-
1
-
-
0025978216
-
A phase I clinical, plasma, and cellular pharmacology study of gemcitabine
-
Abbruzzese JL, Grunewald R, Weeks EA, Gravel D, Adams T, Nowak B, Mineishi S, Tarassoff P, Satterlee W, Raber MN, et al. 1991. A phase I clinical, plasma, and cellular pharmacology study of gemcitabine. J Clin Oncol 9: 491-498.
-
(1991)
J Clin Oncol
, vol.9
, pp. 491-498
-
-
Abbruzzese, J.L.1
Grunewald, R.2
Weeks, E.A.3
Gravel, D.4
Adams, T.5
Nowak, B.6
Mineishi, S.7
Tarassoff, P.8
Satterlee, W.9
Raber, M.N.10
-
2
-
-
79953154967
-
CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans
-
Beatty GL, Chiorean EG, Fishman MP, Saboury B, Teitelbaum UR, Sun W, Huhn RD, Song W, Li D, Sharp LL, et al. 2011. CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science 331: 1612-1616.
-
(2011)
Science
, vol.331
, pp. 1612-1616
-
-
Beatty, G.L.1
Chiorean, E.G.2
Fishman, M.P.3
Saboury, B.4
Teitelbaum, U.R.5
Sun, W.6
Huhn, R.D.7
Song, W.8
Li, D.9
Sharp, L.L.10
-
3
-
-
0036462584
-
Determinants of resistance to 2′,2′-difluorodeoxycytidine (gemcitabine)
-
Bergman AM, Pinedo HM, Peters GJ. 2002. Determinants of resistance to 2′,2′-difluorodeoxycytidine (gemcitabine). Drug Resist Updat 5: 19-33.
-
(2002)
Drug Resist Updat
, vol.5
, pp. 19-33
-
-
Bergman, A.M.1
Pinedo, H.M.2
Peters, G.J.3
-
4
-
-
0030615230
-
A PMLRARalpha transgene initiates murine acute promyelocytic leukemia
-
Brown D, Kogan S, Lagasse E, Weissman I, Alcalay M, Pelicci PG, Atwater S, Bishop JM. 1997. A PMLRARalpha transgene initiates murine acute promyelocytic leukemia. Proc Natl Acad Sci 94: 2551-2556.
-
(1997)
Proc Natl Acad Sci
, vol.94
, pp. 2551-2556
-
-
Brown, D.1
Kogan, S.2
Lagasse, E.3
Weissman, I.4
Alcalay, M.5
Pelicci, P.G.6
Atwater, S.7
Bishop, J.M.8
-
5
-
-
8244254377
-
Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
-
Burris HA III, Moore MJ, Andersen J, Green MR, Rothenberg ML, Modiano MR, Cripps MC, Portenoy RK, Storniolo AM, Tarassoff P, et al. 1997. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial. J Clin Oncol 15: 2403-2413.
-
(1997)
J Clin Oncol
, vol.15
, pp. 2403-2413
-
-
Burris, H.A.1
Moore, M.J.2
Andersen, J.3
Green, M.R.4
Rothenberg, M.L.5
Modiano, M.R.6
Cripps, M.C.7
Portenoy, R.K.8
Storniolo, A.M.9
Tarassoff, P.10
-
6
-
-
79955975429
-
Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer
-
Carver BS, Chapinski C, Wongvipat J, Hieronymus H, Chen Y, Chandarlapaty S, Arora VK, Le C, Koutcher J, Scher H, et al. 2011. Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. Cancer Cell 19: 575-586.
-
(2011)
Cancer Cell
, vol.19
, pp. 575-586
-
-
Carver, B.S.1
Chapinski, C.2
Wongvipat, J.3
Hieronymus, H.4
Chen, Y.5
Chandarlapaty, S.6
Arora, V.K.7
Le, C.8
Koutcher, J.9
Scher, H.10
-
7
-
-
84862777541
-
A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response
-
Chen Z, Cheng K, Walton Z, Wang Y, Ebi H, Shimamura T, Liu Y, Tupper T, Ouyang J, Li J, et al. 2012. A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response. Nature 483: 613-617.
-
(2012)
Nature
, vol.483
, pp. 613-617
-
-
Chen, Z.1
Cheng, K.2
Walton, Z.3
Wang, Y.4
Ebi, H.5
Shimamura, T.6
Liu, Y.7
Tupper, T.8
Ouyang, J.9
Li, J.10
-
8
-
-
84860374357
-
Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma
-
Cook N, Frese KK, Bapiro TE, Jacobetz MA, Gopinathan A, Miller JL, Rao SS, Demuth T, Howat WJ, Jodrell DI, et al. 2012. Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma. J Exp Med 209: 437-444.
