MG132 ameliorates kidney lesions by inhibiting the degradation of smad7 in streptozotocin-induced diabetic nephropathy

Journal of Diabetes Research

Volumn 2014, Issue , 2014, Pages

  Gao, Chenlin ^a   Aqie, Keri ^b   Zhu, Jianhua ^a   Chen, Guo ^a   Xu, Ling ^a   Jiang, Lan ^a   Xu, Yong ^a  

^a THE AFFILIATED HOSPITAL OF SOUTHWEST MEDICAL UNIVERSITY   (China)

^b Department of Gynaecology and Obstetrics   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ASPARTATE AMINOTRANSFERASE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BREAKPOINT CLUSTER REGION PROTEIN; CREATININE; FIBRONECTIN; LIGASE; MESSENGER RNA; SMAD PROTEIN; SMAD7 PROTEIN; SMURF2 PROTEIN; STREPTOZOCIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; BENZYLOXYCARBONYLLEUCYL LEUCYL LEUCINE ALDEHYDE; BENZYLOXYCARBONYLLEUCYL-LEUCYL-LEUCINE ALDEHYDE; LEUPEPTIN; PROTEASOME; PROTEASOME INHIBITOR; SMAD7 PROTEIN, RAT; SMURF2 PROTEIN, RAT; TGFB1 PROTEIN, RAT; TRANSFORMING GROWTH FACTOR BETA1; UBIQUITIN PROTEIN LIGASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY MASS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CREATININE URINE LEVEL; KIDNEY INJURY; KIDNEY MASS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN URINE LEVEL; RAT; SIGNAL TRANSDUCTION; STREPTOZOTOCIN-INDUCED DIABETIC NEUROPATHY; THERAPY EFFECT; ALBUMINURIA; ANIMAL; CHEMISTRY; DIABETIC NEPHROPATHY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; KIDNEY; METABOLISM; ORGAN SIZE; PATHOLOGY; RANDOMIZATION; UBIQUITINATION; ULTRASTRUCTURE; WISTAR RAT;

ALBUMINURIA; ANIMALS; DIABETIC NEPHROPATHIES; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBRONECTINS; GENE EXPRESSION REGULATION; KIDNEY; LEUPEPTINS; MALE; ORGAN SIZE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEASOME INHIBITORS; PROTEOLYSIS; RANDOM ALLOCATION; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; SMAD7 PROTEIN; STREPTOZOCIN; TRANSFORMING GROWTH FACTOR BETA1; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84893360692     PISSN: 23146745     EISSN: 23146753     Source Type: Journal    
DOI: 10.1155/2014/918396     Document Type: Article

References (34)

