메뉴 건너뛰기




Volumn 53, Issue 2, 2014, Pages 141-153

Clinical pharmacokinetic drug interactions associated with artemisinin derivatives and HIV-antivirals

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ARTEMETHER; ARTEMETHER PLUS BENFLUMETOL; ARTEMISININ DERIVATIVE; ARTESUNATE; ARTESUNATE PLUS PYRONARIDINE; BENFLUMETOL; DARUNAVIR PLUS RITONAVIR; DIHYDROARTEMISININ; ETRAVIRINE; LOPINAVIR PLUS RITONAVIR; NEVIRAPINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; RITONAVIR;

EID: 84893277854     PISSN: 03125963     EISSN: 11791926     Source Type: Journal    
DOI: 10.1007/s40262-013-0110-5     Document Type: Review
Times cited : (22)

References (44)
  • 1
    • 31444454856 scopus 로고    scopus 로고
    • World Health Organization Second edition. March Accessed 14 Jul 2013
    • World Health Organization. Guidelines for the treatment of malaria. Second edition. March 2010. http://www.who.int/malaria/publications/atoz/ 9789241547925/en/index.html. Accessed 14 Jul 2013.
    • (2010) Guidelines for the Treatment of Malaria
  • 2
    • 36549011407 scopus 로고    scopus 로고
    • Joint United Nations Programme on HIV/AIDS (UNAIDS) December Accessed 14 Jul 2013
    • Joint United Nations Programme on HIV/AIDS (UNAIDS). AIDS epidemic update. December 2007. http://data.unaids.org/pub/EPISlides/2007/2007-epiupdate- en.pdf. Accessed 14 Jul 2013.
    • (2007) AIDS Epidemic Update
  • 3
    • 38149059991 scopus 로고    scopus 로고
    • Clinical pharmacology of artemisinin-based combination therapies
    • 18193915 10.2165/00003088-200847020-00002
    • German P, Aweeka FT. Clinical pharmacology of artemisinin-based combination therapies. Clin Pharmacokinet. 2008;47:91-102.
    • (2008) Clin Pharmacokinet , vol.47 , pp. 91-102
    • German, P.1    Aweeka, F.T.2
  • 5
    • 66149106672 scopus 로고    scopus 로고
    • Increased risk for severe malaria in HIV-1-infected adults, Zambia
    • 19402961 10.3201/eid1505.081009
    • Chalwe V, Van Geertruyden JP, Mukwamataba D, et al. Increased risk for severe malaria in HIV-1-infected adults, Zambia. Emerg Infect Dis. 2009;15:749-55.
    • (2009) Emerg Infect Dis , vol.15 , pp. 749-755
    • Chalwe, V.1    Van Geertruyden, J.P.2    Mukwamataba, D.3
  • 6
    • 1642271238 scopus 로고    scopus 로고
    • HIV infection as a cofactor for severe falciparum malaria in adults living in a region of unstable malaria transmission in South Africa
    • 15090809 10.1097/00002030-200402200-00023
    • Grimwade K, French N, Mbatha DD, et al. HIV infection as a cofactor for severe falciparum malaria in adults living in a region of unstable malaria transmission in South Africa. AIDS. 2004;18:547-54.
    • (2004) AIDS , vol.18 , pp. 547-554
    • Grimwade, K.1    French, N.2    Mbatha, D.D.3
  • 7
    • 0037423868 scopus 로고    scopus 로고
    • The effect of dual infection with HIV and malaria on pregnancy outcome in western Kenya
    • 12598779 10.1097/00002030-200303070-00014
    • Ayisi JG, van Eijk AM, ter Kuile FO, et al. The effect of dual infection with HIV and malaria on pregnancy outcome in western Kenya. AIDS. 2003;17:585-94.
    • (2003) AIDS , vol.17 , pp. 585-594
    • Ayisi, J.G.1    Van Eijk, A.M.2    Ter Kuile, F.O.3
  • 8
    • 0029039346 scopus 로고
    • Maternal HIV infection and infant mortality in Malawi: Evidence for increased mortality due to placental malaria infection
    • 1:STN:280:DyaK28%2FjsFagtw%3D%3D 7546417 10.1097/00002030-199507000-00009
    • Bloland PB, Wirima JJ, Steketee RW, et al. Maternal HIV infection and infant mortality in Malawi: evidence for increased mortality due to placental malaria infection. AIDS. 1995;9:721-6.