-
(2012)
J Exp Med
, vol.209
, pp. 437-444
-
-
Cook, N.1
Frese, K.K.2
Bapiro, T.E.3
Jacobetz, M.A.4
Gopinathan, A.5
Miller, J.L.6
Rao, S.S.7
Demuth, T.8
Howat, W.J.9
Jodrell, D.I.10
-
9
-
-
80052557069
-
Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors
-
De Raedt T, Walton Z, Yecies JL, Li D, Chen Y, Malone CF, Maertens O, Jeong SM, Bronson RT, Lebleu V, et al. 2011. Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors. Cancer Cell 20: 400-413.
-
(2011)
Cancer Cell
, vol.20
, pp. 400-413
-
-
de Raedt, T.1
Walton, Z.2
Yecies, J.L.3
Li, D.4
Chen, Y.5
Malone, C.F.6
Maertens, O.7
Jeong, S.M.8
Bronson, R.T.9
Lebleu, V.10
-
10
-
-
74949093142
-
A high-throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2-deficient tumors
-
Evers B, Schut E, van der Burg E, Braumuller TM, Egan DA, Holstege H, Edser P, Adams DJ, Wade-Martins R, Bouwman P, et al. 2010. A high-throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2-deficient tumors. Clin Cancer Res 16: 99-108.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 99-108
-
-
Evers, B.1
Schut, E.2
van der Burg, E.3
Braumuller, T.M.4
Egan, D.A.5
Holstege, H.6
Edser, P.7
Adams, D.J.8
Wade-Martins, R.9
Bouwman, P.10
-
11
-
-
84865739094
-
Dual targeting of the Akt/mTOR signaling pathway inhibits castration-resistant prostate cancer in a genetically engineered mouse model
-
Floc'h N, Kinkade CW, Kobayashi T, Aytes A, Lefebvre C, Mitrofanova A, Cardiff RD, Califano A, Shen MM, Abate-Shen C. 2012. Dual targeting of the Akt/mTOR signaling pathway inhibits castration-resistant prostate cancer in a genetically engineered mouse model. Cancer Res 72: 4483-4493.
-
(2012)
Cancer Res
, vol.72
, pp. 4483-4493
-
-
Floc'H, N.1
Kinkade, C.W.2
Kobayashi, T.3
Aytes, A.4
Lefebvre, C.5
Mitrofanova, A.6
Cardiff, R.D.7
Califano, A.8
Shen, M.M.9
Abate-Shen, C.10
-
12
-
-
84863849090
-
Nab-Paclitaxel potentiates gemcitabine activity by reducing cytidine deaminase levels in a mouse model of pancreatic cancer
-
Frese KK, Neesse A, Cook N, Bapiro TE, Lolkema MP, Jodrell DI, Tuveson DA. 2012. nab-Paclitaxel potentiates gemcitabine activity by reducing cytidine deaminase levels in a mouse model of pancreatic cancer. Cancer Discov 2: 260-269.
-
(2012)
Cancer Discov
, vol.2
, pp. 260-269
-
-
Frese, K.K.1
Neesse, A.2
Cook, N.3
Bapiro, T.E.4
Lolkema, M.P.5
Jodrell, D.I.6
Tuveson, D.A.7
-
13
-
-
35648965243
-
Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas
-
Gong Y, Somwar R, Politi K, Balak M, Chmielecki J, Jiang X, Pao W. 2007. Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas. PLoS Med 4: e294.
-
(2007)
PLoS Med
, vol.4
-
-
Gong, Y.1
Somwar, R.2
Politi, K.3
Balak, M.4
Chmielecki, J.5
Jiang, X.6
Pao, W.7
-
14
-
-
78649291031
-
Deploying mouse models of pancreatic cancer for chemoprevention studies
-
Grippo PJ, Tuveson DA. 2010. Deploying mouse models of pancreatic cancer for chemoprevention studies. Cancer Prev Res (Phila) 3: 1382-1387.
-
(2010)
Cancer Prev Res (Phila)
, vol.3
, pp. 1382-1387
-
-
Grippo, P.J.1
Tuveson, D.A.2
-
15
-
-
0031033221
-
Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR under control of cathepsin G regulatory sequences
-
Grisolano JL, Wesselschmidt RL, Pelicci PG, Ley TJ. 1997. Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR under control of cathepsin G regulatory sequences. Blood 89: 376-387.