1. Liu L., Gao C., Chen G., Notch signaling molecules activate TGF- β in rat mesangial cells under high glucose conditions. Journal of Diabetes Research 2013 2013 8 979702 10.1155/2013/979702
2. Heistad D. D., Oxidative stress and vascular disease: 2005 Duff lecture. Arteriosclerosis, Thrombosis, and Vascular Biology 2006 26 4 689 695 2-s2.0-33646678173 10.1161/01.ATV.0000203525.62147.28 (Pubitemid 43732139)
3. Ford E. S., Mokdad A. H., Giles W. H., Brown D. W., The metabolic syndrome and antioxidant concentrations: findings from the Third National Health and Nutrition Examination Survey. Diabetes 2003 52 9 2346 2352 2-s2.0-0042822019 10.2337/diabetes.52.9.2346 (Pubitemid 37059506)
4. Hansel B., Giral P., Nobecourt E., Chantepie S., Bruckert E., Chapman M. J., Kontush A., Metabolic syndrome is associated with elevated oxidative stress and dysfunctional dense high-density lipoprotein particles displaying impaired antioxidative activity. The Journal of Clinical Endocrinology and Metabolism 2004 89 10 4963 4971 2-s2.0-6344267152 10.1210/jc.2004-0305 (Pubitemid 39391435)
5. Mendez J. I., Nicholson W. J., Taylor W. R., SOD isoforms and signaling in blood vessels: evidence for the importance of ROS compartmentalization. Arteriosclerosis, Thrombosis, and Vascular Biology 2005 25 5 887 888 2-s2.0-18244364147 10.1161/01.ATV.0000164043.24549.50 (Pubitemid 40627829)
6. Fukasawa H., Yamamoto T., Togawa A., Ohashi N., Fujigaki Y., Oda T., Uchida C., Kitagawa K., Hattori T., Suzuki S., Kitagawa M., Hishida A., Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice. Proceedings of the National Academy of Sciences of the United States of America 2004 101 23 8687 8692 2-s2.0-2942535966 10.1073/pnas.0400035101 (Pubitemid 38745832)
7. Shibuya K., Kanasaki K., Isono M., N-acetyl-seryl-aspartyl-lysyl-proline prevents renal insufficiency and mesangial matrix expansionin diabetic db/db mice. Diabetes 2005 54 3 838 845 (Pubitemid 40322089)
8. Ziyadehf F. N., Medicators of diabetic renal disease: the case for TGF- β as the major mediator. Journal of the American Sociaty Nephrology 2004 15 1 555 557
9. Rossing P., Diabetic nephropathy: worldwide epidemic and effects of current treatment on natural history. Current Diabetes Reports 2006 6 6 479 483 2-s2.0-33845388491 10.1007/s11892-006-0083-y (Pubitemid 44896409)
10. Kattla J. J., Carew R. M., Heljić M., Godson C., Brazil D. P., Protein kinase B/Akt activity is involved in renal TGF- β 1-driven epithelial-mesenchymal transition in vitro and in vivo. American Journal of Physiology: Renal Physiology 2008 295 1 F215 F225 2-s2.0-49949114895 10.1152/ajprenal.00548.2007
11. Kanwar Y. S., Wada J., Sun L., Xie P., Wallner E. I., Chen S., Chugh S., Danesh F. R., Diabetic nephropathy: mechanisms of renal disease progression. Experimental Biology and Medicine 2008 233 1 4 11 2-s2.0-37549035027 10.3181/0705-MR-134
12. Glickman M. H., Ciechanover A., The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiological Reviews 2002 82 2 373 428 2-s2.0-0036083396 (Pubitemid 34654457)
13. Gao C., Chen G., Liu L., Impact of high glucose and proteasome inhibitor MG132 on histone H2A and H2B ubiquitination in rat glomerular mesangial cells. Journal of Diabetes Research 2013 2013 10 589474 10.1155/2013/589474
14. Cui W., Li B., Bai Y., Potential role for Nrf2 activation in the therapeutic effect of MG132 on diabetic nephropathy in OVE26 diabetic mice. American Journal of Phisology, Endocrinology and Metabolism 2013 304 1 87 99
15. Luo Z.-F., Qi W., Feng B., Mu J., Zeng W., Guo Y.-H., Pang Q., Ye Z.-L., Liu L., Yuan F.-H., Prevention of diabetic nephropathy in rats through enhanced renal antioxidative capacity by inhibition of the proteasome. Life Sciences 2011 88 11-12 512 520 2-s2.0-79952455513 10.1016/j.lfs.2010.12.023
16. Zhang Y., Ye C., Wang G., Kidney-targeted transplantation of mesenchymal stem cells by ultrasound-targeted microbubble destruction promotes kidney repair in diabetic nephropathy rats. BioMed Research International 2013 2013 13 526367 10.1155/2013/526367
17. Hsieh C.-H., Liang K.-H., Hung Y.-J., Huang L.-C., Pei D., Liao Y.-T., Kuo S.-W., Bey M.-S., Chen J.-L., Chen E. Y., Analysis of epistasis for diabetic nephropathy among type 2 diabetic patients. Human Molecular Genetics 2006 15 18 2701 2708 2-s2.0-33748756609 10.1093/hmg/ddl203 (Pubitemid 44400397)