    • (1995) AIDS , vol.9 , pp. 721-726
    • Bloland, P.B.1    Wirima, J.J.2    Steketee, R.W.3
  • 9
    • 33749003118 scopus 로고    scopus 로고
    • HIV-1 immune suppression and antimalarial treatment outcome in Zambian adults with uncomplicated malaria
    • 16960779 10.1086/507310
    • Van Geertruyden JP, Mulenga M, Mwananyanda L, et al. HIV-1 immune suppression and antimalarial treatment outcome in Zambian adults with uncomplicated malaria. J Infect Dis. 2006;194:917-25.
    • (2006) J Infect Dis , vol.194 , pp. 917-925
    • Van Geertruyden, J.P.1    Mulenga, M.2    Mwananyanda, L.3
  • 10
    • 12344266741 scopus 로고    scopus 로고
    • Effect of Plasmodium falciparum malaria on concentration of HIV-1-RNA in the blood of adults in rural Malawi: A prospective cohort study
    • 15652606
    • Kublin JG, Patnaik P, Jere CS, et al. Effect of Plasmodium falciparum malaria on concentration of HIV-1-RNA in the blood of adults in rural Malawi: a prospective cohort study. Lancet. 2005;365:233-40.
    • (2005) Lancet , vol.365 , pp. 233-240
    • Kublin, J.G.1    Patnaik, P.2    Jere, C.S.3
  • 11
    • 21844449462 scopus 로고    scopus 로고
    • The potential for interactions between antimalarial and antiretroviral drugs
    • 15958830 10.1097/01.aids.0000174445.40379.e0
    • Khoo S, Back D, Winstanley P. The potential for interactions between antimalarial and antiretroviral drugs. AIDS. 2005;19:995-1005.
    • (2005) AIDS , vol.19 , pp. 995-1005
    • Khoo, S.1    Back, D.2    Winstanley, P.3
  • 12
    • 0344760902 scopus 로고    scopus 로고
    • The Department for Health and Human Services [DHHS] guidelines Panel on antiretroviral guidelines for adults and adolescents Accessed 14 Jul 2013
    • The Department for Health and Human Services [DHHS] guidelines Panel on antiretroviral guidelines for adults and adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents; Feb 2013. http://aidsinfo.nih.gov/contentfiles/lvguidelines/adultandadolescentgl.pdf. Accessed 14 Jul 2013.
    • Guidelines for the Use of Antiretroviral Agents in HIV-1-infected Adults and Adolescents; Feb 2013
  • 13
    • 77950850784 scopus 로고    scopus 로고
    • Update on the efficacy, effectiveness and safety of artemether- lumefantrine combination therapy for treatment of uncomplicated malaria
    • 1:CAS:528:DC%2BC3cXisF2nug%3D%3D 2817784 20169032
    • Byakika-Kibwika P, Lamorde M, Mayanja-Kizza H, et al. Update on the efficacy, effectiveness and safety of artemether-lumefantrine combination therapy for treatment of uncomplicated malaria. Ther Clin Risk Manag. 2010;6:11-20.
    • (2010) Ther Clin Risk Manag , vol.6 , pp. 11-20
    • Byakika-Kibwika, P.1    Lamorde, M.2    Mayanja-Kizza, H.3
  • 14
    • 0034968177 scopus 로고    scopus 로고
    • Pharmacokinetic interactions of antimalarial agents
    • 1:CAS:528:DC%2BD3MXltV2ks7Y%3D 11432537 10.2165/00003088-200140050-00003
    • Giao PT, de Vries PJ. Pharmacokinetic interactions of antimalarial agents. Clin Pharmacokinet. 2001;40:343-73.