-
(1997)
Blood
, vol.89
, pp. 376-387
-
-
Grisolano, J.L.1
Wesselschmidt, R.L.2
Pelicci, P.G.3
Ley, T.J.4
-
16
-
-
0031000207
-
Acute leukemia with promyelocytic features in PML/RAR transgenic mice
-
He LZ, Tribioli C, Rivi R, Peruzzi D, Pelicci PG, Soares V, Cattoretti G, Pandolfi PP. 1997. Acute leukemia with promyelocytic features in PML/RAR transgenic mice. Proc Natl Acad Sci 94: 5302-5307.
-
(1997)
Proc Natl Acad Sci
, vol.94
, pp. 5302-5307
-
-
He, L.Z.1
Tribioli, C.2
Rivi, R.3
Peruzzi, D.4
Pelicci, P.G.5
Soares, V.6
Cattoretti, G.7
Pandolfi, P.P.8
-
17
-
-
34548863946
-
Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
-
Herschkowitz JI, Simin K, Weigman VJ, Mikaelian I, Usary J, Hu Z, Rasmussen KE, Jones LP, Assefnia S, Chandrasekharan S, et al. 2007. Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol 8: R76.
-
(2007)
Genome Biol
, vol.8
-
-
Herschkowitz, J.I.1
Simin, K.2
Weigman, V.J.3
Mikaelian, I.4
Usary, J.5
Hu, Z.6
Rasmussen, K.E.7
Jones, L.P.8
Assefnia, S.9
Chandrasekharan, S.10
-
18
-
-
2942511506
-
Antitumor activity of erlotinib (OSI-774, Tarceva) alone or in combination in human non-small cell lung cancer tumor xenograft models
-
Higgins B, Kolinsky K, Smith M, Beck G, Rashed M, Adames V, Linn M, Wheeldon E, Gand L, Birnboeck H, et al. 2004. Antitumor activity of erlotinib (OSI-774, Tarceva) alone or in combination in human non-small cell lung cancer tumor xenograft models. Anti-cancer Drugs 15: 503-512.
-
(2004)
Anti-cancer Drugs
, vol.15
, pp. 503-512
-
-
Higgins, B.1
Kolinsky, K.2
Smith, M.3
Beck, G.4
Rashed, M.5
Adames, V.6
Linn, M.7
Wheeldon, E.8
Gand, L.9
Birnboeck, H.10
-
19
-
-
84871157346
-
Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
-
Jacobetz MA, Chan DS, Neesse A, Bapiro TE, Cook N, Frese KK, Feig C, Nakagawa T, Caldwell ME, Zecchini HI, et al. 2012. Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer. Gut 62: 112-120.
-
(2012)
Gut
, vol.62
, pp. 112-120
-
-
Jacobetz, M.A.1
Chan, D.S.2
Neesse, A.3
Bapiro, T.E.4
Cook, N.5
Frese, K.K.6
Feig, C.7
Nakagawa, T.8
Caldwell, M.E.9
Zecchini, H.I.10
-
20
-
-
84893283555
-
Activity and tolerability of afatinib (BIBW 2992) and cetuximab in NSCLC patients with acquired resistance to erlotinib or gefitinib
-
Janjigian Y, Groen H, Horn H, Smit E, Fu Y, Wang F, Shahidi M, Denis L, Pao W, Miller V. 2011. Activity and tolerability of afatinib (BIBW 2992) and cetuximab in NSCLC patients with acquired resistance to erlotinib or gefitinib. PASCO 54: 936-943.
-
(2011)
PASCO
, vol.54
, pp. 936-943
-
-
Janjigian, Y.1
Groen, H.2
Horn, H.3
Smit, E.4
Fu, Y.5
Wang, F.6
Shahidi, M.7
Denis, L.8
Pao, W.9
Miller, V.10
-
21
-
-
84872837247
-
Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors
-
Jaspers JE, Kersbergen A, Boon U, Sol W, van Deemter L, Zander SA, Drost R, Wientjens E, Ji J, Aly A, et al. 2013. Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors. Cancer Discov 3: 68-81.
