The anti-inflammatory effect of a pomegranate husk extract on inflamed adipocytes and macrophages cultivated independently, but not on the inflammatory vicious cycle between adipocytes and macrophages

Food and Function

Volumn 5, Issue 2, 2014, Pages 310-318

  Winand, Julie ^a   Schneider, Yves Jacques ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOSE TISSUE; ANTI-INFLAMMATORY ACTION; ANTI-INFLAMMATORY EFFECTS; CO-CULTURE SYSTEM; ELLAGITANNIN; IL-6 EXPRESSION; RAW 264.7 MACROPHAGES; SYSTEMIC INFLAMMATION;

CYTOLOGY; ELLAGIC ACID; MOLECULAR WEIGHT; PATHOLOGY; PHYSIOLOGY; SELF ASSEMBLY; TISSUE;

MACROPHAGES;

ANTIINFLAMMATORY AGENT; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; PLANT EXTRACT; TUMOR NECROSIS FACTOR ALPHA;

3T3 CELL LINE; ADIPOCYTE; ANIMAL; ARTICLE; CHEMISTRY; DRUG EFFECT; IMMUNOLOGY; LYTHRACEAE; MACROPHAGE; MOUSE; WASTE;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; ANTI-INFLAMMATORY AGENTS; CHEMOKINE CCL2; INTERLEUKIN-6; MACROPHAGES; MICE; PLANT EXTRACTS; PUNICACEAE; TUMOR NECROSIS FACTOR-ALPHA; WASTE PRODUCTS;

EID: 84893214579     PISSN: 20426496     EISSN: 2042650X     Source Type: Journal    
DOI: 10.1039/c3fo60443h     Document Type: Article

References (26)

1. W. H. O. (WHO), Obesity and overweight-Fact sheet no. 311, http://www.who.int/mediacentre/factsheets/fs311/en/
2. N. Ouchi J. L. Parker J. J. Lugus K. Walsh Adipokines in inflammation and metabolic disease Nat. Rev. Immunol. 2011 11 85 97
3. N. Kamei K. Tobe R. Suzuki et al., Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance J. Biol. Chem. 2006 281 26602 26614
4. S. Medjakovic A. Jungbauer Pomegranate: a fruit that ameliorates metabolic syndrome Food Funct. 2013 4 1 19 39
5. B. Cerdá R. Llorach J. J. Cerón J. C. Espín F. A. Tomás-Barberán Evaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice Eur. J. Nutr. 2003 42 18 28
6. N. P. Seeram R. Lee D. Heber Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice Clin. Chim. Acta 2004 348 63 68
7. S. Hollebeeck J. Winand M.-F. Hérent et al., Anti-inflammatory effects of pomegranate (Punica granatum L.) husk ellagitannins in Caco-2 cells, an in vitro model of human intestine Food Funct. 2012 3 875 885
8. S. H. Tsai S. Y. Lin-Shiau J. K. Lin Suppression of nitric oxide synthase and the down-regulation of the activation of NFkappaB in macrophages by resveratrol Br. J. Pharmacol. 1999 126 673 680
9. T. Suganami K. Tanimoto-Koyama J. Nishida et al., Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages Arterioscler., Thromb., Vasc. Biol. 2007 27 84 91
10. M. Nasser Al-Muammar F. Khan Obesity: the preventive role of the pomegranate (Punica granatum) Nutrition 2012 28 595 604
11. M. Baranowski J. Enns H. Blewett U. Yakandawala P. Zahradka C. G. Taylor Dietary flaxseed oil reduces adipocyte size, adipose monocyte chemoattractant protein-1 levels and T-cell infiltration in obese, insulin-resistant rats Cytokine 2012 59 382 391
12. A. Yamashita Y. Soga Y. Iwamoto et al., DNA microarray analyses of genes expressed differentially in 3T3-L1 adipocytes co-cultured with murine macrophage cell line RAW264.7 in the presence of the toll-like receptor 4 ligand bacterial endotoxin Int. J. Obes. 2008 32 1725 1729
13. D. Wu X. Ma W. Tian Pomegranate husk extract, punicalagin and ellagic acid inhibit fatty acid synthase and adipogenesis of 3T3-L1 adipocyte J. Funct. Foods 2013 5 633 641
14. J. Kurokawa S. Arai K. Nakashima et al., Macrophage-Derived AIM Is Endocytosed into Adipocytes and Decreases Lipid Droplets via Inhibition of Fatty Acid Synthase Activity Cell Metab. 2010 11 479 492
15. J. N. Fain S. W. Bahouth A. K. Madan TNFalpha release by the nonfat cells of human adipose tissue Int. J. Obes. 2004 28 616 622
16. A. Yamashita Y. Soga Y. Iwamoto et al., Macrophage-Adipocyte Interaction: Marked Interleukin-6 Production by Lipopolysaccharide Obesity 2007 15 2549 2552
17. T. Hien Tu C.-S. Kim T. Goto T. Kawada B.-S. Kim R. Yu 4-1BB/4-1BBL Interaction Promotes Obesity-Induced Adipose Inflammation by Triggering Bidirectional Inflammatory Signaling in Adipocytes/Macrophages Mediators Inflammation 2012 972629
18. V. Rotter I. Nagaev U. Smith Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects J. Biol. Chem. 2003 278 45777 45784
19. E. Maury S. M. Brichard Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome Mol. Cell. Endocrinol. 2010 314 1 16
20. R. Hontecillas M. O'Shea A. Einerhand M. Diguardo J. Bassaganya-Riera Activation of PPAR γ and α by Punicic Acid Ameliorates Glucose Tolerance and Suppresses Obesity-Related Inflammation J. Am. Coll. Nutr. 2009 28 184 195
21. M. Shiner B. Fuhrman M. Aviram Macrophage paraoxonase 2 (PON2) expression is up-regulated by pomegranate juice phenolic anti-oxidants via PPAR gamma and AP-1 pathway activation Atherosclerosis 2007 195 313 321
22. P. Tontonoz B. M. Spiegelman Fat and beyond: the diverse biology of PPARgamma Annu. Rev. Biochem. 2008 77 289 312
23. A. Okuno H. Tamemoto K. Tobe et al., Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats J. Clin. Invest. 1998 101 1354 1361
24. K. C. Choi O. H. Ryu K. W. Lee et al., Effect of PPAR-[alpha] and -[gamma] agonist on the expression of visfatin, adiponectin, and TNF-[alpha] in visceral fat of OLETF rats Biochem. Biophys. Res. Commun. 2005 336 747 753
25. F. De Nigris M. L. Balestrieri S. Williams-Ignarro et al., The influence of pomegranate fruit extract in comparison to regular pomegranate juice and seed oil on nitric oxide and arterial function in obese Zucker rats Nitric Oxide 2007 17 50 54
26. L. Shema-Didi S. Sela L. Ore et al., One year of pomegranate juice intake decreases oxidative stress, inflammation, and incidence of infections in hemodialysis patients: A randomized placebo-controlled trial Free Radicals Biol. Med. 2012 53 297 304