    • (2001) Clin Pharmacokinet , vol.40 , pp. 343-373
    • Giao, P.T.1    De Vries, P.J.2
  • 15
    • 70350146352 scopus 로고    scopus 로고
    • Pharmacokinetic and toxicological profile of artemisinin compounds: An update
    • 1:CAS:528:DC%2BD1MXhsFaqt7nO 19851082 10.1159/000252658
    • Medhi B, Patyar S, Rao RS, et al. Pharmacokinetic and toxicological profile of artemisinin compounds: an update. Pharmacology. 2009;84:323-32.
    • (2009) Pharmacology , vol.84 , pp. 323-332
    • Medhi, B.1    Patyar, S.2    Rao, R.S.3
  • 16
    • 80054694537 scopus 로고    scopus 로고
    • In vitro activity of antiretroviral drugs against Plasmodium falciparum
    • 1:CAS:528:DC%2BC3MXhsVSru7jO 3194998 21876053 10.1128/AAC.05130-11
    • Nsanzabana C, Rosenthal P. In vitro activity of antiretroviral drugs against Plasmodium falciparum. Antimicrob Agents Chemother. 2011;55:5073-7.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 5073-5077
    • Nsanzabana, C.1    Rosenthal, P.2
  • 17
    • 68049121902 scopus 로고    scopus 로고
    • Lopinavir/ritonavir affects pharmacokinetic exposure of artemether/lumefantrine in HIV-uninfected healthy volunteers
    • 1:CAS:528:DC%2BD1MXotlehurs%3D 19506482 10.1097/QAI.0b013e3181acb4ff
    • German P, Parikh S, Lawrence J, et al. Lopinavir/ritonavir affects pharmacokinetic exposure of artemether/lumefantrine in HIV-uninfected healthy volunteers. J Acquir Immune Defic Syndr. 2009;51:424-9.
    • (2009) J Acquir Immune Defic Syndr , vol.51 , pp. 424-429
    • German, P.1    Parikh, S.2    Lawrence, J.3
  • 18
    • 84859609445 scopus 로고    scopus 로고
    • Lopinavir/ritonavir significantly influences pharmacokinetic exposure of artemether/lumefantrine in HIV-infected Ugandan adults
    • 1:CAS:528:DC%2BC38Xlt1Gns7Y%3D 22316571 10.1093/jac/dkr596
    • Byakika-Kibwika P, Lamorde M, Okaba-Kayom V, et al. Lopinavir/ritonavir significantly influences pharmacokinetic exposure of artemether/lumefantrine in HIV-infected Ugandan adults. J Antimicrob Chemother. 2012;67:1217-23.
    • (2012) J Antimicrob Chemother , vol.67 , pp. 1217-1223
    • Byakika-Kibwika, P.1    Lamorde, M.2    Okaba-Kayom, V.3
  • 19
    • 84879837326 scopus 로고    scopus 로고
    • Pharmacokinetic interaction between etravirine or darunavir/ritonavir and artemether/lumefantrine in healthy volunteers: A two-panel, two-way, two-period, randomized trial
    • 1:CAS:528:DC%2BC3sXhtVGksL7P 23441978 10.1111/hiv.12019
    • Kakuda T, Demasi R, van Delft Y, et al. Pharmacokinetic interaction between etravirine or darunavir/ritonavir and artemether/lumefantrine in healthy volunteers: a two-panel, two-way, two-period, randomized trial. HIV Med. 2013;14:421-9.
    • (2013) HIV Med , vol.14 , pp. 421-429
    • Kakuda, T.1    Demasi, R.2    Van Delft, Y.3
  • 20
    • 45549095805 scopus 로고    scopus 로고
    • Effect of an antiretroviral regimen containing ritonavir boosted lopinavir on intestinal and hepatic CYP3A, CYP2D6 and P-glycoprotein in HIV-infected patients
    • 1:CAS:528:DC%2BD1cXnt1Kqs7c%3D 18183034 10.1038/sj.clpt.6100452
    • Wyen C, Fuhr U, Frank D, et al. Effect of an antiretroviral regimen containing ritonavir boosted lopinavir on intestinal and hepatic CYP3A, CYP2D6 and P-glycoprotein in HIV-infected patients. Clin Pharmacol Ther. 2008;84:75-82.