-
(2013)
Cancer Discov
, vol.3
, pp. 68-81
-
-
Jaspers, J.E.1
Kersbergen, A.2
Boon, U.3
Sol, W.4
van Deemter, L.5
Zander, S.A.6
Drost, R.7
Wientjens, E.8
Ji, J.9
Aly, A.10
-
22
-
-
84855520069
-
CDDO-methyl ester delays breast cancer development in BRCA1-mutated mice
-
Kim EH, Deng C, Sporn MB, Royce DB, Risingsong R, Williams CR, Liby KT. 2012. CDDO-methyl ester delays breast cancer development in BRCA1-mutated mice. Cancer Prev Res (Phila) 5: 89-97.
-
(2012)
Cancer Prev Res (Phila)
, vol.5
, pp. 89-97
-
-
Kim, E.H.1
Deng, C.2
Sporn, M.B.3
Royce, D.B.4
Risingsong, R.5
Williams, C.R.6
Liby, K.T.7
-
23
-
-
84870289371
-
Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma
-
Kwong LN, Costello JC, Liu H, Jiang S, Helms TL, Langsdorf AE, Jakubosky D, Genovese G, Muller FL, Jeong JH, et al. 2012. Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma. Nat Med 18: 1503-1510.
-
(2012)
Nat Med
, vol.18
, pp. 1503-1510
-
-
Kwong, L.N.1
Costello, J.C.2
Liu, H.3
Jiang, S.4
Helms, T.L.5
Langsdorf, A.E.6
Jakubosky, D.7
Genovese, G.8
Muller, F.L.9
Jeong, J.H.10
-
24
-
-
49149118719
-
BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models
-
Li D, Ambrogio L, Shimamura T, Kubo S, Takahashi M, Chirieac LR, Padera RF, Shapiro GI, Baum A, Himmelsbach F, et al. 2008. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene 27: 4702-4711.
-
(2008)
Oncogene
, vol.27
, pp. 4702-4711
-
-
Li, D.1
Ambrogio, L.2
Shimamura, T.3
Kubo, S.4
Takahashi, M.5
Chirieac, L.R.6
Padera, R.F.7
Shapiro, G.I.8
Baum, A.9
Himmelsbach, F.10
-
25
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, Harris PL, Haserlat SM, Supko JG, Haluska FG, et al. 2004. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 350: 2129-2139.
-
(2004)
N Engl J Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
Gurubhagavatula, S.4
Okimoto, R.A.5
Brannigan, B.W.6
Harris, P.L.7
Haserlat, S.M.8
Supko, J.G.9
Haluska, F.G.10
-
26
-
-
0032522603
-
Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors
-
McClatchey AI, Saotome I, Mercer K, Crowley D, Gusella JF, Bronson RT, Jacks T. 1998. Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors. Genes Dev 12: 1121-1133.
-
(1998)
Genes Dev
, vol.12
, pp. 1121-1133
-
-
McClatchey, A.I.1
Saotome, I.2
Mercer, K.3
Crowley, D.4
Gusella, J.F.5
Bronson, R.T.6
Jacks, T.7
-
27
-
-
84859440747
-
The APL paradigm and the "co-clinical trial" project
-
Nardella C, Lunardi A, Patnaik A, Cantley LC, Pandolfi PP. 2011. The APL paradigm and the "co-clinical trial" project. Cancer Discov 1: 108-116.
-
(2011)
Cancer Discov
, vol.1
, pp. 108-116
-
-
Nardella, C.1
Lunardi, A.2
Patnaik, A.3
Cantley, L.C.4
Pandolfi, P.P.5
-
28
-
-
33749337828
-
The use of targeted mouse models for preclinical testing of novel cancer therapeutics
-
Olive KP, Tuveson DA. 2006. The use of targeted mouse models for preclinical testing of novel cancer therapeutics. Clin Cancer Res 12: 5277-5287.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 5277-5287
-
-
Olive, K.P.1
Tuveson, D.A.2
-
29
-
-
67149143399
-
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
-
Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, Honess D, Madhu B, Goldgraben MA, Caldwell ME, Allard D, et al. 2009. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 324: 1457-1461.
-
(2009)
Science
, vol.324
, pp. 1457-1461
-
-
Olive, K.P.1
Jacobetz, M.A.2
Davidson, C.J.3
Gopinathan, A.4
McIntyre, D.5
Honess, D.6
Madhu, B.7
Goldgraben, M.A.8
Caldwell, M.E.9
Allard, D.10
-
30
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel S, Herman P, Kaye FJ, Lindeman N, Boggon TJ, et al. 2004. EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy. Science 304: 1497-1500.