18. Caramori M. L., Mauer M., Diabetes and nephropathy. Current Opinion in Nephrology and Hypertension 2003 12 3 273 282 2-s2.0-0037614775 10.1097/00041552-200305000-00008 (Pubitemid 36578062)
19. Wolf G., Ritz E., Diabetic nephropathy in type 2 diabetes prevention and patient management. Journal of the American Society of Nephrology 2003 14 5 1396 1405 2-s2.0-0037408389 10.1097/01.ASN.0000065639.19190.CF (Pubitemid 36514679)
20. Huang W., Xu L., Zhou X., High glucose induces activation ofNF- B inflammatory signaling through I B sumoylation in rat mesangialcells. Biochemical and Biophysical Research Communications 2013 483 3 568 574
21. Rane M. J., Song Y., Jin S., Interplay between Akt and p38MAPK pathways in the regulation of renal tubular cell apoptosis associatedwith diabetic nephropathy. American Journal of Physiology. RenalPhysiology 2010 298 1 49 61
22. Myung J., Kim K. B., Crews C. M., The ubiquitin-proteasomepathway and proteasome inhibitors. Medicinal Research Reviews 2001 21 4 245 273
23. Lecker S. H., Goldberg A. L., Mitch W. E., Protein degradation by the ubiquitin-proteasome pathway in normal and disease states. Journal of the American Society of Nephrology 2006 17 7 1807 1819 2-s2.0-33745816760 10.1681/ASN.2006010083 (Pubitemid 44036165)
24. Nakao A., Afrakhte M., Morén A., Nakayama T., Christian J. L., Heuchef R., Itoh S., Kawabata M., Heldin N.-E., Heldin C.-H., Ten Dijke P., Identification of Smad7, a TGFß-inducible antagonist of TGF-ß signalling. Nature 1997 389 6651 631 635 2-s2.0-0030611757 10.1038/39369 (Pubitemid 27446184)
25. Nakao A., Afrakhte M., Moren A., Idebtification of smad7, aTGF-ß inducible antagonist of TGF-ß signaling. Nature 1997 389 6651 631 635
26. Zhang F., Laiho M., On and off: proteasome and TGF-ß signaling. Experimental Cell Research 2003 291 2 275 281 2-s2.0-0344873297 10.1016/j.yexcr.2003.07.007 (Pubitemid 37485717)
27. Akarsu E., Pirim I., Çapolu I., Deniz O., Akçay G., Ünüvar N., Relationship between electroneurographic changes and serum ubiquitin levels in patients with type 2 diabetes. Diabetes Care 2001 24 1 100 103 2-s2.0-0035138313 (Pubitemid 32104228)
28. Kaniuk N. A., Kiraly M., Bates H., Vranic M., Volchuk A., Brumell J. H., Ubiquitinated-protein aggregates form in pancreatic β -cells during diabetes-induced oxidative stress and are regulated by autophagy. Diabetes 2007 56 4 930 939 2-s2.0-34047179973 10.2337/db06-1160 (Pubitemid 46525060)
29. Tashiro K., Tamada S., Kuwabara N., Komiya T., Takekida K., Asai T., Iwao H., Sugimura K., Matsumura Y., Takaoka M., Nakatani T., Miura K., Attenuation of renal fibrosis by proteasome inhibition in rat obstructive nephropathy: possible role of nuclear factor kappaB. International Journal of Molecular Medicine 2003 12 4 587 592 2-s2.0-2842593814
30. Terada Y., Hanada S., Nakao A., Kuwahara M., Sasaki S., Marumo F., Gene transfer of Smad7 using electroporation of adenovirus prevents renal fibrosis in post-obstructed kidney. Kidney International 2002 61 1 S94 S98 2-s2.0-0036181284 (Pubitemid 34155574)
31. Mtango N. R., Latham K. E., Ubiquitin proteasome pathway gene expression varies in rhesus monkey oocytes and embryos of different developmental potential. Physiological Genomics 2007 31 1 1 14 2-s2.0-34548818472 10.1152/physiolgenomics.00040.2007 (Pubitemid 47443843)
32. Baricos W. H., Cortez S. L., Deboisblanc M., Shi X., Transforming growth factor- β is a potent inhibitor of extracellular matrix degradation by cultured human mesangial cells. Journal of the American Society of Nephrology 1999 10 4 790 795 2-s2.0-0032983588 (Pubitemid 29149529)
33. Holecek M., Muthny T., Kovarik M., Sispera L., Proteasome inhibitor MG-132 enhances whole-body protein turnover in rat. Biochemical and Biophysical Research Communications 2006 345 1 38 42 2-s2.0-33646417085 10.1016/j.bbrc.2006. 04.053
34. Yang Y. L., Liu Y. S., Chuang L. Y., Bone morphogeneticprotein-2 antagonizes renal interstitial fibrosis by promoting catabolism oftype I transforming growth factor-beta receptors. Endocriology 2009 150 2 727 740