    • (2008) Clin Pharmacol Ther , vol.84 , pp. 75-82
    • Wyen, C.1    Fuhr, U.2    Frank, D.3
  • 21
    • 64649102226 scopus 로고    scopus 로고
    • Darunavir: A review of its use in the management of HIV infection in adults
    • 1:CAS:528:DC%2BD1MXmtFelsL8%3D 19323590 10.2165/00003495-200969040-00007
    • McKeage K, Perry CM, Keam SJ. Darunavir: a review of its use in the management of HIV infection in adults. Drugs. 2009;69:477-503.
    • (2009) Drugs , vol.69 , pp. 477-503
    • McKeage, K.1    Perry, C.M.2    Keam, S.J.3
  • 22
    • 0036435747 scopus 로고    scopus 로고
    • Pharmacokinetics and electrocardiographic pharmacodynamics of artemether-lumefantrine (Riamet) with concomitant administration of ketoconazole in healthy subjects
    • 1:CAS:528:DC%2BD38Xps1Olsb8%3D 12445027 10.1046/j.1365-2125.2002.01696.x
    • Lefevre G, Carpenter P, Souppart C, et al. Pharmacokinetics and electrocardiographic pharmacodynamics of artemether-lumefantrine (Riamet) with concomitant administration of ketoconazole in healthy subjects. Br J Clin Pharmacol. 2002;54:485-92.
    • (2002) Br J Clin Pharmacol , vol.54 , pp. 485-492
    • Lefevre, G.1    Carpenter, P.2    Souppart, C.3
  • 23
    • 0033067324 scopus 로고    scopus 로고
    • Multiple dose pharmacokinetics of artemether in Chinese patients with uncomplicated falciparum malaria
    • 10418761 10.1016/S0924-8579(99)00063-1
    • van Agtmael MA, Cheng-Qi S, Qing JX, et al. Multiple dose pharmacokinetics of artemether in Chinese patients with uncomplicated falciparum malaria. Int J Antimicrob Agents. 1999;12:151-8.
    • (1999) Int J Antimicrob Agents , vol.12 , pp. 151-158
    • Van Agtmael, M.A.1    Cheng-Qi, S.2    Qing, J.X.3
  • 24
    • 33745433348 scopus 로고    scopus 로고
    • Lopinavir/ritonavir induces the hepatic activity of cytochrome P450 enzymes CYP2C9, CYP2C19, and CYP1A2 but inhibits the hepatic and intestinal activity of CYP3A as measured by a phenotyping drug cocktail in healthy volunteers
    • 1:CAS:528:DC%2BD28XlsFGqtrY%3D 16639344
    • Yeh RF, Gaver VE, Patterson KB, et al. Lopinavir/ritonavir induces the hepatic activity of cytochrome P450 enzymes CYP2C9, CYP2C19, and CYP1A2 but inhibits the hepatic and intestinal activity of CYP3A as measured by a phenotyping drug cocktail in healthy volunteers. J Acquir Immune Defic Syndr. 2006;42:52-60.
    • (2006) J Acquir Immune Defic Syndr , vol.42 , pp. 52-60
    • Yeh, R.F.1    Gaver, V.E.2    Patterson, K.B.3
  • 25
    • 48249104628 scopus 로고    scopus 로고
    • Induction effects of ritonavir: Implications for drug interactions
    • 1:CAS:528:DC%2BD1cXps1GqsLk%3D 18577765 10.1345/aph.1K615
    • Foisy MM, Yakiwchuk EM, Hughes CA. Induction effects of ritonavir: implications for drug interactions. Ann Pharmacother. 2008;42:1048-59.
    • (2008) Ann Pharmacother , vol.42 , pp. 1048-1059
    • Foisy, M.M.1    Yakiwchuk, E.M.2    Hughes, C.A.3
  • 26
    • 0036707622 scopus 로고    scopus 로고
    • Glucuronidation of dihydroartemisinin in vivo and by human liver microsomes and expressed UDP-glucuronosyltransferases
    • 1:CAS:528:DC%2BD38XmsVShurY%3D 12167566 10.1124/dmd.30.9.1005
    • Ilett KF, Ethell BT, Maggs JL, et al. Glucuronidation of dihydroartemisinin in vivo and by human liver microsomes and expressed UDP-glucuronosyltransferases. Drug Metab Dispos. 2002;30:1005-12.