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
Tracy, S.4
Greulich, H.5
Gabriel, S.6
Herman, P.7
Kaye, F.J.8
Lindeman, N.9
Boggon, T.J.10
-
31
-
-
4444344330
-
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
-
Pao W, Miller V, Zakowski M, Doherty J, Politi K, Sarkaria I, Singh B, Heelan R, Rusch V, Fulton L, et al. 2004. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci 101: 13306-13311.
-
(2004)
Proc Natl Acad Sci
, vol.101
, pp. 13306-13311
-
-
Pao, W.1
Miller, V.2
Zakowski, M.3
Doherty, J.4
Politi, K.5
Sarkaria, I.6
Singh, B.7
Heelan, R.8
Rusch, V.9
Fulton, L.10
-
32
-
-
18244371651
-
Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
-
Pao W, Miller VA, Politi KA, Riely GJ, Somwar R, Zakowski MF, Kris MG, Varmus H. 2005. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med 2: e73.
-
(2005)
PLoS Med
, vol.2
-
-
Pao, W.1
Miller, V.A.2
Politi, K.A.3
Riely, G.J.4
Somwar, R.5
Zakowski, M.F.6
Kris, M.G.7
Varmus, H.8
-
33
-
-
84893324828
-
Generation of drug-resistant tumors using intermittent dosing of tyrosine kinase inhibitors in mouse
-
doi: 10.1101/pdb.prot077842
-
Pirazzoli V, Politi K. 2014. Generation of drug-resistant tumors using intermittent dosing of tyrosine kinase inhibitors in mouse. Cold Spring Harb Protoc doi: 10.1101/pdb.prot077842.
-
(2014)
Cold Spring Harb Protoc
-
-
Pirazzoli, V.1
Politi, K.2
-
34
-
-
79957936388
-
How genetically engineered mouse tumor models provide insights into human cancers
-
Politi K, Pao W. 2011. How genetically engineered mouse tumor models provide insights into human cancers. J Clin Oncol 29: 2273-2281.
-
(2011)
J Clin Oncol
, vol.29
, pp. 2273-2281
-
-
Politi, K.1
Pao, W.2
-
35
-
-
33744814638
-
Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors
-
Politi K, Zakowski MF, Fan PD, Schonfeld EA, Pao W, Varmus HE. 2006. Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors. Genes Dev 20: 1496-1510.
-
(2006)
Genes Dev
, vol.20
, pp. 1496-1510
-
-
Politi, K.1
Zakowski, M.F.2
Fan, P.D.3
Schonfeld, E.A.4
Pao, W.5
Varmus, H.E.6
-
36
-
-
77949320964
-
Erlotinib resistance in mouse models of epidermal growth factor receptor-induced lung adenocarcinoma
-
Politi K, Fan PD, Shen R, Zakowski M, Varmus H. 2010. Erlotinib resistance in mouse models of epidermal growth factor receptor-induced lung adenocarcinoma. Disease Models Mech 3: 111-119.
-
(2010)
Disease Models Mech
, vol.3
, pp. 111-119
-
-
Politi, K.1
Fan, P.D.2
Shen, R.3
Zakowski, M.4
Varmus, H.5
-
37
-
-
84858602107
-
Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma
-
Provenzano PP, Cuevas C, Chang AE, Goel VK, Von Hoff DD, Hingorani SR. 2012. Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell 21: 418-429.
-
(2012)
Cancer Cell
, vol.21
, pp. 418-429
-
-
Provenzano, P.P.1
Cuevas, C.2
Chang, A.E.3
Goel, V.K.4
von Hoff, D.D.5
Hingorani, S.R.6
-
38
-
-
70349684791
-
Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer
-
Regales L, Gong Y, Shen R, de Stanchina E, Vivanco I, Goel A, Koutcher JA, Spassova M, Ouerfelli O, Mellinghoff IK, et al. 2009. Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer. J Clin Invest 119: 3000-3010.
-
(2009)
J Clin Invest
, vol.119
, pp. 3000-3010
-
-
Regales, L.1
Gong, Y.2
Shen, R.3
de Stanchina, E.4
Vivanco, I.5
Goel, A.6
Koutcher, J.A.7
Spassova, M.8
Ouerfelli, O.9
Mellinghoff, I.K.10
-
39
-
-
34547504504
-
Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer
-
Rottenberg S, Nygren AO, Pajic M, van Leeuwen FW, van der Heijden I, van de Wetering K, Liu X, de Visser KE, Gilhuijs KG, van Tellingen O, et al. 2007. Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer. Proc Natl Acad Sci 104: 12117-12122.
