collateral blood flow and isolated vessel size and gene expression after femoral artery occlusion in rats. Am J Physiol Heart Circ Physiol 287: H2434-H2447, 2004.
34. Ramer MS, Bradbury EJ, McMahon SB. Nerve growth factor induces P2X(3) expression in sensory neurons. J Neurochem 77: 864-875, 2001.
35. Reinohl J, Hoheisel U, Unger T, Mense S. Adenosine triphosphate as a stimulant for nociceptive and non-nociceptive muscle group IV receptors in the rat. Neurosci Lett 338: 25-28, 2003.
36. Rotto DM, Kaufman MP. Effects of metabolic products of muscular contraction on the discharge of group III and IV afferents. J Appl Physiol 64: 2306-2313, 1988.
37. Smith SA, Mitchell JH, Garry MG. Electrically induced static exercise elicits a pressor response in the decerebrate rat. J Physiol 537: 961-970, 2001.
38. Smith SA, Mitchell JH, Naseem RH, Garry MG. Mechanoreflex mediates the exaggerated exercise pressor reflex in heart failure. Circulation 112: 2293-2300, 2005.
39. Sprague RS, Ellsworth ML, Stephenson AH, Kleinhenz ME, Lonigro AJ. Deformation-induced ATP release from red blood cells requires CFTR activity. Am J Physiol Heart Circ Physiol 275: H1726-H1732, 1998.
40. Stebbins CL, Brown B, Levin D, Longhurst JC. Reflex effect of skeletal muscle mechanoreceptor stimulation on the cardiovascular system. J Appl Physiol 65: 1539-1547, 1988.
41. Tsuchimochi H, McCord JL, Hayes SG, Koba S, Kaufman MP. Chronic femoral artery occlusion augments exercise pressor reflex in decerebrated rats. Am J Physiol Heart Circ Physiol 299: H106-H113, 2010.
42. Tsuchimochi H, McCord JL, Kaufman MP. Peripheral mu-opioid receptors attenuate the augmented exercise pressor reflex in rats with chronic femoral artery occlusion. Am J Physiol Heart Circ Physiol 299: H557-H565, 2010.
43. Victor RG, Rotto DM, Pryor SL, Kaufman MP. Stimulation of renal sympathetic activity by static contraction: evidence for mechanoreceptorinduced reflexes from skeletal muscle. Circ Res 64: 592-599, 1989.
44. Wang HJ, Li YL, Gao L, Zucker IH, Wang W. Alteration in skeletal muscle afferents in rats with chronic heart failure. J Physiol 588: 5033-5047, 2010.
45. Xing J, Lu J, Li J. Contribution of nerve growth factor to augmented TRPV1 responses of muscle sensory neurons by femoral artery occlusion. Am J Physiol Heart Circ Physiol 296: H1380-H1387, 2009.
46. Xing J, Lu J, Li J. Augmented P2X response and immunolabeling in dorsal root ganglion neurons innervating skeletal muscle following femoral artery occlusion. J Neurophysiol 109: 2161-2168, 2013.
47. Yang HT, Feng Y, Allen LA, Protter A, Terjung RL. Efficacy and specificity of bFGF increased collateral flow in experimental peripheral arterial insufficiency. Am J Physiol Heart Circ Physiol 278: H1966-H1973, 2000.