    • (2002) Drug Metab Dispos , vol.30 , pp. 1005-1012
    • Ilett, K.F.1    Ethell, B.T.2    Maggs, J.L.3
  • 27
    • 27544468948 scopus 로고    scopus 로고
    • In vitro inhibition of UDP glucuronosyltransferases by atazanavir and other HIV protease inhibitors and the relationship of this property to in vivo bilirubin glucuronidation
    • 1:CAS:528:DC%2BD2MXhtFOru7rI 16118329 10.1124/dmd.105.005447
    • Zhang D, Chando TJ, Everett DW, et al. In vitro inhibition of UDP glucuronosyltransferases by atazanavir and other HIV protease inhibitors and the relationship of this property to in vivo bilirubin glucuronidation. Drug Metab Dispos. 2005;33:1729-39.
    • (2005) Drug Metab Dispos , vol.33 , pp. 1729-1739
    • Zhang, D.1    Chando, T.J.2    Everett, D.W.3
  • 28
    • 33646736568 scopus 로고    scopus 로고
    • Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant Plasmodium falciparum malaria
    • 1:CAS:528:DC%2BD28XlvVOrsr8%3D 16652314 10.1086/503423
    • Price RN, Uhlemann AC, van Vugt M, et al. Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant Plasmodium falciparum malaria. Clin Infect Dis. 2006;42:1570-7.
    • (2006) Clin Infect Dis , vol.42 , pp. 1570-1577
    • Price, R.N.1    Uhlemann, A.C.2    Van Vugt, M.3
  • 29
    • 84859572371 scopus 로고    scopus 로고
    • Cardiac conduction safety during coadministration of artemether- lumefantrine and lopinavir/ritonavir in HIV-infected Ugandan adults
    • 10.1155/2011/393976
    • Byakika-Kibwika P, Lamorde M, Lwabi P, et al. Cardiac conduction safety during coadministration of artemether-lumefantrine and lopinavir/ritonavir in HIV-infected Ugandan adults. Chemother Res Pract. 2011;2011:1-4.
    • (2011) Chemother Res Pract , vol.2011 , pp. 1-4
    • Byakika-Kibwika, P.1    Lamorde, M.2    Lwabi, P.3
  • 30
    • 84865350852 scopus 로고    scopus 로고
    • Significant pharmacokinetic interactions between artemether/lumefantrine and efavirenz or nevirapine in HIV-infected Ugandan adults
    • 10.1093/jac/dks207
    • Byakika-Kibwika P, Lamorde M, Mayito J, et al. Significant pharmacokinetic interactions between artemether/lumefantrine and efavirenz or nevirapine in HIV-infected Ugandan adults. J Antimicrob Chemother. 2012;69:2213-21.
    • (2012) J Antimicrob Chemother , vol.69 , pp. 2213-2221
    • Byakika-Kibwika, P.1    Lamorde, M.2    Mayito, J.3
  • 31
    • 85027955343 scopus 로고    scopus 로고
    • Concomitant efavirenz reduces pharmacokinetic exposure to the antimalarial drug artemether-lumefantrine in healthy volunteers
    • 1:CAS:528:DC%2BC38XhsFOltLbK 3511816 22918158 10.1097/QAI. 0b013e31826ebb5c
    • Huang L, Parikh S, Rosenthal PJ, et al. Concomitant efavirenz reduces pharmacokinetic exposure to the antimalarial drug artemether-lumefantrine in healthy volunteers. J Acquir Immune Defic Syndr. 2012;61:310-6.