-
(2007)
Proc Natl Acad Sci
, vol.104
, pp. 12117-12122
-
-
Rottenberg, S.1
Nygren, A.O.2
Pajic, M.3
van Leeuwen, F.W.4
van der Heijden, I.5
van de Wetering, K.6
Liu, X.7
de Visser, K.E.8
Gilhuijs, K.G.9
van Tellingen, O.10
-
40
-
-
55949092708
-
High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs
-
Rottenberg S, Jaspers JE, Kersbergen A, van der Burg E, Nygren AO, Zander SA, Derksen PW, de Bruin M, Zevenhoven J, Lau A, et al. 2008. High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs. Proc Natl Acad Sci 105: 17079-17084.
-
(2008)
Proc Natl Acad Sci
, vol.105
, pp. 17079-17084
-
-
Rottenberg, S.1
Jaspers, J.E.2
Kersbergen, A.3
van der Burg, E.4
Nygren, A.O.5
Zander, S.A.6
Derksen, P.W.7
de Bruin, M.8
Zevenhoven, J.9
Lau, A.10
-
41
-
-
84906525388
-
Acquisition of mouse tumor biopsies through abdominal laparotomy
-
doi: 10.1101/pdb.prot077834
-
Sastra SA, Olive KP. 2014. Acquisition of mouse tumor biopsies through abdominal laparotomy. Cold Spring Harb Protoc doi: 10.1101/pdb.prot077834.
-
(2014)
Cold Spring Harb Protoc
-
-
Sastra, S.A.1
Olive, K.P.2
-
42
-
-
76549137233
-
Intravesical delivery of rapamycin suppresses tumorigenesis in a mouse model of progressive bladder cancer
-
Seager CM, Puzio-Kuter AM, Patel T, Jain S, Cordon-Cardo C, Mc Kiernan J, Abate-Shen C. 2009. Intravesical delivery of rapamycin suppresses tumorigenesis in a mouse model of progressive bladder cancer. Cancer Prev Res (Phila) 2: 1008-1014.
-
(2009)
Cancer Prev Res (Phila)
, vol.2
, pp. 1008-1014
-
-
Seager, C.M.1
Puzio-Kuter, A.M.2
Patel, T.3
Jain, S.4
Cordon-Cardo, C.5
McKiernan, J.6
Abate-Shen, C.7
-
43
-
-
23844438209
-
Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition
-
Sun SY, Rosenberg LM, Wang X, Zhou Z, Yue P, Fu H, Khuri FR. 2005. Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition. Cancer Res 65: 7052-7058.
-
(2005)
Cancer Res
, vol.65
, pp. 7052-7058
-
-
Sun, S.Y.1
Rosenberg, L.M.2
Wang, X.3
Zhou, Z.4
Yue, P.5
Fu, H.6
Khuri, F.R.7
-
44
-
-
11244258643
-
An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis
-
Sweet-Cordero A, Mukherjee S, Subramanian A, You H, Roix JJ, Ladd-Acosta C, Mesirov J, Golub TR, Jacks T. 2005. An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis. Nat Genet 37: 48-55.
-
(2005)
Nat Genet
, vol.37
, pp. 48-55
-
-
Sweet-Cordero, A.1
Mukherjee, S.2
Subramanian, A.3
You, H.4
Roix, J.J.5
Ladd-Acosta, C.6
Mesirov, J.7
Golub, T.R.8
Jacks, T.9
-
45
-
-
80755126040
-
Administration of substances to laboratory animals: Routes of administration and factors to consider
-
Turner PV, Brabb T, Pekow C, Vasbinder MA. 2011a. Administration of substances to laboratory animals: Routes of administration and factors to consider. J Am Assoc Laboratory Animal Sci 50: 600-613.
-
(2011)
J Am Assoc Laboratory Animal Sci
, vol.50
, pp. 600-613
-
-
Turner, P.V.1
Brabb, T.2
Pekow, C.3
Vasbinder, M.A.4
-
46
-
-
80755126021
-
Administration of substances to laboratory animals: Equipment considerations, vehicle selection, and solute preparation
-
Turner PV, Pekow C, Vasbinder MA, Brabb T. 2011b. Administration of substances to laboratory animals: Equipment considerations, vehicle selection, and solute preparation. J Am Assoc Laboratory Animal Sci 50: 614-627.
-
(2011)
J Am Assoc Laboratory Animal Sci
, vol.50
, pp. 614-627
-
-
Turner, P.V.1
Pekow, C.2
Vasbinder, M.A.3
Brabb, T.4
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