Connexin40 regulates platelet function

Nature Communications

Volumn 4, Issue , 2013, Pages

  Vaiyapuri, Sakthivel ^a   Moraes, Leonardo A ^a   Sage, Tanya ^a   Ali, Marfoua S ^a   Lewis, Kirsty R ^a   Mahaut Smith, Martyn P ^b   Oviedo Orta, Ernesto ^c   Simon, Alexander M ^d   Gibbins, Jonathan M ^a  

^a UNIVERSITY OF READING   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

^c UNIVERSITY OF SURREY   (United Kingdom)

^d UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APYRASE; CONNEXIN 37; CONNEXIN 40; FIBRINOGEN; INTEGRIN; PADGEM PROTEIN; THROMBIN; VERY LATE ACTIVATION ANTIGEN 2;

AGGREGATION; INHIBITOR; PHYSIOLOGICAL RESPONSE; RODENT;

ANIMAL EXPERIMENT; ANTICOAGULATION; ARTICLE; BLOOD CLOT RETRACTION; CELL COMMUNICATION; CONTROLLED STUDY; ERYTHROCYTE; FIBRIN CLOT; FLOW CYTOMETRY; GAP JUNCTION; HEMOSTASIS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MOUSE; NONHUMAN; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; THROMBOCYTE RELEASE REACTION; THROMBOCYTE RICH PLASMA; THROMBOSIS;

ANIMALS; BLOOD COAGULATION; BLOOD PLATELETS; CELL COMMUNICATION; CELL DEGRANULATION; CONNEXINS; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; GAP JUNCTIONS; GENE EXPRESSION; HUMANS; MICE; MICE, KNOCKOUT; PEPTIDES; PLATELET ACTIVATION; PLATELET AGGREGATION; SIGNAL TRANSDUCTION;

EID: 84893350811     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms3564     Document Type: Article

References (28)

1. Goodenough, D. A. & Paul, D. L. Gap junctions. Cold Spring Harb. Perspect. Biol. 1, a002576 (2009).
2. Goodenough, D. A. & Paul, D. L. Beyond the gap: functions of unpaired connexon channels. Nat. Rev. Mol. Cell Biol. 4, 285-294 (2003).
3. John, S., Cesario, D. & Weiss, J. N. Gap junctional hemichannels in the heart. Acta Physiol. Scand. 179, 23-31 (2003).
4. Goodenough, D. A., Goliger, J. A. & Paul, D. L. Connexins, connexons, and intercellular communication. Annu. Rev. Biochem. 65, 475-502 (1996).
5. Harris, A. L. Emerging issues of connexin channels: biophysics fills the gap. Q. Rev. Biophys. 34, 325-472 (2001).
6. Harris, A. L. Connexin channel permeability to cytoplasmic molecules. Prog. Biophys. Mol. Biol. 94, 120-143 (2007).
7. Laird, D. W. Life cycle of connexins in health and disease. Biochem. J. 394, 527-543 (2006).
8. Sosinsky, G. E. & Nicholson, B. J. Structural organization of gap junction channels. Biochim. Biophys. Acta 1711, 99-125 (2005).
9. Bruzzone, R. & Dermietzel, R. Structure and functions of gap junctions in the developing brain. Cell Tissue Res. 326, 239-248 (2006).
10. Dorshkind, K., Green, L., Godwin, A. & Fletcher, W. H. Connexin-43-type gap junctions mediate communication between bone marrow stromal cells. Blood 82, 38-45 (1993).
11. Kidder, G. M. & Mhawi, A. A. Gap junctions and ovarian folliculogenesis. Reproduction 123, 613-620 (2002).
12. Rohr, S. Role of gap junctions in the propagation of the cardiac action potential. Cardiovasc. Res. 62, 309-322 (2004).
13. Wong, C. W. et al. Connexin37 protects against atherosclerosis by regulating monocyte adhesion. Nat. Med. 12, 950-954 (2006).
14. Bermudez-Fajardo, A., Yliharsila, M., Evans, W. H., Newby, A. C. & Oviedo-Orta, E. CD4+ T lymphocyte subsets express connexin 43 and establish gap junction channel communication with macrophages in vitro. J. Leukoc. Biol. 82, 608-612 (2007).
15. Oviedo-Orta, E., Perreau, M., Evans, W. H. & Potolicchio, I. Control of the proliferation of activated CD4+ T cells by connexins. J. Leukoc. Biol. 88, 79-86 (2010).
16. Angelillo-Scherrer, A. et al. Connexin37 limits thrombus propensity by downregulating platelet reactivity. Circulation 124, 930-939 (2011).
17. Vaiyapuri, S. et al. Gap junctions and connexin hemichannels underpin hemostasis and thrombosis. Circulation 125, 2479-2491 (2012).
18. Gibbins, J. M. Platelet adhesion signalling and the regulation of thrombus formation. J. Cell Sci. 117, 3415-3425 (2004).
19. Evans, W. H., Bultynck, G. & Leybaert, L. Manipulating connexin communication channels: use of peptidomimetics and the translational outputs. J. Membr. Biol. 245, 437-449 (2012).
20. Evans, W. H. & Leybaert, L. Mimetic peptides as blockers of connexin channel-facilitated intercellular communication. Cell Commun. Adhes. 14, 265-273 (2007).
21. Vaiyapuri, S., Harrison, R. A., Bicknell, A. B., Gibbins, J. M. & Hutchinson, G. Purification and functional characterisation of rhinocerase, a novel serine protease from the venom of Bitis gabonica rhinoceros. PLoS One 5, e9687 (2010).
22. Vaiyapuri, S. et al. Rhinocetin, a venom-derived integrin-specific antagonist inhibits collagen-induced platelet and endothelial cell functions. J. Biol. Chem. 287, 26235-26244 (2012).
23. Vaiyapuri, S., Wagstaff, S. C., Harrison, R. A., Gibbins, J. M. & Hutchinson, E. G. Evolutionary analysis of novel serine proteases in the venom gland transcriptome of Bitis gabonica rhinoceros. PLoS One 6, e21532 (2011).
24. Vaiyapuri, S. et al. Purification and functional characterisation of rhiminopeptidase A, a novel aminopeptidase from the venom of Bitis gabonica rhinoceros. PLoS Negl. Trop. Dis. 4, e796 (2010).
25. Simon, A. M., Goodenough, D. A. & Paul, D. L. Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block. Curr. Biol. 8, 295-298 (1998).
26. Simon, A. M. & McWhorter, A. R. Vascular abnormalities in mice lacking the endothelial gap junction proteins connexin37 and connexin40. Dev. Biol. 251, 206-220 (2002).
27. Simon, A. M., Goodenough, D. A., Li, E. & Paul, D. L. Female infertility in mice lacking connexin 37. Nature 385, 525-529 (1997).
28. Kanady, J. D., Dellinger, M. T., Munger, S. J., Witte, M. H. & Simon, A. M. Connexin37 and Connexin43 deficiencies in mice disrupt lymphatic valve development and result in lymphatic disorders including lymphedema and chylothorax. Dev. Biol. 354, 253-266 (2011).