    • (2012) J Acquir Immune Defic Syndr , vol.61 , pp. 310-316
    • Huang, L.1    Parikh, S.2    Rosenthal, P.J.3
  • 32
    • 81555206726 scopus 로고    scopus 로고
    • Interaction between artemether-lumefantrine and nevirapine-based antiretroviral therapy in HIV-1-infected patients
    • 1:CAS:528:DC%2BC3MXhsFehsLzI 3232823 21947399 10.1128/AAC.05265-11
    • Kredo T, Mauff K, Van der Walt JS, et al. Interaction between artemether-lumefantrine and nevirapine-based antiretroviral therapy in HIV-1-infected patients. Antimicrob Agents Chemother. 2011;55:5616-23.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 5616-5623
    • Kredo, T.1    Mauff, K.2    Van Der Walt, J.S.3
  • 33
    • 6344240478 scopus 로고    scopus 로고
    • Induction of CYP3A4 by efavirenz in primary human hepatocytes: Comparison with rifampin and phenobarbital
    • 1:CAS:528:DC%2BD2cXhtVajsbvP 15496645 10.1177/0091270004269142
    • Hariparsad N, Nallani SC, Sane RS, et al. Induction of CYP3A4 by efavirenz in primary human hepatocytes: comparison with rifampin and phenobarbital. J Clin Pharmacol. 2004;44:1273-81.
    • (2004) J Clin Pharmacol , vol.44 , pp. 1273-1281
    • Hariparsad, N.1    Nallani, S.C.2    Sane, R.S.3
  • 34
    • 33845881481 scopus 로고    scopus 로고
    • Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers
    • 1:CAS:528:DC%2BD2sXjsFeruw%3D%3D 17041008 10.1124/jpet.106.112136
    • Faucette SR, Zhang TC, Moore R, et al. Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers. J Pharmacol Exp Ther. 2007;320:72-80.
    • (2007) J Pharmacol Exp Ther , vol.320 , pp. 72-80
    • Faucette, S.R.1    Zhang, T.C.2    Moore, R.3
  • 35
    • 84858394506 scopus 로고    scopus 로고
    • Biotransformation of the antiretroviral drug etravirine: Metabolite identification, reaction phenotyping, and characterization of autoinduction of cytochrome P450-dependent metabolism
    • 1:CAS:528:DC%2BC38XkvVOhsbk%3D 22269145 10.1124/dmd.111.044404
    • Yanakakis LJ, Bumpus NN. Biotransformation of the antiretroviral drug etravirine: metabolite identification, reaction phenotyping, and characterization of autoinduction of cytochrome P450-dependent metabolism. Drug Metab Dispos. 2012;40:803-14.
    • (2012) Drug Metab Dispos , vol.40 , pp. 803-814
    • Yanakakis, L.J.1    Bumpus, N.N.2
  • 36
    • 84876398361 scopus 로고    scopus 로고
    • Lower artemether, dihydroartemisinin and lumefantrine concentrations during rifampicin-based tuberculosis treatment
    • 1:CAS:528:DC%2BC3sXntV2hs78%3D 23698061 10.1097/QAD.0b013e32835cae3b
    • Lamorde M, Byakika-Kibwika P, Mayito J, et al. Lower artemether, dihydroartemisinin and lumefantrine concentrations during rifampicin-based tuberculosis treatment. AIDS. 2013;27:961-5.
    • (2013) AIDS , vol.27 , pp. 961-965
    • Lamorde, M.1    Byakika-Kibwika, P.2    Mayito, J.3
  • 37
    • 84873831726 scopus 로고    scopus 로고
    • Nevirapine-based antiretroviral therapy impacts artesunate and dihydroartemisinin disposition in HIV-infected Nigerian adults
    • 10.1155/2012/703604
    • Fehintola FA, Scarsi KK, Ma Q, et al. Nevirapine-based antiretroviral therapy impacts artesunate and dihydroartemisinin disposition in HIV-infected Nigerian adults. AIDS Res Treat. 2012;2012:1-6.
    • (2012) AIDS Res Treat , vol.2012 , pp. 1-6
    • Fehintola, F.A.1    Scarsi, K.K.2    Ma, Q.3
  • 38
    • 84859561800 scopus 로고    scopus 로고
    • Drug-drug interaction analysis of pyronaridine/artesunate and ritonavir in healthy volunteers
    • 1:CAS:528:DC%2BC38Xlt1Kgsbk%3D 22403324 10.4269/ajtmh.2012.11-0558
    • Morris CA, Lopez-Lazaro L, Jung D, et al. Drug-drug interaction analysis of pyronaridine/artesunate and ritonavir in healthy volunteers. Am J Trop Med Hyg. 2012;86:489-95.
    • (2012) Am J Trop Med Hyg , vol.86 , pp. 489-495
    • Morris, C.A.1    Lopez-Lazaro, L.2    Jung, D.3
  • 39
    • 0141483123 scopus 로고    scopus 로고
    • Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data
    • 1:CAS:528:DC%2BD3sXnt1KitrY%3D 12920490 10.1007/s00228-003-0636-9
    • Li XQ, Bjorkman A, Andersson TB, et al. Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data. Eur J Clin Pharmacol. 2003;59:429-42.
    • (2003) Eur J Clin Pharmacol , vol.59 , pp. 429-442
    • Li, X.Q.1    Bjorkman, A.2    Andersson, T.B.3
  • 40
    • 0001474469 scopus 로고    scopus 로고
    • Nevirapine induces both CYP3A4 and CYP2B6 metabolic pathways
    • 10.1016/S0009-9236(99)80079-4
    • Lamson M, MacGregor T, Riska P, et al. Nevirapine induces both CYP3A4 and CYP2B6 metabolic pathways. Clin Pharmacol Ther. 1999;65:137.
    • (1999) Clin Pharmacol Ther , vol.65 , pp. 137
    • Lamson, M.1    Macgregor, T.2    Riska, P.3
  • 41
    • 28844482323 scopus 로고    scopus 로고
    • Effect of low-dose ritonavir (100 mg twice daily) on the activity of cytochrome P450 2D6 in healthy volunteers
    • 1:CAS:528:DC%2BD2MXhtlShsLbM 16338282 10.1016/j.clpt.2005.09.001
    • Aarnoutse RE, Kleinnijenhuis J, Koopmans PP, et al. Effect of low-dose ritonavir (100 mg twice daily) on the activity of cytochrome P450 2D6 in healthy volunteers. Clin Pharmacol Ther. 2005;78:664-74.
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 664-674
    • Aarnoutse, R.E.1    Kleinnijenhuis, J.2    Koopmans, P.P.3
  • 42
    • 84864685075 scopus 로고    scopus 로고
    • Review of pyronaridine anti-malarial properties and product characteristics
    • 3483207 22877082 10.1186/1475-2875-11-270
    • Croft SL, Duparc S, Arbe-Barnes SJ, et al. Review of pyronaridine anti-malarial properties and product characteristics. Malar J. 2012;11:270-98.
    • (2012) Malar J , vol.11 , pp. 270-298
    • Croft, S.L.1    Duparc, S.2    Arbe-Barnes, S.J.3
  • 43
    • 0035684848 scopus 로고    scopus 로고
    • Comparative pharmacokinetics and effect kinetics of orally administered artesunate in healthy volunteers and patients with uncomplicated falciparum malaria
    • 1:CAS:528:DC%2BD38XmvVOmug%3D%3D 11791963
    • Teja-Isavadharm P, Watt G, Eamsila C, et al. Comparative pharmacokinetics and effect kinetics of orally administered artesunate in healthy volunteers and patients with uncomplicated falciparum malaria. Am J Trop Med Hyg. 2001;65:717-21.
    • (2001) Am J Trop Med Hyg , vol.65 , pp. 717-721
    • Teja-Isavadharm, P.1    Watt, G.2    Eamsila, C.3
  • 44
    • 42049111191 scopus 로고    scopus 로고
    • Differences in the pharmacokinetics of protease inhibitors between healthy volunteers and HIV-infected persons
    • 19372982 10.1097/COH.0b013e3282f82bf1
    • Dickinson L, Khoo S, Back D, et al. Differences in the pharmacokinetics of protease inhibitors between healthy volunteers and HIV-infected persons. Curr Opin HIV AIDS. 2008;3:296-305.
    • (2008) Curr Opin HIV AIDS , vol.3 , pp. 296-305
    • Dickinson, L.1    Khoo, S.2    Back, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.